• Asian-Australasian Journal of Animal Sciences
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• 제28권4호
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• pp.573-583
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• 2015

B-32 is one of a panel of monoclonal anti-idiotypic antibodies to growth hormone (GH) that we developed. To characterize and identify its potential role as a novel growth hormone receptor (GHR) agonist, we determined that B-32 behaved as a typical $Ab2{\beta}$ based on a series of enzyme-linked immunosorbent assay assays. The results of fluorescence-activated cell sorting, indirect immunofluorescence and competitive receptor binding assays demonstrated that B-32 specifically binds to the GHR expressed on target cells. Next, we examined the resulting signal transduction pathways triggered by this antibody in primary porcine hepatocytes. We found that B-32 can activate the GHR and Janus kinase (2)/signal transducers and activators of transcription (JAK2/STAT5) signalling pathways. The phosphorylation kinetics of JAK2/STAT5 induced by either GH or B-32 were analysed in dose-response and time course experiments. In addition, B32 could also stimulate porcine hepatocytes to secrete insulin-like growth factors-1. Our work indicates that a monoclonal anti-idiotypic antibody to GH (B-32) can serve as a GHR agonist or GH mimic and has application potential in domestic animal (pig) production.

• 한국정보시스템학회지:정보시스템연구
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• 제12권2호
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• pp.57-72
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• 2003

The purpose of this paper is to propose the modeling of multiagent based SCM and implement the prototype in the Internet environment. SCM process follows the supply chain operations reference (SCOR) model which has been suggested by Supply Chain Counsil. SCOR model has been positioned to become the industry standard for describing and improving operational process in SCM. Five basic processes, plan, source, matte, deliver and return are defined in the SCOR model, through which a company establishes its supply chain competitive objectives. A supply chain is a world wide network of suppliers, factories, warehouses, distribution centers and retailers through which raw materials are acquired, transformed or manufactured and delivered to customers by autonomous or semiautonomous process. With the pressure from the higher standard of customer compliance, a frequent model change, product complexity and globalization, the combination of supply chain process with an advanced infrastructure in terms of multiagent systems have been highly required. Since SCM is fundamentally concerned with coherence among multiple decision makers, a multiagent framework based on explicit communication between constituent agents such as suppliers, manufacturers, and distributors is a natural choice. Multiagent framework is defined to perform different activities within a supply chain. Dynamic and changing functions of supply chain can be dealt with multi-agent by cooperating with other agents. In the areas of inventory management, remote diagnostics, communications with field workers, order fulfillment including tracking and monitoring, stock visibility, real-time shop floor data collection, asset tracking and warehousing, customer-centric supply chain can be applied and implemented utilizing multiagent. In this paper, for the order processing event between the buyer and seller relationship, multiagent were defined corresponding to the SCOR process. A prototype system was developed and implemented on the actual TCP/IP environment for the purchase order processing event. The implementation result assures that multiagent based SCM enhances the speed, visibility, proactiveness and responsiveness of activities in the supply chain.

• 한국가구학회지
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• 제27권3호
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• pp.237-245
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• 2016

Single households currently account for 26.5% of all households and their number is expected to continue to rise, reaching 34.5% by 2035. An analysis of the consumption trends and needs of single households shows that they are rising as a new consumer group with a focus on investment on the individual and favouring: small but high-tech products: efficient use of limited resources: safety and peace of mind: self-improvement and leisure. Products which meet such demands are having an impact on the growth of home-furnishing market. An analysis of companies in Korea's home-furnishing market, with examples like the lifestyle company IKEA, shows a variety of brands such as SPA brand, furniture specialist, distributor and character products. And yet most are OEM products which lack differentiated product lines and compete with similar display and distribution structure. We needs the Single household consumption tendency of home-furnishing market and differentiation strategy through product analysis. In order to increase the value of companies in the home-furnishing market, in addition to differentiated design, product competitiveness must aspire to higher customer satisfaction with easy assembly, innovation in logistics, innovative sales methods such as virtual-reality simulation for products and space, individually-tailored furniture for the needs of single household and products which combine smart technology. For home-grown home-furnishing brands to have competitiveness, they must leverage on the strengths of the industry, offering differentiated and competitive products in a wider range of areas with convergence functions as well as differentiation in consumer interface and application of advancing technology; in-depth product research is called for.

