• Journal of Genetic Medicine
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• v.14 no.1
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• pp.8-17
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• 2017

Purpose: Pulse wave velocity (PWV) is an indicator of arterial stiffness, and is considered a marker of vascular damage. However, a genome-wide association study analyzing single nucleotide polymorphisms (SNPs) associated with brachial-ankle PWV (baPWV) has not been conducted in healthy populations. We performed this study to identify SNPs associated with baPWV in healthy populations in Korea. Materials and Methods: Genomic SNPs data for 2,407 individuals from three sites were analyzed as part of the Korean Genomic Epidemiologic Study. Without replication samples, we performed multivariable analysis as a post hoc analysis to verify the findings in site adjusted analysis. Healthy subjects aged between 40 and 70 years without self-reported history or diagnosis of hypertension, diabetes, hyperlipidemia, heart disease, cerebrovascular disease and cancer were included. We excluded subjects with a creatinine level >1.4 mg/dL (men) and 1.2 mg/dL (women). Results: In the site-adjusted association analysis, significant associations (P<$5{\times}10^{-8}$) with baPWV were detected for only 5 SNPs with low minor allele frequency. In multivariable analysis adjusted by age, sex, height, body mass index, mean arterial pressure, site, smoking, alcohol, and exercise, 11 SNPs were found to be associated (P<$5{\times}10^{-8}$) with baPWV. The 5 SNPs (P<$5{\times}10^{-8}$) linked to three genes (OPCML, PRR35 and RAB40C) were common between site-adjusted analysis and multivariable analysis. However, meta-analysis of the result from three sites for the 11 SNPs showed no significant associations. Conclusion: Using the recent standard for genome-wide association study, we did not find any evidence of significant association signals with baPWV.

• Journal of the Society of Naval Architects of Korea
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• v.30 no.3
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• pp.116-126
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• 1993

The finite element method(FEM) has been commonly used for structural dynamic analysis. However, the direct global application of FEM to large complex structures such as ships and offshore structures requires considerable computational efforts, and remarkably more in structural dynamic optimization problems. Adoption of the component-mode synthesis method is an efficient means to overcome the above difficulty. Among three classes of the component-mode synthesis method, the free-interface mode method is recognized to have the advantages of better computational efficiency and easier implementation of substructures' experimental results, but the disadvantage of lower accuracy in analytical results. In this paper, an advanced method to improve the accuracy in the application of the free-interface mode method for the vibration analysis of large complex structures is presented. In order to compensate the truncation effect of the higher modes of substructures in the synthesis process, both residual inertia and stiffness effects are taken into account and a frequency shifting technique is introduced in the formulation of the residual compliance of substructures. The introduction of the frequency shrift ins not only excludes cumbersome manipulation of singular matrices for semi-definite substructural systems but gives more accurate results around the specified shifting frequency. Numerical examples of typical structural models including a ship-like two dimensional finite element model show that the analysis results based on the presented method are well competitive in accuracy with those obtained by the direst global FEM analysis for the frequencies which are lower than the highest one employed in the synthesis with remarkably higher computational efficiency and that the presented method is more efficient and accurate than the fixed-interface mode method.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.6
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• pp.19-26
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• 2021

The lattice structure is attracting attention from industry because of its excellent strength and stiffness, ultra-lightweight, and energy absorption capability. Despite these advantages, widespread commercialization is limited by the difficult manufacturing processes for complex shapes. Additive manufacturing is attracting attention as an optimal technology for manufacturing lattice structures as a technology capable of fabricating complex geometric shapes. In this study, a unit cell was formed using a three-dimensional coordinate method. The relative density relational equation according to the boundary box size and strut radius of the unit cell was derived. Simple cubic (SC), body-centered cubic (BCC), and face-centered cubic (FCC) with a controlled relative density were designed using modeling software. The accuracy of the equations for calculating the relative density proposed in this study secured 98.3%, 98.6%, and 96.2% reliability in SC, BCC, and FCC, respectively. A simulation of the lattice structure revealed an increase in compressive yield load with increasing relative density under the same cell arrangement condition. The compressive yield load decreased in the order of SC, BCC, and FCC under the same arrangement conditions. Finally, structural optimization for the compressive load of a 20 mm × 20 mm × 20 mm structure was possible by configuring the SC unit cells in a 3 × 3 × 3 array.

