• 동의생리병리학회지
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• 제19권4호
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• pp.1078-1081
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• 2005

Lung abscess is often ocuured by aspiration of infectious secretion in stroke patients that has symptom of dysphagia. So we studied the effects of combined eastern and western treatment in lung abscess patient combined with stroke. We performed both antibiotic therapy and herbal medication in a lung abscess patient. We compared a chest x-ray film of early stage of disease with a film of after stage of disease, also compared change of symptom-cough, sputum, flank pain, blood phlem. After dispending antibiotic therapy and herbal medication, a lung abscess patient improved symptoms and in result of chest x-ray. The above results suggest that combined eastern and western trearment can have good effects on improving symptoms of a lung abscess patient.

• 디지털융복합연구
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• 제11권1호
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• pp.389-394
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• 2013

본 연구의 목적은 복합운동프로그램이 고령층에 있어 낙상관련체력 요소와 주관적 통증반응에 미치는 영향을 살펴보고자 하였다. 22명의 고령층을 대상으로 낙상관련 체력요소와 통증반응을 측정하였다. 복합운동프로그램은 10주 동안 주당 4일 1시간동안 유산소운동과 근력운동을 실시한 후 다음과 같은 결과를 얻었다. 유연성, 민첩성과 균형성에서 유의한 향상을 보였고 만성통증 증상, 걷기 시 통증과 앉을 때 통증, 일상생활에서의 통증에서 유의한 향상을 나타내었다. 결론적으로 고령층에서 10주간 복합운동프로그램이 낙상관련체력과 통증지수에 개선을 가져오는 것을 확인할 수 있었다.

• 한국실내디자인학회:학술대회논문집
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• 한국실내디자인학회 2005년도 추계학술발표대회 논문집
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• pp.191-192
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• 2005

This project is to establish an annex clinic center under 5 floors with gross floor area of 3,000 Pyeong behind existing Chosun university Hospital main building with 600 beds. The goal of the design is connecting the new clinic center with the existing main building and completing a combined hospital that has synergy effects. Given the old condition of the hospital and characteristics of the ground, I tried to embody the image of Medical Pulse, which is very alive with strong pulse, and suggest vision of 21st century hospital. First, one main entrance as a combined hospital. For optimum access and functions, I used the entrance of existing building as the only main entrance of new combined hospital, rearrange the road in front of the main building and improve traffic system, and upgrade the image and function of combined main entrance by planning new atrium united robby that makes link to the main building easier. Second, section planning considering the optimum functions and convenience. I established 4 floors linking functionally with the existing building, minimized vertical traffic line, and enhanced convenience through barrier free environment, which is a horizontal traffic line without barriers, crucial to hospital. Third, combined zoning generating synergy effects. I linked sterilizing room with logistics center by operating room and service bridge, and arranged central treatment department horizontally, Also, by horizontally arranging cancer center and department of nuclear medicine close with PET and cyclotron center, I established identity of specialized departments.

• 한국해양생명과학회지
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• 제4권2호
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• pp.45-52
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• 2019

다환방향족탄화수소류(PAHs)는 해양 환경에 오랜 기간 잔류하며 해양 생태계에 유해한 보편적인 환경 오염 물질이다. PAH류는 대부분 해양 환경에서 금속을 비롯한 다양한 오염 물질과 복합적으로 존재하지만 혼합 오염 물질이 개체에 미치는 영향에 대한 연구는 부족하다. 본 연구는 HgCl₂와 Benzo[a]pyrene (B[a]P)이 해양 생물에 미치는 영향을 개체 수준에서 평가하기 위하여 기수산 물벼룩(Diaphanosoma celebensis)을 이용하여 단일 및 혼합 급성 독성 시험을 진행하였다. 혼합 독성 평가에 사용한 혼합물의 농도는 단일 독성 시험을 통하여 얻은 각각의 LC₅₀을 기준으로 3:7 (Mixture A), 5:5 (Mixture B), 7:3 (Mixture C)의 비율로 혼합하여 결정하였다. 실험 결과 B[a]P와 HgCl₂의 48 h - LC₅₀은 각각 25.75 ㎍ l^-1와 3.6 ㎍ l^-1로 나타났다. 혼합 독성 평가 결과 Mixture A, B, C에서 TU는 각각 1.06, 0.83, 0.96로 나타났다. 이는 Mixture A, B, C가 CA 모델에 따라 작용함을 보여주며, HgCl₂와 B[a]P의 상호작용을 연구하기 위해 CA 모델을 사용하는 것이 적합할 것으로 생각된다. 본 연구는 금속과 PAH류의 혼합 독성 평가를 위한 기초 자료가 될 수 있을 것이다.

