• KSII Transactions on Internet and Information Systems (TIIS)
• /
• v.18 no.4
• /
• pp.843-859
• /
• 2024

The university course scheduling problem (UCSP) aims at optimally arranging courses to corresponding rooms, faculties, students, and timeslots with constraints. Previously, the university staff solved this thorny problem by hand, which is very time-consuming and makes it easy to fall into chaos. Even some meta-heuristic algorithms are proposed to solve UCSP automatically, while most only utilize one single algorithm, so the scheduling results still need improvement. Besides, they lack an in-depth analysis of the inner algorithms. Therefore, this paper presents a novel and practical approach based on Tabu search and simulated annealing algorithms for solving USCP. Firstly, the initial solution of the UCSP instance is generated by one construction heuristic algorithm, the first fit algorithm. Secondly, we defined one union move selector to control the moves and provide diverse solutions from initial solutions, consisting of two changing move selectors. Thirdly, Tabu search and simulated annealing (SA) are combined to filter out unacceptable moves in a parallel mode. Then, the acceptable moves are selected by one adaptive decision algorithm, which is used as the next step to construct the final solving path. Benefits from the excellent design of the union move selector, parallel tabu search and SA, and adaptive decision algorithm, the proposed method could effectively solve UCSP since it fully uses Tabu and SA. We designed and tested the proposed algorithm in one real-world (PKNU-UCSP) and ten random UCSP instances. The experimental results confirmed its effectiveness. Besides, the in-depth analysis confirmed each component's effectiveness for solving UCSP.

• Biomedical Science Letters
• /
• v.30 no.2
• /
• pp.37-48
• /
• 2024

Liposomes are one of the most actively studied and promising drug delivery systems for the treatment of various diseases. In this study, an aptamer-conjugated liposome called "aptamosome" was used, in which an anti-PD-L1 aptamer targeting cancer cells was conjugated to the liposome. These aptamosomes showed remarkable cellular uptake and efficient delivery to Lewis lung carcinoma 2 (LL/2) cancer cells. In addition, suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor (HDACi), was delivered through this aptamer to induce a strong anticancer immunotherapeutic effect. The results of this study showed that when LL/2 cells were treated with SAHA-entrapped aptamosome [SAHA] and liposome [SAHA] and free SAHA, aptamosome [SAHA] improved cell death compared with that of liposomes [SAHA] or free SAHA, and it has demonstrated anticancer efficacy. Moreover, aptamosome [SAHA] induce the secretion of chemokines that promote the migration of activated T cells into tumor tissues. Finally, in vivo experiments showed that aptamosome [SAHA] significantly inhibited the growth rate of LL/2 tumors. Therefore, liposomes combined with an anti-PD-L1 aptamer for efficient SAHA delivery are suggested as an excellent model for drug delivery systems suitable for targeting cancer cells.

• The Journal of Information Systems
• /
• v.33 no.3
• /
• pp.175-185
• /
• 2024

Purpose This study aims to analyze the relationship between consumption patterns and default risk among financially vulnerable households in a rapidly changing economic environment. Financially vulnerable households are more susceptible to economic shocks, and their consumption patterns can significantly contribute to an increased risk of default. Therefore, this study seeks to provide a systematic approach to predict and manage these risks in advance. Design/methodology/approach The study utilizes data from the Korea Welfare Panel Study (KOWEPS) to analyze the consumption patterns and default status of financially vulnerable households. To address the issue of data imbalance, sampling techniques such as SMOTE, SMOTE-ENN, and SMOTE-Tomek Links were applied. Various machine learning algorithms, including Logistic Regression, Decision Tree, Random Forest, and Support Vector Machine (SVM), were employed to develop the prediction model. The performance of the models was evaluated using Confusion Matrix and F1-score. Findings The findings reveal that when using the original imbalanced data, the prediction performance for the minority class (default) was poor. However, after applying imbalance handling techniques such as SMOTE, the predictive performance for the minority class improved significantly. In particular, the Random Forest model, when combined with the SMOTE-Tomek Links technique, showed the highest predictive performance, making it the most suitable model for default prediction. These results suggest that effectively addressing data imbalance is crucial in developing accurate default prediction models, and the appropriate use of sampling techniques can greatly enhance predictive performance.

