• Title/Summary/Keyword: comparison of efficacy

Search Result 922, Processing Time 0.024 seconds

The Predilution Effect of Al-based Liquid Coagulants for the Optimal Efficacy (최적 응집 효율을 위한 Al계 액상 응집제의 희석 효과)

  • Heo, Jae-Yong;Lee, Sang-Wha
    • Applied Chemistry for Engineering
    • /
    • v.17 no.1
    • /
    • pp.37-43
    • /
    • 2006
  • The coagulation efficacy of Al-based coagulants (such as Alum, PACS, and PACC) was investigated to ascertain removal efficiencies of turbidity and phosphate with variation of solution pH, coagulant dosages, and pre-dilution ratios. The efficacy of Al-based coagulants was maximized in the pH range of 6~9. Under the initial condition of pH 8, $10mg/L\;{PO_4}^{3-}$, and 20 NTU, Al-based coagulants exhibited a similar efficacy in the removal of turbidity, whereas the removal efficiency of phosphate was clearly dependent on the basicity of coagulants: Alum (0%) > PACS (45~50%) > PACC (70%). At high initial turbidity of 100 NTU, polymeric coagulants, such as PACS and PACC, exhibited a higher removal efficiency of turbidity compared to Alum. In comparison to direct injection of coagulants at low initial turbidity (20 NTU), 500~2000 times pre-diluted Alum, exhibited reduced coagulation efficacy; however, removal efficiencies of turbidity and phosphate increased with the increase of retention time. Pres-diluted PACC exhibited the enhanced coagulation efficacy followed by silght decrease of the removal efficiencies with increase of the retention time. At high initial turbidity of 100 NTU, pre-diluted Alum and PACC exhibited higher removal efficiencies of turbidity and phosphate.

Efficacy and Tolerability of Moclobemide Compared with Amitriptyline in Dysthymic Disorder (기분부전장애에서 Moclobemide와 Amitriptyline의 치료 효과와 내약성 비교 연구)

  • Lee, Min Soo;Nam, Jong Won;Ryu, Seung Ho;Cha, Ji Hyun;Kim, Yong Ku
    • Korean Journal of Biological Psychiatry
    • /
    • v.6 no.1
    • /
    • pp.96-101
    • /
    • 1999
  • Background : Since dysthymia begins in late childhood or adolescence and has a chronic course, long-term pharmacotherapy may be required. New generation antidepressant, moclobemide, with more acceptable side effect profiles, is effective in the treatment of dysthymia. The main objective of this study was to determine whether they exhibit comparable efficacy and tolerability in dysthymia to amitriptyline. Method and Materials : The efficacy and tolerability of the moclobemide and amitriptyline, were compared in a eight-week single-centre double-blind study in patients(n=37) with dysthymia using he HAMD-17, the Clinical Global Impression Scale(CGI), the Montgomery-Asberg Depression Rating Scale (MADRS), Efficacy Index-Therapeutic Index(EITE), 4-point Index Side Effect Scale(4-PISES), and Efficacy Index- Side Effect Scale(EISE). Results : A total of 37 patients entered the study, 19 were randomly assigned to the moclobemide group and 18 to be amitriptyline group. Demo-graphic and illness characteristics were similar in both groups. There were no significant difference between two groups at the total 17-HDRS score, the HAMD-17% improvement, the total MADRS score, CGI response, and the EITE. In the comparison of EISE between two groups, the scores of the moclobemide group were relatively lower than the amitriptylinen group in full treatment. And the differences were significant(moclobemide group $1.39{\pm}0.61$ ; amitriptyline group $2.00{\pm}0.85$, p<.001). At the 4-PISE, There was no serious or treatment threatening side effects. And there was no specific difference in side effects between two groups. The moclobemide group reported higher EIR scores than the amitriptyline group at every follow up day, but the differences were not significant. And, there was no significant differences in the scores of five HRQOL subcategories which is compared between two groups at every follow up days. Conclusions : In terms of 17-HDRS and MADRS, moclobemide and amitriptyline are equally effective at least in allevating dysthymic symptoms. But moclobemide tended to be less troubling and better tolerated than amitriptyline. Therefore, moclobemide treatment can be used as a safe, and higher satisfactory treatment strategy for the dysthymia.