• 대한가정학회지
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• 제50권1호
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• pp.141-154
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• 2012

The purpose of this study was to examine consumers' product experiences from the time when the consumer purchases a smart phone, through to the period of use, and to evaluate the product after a period of usage by comparing two groups of smart phone users of the two leading brands, Galaxy S and iPhone 4G. Product experiences were considered through the process of a consumer purchasing and using a product throughout the whole cycle of product consumption. Product experiences were compared between the two brand users according to their demographic backgrounds. The results indicated that iPhone 4G users were more likely to experience functional superiorities and emotional varieties than Galaxy S users. Especially, iPhone 4G users were more likely to experience enjoyment, aesthetics, enhanced self-images and good relationships with others through the smart phone than the Galaxy S users. Galaxy S users were more likely to identify a corporate's image as a superior feature, while iPhone 4G users were more likely to identify multi-functions and endless applications. This study implies that not only the product's functional superiorities but also the consumers' entire cycle of product experiences should be carefully examined and reflected in the development of successful new products in this competitive market.

• 약학회지
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• 제45권6호
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• pp.694-700
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• 2001

Synthetic pyrethroids are analysis of a natural chemical moiety, pyrethrin derived from the pyrethrum plant Chrysanthemum. The natural pyrethrin structure has been modified to be highly lipophilic and photostable, creating an effective pesticide and resulting in an increased presence in the environment. Worldwide, they are commonly used insecticides against ticks, mites, mosquitoes, and as treatment for human head lice and scabies. Therefore, human exposure to their compounds in extensive. Several studies on the effects of pyrethroids on thyroid hormone regulation, estrogen and androgen function have been reported and yet little has been done try assess their potential hormonal activities. Among humans, a pyrethroid compound was suggested to be the causal agent for gynecomastia in a group of Haitian men. The reports suggest that some pyrethroid compounds are capable of disrupting endocrine function. Therefore, we examined estrogenic/antiestrogenic potential of three pyrethroid insecticides, that is permethrin, allethrin and fenvalerate in human breast cancer cell and action mechanism mediated by the estrogen receptor. Fenvalerate showed weak estrogenic activity but aallethrin and permethrin showed no effect. In combination with high levels (10$^{-10}$ M, 10$^{-11}$ M) of 17$\beta$-estradiol and three synthetic pyrethroids inhibited cert proliferations in MCF7-BUS cell by 17$\beta$-estradiol. Whereas, fenvalerate increased cell proliferative activity at lower level of estradiol (10$^{-12}$ M, 10$^{-13}$ M). The relative affinities to the estrogen receptor were observed by allethrin and permethrin treatment, but not by fenvalerate. These results indicated that some of pyrethroid insecticides may modulate estrogen functions in human breast cancer cell. The action mechanisms of estrogen receptor mediated antiestrogenicity by allethrin and permethrin were postulated.

• 정보과학회 컴퓨팅의 실제 논문지
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• 제21권3호
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• pp.269-274
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• 2015

최근 구글, 애플 등 스마트 디바이스 업체들이 모바일 운영체제를 활용한 차량용 운영체제 및 내비게이션을 경쟁적으로 공개함에 따라 차량용 운영체제 및 내비게이션 시장에서 사용자의 선택의 폭이 넓어지고 있다. 모바일 운영체제를 탑재한 내비게이션은 기존 내비게이션과 차별화된 기능을 제공하여 사용자의 편의성을 높였다. 그러나, 내비게이션에서 사용하는 POI 데이터베이스를 내비게이션 상의 응용 프로그램이 편하게 이용할 수 있는 API가 없어 POI 데이터를 활용한 애플리케이션이 부족하다. 본 논문에서는 이러한 한계점을 극복하기 위한 내비게이션 운영체제용 POI 검색 관련 시스템 콜을 설계하고 구현하였다. 집합 기반 POI 검색을 지원하므로 잘못된 입력에 의한 검색 성능 저하 문제도 해결한다. 성능평가 결과, 검색 성능이 향상되었을 뿐만 아니라 응용 프로그램에서 API를 활용하는 데 문제가 없었다.

• 한국언론정보학보
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• 제46권
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• pp.9-36
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• 2009

본 연구는 IPTV-VOD 서비스의 선택에 영향을 주는 요인들을 밝히고, 기존 다채널 유료TV와 IPTV-VOD 서비스 간에 대체 혹은 보완 관계가 있는지의 여부를 분석하였다. 연구결과, VOD 형식으로 제공되는 IPTV-VOD 서비스는 기존의 유료방송서비스와 콘텐츠에 있어서 큰 차별성을 보이고 있지 않으나, IPTV-VOD 서비스의 이용자들은 IPTV-VOD 서비스가 가지고 있는 양방향 서비스 특성들 - 능동적으로 선택할 수 있고, 시청시 중단, 되돌리기, 다시보기 등 - 을 이용하여 이용시간을 스스로 선택하여 기존 유료방송과는 다른 양방향적 특성들을 즐기면서 시청하고 있는 것으로 나타났다. 또한 이미 케이블/위성 서비스에 가입한 이용자와 가입하지 않은 이용자 간에 IPTV를 선택할 확률이 실시간 지상파방송 등 다른 요인들이 통제된 상태에서 차이가 나타났기 때문에 두 서비스가 어느 정도의 대체성을 가지고 있음을 예측할 수 있다.