• Korean Journal of Agricultural Science
• /
• v.20 no.2
• /
• pp.117-124
• /
• 1993

This study was conducted to determine the effects of alternating planting systems of soybean and tillering hybrid corn on yield of both crops. The planting systems included monocultures of both crops. 1 to 1 row ratio, 1 to 2 row ratio, 1 to 3 row ratio, 2 to 1 row ratio, 2 to 3 row ratio, 3 to 1 row ratio, 3 to 2 row ratio and 3 to 3 row ratio of soybean and corn. The results obtained are summarized as follows : The plant height of soybean was increased as the number of planting rows of corn increased. But the plant, height of soybean was quite stabilized when the ratio of soybean planting rows increased. When the plant height of soybean was increased due to the increased row number of corn, the branch number and diameter of soybean decreased and lodging ratio increased. Total fresh weight of soybean per 10a was decreased as the ratio of soybean planting decreased and it was increased when the ratio of soybean planting increased over monoculture of soybean. Dry weight of soybean per 10a showed the same tendency of the fresh weight. But the highest grain yield of soybean was obtained in the monoculture of soybean and it was 276 kg/10a. Comparatively high yield of soybean was obtained in the systems of 2 to 1 and 3 to 3 ratios. The plant height, number of tillers and number of ears per plant of tillering corn were greatly affected by the alternating planting of soybean and they were 208.9cm, 2.1 and 4 per plant, respectively. The fresh and dry weights and yield of corn per 10a showed significant differences among systems. The average fresh and dry weight of corn in the systems of 3 to 1 and 2 to 1 were 1000 kg and 100 kg higher than those of monoculture of corn. The kernel yields of corn per 10a were 438 kg in the monoculture system and 530 kg in the systems of 3 to 2 and 2 to 1. The total fresh weights of corn and soybean in systems of 3 to 1, 3 to 2 and 2 to 1 were higher than 5721 kg of soybean and 4358 kg of corn in the monoculture. Combined dry weight was high in the order of monoculture, 2 to 1 and 3 to 1 row ratios. Combined grain yield was high in the systems of 2 to 1 and 3 to 1 row ratios and it was over 430 kg per 10a.

• International Journal of Railway
• /
• v.1 no.4
• /
• pp.149-156
• /
• 2008

During maintenance or construction works in or at the tracks of railways, high risks for passengers and railway staff, especially for the workers on the construction site exist. The high risks result out of the movement of rail vehicles, like trains or construction vehicles, which must be faced by using any available technical and operational technologies for securing them against the environment. Therefore, it is necessary to evaluate the level of protection continuously and to identify new and innovative methods and technologies for the protection of the gang (construction worker, machines and material). Especially on construction sites at line sections with two or more parallel tracks but also with single tracks, there are still a lot of incidents and accidents mostly with seriously injured persons or fatalities. These were mainly gang members that breach the railway-loading gage. By using proper warning or protection systems, the avoidance of such accidents must be achieved. The latest developments. in gang protection systems concern on the one hand fixed barriers in the middle between the construction site and the operated track and on the other hand construction vehicles equipped with automatic warning systems. The disadvantage of such protection methods is that the gang can be warned against an approaching train but a monitoring of the gang members cannot be performed. Only one part of a potential dangerous situation will be detected. If the gang members will overhear the acoustic warning signal of the security staff and the workers will not leave the danger zone in the track, the driver of the approaching train had no chance to react to the dangerous situation. An accident is often inevitable. While the detection of acoustic warning signals by the gang members working on a construction site is very difficult, the acoustical planning of an automatic warning system has to be designed for an acoustic short range level of one meter besides the construction vehicle. The decision about the use of today's technical warning system (fixed systems, automatic warning systems, etc.) must be geared to the technical feasibility and the level of safety which is needed. Criteria for decision guidance to block a track should be developed by danger estimation and economical variables. To realize the actual jurisdiction and to minimize the hazards of railway operations by the use of construction vehicles near the tracks further developments are needed. This means, that the warning systems have to be enhanced to systems for protection, which monitor the realization of the warning signal as a precondition for giving a movement authority to a train. This method can protect against accidents caused by predictable wrongdoing. The actual state of the art technique of using a collective warning combined with additional security staff is no longer acceptable. Therefore, the Institute of Transportation System of the German Aerospace Center in Braunschweig (Germany) will develop a gang warning and protection system based upon imaging methods, with optical sensors such as video in visible and invisible ranges, radar, laser, and other. The advantage of such a system based on the possibility to monitor both the gang itself and the railway-loading gauge either of the parallel track or of the same track still in use. By monitoring both situations, the system will be able to generate a warning message for the approaching train, that there are obstacles in the track, so that the train can be stopped to prevent an accident. And also the gang workers will be warned, while they breach their area.