  • PDF

A Study of the Obesity Index and Psychosocial Factors Influencing Obesity among Adolescent Girls (여고생들의 비만도 및 비만과 관련된 사회심리적 요인 분석)

  • 김경원;김영아;김정희
    • Korean Journal of Community Nutrition
    • /
    • v.2 no.4
    • /
    • pp.496-504
    • /
    • 1997
  • The purpose of this study was to investigate the dietary intake, obesity index and psychosocial factors influencing obesity among 200 high school girls in Seoul. The Social Cognitive Theory provided the Conceptual basis for this study. A cross-sectional survey was conducted to examine factors related to obesity, including self-efficacy for controlling overeating, social support for eating behavior, perception of body image and weight control, nutrition knowledge, and attitudes toward obesity. The data were analyzed using t-test and multiple logistic regression. The results of this study are as follows : 1) The mean age of the girls was 16.4 years, and the rate of overweight and obesity(measured by obesity index) was 27.0$\%$. 2) The mean energy intake of subjects was 1832.3$\pm$384.0kcal. The energy derived from carbohydrates, proteins and fats was 62.7$\%$, 13.8$\%$, and 23.5$\%$, respectively. There was no significant difference between the obese and the comparison group in energy intake. 3) The result of multivariate analysis indicated that obesity had a significant relation to the perception of ideal body image, social support for eating behavior, and self-efficacy for controlling overeating(p〈0.01). As subjects preferred thinner body images(OR=0.39) and received less social support(OR=0.93), the odds of being classified as obese increased. The odds of being obese were also associated with self-efficacy, however, the relation was not strong(OR=1.04). 4) Specific social support was related to obesity among adolescent girls. As subjects received more support from family member, the odds of being obese decreased. The emotional support as well as family member's positive nutrition behavior plays a significant role. In addition, instrumental support from friends was associated with obesity. With repect to self-efficacy, the odds of being obese were increased as subjects felt less confident in controlling overeating when tempting food was placed in front of them or after an argument. In contrast, the obese group felt more confident in controlling overeating for the rest of the specific situations examined. These findings suggest that educational interventions for weight control should incorporate strategies to help participants realize their degree of obesity, to reduce the discrepancy between current and ideal body image, to elicit and maintain social support from friends and family, and to increase the self-efficacy for changing eating behaviors. (Korean J Community Nutrition 2(4) : 496-504, 1997)

  • PDF

Effect of Individual Health Education the Medical Clinic of Public Health Centers on Knowledge, Self-efficacy, and Self-care behavior in Clients with Hypertension (보건소 진료실을 이용한 개별보건교육이 고혈압혼자의 지식, 자기효능감, 자가간호행위에 미치는 효과)

  • Lee Hyun Jung
    • Journal of Korean Public Health Nursing
    • /
    • v.18 no.1
    • /
    • pp.80-89
    • /
    • 2004
  • This study focused on individual health education for people with hypertension who were being seen in public health centers. The program was an adjusted intervention program that considered the characteristics of each individual and reflected the individual's will to change. Each individual had a different lifestyle with different characteristics and habits so the study considered these individual's characteristics. A comparison was done of knowledge related to hypertension, self-efficacy, and self-care in these individuals. In order to determine the effectiveness of education given by the nurses the variables were measured before and after the individual health education program. The participants in this study were 85 people with hypertension who were seen at a public health center in G city. They were assigned to an experimental group (43) and a control group (42). A tool developed by Park Young-Im (1994) was used to measure knowledge related to hypertension and self-efficacy. A tool developed by Lee Young-Whee (1994) was used for self-care. Data collection was done for 10 weeks from March 24 to May 31, 2003 using interviews with questionnaires. The following is a summary of the results of the study. Hypothesis 1, 'the experimental group which had the individual health education will have higher knowledge scores on hypertension than the control group that did not have the individual health education' was supported (t=4.17, P=0.00). Hypothesis 2, 'the experimental group which had the individual health education will have higher self-efficacy scores than the control group that did not have the individual health education' was supported (t=4.06, P=0.00). Hypothesis 3, 'the experimental group which had the individual health education will have better self-care ability than the control group that did not have the individual health education' was supported (t=4.94, P=0.00). Based on the results of this study, the public health centers should develop an educational program that uses a variety of visual aids and assess the effects of the education on patients with different chronic diseases. After the development of an inclusive education program which will standardize health education effectively and provide a variety of teaching methods, study is needed to measure changes in lifestyle after education and to determine how much knowledge related to hypertension, self-efficacy, and self-care increase

  • PDF

The Effects of Family Strengths Perceived by College Students on Self-esteem: Focusing on the Double Mediation of Interpersonal Relationship Ability and Self-Efficacy (대학생이 지각한 가족건강성이 자아존중감에 미치는 영향: 대인관계능력과 자기효능감의 이중매개효과)

