• Proceedings of the Computational Structural Engineering Institute Conference
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• 2002.04a
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• pp.433-450
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• 2002

The concept of VDD(Virtual Design & Development) based on high performance computing technology is introduced. The whole process of design and development could be carried out in cyber space through VDD technology in which high-precision simulation technology is combined with virtual reality technology. Therefore, time for design and development of a new product can be shorten and quality of product can be also improved. However, efficient simulation technology must be developed and appropriate supercomputing system must be available to realize VDD technology. In this work, several technologies for obtaining cost-effective supercomputing systems for VDD technology are introduced and investigated. The detail informations about optimization technology for PC(Personal Computer) computing, clustering technology, Internet Supercomputing technology, and Piggyback technology are provided and numerical results are also presented.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2002.04a
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• pp.249-256
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• 2002

A new optimization procedure with approximate reanalysis module, using the staged hybrid methods with substructuring, is proposed in is study. In this procedure, displacements are calculated with two step mixed procedures. First step is to introduce the conservative approximation, which is a hybrid form of the linear and reciprocal approximation, as local approximation. In the next step, it is combined with the global approximation by reduced basis approach. The quality of reanalyzed quantities can be greatly improved through these staged hybrid approximations, specially for large changes in the design. Overall procedures are based on substructuring scheme. Several numerical examples illustrate the validity and effectiveness of the proposed methods.

• Bulletin of the Korean Chemical Society
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• v.25 no.11
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• pp.1681-1686
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• 2004

Self-assembled systems with polyamidoamine (PAMAM) dendrimers combined with gold nanoparticles have been widely studied because of their potential applications in molecular electronics, catalyst carriers, chemical sensors, and biomedical devices. In our work, gold nanoparticle monolayers and multilayers with pure and ferrocene-tethered PAMAM dendrimers as cross-linking molecules were deposited on a mixed self-assembled monolayer of gold substrates. The various generations of PAMAM dendrimers can be covalently attached to mercaptoundecanoic acid mixed with a mercaptoundecanol self-assembled monolayer. Cyclic voltammograms show that redox peak currents on the alternate multilayers of gold nanoparticles and ferrocene-tethered PAMAM dendrimers increase as the number of layers increases. Fourier transform IR external reflection spectroscopy and scanning electron microscopy support the results from electrochemical measurements.

• Journal of the Korea Society for Simulation
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• v.6 no.1
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• pp.71-84
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• 1997

For many optimization problems where some of the system components are stochastic, the objective functions cannot be represented analytically. Therefore, modeling by computer simulation is one of the most effective means of studying such complex systems. Many, if not most, simulation optimization problems have multiple aspects. Historically, multiple aspects have been combined ad hoc to form a scalar objective function, usually through a linear combination (weighted sum) of the multiple attributes, or by turning objectives into constraints. The genetic algorithm (GA), however, is readily modified to deal with multiple aspects. In this paper we propose a MAGA (Multiple Aspects-based Genetic Algorithm) as an algorithm for finding the Pareto optimal set. We demonstrate its ability to find and maintain a diverse "Pareto optimal population" on two problems.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.25 no.2
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• pp.27-34
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• 2002

Many organizations attempt to plan information strategy reflecting their overall business and direction using the information engineering methodology. They also try to redesign the process for partial business area. The above two approaches can be combined because information technology Plays an important role as an enabler for business process reengineering. For theses organizations, a new information strategy planning procedure that considers reengineering of partial business is proposed in this study. The proposed procedure is designed to minimize the change of information strategy planning procedure of the information engineering methodology. The project of K company is used as the case study.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.3 no.3
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• pp.13-22
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• 1980

Research and Development has a property that involves uncertainity and risk in itself. Therefore, in order to scheduling of R & D activity, it Is needed of a certain probabilistic network technique with due regard to feedback process used to occur in the R & D proceeding. It is GERT that was developed as the need arises . In this study, the network structure of GERT-I and GERT-II was combined and then simulation analysis was used to it. According to that analysis , an advanced GERT model which covers the following stochastic problems was examined. 1 Evaluating success feasibility under the complex condition (time and cost). 2 Selecting acceptance range for the worst. 3. Selecting optimum path on basis of time, cost and success. 4. Evaluating project utility among the project alternatives. It is for managing R&D projects more effectively.

• Journal of the Korea Safety Management & Science
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• v.7 no.2
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• pp.141-151
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• 2005

EPC seeks to minimize variability by transferring the output variable to a related process input(controllable) variable, while SPC seeks to reduce variability by detecting and eliminating assignable causes of variation. In the case of product control, a very reasonable objective is to try to minimize the variance of the output deviations from the target or set point. We consider an alternative EPC model with second-order autoregressive disturbance. We compare three control systems; EPC, EPC combined with EWMA. This paper shows through simulation that tlhe performance of the integrated model of EPC and EWMA is more preferable than that of EPC.

• Archives of Pharmacal Research
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• v.18 no.3
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• pp.159-163
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• 1995

Previously, we have reported that methylene blue (MB) induces cytotoxicity in human brain tumor cells through the generation of free radicals. In this study the effect of deferoxamine (DFO), an iron chelator, on MB-induced cytotoxicity was investigated using SK-N-MC human neuroblastoma and U-373 MG human astrocytoma cells as model cellular systems. The cytotoxic effect of MB was potentiated by DFO. The potentiation effect of DFO was significantly blocked by either stoichiometric amounts of ferric ion, various antioxidants, hydroxyl radical scavengers or intracellular $Ca^{2+}$ release blockers. These results suggest that hydroxyl radical and intracellular $Ca^{2+}$ may act as important mediators of the enhanced cytotoxicity by MB and DFO. These results further suggest that the combined treatment with MB and DFO may be useful for the therapeutical applications of human brain tumors.

• Proceedings of the Membrane Society of Korea Conference
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• 1999.07a
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• pp.31-34
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• 1999

Membrane technology can be applied in two ways to produce pure enantiomers. In one case, a membrane separation process can be combined with an enantiospecific reaction to obtain so-called 'enantiospecific membrane reactor'. These systems are useful to carry out asymmetric synthesis or kinetic resolution and simultaneously separate the produced enantiomer. As for general membrane reactors, the result is a were compact system with a higher conversion; in fact, removal of a product drives equilibrium-limited reactions towards completion. The other way to apply membrane technology to chiral production is the use of intrinsically enantioselective membranes that are able to distinguish between two isomers favouring preperential transport of only one isomer in absence of reaction. In This paper, the current development of chiral membrane processes will be discussed.

• Membrane Journal
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• v.2 no.1
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• pp.49-58
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• 1992

Functionalized organic polymers have been used as supports for heterogenized homogeneous catalytic process[1]. Sprcific advantages of using these resins as support reagents have been reviewed[2-4]. These include: -ease of by-product separation from the main reaction product usuallyby simple filtration. -prevention of intermolecular reaction of reactive species or functional groups by simulating high dilution conditions[5]. -utility of the "fish-hook" principle in which a minor component in fished out of a large excess substrate by the insoluble polymer[6]. -the possibility of reusing recovered reagents as well as eliminating the use of volatile or noxious substances[7]. Catalysis by ion-exchange membranes is perhaps one of the latest examples of the use of a polymer-supported species. Conceptually, catalysts on membrane supports offer several possible advantages over traditional powder type systems. They are: (1) Membranes immobilize the catalyst, preventing agglomeration. (2) Filtration is unnecessary for the catalyst separation and so complete catalyst recovery is facilitated. (3) Catalytyic and separation processes can be combined, allowing membrane supported catalysts for the continous flow reactors. reactors.