• Journal of the Earthquake Engineering Society of Korea
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• v.10 no.6 s.52
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• pp.19-28
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• 2006

Most conventional model updating methods must use mathematical objective function with experimental modal matrices and analytical system matrices or must use information about the gradient or higher derivatives of modal properties with respect to each updating parameter. Therefore, most conventional methods are not appropriate for complex structural system such as bridge structures due to stability problem in inverse analysis with ill-conditions. Sometimes, moreover, the updated model may have no physical meaning. In this paper, a new FE model updating method based on a hybrid optimization technique using genetic algorithm (GA) and Holder-Mead simplex method (NMS) is proposed. The performance of hybrid optimization technique on the nonlinear problem is demonstrated by the Goldstein-Price function with three local minima and one global minimum. The influence of the objective function is evaluated by the case study of a simulated 10-dof spring-mass model. Through simulated case studies, finally, the objective function is proposed to update mass as well as stiffness at the same time. And so, the proposed hybrid optimization technique is proved to be an efficient method for FE model updating.

• Journal of the Earthquake Engineering Society of Korea
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• v.19 no.2
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• pp.55-62
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• 2015

Shear wall systems behave as individual wall because of openings like window and elevator cage. When coupling beams are installed in shear walls, they will have high strength and stiffness so that be less damaged by lateral loads like earthquake. However, coupling beam is difficult construction method. And arranging reinforcement of slender coupling beams are especially hard. It is because the details of coupling beam provided by ACI 318 are complex. In this paper, experiments were conducted using coupling beams with 3.5 aspect ratio to improve the details of slender coupling beams provided by ACI 318. Two specimens were proposed for this study. One specimen applied with bundled diagonally reinforcement only. Another specimen applied both bundled diagonally reinforcement and High-Performance Fiber Reinforced Cementitious Composite (HPFRCC) so that coupling beams have half of transverse reinforcement. All specimen were compared with a coupling beam designed according to ACI 318 and were evaluated with hysteretic behaviors. Test results showed that the performance of two specimen suggested in this study were similar to that of coupling beam designed according to current criteria. And it was considered that simplification of the details of reinforcement would be available if transverse reinforcement was reduced by using bundled diagonally reinforcement and HPFRCC.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.11 no.1
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• pp.48-60
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• 2007

Palpation of the pulse has been used in Korean traditional medicine since ancient times to assess physical health. Pulse wave contour may be obtained by measuring arterial pressure or blood volume change of skin. The latter is called as Photoplethysmography(PPG) or digital volume pulse(DVP). The PPG signal is measured by a device comprising an infrared light sourece and a photodetector. Although less widely used, this technique deserves further consideration because of its simplicity and ease of use. The contour of the PPG is formed as a result of a complex interaction between the left ventricle and the systemic circulation. It usually exhibits an early systolic peak and an early diastolic peak. the first peak is formed mainly by pressure trasmitted along a direct path from the left ventricle to the finger. The second peak is formed in part by pressure transmitted along the aorta and large arteries to sites of impedance mismatch in the lower body. The contour of the PPG is sensitive to changes in arterial tone and is influenced by ageing and large artery stiffness. Measurements taken directly from the PPG or from its second derivative can be used to assess these properties. In some mathematical approaches, the extraction of periodic components using frequency analysis was tried to analysis of the PPG. But we don't understand yet what kind of factor in the cardiovascular system or human body is related with the respective specific Fourier components of PPG. This review describes the background to measurement principles, representative contour, contour analysis and frequency domain analysis of PPG, and current and future.

