• Parasites, Hosts and Diseases
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• 제62권3호
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• pp.342-350
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• 2024

Although helminth parasites have different life cycles, their hosts share similar immune responses involving Th2 cell-type. Here, we extracted proteins from the larvae of Anisakis simplex complex and Trichinella spiralis to identify common and specific antigens (or allergens) associated with the Th2 immune response. We performed two-dimensional electrophoresis analysis and Matrix-assisted laser desorption ionization-time of flight/time of flight (MALDI-TOF/TOF) experiments. We found 13 potentially immunogenic proteins, which included 5 spots specific to T. spiralis and 8 common to T. spiralis and A. simplex, by tandem mass spectrometry. These molecules were identified structurally as actin, tropomyosin, col cuticle N domain-containing protein, and heat shock proteins. We also identified molecules related to parasite-host immune modulation and interactions. Our results may contribute to reveal potential roles of immunological proteins in parasite-derived immune modulation.

• 국제지역연구
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• 제15권3호
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• pp.55-76
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• 2011

본 논문에서는 북미자유무역협정(NAFTA) 지역의 경기변동을 살펴본다. 이를 위해 경기변동의 전형적 특징인 주요 변수들간의 동조성(co-movement)과 확장/수축기간의 비대칭성을 감안하는 동시에, 경기변동을 초래하는 영구적 요인과 일시적 요인을 모두 포괄하는 모형을 구축하였다. 김창진(1994)이 제시한 칼만 필터에 기반한 근사적 최우추정법을 활용하여 모형을 추정한 후, 추정된 두 요인의 움직임에 기반하여 NAFTA 지역내 경기변동의 국면이 달라지는 전환점(turning point)을 규명하였다. 추정된 두 요인은 경기변동상의 추세와 사이클을 잘 반영하는 것으로 나타났으며, 경기확장기에 비해 급격하고 짧은 경기수축국면, 변수들간의 동조성, 그리고 확장기와 수축기간의 국면 전환 등 경기변동의 전형적인 모습들이 이 지역내에서도 확인되었다. NAFTA의 발효 이전과 비교하여, 발효 이후에는 경기변동 충격의 변동성과 지속성이 증가한 것으로 나타났다. 또한 한국과 NAFTA 지역 경기변동간의 동조성을 측정한 결과, NAFTA 발효 이후에 두 지역 간의 경기변동 동조성이 크게 증가한 결과를 얻었다.

• Journal of Power Electronics
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• 제18권2호
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• pp.343-355
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• 2018

A wide-voltage-conversion range bidirectional DC-DC converter is proposed in this paper. The topology is comprised of one typical LC energy storage component and a special common grounded asymmetric H-bridge with four active power switches/anti-parallel diodes. The narrow output PWM voltage is generated from the voltage difference between two normal (wider) output PWM voltages from the asymmetric H-bridge with duty cycles close to 0.5. The equivalent switching frequency of the output PWM voltage is double the actual switching frequency, and a wide step-down/step-up ratio range is achieved. A 300W prototype has been constructed to validate the feasibility and effectiveness of the proposed bidirectional converter between the variable low voltage side (24V~48V) and the constant high voltage side (200V). The slave active power switches allow ZVS turn-on and turn-off without requiring any extra hardware. The maximum conversion efficiency is 94.7% in the step-down mode and 93.5% in the step-up mode. Therefore, the proposed bidirectional topology with a common ground is suitable for energy storage systems such as renewable power generation systems and electric vehicles with a hybrid energy source.

• Clinical and Experimental Reproductive Medicine
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• 제48권2호
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• pp.142-149
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• 2021

Objective: Bacteriospermia and urogenital infections are common problems in male infertility. This study aimed to evaluate the effects of bacteriospermia on sperm parameters and clinical outcomes in semen samples infected with two common bacteria (Staphylococcus saprophyticus and Escherichia coli) in northern Iran. Methods: Microbiological tests were performed to isolate and identify organisms from 435 semen samples from infertile couples. Semen samples were assessed according to the World Health Organization criteria. The protamine status, chromatin structure, chromatin condensation, and acrosome reaction of sperm and assisted reproductive outcomes were determined in couples with different male infertility factors. Results: Among the total cases, the two most prevalent pathogens were considered: S. saprophyticus (38.2%) and E. coli (52.9%). In the semen samples infected with E. coli, the spontaneous acrosome reaction and abnormal chromatin condensation were more common (p<0.05). Significant increases in abnormal chromatin condensation and deprotamination were seen in the presence of S. saprophyticus. In washed semen, tight adhesion between the sperm midpiece and S. saprophyticus was observed. There was also a significant decrease in the fertilization rate using semen samples infected with S. saprophyticus and E. coli during in vitro fertilization cycles (p<0.001). In addition, the presence of S. saprophyticus and E. coli in semen samples was associated with a lower likelihood of clinical pregnancy in couples with various factors of male infertility. Conclusion: Poor results of assisted reproductive techniques may be correlated with semen samples infected with two common bacteria in northern Iran.

