• KSCE Journal of Civil and Environmental Engineering Research
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• v.38 no.4
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• pp.517-526
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• 2018

As groundwater recharge shows the heterogeneity in space and time due to land use and soil types, estimating daily recharge by integrated hydrologic analysis is needed. In this work, the SWAT-MODFLOW model was applied to compute daily based groundwater recharge in Jangseong region. The accuracy of the model was evaluated by comparing the observed and calculated values of the unsteady groundwater flow levels after calibrating the observed and calculated flow rates of the stream for a hydrological analysis. The estimated hydrologic components showed a strong correlation with each other and significant spatial variations regarding the groundwater recharge rate in accordance with the heterogeneous watershed characteristics such as subbasin slope, land use, and soil type. Overall, it was concluded that the coupled hydrologic models were capable of simulating the spatial variation with respect to the hydrologic component process in surface water and groundwater. The average recharge rate was estimated at approximately 20.8%.

• 한국생물공학회:학술대회논문집
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• 2005.04a
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• pp.37-37
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• 2005

Human chorionic gonadotropin (hCG) is a heterodimeric glycoprotein hormone consisting of non-covalently linked two subunits, the ${\alpha}$ and ${\beta}$ subunit. It has been used as a infertility drug for ovulation to mimic luteinizing hormone $(LH).^{1)}$ A stable cell line was established by transfection of Rc/CMV-i-dhfr-hCG, expression vector containing hCG ${\alpha}-$ and ${\beta}-genes$, into dihydrofolate reductase-deficient CHO cells and subesquent methotrexate-mediated gene amplification. Anchorage-dependent CHO cells were adapted into a serum-free and/or animal component-free suspension medium through gradual serum weaning for the hCG production. The established cell line showed typical morphological characteristics and growth profile of CHO cells, and could produce FSH with passage-to-passage consistency. The high density perfusion culture of the CHO cells was carried out in Celligen Plus bioreactor equipped with a spin-filter as a internal cell retention device. The cell density reached up to $>1x10^{7}$ cells/ml in less than 7 days and a perfusion-control strategy based on cellular consumption rates of glucose was $established.^{2)}$ Biologically active recombinant hCG was purified by a series of chromatographic steps including anion exchange chromatography and hydrophobic interaction chromatography to homogeneity. The highly purified recombinant hCG was characterized for physicochemical, immunological and biological properties.

• Journal of Korean Society of Steel Construction
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• v.26 no.3
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• pp.155-167
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• 2014

Steel-concrete composite beam has been used for a considerable time in building construction. An essential component of a composite beam is the shear connection between the steel section and the concrete slabs, which is provided by mechanical shear connectors. A variety of shapes and devices have been in use as shear connectors. This study summarizes the results of an experimental investigation involving the testing of push-out specimens with angle shear connectors. All of 22 push-out specimens were designed to study the effect of a number of parameters on the shear capacity of angle shear connectors such as the height of the angle connector, the length of welding, and the pitch of angles. Based on the test results, a design equation was developed for predicting the shear strength of angle shear connectors.

• Journal of the Korean Institute of Gas
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• v.1 no.1
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• pp.81-86
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• 1997

This study is to estimate the possibility of accident in chemical plants from the analysis of system component which affects the occurrence of top event. Among the various risk assessment techniques, the Fault Tree Analysis which approaches deductively on the route of accident development was used in this study. By gate-by-gate method and minimal cut set, the qualitative and quantitative risk assessment for hazards in plants was performed. The probability of occurrence and frequency of top event was calculated from failure or reliability data of system components at stage of the quantitative risk assessment. In conclusion, the probability of accident was estimated according to logic pattern based on the Fault Tree Analysis. And the failure path which mostly influences on the occurrence of top event was found from Importance Analysis.

• The KIPS Transactions:PartD
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• v.8D no.2
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• pp.181-192
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• 2001

XML/EDI is different from traditional EDI because it offers the framework necessary for electronic commerce and extends the scope of the traditional EDI which focuses on data transfer. Since existing EDI services are moved to Internet platform and again to Web platform, users can use EDI in the integrated environment without inconvenience of using different EDI softwares, which have their own configurations. This paper describes the overall design and implementation of a Web-based XML/EDI system that is a core component for the electronic commerce. The constructed XML/EDI system in this paper is comprised of document generation module, document storage module, document search module, document management module, template document management module and e-mail transmission module. Requirements and design goal of XML/EDI system are introduced, detailed functionalities of modules and design facts are described and execution and execution procedures of the implemented system are explained.

