• 치위생과학회지
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• 제20권3호
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• pp.146-154
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• 2020

Background: The objective of this study is to investigate the needs and importance of basic core competencies required for future society by dental hygienists' viewpoints who are working in the clinical practices and to provide the fundamental data to develop the educational programs based on the competencies in the 21st century so as to enhance their working capability. Methods: A total of 38 questionnaires were used in this study, 3 questionnaires on the general characteristics (age, service years, main job functions) and those in 11 sub-factors of basic core competencies including 4 questionnaires on creativity, 3 on collaboration, 3 on communication, 3 on interpersonal relationship, 3 on problem-solving, 4 on resource control, 4 on self-control and development, 2 on vocational ethics, 3 on knowledge information utilization, 3 on global mind, and 3 on emotional intelligence. Self-reported survey was conducted in the dental hygienists who were working in Seoul and Gyeonggi Province and a total of 195 data were analyzed. Results: Vocational ethics, communication, and collaboration showed the highest on both importance and needs with 4.49 points and 4.34; 4.41 and 4.28; and 4.39 and 4.22, respectively, while global mind showed the lowest with 3.51 and 3.59. Upon Importance-Performance Analysis, 7 items were defined to require maintain the status including vocational ethics, communication, collaboration, interpersonal relationship, self-control, emotional intelligence, and problem-solving while 4 items with lower priority were resource control and development, knowledge information utilization, creativity, and global mind. Conclusion: Based on this study results that suggested the basic core competencies of dental hygienists in alignment with their jobs in the future society, competitive dental hygienists should be developed with the educational programs applied with these competencies.

• 한국HCI학회:학술대회논문집
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• 한국HCI학회 2008년도 학술대회 2부
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• pp.424-429
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• 2008

본 연구의 목적은 사용자 행태에 따른 기기 사용과 니즈에 대한 리서치를 진행한 후 사용자에게 필요한 기능과 요소를 도출하여, 경쟁력 있는 디자인을 제안하는 것이다. 이에 따라 합리적 개인주의의 성향을 가진 20~30대의 유저를 대상으로, 비즈니스 업무 시 홈에서든 직장에서든 공간에 구애 받기 않고 사용할 수 있는 스마트한 문서 편집 기기 디자인을 목표로 하여 연구를 진행하였다. 본 연구 방법으로 첫째, 타켓 유저를 선정하고 그들에 대한 충분한 이해를 위해 사용자 인터뷰를 바탕으로 하는 리서치를 수행하였다. 둘째, 리서치를 바탕으로 타켓 유저를 결정한 다음 퍼소나를 설정하여 문제점에 따른 니즈를 도출하였다. 셋째, 도출된 컨셉으로 디자인 형태를 구성하고 디자인 시각화 작업을 실행하였다. 더불어 시나리오를 기반으로 인터랙션 디자인을 전개하였다. 넷째, 프로토타입을 제작하여 사용자 평가를 실시하였다. 그 결과 입력, 편집, 출력을 번거로운 절차 없이 효율적으로 작업할 수 있고, 합리적 개인주의 성향에 맞추어 이동성과 간편성을 강조한 디자인을 완성하였다. 또한 사용성 평가를 통해 디자인의 타당성을 입증할 수 있었다.

• BMB Reports
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• 제53권3호
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• pp.142-147
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• 2020

Lipid accumulation in white adipose tissue is the key contributor to the obesity and orchestrates numerous metabolic health problems such as type 2 diabetes, hypertension, atherosclerosis, and cancer. Nonetheless, the prevention and treatment of obesity are still inadequate. Recently, scientists found that brown adipose tissue (BAT) in adult humans has functions that are diametrically opposite to those of white adipose tissue and that BAT holds promise for a new strategy to counteract obesity. In this study, we evaluated the potential of sinapic acid (SA) to promote the thermogenic program and lipolysis in BAT. SA treatment of brown adipocytes induced the expression of brown-adipocyte activation-related genes such as Ucp1, Pgc-1α, and Prdm16. Furthermore, structural analysis and western blot revealed that SA upregulates protein kinase A (PKA) phosphorylation with competitive inhibition by a pan-PKA inhibitor, H89. SA binds to the adenosine triphosphate (ATP) site on the PKA catalytic subunit where H89 binds specifically. PKA-cat-α1 gene-silencing experiments confirmed that SA activates the thermogenic program via a mechanism involving PKA and cyclic AMP response element-binding protein (CREB) signaling. Moreover, SA treatment promoted lipolysis via a PKA/p38-mediated pathway. Our findings may allow us to open a new avenue of strategies against obesity and need further investigation.