• KIEE International Transaction on Electrical Machinery and Energy Conversion Systems
• /
• v.5B no.3
• /
• pp.248-252
• /
• 2005

This paper deals with a new design method for a small-size rotating machine with high power. In order to achieve high performance, secondary excitation by Nd-Fe-B magnets and the grain oriented electrical steel sheets were selected and a new design using dual rotors is proposed. The outline of the high-performance rotating machine will be presented and the results of the finite element analysis by using this method combined with the E&SS modeling will be shown in the paper.

• KIEE International Transaction on Electrical Machinery and Energy Conversion Systems
• /
• v.5B no.3
• /
• pp.207-214
• /
• 2005

After more than 100 years of development, rotating electric machines are a mature industrial product. Nevertheless, improvements are still possible for specific applications, and it is likely that the major evolution will be promoted by new materials and unconventional structures. Till now, plastic materials are an infrequent choice for the electric machines structural parts, but pioneering applications, such as aeronautical components, let some technological scouting: a low-weight/high-efficiency plastic axial flux motor for a solar flying platform is presented as an example of combined new-material/new-geometry development. The basic design aspects and the prototyping choices are presented and discussed together with the first experimental results.

• Animal cells and systems
• /
• v.8 no.3
• /
• pp.221-229
• /
• 2004

The projections from the dorsal raphe (DR) to the locus coeruleus (LC) or vice versa were analyzed in the rat using an anterograde tracer, Phaseolus vulgaris leucoagglutinin (PHA-L) combined with serotonin (5-hydroxytryptamine, 5-HT) or dopamine-beta-hydroxylase (DBH) immunostaining. Following the injection of PHA-L into the middle DR, DR-originating fibers with varicosities have contacted DBH-immunolabeled cells in the rostral, middle, and caudal LC. Axon terminals were also observed in the subcoeruleus nucleus. When the PHA-L injection was confined within the caudal DR, axonal fibers with varicosities were observed mainly at the rostral pole of the LC. Following the injection of PHA-L into the caudal, principal LC, labeled fibers with varicosities have contacted 5-HT-immunolabeled neurons at dorsomedial, ventromedial, lateral wing, and caudal sub-divisions of the DR. The present anterograde study suggests that the DR or the LC nuclei communicate with each other in order to perform a variety of functions including vigilance, analgesia, and stress responses.

• Journal of Theoretical and Applied Mechanics
• /
• v.3 no.1
• /
• pp.1-15
• /
• 2002

Reduction methods for large structural systems have been reviewed. Mai emphasis is put on the dynamic reduction. Recently, the computing resources and technologies have been expanded so fast that the huge matrices Invoked In the analysis of structural system can be processed without serious difficulties. For most users, however, the computer facilities are limited and the system reductions in some forms are required. The reduction procedure in static problems is simple and straightforward. The major task is the book-keeping in computations. In dynamic problems and structural optimization. however. the problem is much more complicated. The problem is, in general, nonlinear and hence the exact solution is not available. Therefore, approximate solutions are sought in an iterative manner. A proper convergence criterion needs to be employed in order to get an accurate solution efficiently. Several research works have been reported fer the structural optimization combined with system reductions.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2008.05a
• /
• pp.985-988
• /
• 2008

This paper introduces a new TR-UWB system, using frequency-domain components of UWB pulses. This is achieved by separating converted frequency-components into real and imaginary parts, and both parts are correlated and effectively combined. We make an analysis that the new scheme improves performance compared with a conventional by complex correlation computing. The simulation results confirmed that the proposed scheme has better performance than existing system.