• International Journal of Highway Engineering
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• v.16 no.5
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• pp.9-18
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• 2014

PURPOSES : The objective of this study is to evaluate the applicability of the pitch, which is produced during SDA petroleum upgrading process, as a pavement paving material. In order for the purpose, the physical and chemical properties of the pitch are analyzed, and then the various plasticizers are applied in the pitch. METHODS : Two types of pitch are selected from oil refinery companies, which are owned the SDA petroleum upgrading process. Also, two types of asphalt binders, PG 64-22 and PG 58-22, are employed to compare with the pitch because these two types of asphalt binders are currently used as paving materials. For the chemical property of the pitch, the composition of SARA (Saturate, Aromatic, Resin, Asphaltene), the elementary composition, and the functional group are analyzed. For the physical property of the pitch, the basic material property tests, such as penetration test, softening point test, flash point test, ductility test, and rotational viscometer test, are performed. Also, the DSR (Dynamic Shear Rheometer) test and the BBR (Bending Beam Rheometer) test are conducted using asphalt binder specimens obtained by both short term aging (Rolling Thin Film Oven, RTFO) and long term aging (Pressure Aging Vessel, PAV) processes. The rheological property of each pitch type is evaluated as a function of temperatures and loading cycles. PG 64-22 asphalt binder is used as a control material. RESULTS AND CONCLUSIONS : The Pitch may not be suitable for the pavement paving material without modifications, but the pitch can be used as alternatives of modified addictive or asphalt. If low molecular component, such as saturate and aromatic components, are added in the pitch based on the development of various plasticizers, it has a strong possibility for the pitch to be used as a alternative. However, in order to verify the performance property of the pitch, further research is needed.

• Journal of Biomedical Engineering Research
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• v.38 no.4
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• pp.168-174
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• 2017

To improve and downsize the KIOM-Pulse Analysis System(KIOM-PAS), which has been traditionally used in clinical trials, a miniaturized PAS(M-PAS) with a pneumatic pump has been developed. M-PAS is composed of a measurement module and an arm-mounting module, on which an arm can be placed. The measurement module is equipped with a pressing component and sensor, which is a wearable wristband. The arm-mounting module includes a pneumatic motor, data acquisition board and valves. In addition, the measurement module is divided into a fixing module of band type for attachment to a pulsation site and a sensing module, which includes a sensor and a tube. The fixing module and sensing module are constructed independently, and the detachable fastening method improves the posture convenience of the subject during measurement. M-PAS has been reduced to 1/6 the size of KIOM-PAS, and the measurement time is shortened by 22%. Using a simulator, the difference between the waveforms measured by the two devices exhibited a high degree of similarity of within 3.65%. M-PAS represents improvements in size and convenience compared with KIOM-PAS, and it is expected to be widely used in clinics in the future because it improves the attachment method of the fixing module.

• The Journal of the Korea Contents Association
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• v.12 no.3
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• pp.421-433
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• 2012

AMGA service, which is one of the EMI gLite middleware components, is widely used for analysis of distributed large scale experiments data as metadata repository by scientific and technological researchers and the use of AMGA is extended farther to include general industries needing metadata Catalogue as well. However AMGA, based unix and Grid UI, has the weakness of being absence of general-purpose user interfaces in comparison to other commercial database systems and that's why it's difficult to use and diffuse it although it has the superiority of the functionality. In this paper, we developed AMGA GUI toolkit to provide work convenience using object-oriented modeling language(UML). Currently, AMGA has been used as the main component among many user communities such as Belle II, WISDOM, MDM, and so on, but we expect that this development can not only lower the barrier to entry for AMGA beginners to use it, but lead to expand the use of AMGA service over more communities.

• Journal of the Korean Society for Advanced Composite Structures
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• v.1 no.2
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• pp.20-28
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• 2010

In this paper, new type CFFT (Concrete Filled FRP Tube) was suggested in order to improve the flexural stiffness. Since the existing CFFT was produced by filament winding process, re-bar for concrete may be necessary in order to ensure structural safety under flexure re-bar. In comparison with existing type CFFT, new type CFFT was reinforced by circular shaped pultrusion FRP without re-bar. Filament winding FRP was attached to the outer layer of pultrusion FRP. Structural behavior of new type CFFT filled with concrete (HCFFT) was investigated by the mechanical property test for the component element and the FE analysis. Furthermore, compressive strength of the HCFFT member based on the equation suggested in previous studies.

• Journal of Microbiology and Biotechnology
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• v.19 no.12
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• pp.1695-1702
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• 2009

An animal-component-free and chemically defined fed-batch process for GS-engineered cell lines producing recombinant antibodies has been developed. The fed-batch process relied on supplying sufficient nutrients to match their consumption, simultaneously minimizing the accumulation of by-products (lactate and osmolality). The proportionalities of nutritional consumption were determined by direct analysis. The robust, metabolically responsive feeding strategy was based on the offline measurement of glucose. The fed-batch process was shown to perform equivalently in GS-CHO and GS-NS0 cultures. Compared with batch cultures, the fed-batch technology generated the greater increase in cell yields (5-fold) and final antibody concentrations (4-8-fold). The majority of the increase in final antibody concentration was a function of the increased cell density and the prolonged culture time. This generic and high-yielding fed-batch process would shorten development time, and ensure process stability, thereby facilitating the manufacture of therapeutic antibodies by GS-engineered cell lines.