• 벤처창업연구
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• 제7권3호
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• pp.133-141
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• 2012

글로벌 경쟁 상황에 처한 현대의 모든 기업들은 고객의 니즈를 충족시키고, 이를 통한 경쟁력을 강화하기 위한 방안으로서 서비스를 이해하기 시작하면서 서비스에 대한 관심이 날로 증가하고 있다. 기업들이 제공하는 제품이나 서비스의 가치는 주로 고객과 서비스 제공자 간의 관계에서 형성되는 만족도의 정도로 정의되는 서비스 신뢰도에 의해 크게 좌우된다. 본 연구에서는, 유형의 제품이나 시스템의 실패 유형과 영향을 평가하는데 널리 사용되는 FMEA를 서비스의 신뢰도 평가에 적용하였다. 이를 위해, 서비스의 설계와 서비스 기능과 실패 간의 관계를 용이하게 표현할 수 있는 사건중심 프로세스 모델을 이용하였다. 본 연구의 목적은 서비스 프로세스 관점에서의 서비스 신뢰도를 평가하는 방법을 제시하는 것으로서, 이를 위해 fuzzy FMEA와 grey 이론을 이용하였다. 제안된 방법은 자동차정비 프로세스 사례에 적용하여 평가하였다.

• 정보기술응용연구
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• 제3권2호
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• pp.67-82
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• 2001

오늘날 날로 증가하는 물류비는 개별 기업은 물론 국가 전체의 수출 경쟁력을 약화시키는 주요 원인으로 지적되고 있다. 그러나 특히 육상물류의 경우 그 비중이 전체 화물 운송의 60% 이상을 차지함에도 불구하고 심각한 교통체증 및 물류기반 시설의 미비, 효율적인 정보시스템의 미비 등으로 인하여 물류비가 계속 증가하는 양상을 보여 왔다. 따라서 본 논문에서는 우리나라 육상물류산업이 안고 있는 문제점의 해결을 위한 방안들 중의 하나로 공급사슬관리(Supply Chain Management) 개념을 운송산업에 적용한 e-logistics 시스템 개발 프로젝트의 길과를 소개하고 있다. 본 논문에서 소개하는 육상물류중개시스템은 공급사슬개념을 운송산업에 적용하여 화주, 물류중개회사 및 운송사 사이의 업무처리 프로세스 및 데이터 베이스를 공유하면서 차량의 흐름과 정보흐름을 원활하게 하여, 고객에 대한 서비스를 제고하는 한편 인건비, 통신비, 차량유지비 등을 절감할 수 있게 한다. 특히 육상물류중개시스템은 화물의 운송과 관련하여 발생하는 다양한 정보들을 데이터베이스에 저장하여 두었다가 세관 및 터미널에 대한 각종 신고업무에 이용할 수 있으며, 이밖에도 교통정보 및 화물 위치정보 등 다양한 서비스를 제공해 주고 있다. 육상물류중개시스템은 현재 개발중인 항만물류통합데이터베이스를 기반으로 한 항만물류원스톱서비스 시스템과 연계되어 차후에는 물류원스톱시스템으로 발전할 수 있을 것이다.

• Journal of Dairy Science and Biotechnology
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• 제23권2호
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• pp.149-153
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• 2005

Lactic acid bacteria had been widely utilized in fermented foods such as fermented dairy products, traditional sauces, kimchi, fermented sausages, medicines or probiotic feed additives for a long time. LAB are also widely distributed in the mammalian gastrointestinal tracts, oral cavity, vagina, and various foods or soils. The most familiar examples of using LAB would be the fermented milk products, and those had become one of the favorite foods in Korea f3r more than 34 years of history. The main benefits of the fermented milk products were originally the improvement of the balance of intestinal flora to control diarrhea and congestion disorders, and gradually, they were chosen by the consumer preference of the taste. The very beginning of the fermented milk products in Korea was the Yakult type products in 1971, and it was the commencement of the solid foundation of the dairy industry and the understanding beneficial effect of probiotic yogurt. After middle of 80's, stirred type fermented milk products had been firstly produced, and it was the time that the domestic dairy industry took root in Korea. From 90's, functional fermented milk products were produced, and drink type yogurt sales a mount increased drastically, and these products began to be chosen not only with the values of nutrition but also with physiological functions. The health claims are classified into intestinal health, gastric health and hepatic health. The prospects for the Korean market are as follows; The majority of leading products would be the premium functional yogurt products as it was last year. It is because the sales of lower cost products shows slow-down, and industries tend to increase the commercial advertisements of premium functional yogurt products through mass media. These tendencies would make the market situation become more competitive.