  • Shin, Eun-Mi;Lee, Jong-Woo;Lee, Hwa-Sung
    • Journal of Digital Convergence
    • /
    • v.19 no.4
    • /
    • pp.177-183
    • /
    • 2021
  • The purpose of this study was to investigate the double mediation effects of interpersonal relationship ability and self-efficacy in the link between family strengths and self-esteem of college students. To this end, a survey was conducted for 1 month in November 2019, targeting 340 students conveniently sampled from C city in Chungcheongbuk-do and J city in Jeollabuk-do, and the analysis was conducted using SPSS Win. 25 and SPSS PROCESS Macro. The applied statistical techniques were mean comparison analysis (t-test, One-ANOVA), correlation analysis, and PROCESS Macro model No. 6 to analyze the double mediating effect. The main findings of the study are: First, self-esteem was significantly higher in education major than in other majors. Second, as a result of correlation analysis, self-esteem showed a significant positive correlation with family strength, interpersonal relationship ability, and self-efficacy. Third, as a result of the double mediation effect analysis, interpersonal relationship ability and self-efficacy double mediated in the relationship between family strength and self-esteem. The results of this study can be used as basic data to enhance the self-esteem of college students by utilizing interpersonal relationship ability and self-efficacy.

The Effects of Daesiho-Tang on Body Weight and Biochemical Changes of Rats Fed High Diet (대시호탕이 고지방식이로 유발한 비만 흰쥐의 체중 및 생화학적 변화에 미치는 영향)

  • Han, Moo-Gyu;Seo, Hae-Gyoung;Kim, Eun-Ha
    • The Journal of Korea CHUNA Manual Medicine
    • /
    • v.2 no.1
    • /
    • pp.177-186
    • /
    • 2001
  • Objectives : We experimented with Daesiho-tang in order to investigate the effects on the weight of obesity. Methods : We fed a control group of rats a high fat diet and administerd normal saline for 6 weeks. And we fed an experimental group of rats a high fat diet and administered an extracted of Daesiho-tang for 6 weeks. Results : Daesiho-tang suppressed the increasing amount of body weight in comparison with control group. The serum total cholesterol level, free fatty acid level in Daesiho-tang group showed a significant decrease in comparison with control group. The serum triglyceride, total lipid level in Daesiho-tang group showed a decrease in comparison with control group, but this result showed no efficacy. Conclusions : We concluded that the clinical application of Daesiho-tang can help the treatment of obesity.

  • PDF

Efficacy of Auxiliary Traits in Estimation of Breeding Value of Sires for Milk Production

  • Sahana, G.;Gurnani, M.
    • Asian-Australasian Journal of Animal Sciences
    • /
    • v.12 no.4
    • /
    • pp.511-514
    • /
    • 1999
  • Data pertaining to 1111 first lactation performance record of Karan Fries (Holstein-Friesian $\times$ Zebu) cows spread over a period of 21 years and sired by 72 bulls were used to examine the efficiency of sire indices for lactation milk production using auxiliary traits. First lactation length, first service period, first calving interval, first dry period and age at first calving were considered as auxiliary traits. The efficiency of this method was compared with simple daughter average index (D), contemporary comparison method (CC), least-square method (LSQ), simplified regressed least-squares method (SRLS) and best linear unbiased prediction (BLUP) for lactation milk production. The relative efficiency of sire evaluation methods using one auxiliary trait was lower (24.2-32.8%) in comparison to CC method, the most efficient method observed in this study. Use of two auxiliary traits at a time did not further improve the efficiency. The auxiliary sire indices discriminate better among bulls as the range of breeding values were higher in these methods in comparison to conventional sire evaluation methods. The rank correlation between breeding values estimated using auxiliary traits were high (0.77-0.78) with CC method. The rank correlation among auxiliary sire indices ranged from 0.98 to 0.99, indicating similar ranking of sire for breeding values of milk production in all the auxiliary sire indices.