• Composites Research
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• v.13 no.3
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• pp.9-20
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• 2000

Free vibration characteristics of a cantilevered laminated composite beam with multiple non-propagating transverse open cracks are investigated. In the present analysis a special ply-angle distribution referred to as asymmetric stiffness configuration inducing the elastic coupling between chord-wise bending and extension is considered. The multiple open cracks are modelled as equivalent rotational springs whose spring constants are calculated based on the fracture mechanics of composite material structures. Governing equations of a composite beam with open cracks are derived via Hamilton's Principle and Timoshenko beam theory encompassing transverse shear and rotary inertia effect is adopted. The effects of various parameters such as the ply angle, fiber volume fraction, crack numbers, crack positions and crack depthes on the free vibration characteristics of the beam with multiple cracks are highlighted. The numerical results show that the existence of the multiple cracks in an anisotropic composite beam affects the free vibration characteristics in a more complex fashion compared with the beam with a single crack.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2006.11a
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• pp.523-530
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• 2006

A rotordynamic analysis was performed with a dry vacuum pump, which is a major equipment in modern semiconductor and LCD manufacturing processes. The system is composed of screw rotors, lobes picking air, helical gears, driving motor, and support rolling element hearings of rotors and motor. The driving motor-screw rotor system has a rated speed of 6,300rpm, and was modeled utilizing a rotordynamic FE method for analysis, which was verified through the results of its 3-D finite element model. As loadings on the bearings due to the gear action were significant in the system considered, each resultant bearing load was calculated determinately and indeterminately by considering the generalized forces of the gear action as veil as the rotor itself. Each resultant hearing loading was used in calculating each stiffness of rolling element bearings. Design goals are to achieve wide separation margins of critical speeds and favorable unbalance responses of the rotor in the operating range. Then, a complex rotordynamic analysis of the system was carried out to evaluate its forward synchronous critical speeds, whirl natural frequencies and mode shapes, and unbalance responses under various unbalance locations. Results show that the entire system is well designed in the operating range. In addition, the procedure of rotordynamic analysis for dry vacuum pump rotor-bearing system was proposed and established.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.25 no.3
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• pp.184-190
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• 2015

NVH engineering has become a hot issue due to radical technology changes and development in automotive industry since customers' expectations and needs for their vehicle is taken to a higher level. However, the source identification and quantification of the road noise within a vehicle is still not at the level where it needs to be to meet their expectations due to its' complex transfer path and difficulties in path optimization. The primary focus of this research is on direct force obtaining method at suspension hard points using suspension test rig. Directly obtained forces at suspension to body mounting points are critical and crucial for determining the effects of design changes of the suspension has on road noise performance. Direct force obtaining method has its limitation in sensor installation within an actual vehicle therefore, many has been indirectly calculating forces using full matrix inversion method or dynamic stiffness method. In this study, to circumvent this limitation, a suspension rig is used. Then, the suspension rig is verified through a comparative analysis of its dynamic behavior between the actual vehicle by cleat test on chassis dynamometer.

• Journal of Korean Tunnelling and Underground Space Association
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• v.8 no.2
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• pp.115-128
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• 2006

The structural anisotropy and heterogeneity of rock mass, caused by discontinuities and weak zones, have a great influence on the deformation behavior of a tunnel. A tunnel construction in these complex ground conditions is very difficult. No matter how excellent a geological investigation is, local uncertainties of rock mass conditions still remain. Under these uncertain circumstances, an accurate forecast of the ground conditions ahead of the advancing tunnel face is indispensable to a safe and economic tunnel construction. This paper presents the effect of anisotropy and heterogeneity of the rock masses to be excavated by numerical analysis. The influences of distance from weak zone, the size or dimension, the different stiffness and the orientation of weak zones are analysed by 3-D finite element analysis. By analysing these numerical results, the tunnel behavior due to excavation can be well understood and the prediction of rock mass condition ahead of the tunnel face can be possible.