• 한국산업융합학회 논문집
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• 제10권2호
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• pp.123-128
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• 2007

The demand for the precision rubber products has been rapidly increasing with the recent growth of industries. And the requirement for the productivity and the quality calls out for the injection molding machines with the precision machining ability as well as the high productivity. Especially modern automobile industry is in urgent need of developing injection molding machines for the high quality rubber products with high productivity. And the inability of the domestic companies to meet the standards causes importing foreign machines and as a result spending good amount of dollars. It is extremely important to develop competitive machines and strengthen the infrastructure of the related industries. In this paper the functions and the structure of a automatic multi-nozzle injection molding machine has been studied to set up a proper test system for the precision rate and the reliability of the machines, which can help build the machines to meet the request of the industry.

• Journal of Ecology and Environment
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• 제40권2호
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• pp.89-106
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• 2016

Many plant species have two modes of reproduction: sexual and asexual. Both modes of reproduction have often been viewed as adaptations to temporally or spatially variable environments. The plant should adjust partitioning to match changes in the estimated success of the two reproductive modes. Perennial plants showed that favorable habitats in soil nutrients or water content tend to promote clonal growth over sexual reproduction. In contrast, under high light-quantity conditions, clonal plants tend to allocate more biomass to sexual reproduction and less to clonal propagation. On the other hand, plants with chasmogamous and cleistogamous flowers provides with a greater tendency of the opportunity to ensure some seed set in any stressful environmental conditions such as low light, low soil nutrients, or low soil moisture. It is considered that vegetative reproduction has high competitive ability and is the major means to expand established population of perennial plants, whereas cleistogamous reproduction is insurance to persist in stressful sites due to being strong. Chasmogamous reproduction mainly enhances established and new population. Therefore, the functions of sexual and asexual propagules of perennial or annual plants differ from each other. These traits of propagule thus determine its success at a particular region of any environmental gradients. Eventually, if environmental resources or stress levels change in either space or time, species composition will probably also change. The reason based on which the plants differ with respect to favored reproduction modes in each environmental condition, may be involved in their specific realized niche.

• Genomics & Informatics
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• 제8권1호
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• pp.41-49
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• 2010

Statins are competitive inhibitors of hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase and used most frequently to reduce plasma cholesterol levels and to decrease cardiovascular events. However, statins also have been reported to have undesirable side effects such as myotoxicity and hepatotoxicity associated with their intrinsic efficacy mechanisms. Clinical studies recurrently reported that statin therapy elevated the level of liver enzymes such as ALT and AST in patients suggesting possible liver toxicity due to statins. This observation has been drawn great attention since statins are the most prescribed drugs and statin-therapy was extended to a larger number of high-risk patients. Here we employed rat primary hepatocytes and microarray technique to understand underlying mechanism responsible for statin-induced liver toxicity on cell level. We isolated genes whose expressions were commonly modulated by statin treatments and examined their biological functions. It is of interest that those genes have function related to response to stress in particular immunity and defense in cells. Our study provided the basic information on cellular mechanism of statin-induced cytotoxicity and may serve for finding indicator genes of statin -induced toxicity in rat primary hepatocytes.

• Earthquakes and Structures
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• 제11권6호
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• pp.1077-1099
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• 2016

One of the main shortcomings in the current passive base isolation system is lack of adaptability. The recent research and development of a novel adaptive seismic isolator based on magnetorheological elastomer (MRE) material has created an opportunity to add adaptability to base isolation systems for civil structures. The new MRE based base isolator is able to significantly alter its shear modulus or lateral stiffness with the applied magnetic field or electric current, which makes it a competitive candidate to develop an adaptive base isolation system. This paper aims at exploring suitable control algorithms for such adaptive base isolation system by developing a close-loop semi-active control system for a building structure equipped with MRE base isolators. The MRE base isolator is simulated by a numerical model derived from experimental characterization based on the Bouc-Wen Model, which is able to describe the force-displacement response of the device accurately. The parameters of Bouc-Wen Model such as the stiffness and the damping coefficients are described as functions of the applied current. The state-space model is built by analyzing the dynamic property of the structure embedded with MRE base isolators. A Lyapunov-based controller is designed to adaptively vary the current applied to MRE base isolator to suppress the quake-induced vibrations. The proposed control method is applied to a widely used benchmark base-isolated structure by numerical simulation. The performance of the adaptive base isolation system was evaluated through comparison with optimal passive base isolation system and a passive base isolation system with optimized base shear. It is concluded that the adaptive base isolation system with proposed Lyapunov-based semi-active control surpasses the performance of other two passive systems in protecting the civil structures under seismic events.