• Nutrition Research and Practice
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• 제6권1호
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• pp.16-20
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• 2012

The effects of retrograded rice on body weight gain, gut functions, and hypolipidemic actions in rats were examined. When the retrograded rice was produced by repetitive heating and cooling cycles, it contained significantly higher amounts of resistant starch ($13.9{\pm}0.98%$) than is found in common rice ($9.1{\pm}1.02%$) (P < 0.05). Sprague-Dawley rats were fed either common rice powder or retrograded rice powder, and mean body weight gain was significantly lower in the retrograded rice group (P < 0.05). The liver weight of the retrograded rice group ($14.5{\pm}0.5\;g$) was significantly lower than that of the common rice group ($17.1{\pm}0.3\;g$, P < 0.05). However, the weights of other organs, such as the kidney, spleen, thymus, and epididymal fat pad were not significantly affected by rice feeding. Intestinal transit time tended to be lower in rats fed retrograded rice when compared to rats fed the common rice, but the difference was not significant. The retrograded rice diet significantly increased stool output when compared to that in the common rice powder diet (P < 0.05), whereas fecal moisture content (%) was significantly higher in the retrograded rice group ($23.3{\pm}1.2$) than that in the common rice group ($19.1{\pm}1.2$) (P < 0.05). The retrograded rice group had significantly lower plasma cholesterol (P < 0.05), liver cholesterol (P < 0.05), and triacylglycerol contents in adipose tissue (P < 0.05) when compared to those in the common rice group. In conclusion, retrograded rice had higher resistant starch levels compared with those of common rice powder, and it lowered body weight gain and improved lipid profiles and gut function in rats.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 1997년도 춘계학술대회 논문집
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• pp.475-480
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• 1997

It is common to assum identical allowable safety factors in static strength, defined by mean stress and in fatigue, defined by stress amplitude. Under the load with asymmetrical cycles the safety factor is not the same. In this paper, with the consideration of unequal allowable safety factors a general method for estimating fatigue reliability of a machine element under a combined state of stress is derived based on the theory proposed by Prof. Kececioglu and normal distribution. The calculation of fatigue reliability for limited life is discussed with example.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.154.2-154.2
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• 2003

Mammalian cell cycles are tightly regulated by cyclins, cyclin dependent kinase (CDK), Retinoblatoma (Rb) protein, and cellular CDK inhibitors (CDKI). Cyelin dependent kinases (CDK) are key enzymes regulating eukaryotic cell cycle. And also it is recognized that the abnormal increase of CDK activities is one of the common events in human cancer and CDK inhibitors have therapeutic values in cancer treatment. Until now it is known that over 10 different CKDs participate in cell cycle regulation. (omitted)

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.314.2-314.2
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• 2002

DNA topoisomerases catalyze changes in DNA topology through cycles of transient DNA strand breakage and religation. During this process. the active site tyrosine in human DNA topoisomerase Ⅰ(Top Ⅰ) becomes covalently linked to the 3'-ends of a single-stranded nick in the DNA duplex, Stabilization of the Top Ⅰ-DNA cleavable complex is the common initial event leading to the cytotoxicity of top 1 inhibitors. (omitted)

• 한국정보통신학회논문지
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• 제17권5호
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• pp.1203-1212
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• 2013

본 논문에서는 HEVC 복호기내 화면내 예측의 연산 복잡도를 감소시키기 위해 공유 연산기, 공통 연산기, 고속 smoothing 결정 알고리즘, 고속 필터계수 생성 알고리즘을 적용한 하드웨어 구조를 제안한다. 공유 연산기는 공통수식을 공유하여 smoothing 과정의 연산 중복성을 제거하고, DC모드의 평균값을 미리 계산하여 수행 사이클 수를 감소시킨다. 공통 연산기는 모든 예측모드의 예측픽셀 생성과 필터링 과정을 하나의 연산기로 처리하기 때문에 연산기의 개수를 감소시킨다. 고속 smoothing 결정 알고리즘은 비트 비교기만을 사용하고, 고속 필터계수 생성 알고리즘은 곱셈연산 대신 LUT를 사용하여 연산 개수, 하드웨어 면적과 처리 시간을 감소시킨다. 또한 제안하는 구조는 2개의 공유 연산기와 8개의 공통 연산기를 사용하여 병렬처리함으로써 화면내 예측의 수행 사이클 수를 감소시킨다. 제안하는 구조를 TSMC 0.13um CMOS 공정 라이브러리를 이용하여 합성한 결과 게이트 수는 40.5k, 최대 동작 주파수는 164MHz이다. HEVC 참조 소프트웨어 HM 7.1에서 추출한 데이터를 이용하여 성능을 측정한 결과 제안하는 구조의 수행 사이클 수가 기존 구조 대비 93.7% 감소하였다.

• 한국초지조사료학회지
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• 제18권4호
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• pp.351-354
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• 1998

Centipedegrass는 미국 동남부지역에서 잔디용으로 많이 이용하고 있는데 토양을 가리지 않고 잘 자라며 잎이 연녹색이어서 잔디로서 선호도가 높다. 그러나 이 식물의 유전자원이 지니고 있는 유전변이 폭이 매우 한정되어 있어 활용 가능한 유전변이의 폭을 확대하기 위해 Centipedegrass의 종자에 감마선 10Kr을 조사한 뒤 계통을 조성하고 이를 다시 감마선 10Kr을 조사하여 계통을 조성하는형태로 순환 조사하여 순환 처리회수를 각각 0회, 4회, 5회, 6회, 8회 하여 얻은 계통집단 TC 201, TC 202, TC 241, TC 306, TC 318에 대하여 이들 계통집단이 지니고 있는 식물 형태적 특성의 평균과 변이의 범위 폭을 측정하여 비교한 결과 이미 품종으로 고정되어 있는 TC318을 제외하고 감마선을 종자에 순환처리한 계통집단에서 총지하경수, 총지하경길이, 최장지하경장, 엽장 및 엽폭의 변이폭이 감마선 조사로 확대되었음을 확인하였다. 이러한 변이의 범위 확대 정도는 지하경과 같은 생식기관에서 뚜렷하였는데 방사선 순환조사 정도와 관련하여 일정한 방향성은 인정되지 않았다.