• International Journal of Oral Biology
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• 제36권2호
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• pp.71-78
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• 2011

Using whole cell current- and voltage-clamp recording we investigated the characteristics and pharmacology of group I metabotropic glutamate receptor (mGluR)-mediated responses in rat medial vestibular nucleus (MVN) neurons. In current clamp conditions, activation of mGluR I by application of the group I mGluR agonist (R,S)-3,5-dihydroxyphenylglycine (DHPG) induced a direct excitation of MVN neurons that is characterized by depolarization and increased spontaneous firing frequency. To identify which of mGluR subtypes are responsible for the various actions of DHPG in MVN, we used two subtype-selective antagonists. (S)-(+)- alpha-amino-a-methylbenzeneacetic acid (LY367385) is a potent competitive antagonist that is selective for mGluR1, whereas 2-methyl-6-(phenylethynyl)-pyridine (MPEP) is a potent noncompetitive antagonist that is selective for mGluR5. In voltage clamp conditions, DHPG application increased the frequency of spontaneous and miniature inhibitory postsynaptic currents (IPSCs) but had no effect on amplitude distributions. Antagonism of the DHPG-induced increase of miniature IPSCs required the blockade of both mGluR1 and mGluR5. DHPG application induced an inward current, which can be enhanced under depolarized conditions. DHPG-induced current was blocked by LY367385, but not by MPEP. Both LY367385 and MPEP antagonized the DHPG-induced suppression of the calcium activated potassium current ($I_{AHP}$). These data suggest that mGluR1 and mGluR5 have similar roles in the regulation of the excitability of MVN neurons, and show a little distinct. Furthermore, mGluR I, via pre- and postsynaptic actions, have the potential to modulate the functions of the MVN.

• 지능정보연구
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• 제12권2호
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• pp.99-123
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• 2006

본 연구는 최적의 공급사슬을 구성하기 위해 다수의 주문을 다수의 참여자에게 할당하기 위한 방법으로 에이전트 협상을 이용하였다. 본 에이전트 협상은 투명한 정보공유를 바탕으로 참여자간의 전략적 협력관계를 형성하기 위한 조정 메커니즘을 제공하고 있으며, 모든 참여자(주문자, 제조자, 공급자)가 자신의 이득을 달성하고, 공급사슬 전체 관점에서도 파레토 최적해가 달성됨을 보여주고 있다. SET 모델기반의 스케줄링에서 지연생산비용과 조기생산비용이 발생되고, 경쟁적 관계에 놓인 다수의 참여자를 고려하였다. 이러한 동적공급사슬 환경에서 에이전트 협상의 결과가 파레토 최적해임을 증명하고, 성능을 검증하기 위해 수리적 모형을 수립하고, 휴리스틱 방법론과 비교하는 실험을 진행하였다.

• 대한전자공학회논문지TC
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• 제44권12호
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• pp.63-72
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• 2007

본 논문은 기존의 E-PON 시스템에 TDM 의사회선 기능을 부가함으로써 데이터와 TDM 신호를 동시에 전달할 수 있는 시스템 개발에 관한 것이다. E-PON 기술은 FTTH를 구현할 수 여러 기술 중 하나이며, 저가의 이더넷 기술과 광 인프라를 결합한 차세대 액세스 네트워크 솔루션으로 대두되고 있다. TDM 의사회선 서비스는 패킷교환 네트워크를 통하여 기존의 TDM 회선교환 음성 및 데이터 트래픽을 전송할 수 있도록 해주는 새로운 음성/데이터 변환기술이다. 본 논문에서는 E-PON 시스템에 TDM 의사회선 서비스 모듈을 부가하고, QoS 제어 기능을 구현함으로써 QoS 손실 없이 데이터 및 TDM 서비스를 효율적으로 제공할 수 있다. 따라서 데이터와 TDM 신호가 동시에 전달될 수 있는 경쟁력 있는 시스템에 구축될 수 있다.