Comparison of Dietary Habit, Lifestyle, Health Attitude and Self-efficacy by Upper Gastrointestinal Disease among Group Mental Health Care Facilities with Chronic Schizophrenia (정신요양시설 만성조현병환자의 상부위장관질환 유무에 따른 식습관, 생활습관, 건강태도 및 자기효능감 비교연구)

  • Oh, Eun-Jung;Park, Keun-Young
    • Journal of Digital Convergence
    • /
    • v.18 no.7
    • /
    • pp.317-330
    • /
    • 2020
  • The purpose of this study was to compare lifestyle, dietary habit, health attitude and self-efficacy among chronic schizophrenia with upper gastrointestinal disease and chronic schizophrenia to improve lifestyle, dietary habit and health attitude, in each mental health care facilities field, it was attempted to provide basic data to search for alternatives to increase self-efficacy. This study surveyed them from February 20th to April 30th in 2019 for data collection. Data were analyzed using Chi-square test, Independent t-test and ANCOVA with SPSS/WIN 22.0. The sociodemographic factor of age and education, the lifestyle factors of carbonated drink and physical activity intensity, the dietary habit factors of overeat, snack, late night meals and fatty food, the other factor of self-efficacy show statistically significant differences among groups. The study provides meaningful data in finding distinctive features of Upper Gastrointestinal Disease among Group with Chronic Schizophrenia. The results indicate that need to develope a variety of intervention methods to promote lifestyle and dietary habit and to enhance self-efficacy of chronic schizophrenia.

Effects of general and preferred exercise programs on balance ability and fall efficacy in elderly people (일반적인 운동 프로그램과 선호하는 운동 프로그램이 노인의 균형능력, 낙상효능감에 미치는 영향)

  • Jung-Ho Lee
    • The Journal of the Convergence on Culture Technology
    • /
    • v.10 no.3
    • /
    • pp.533-539
    • /
    • 2024
  • This study investigated the effects of two exercise programs, which include exercise methods to increase muscle strength, balance, and endurance, on the balance ability and fall efficacy of elderly people, and the differences in effects according to preference. Twenty-one elderly people were divided into a group using assistive devices using elastic bands (Experimental Group 1) and a group using the body (Experimental Group 2) and an exercise program was conducted for 4 weeks. The single leg stand (SLS) and functional reach test (FRT) were used to evaluate the elderly's balance ability, and the fall efficacy scale (FES) was used to evaluate the degree of fear of falling. A pre-evaluation was conducted after a 2-week integrated exercise program, and a post-evaluation was conducted after applying the exercise program for 4 weeks. In the study results, within-group SLS, FRT, and FES analyzes all showed statistically significant improvement in the post-assessment compared to the pre-assessment. However, there were no significant differences in the comparison between groups regarding exercise program and between groups according to preference. In conclusion, in order to increase the balance ability and fall efficacy of the elderly, an exercise program must be applied, and it is necessary to use a program that is easy to apply and includes exercise methods that the elderly can easily perform.

Ginsenoside F1 Attenuates Eosinophilic Inflammation in Chronic Rhinosinusitis by Promoting NK Cell Function

  • Kim, So Jeong;Lee, Jinju;Choi, Woo Sun;Kim, Hyo Jeong;Kim, Mi-Yeon;Kim, Sun Chang;Kim, Hun Sik
    • Journal of Ginseng Research
    • /
    • v.45 no.6
    • /
    • pp.695-705
    • /
    • 2021
  • Background: Ginsenosides have beneficial effects on several airway inflammatory disorders primarily through glucocorticosteroid-like anti-inflammatory activity. Among inflammatory cells, eosinophils play a major pathogenic role in conferring a risk of severe refractory diseases including chronic rhinosinusitis (CRS). However, the role of ginsenosides in reducing eosinophilic inflammation and CRS pathogenesis is unexplored. Methods: We investigated the therapeutic efficacy and underlying mechanism of ginsenoside F1 (G-F1) in comparison with those of dexamethasone, a representative glucocorticosteroid, in a murine model of CRS. The effects of G-F1 or dexamethasone on sinonasal abnormalities and infiltration of eosinophils and mast cells were evaluated by histological analyses. The changes in inflammatory cytokine levels in sinonasal tissues, macrophages, and NK cells were assessed by qPCR, ELISA, and immunohistochemistry. Results: We found that G-F1 significantly attenuated eosinophilic inflammation, mast cell infiltration, epithelial hyperplasia, and mucosal thickening in the sinonasal mucosa of CRS mice. Moreover, G-F1 reduced the expression of IL-4 and IL-13, as well as hematopoietic prostaglandin D synthase required for prostaglandin D2 production. This therapeutic efficacy was associated with increased NK cell function, without suppression of macrophage inflammatory responses. In comparison, dexamethasone potently suppressed macrophage activation. NK cell depletion nullified the therapeutic effects of G-F1, but not dexamethasone, in CRS mice, supporting a causal link between G-F1 and NK cell activity. Conclusion: Our results suggest that potentiating NK cell activity, for example with G-F1, is a promising strategy for resolving eosinophilic inflammation in CRS.