• 동의생리병리학회지
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• 제26권3호
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• pp.381-385
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• 2012

We investigated the eradication rate and the adverse effects of combined treatment with western and oriental medication on Helicobacter pylori infected patients. We studied the eradication rate and the adverse effects of 1-week-triple therapy and 2-week-oriental medication(Banhasasimtang or Hyangsapeungeuysan) on Helicobacter pylori infected patients confirmed by urea breath test. Comparing 5 patients who took combined treatment with western and oriental medication, the results of this study showed that 4 patients got eradication effect of Helicobacter pylori with no influence on liver and kidney function. A patient had diarrhea and another patient had satiety after meals because of an adverse effect. Despite some possitive effect, the treatment did not make the Quality of Life improved. The findings of this study supports the adverse effects of combined treatment with western and oriental medication for the treatment of Helicobacter pylori infection.

• Natural Product Sciences
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• 제13권4호
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• pp.342-346
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• 2007

The antimicrobial activity of the essential oil from Pelargonium graveolens and its effects when it was combined with current antibiotics against antibiotic-resistant strains of Streptococcus pneumoniae were evaluated. The minimal inhibitory concentrations (MICs) of the essential oil fraction and the main components of this plant were determined for two antibiotic-susceptible and two antibiotic-resistant strains of S. pneumoniae using broth microdilution tests. The combined effects of the oil with erythromycin, norfloxacin, or oxacillin were evaluated using a checkerboard microtitre assay. The combination of the oil fraction of P. graveolens, or its main component, together with the antibiotics tested significantly lowered the MICs of the antibiotics against all of the tested strains with fraction inhibiting concentration indices (FICs) ranging from 0.16 to 1.50. In particular, the activity of norfloxacin against all of the tested strains of S. pneumoniae was enhanced significantly by combination with citronellol. In conclusion, the combination of P. graveolens oil with antibiotics could be used to reduce the effective dose of antibiotic and to modulate the resistance of S. pneumoniae strains.

• 대한수의학회지
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• 제62권1호
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• pp.3.1-3.7
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• 2022

Disulfiram (DSF) is a marketed drug to treat patients with alcohol dependence by inhibiting aldehyde dehydrogenase. Over the last few decades, DSF has been shown to have anticancer effects through different mechanisms. Moreover, this effect can be elevated when used with copper (Cu). Subsequent studies have been conducted on various cancers, but few on lymphoma. This study investigated the anticancer effects of DSF on lymphoma and how this effect changed when treated with Cu. DSF synergistically decreased the metabolic activity of EL4 lymphoma cells when combined with Cu. At 1 µM of DSF alone, the metabolic activity of EL4 cells decreased by 49% compared to the control, whereas it decreased by 87% with a DSF + CuCl₂ treatment. Rhodamine 123 and 2',7'-dichlorofluorescein diacetate staining showed that DSF induced the reduction of the mitochondrial membrane potential and promoted the production of reactive oxygen species. In particular, the combined treatment of DSF + Cu induced cell death based on multiple assays, including annexin V-fluorescein isothiocyanate/propidium iodide staining. Overall, DSF has anticancer effects on lymphoma cells and exhibits synergistic effects when combined with Cu. This study provides some valuable information to broaden the use of DSF in clinics and basic research.

• Nutrition Research and Practice
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• 제18권1호
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• pp.62-77
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• 2024

BACKGROUND/OBJECTIVES: Colorectal cancer (CRC) is the third most common cancer worldwide with a high recurrence rate. Oxaliplatin (OXA) resistance is one of the major reasons hindering CRC therapy. β-Carotene (BC) is a provitamin A and is known to have antioxidant and anticancer effects. However, the combined effect of OXA and BC has not been investigated. Therefore, this study investigated the anticancer effects and mechanism of the combination of OXA and BC on CRC. MATERIALS/METHODS: In the present study, the effects of the combination of OXA and BC on cell viability, cell cycle arrest, and cancer stemness were investigated using HCT116, HT29, OXA-resistant cells, and human CRC organoids. RESULTS: The combination of OXA and BC enhanced apoptosis, G₂/M phase cell cycle arrest, and inhibited cancer cell survival in human CRC resistant cells and CRC organoids without toxicity in normal organoids. Cancer stem cell marker expression and self-replicating capacity were suppressed by combined treatment with OXA and BC. Moreover, this combined treatment upregulated apoptosis and the stem cell-related JAK/STAT signaling pathway. CONCLUSIONS: Our results suggest a novel potential role of BC in reducing resistance to OXA, thereby enhances the anticancer effects of OXA. This enhancement is achieved through the regulation of cell cycle, apoptosis, and stemness in CRC.

• 생약학회지
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• 제23권3호
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• pp.158-170
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• 1992

The studies were conducted to investigate the combined effects of several combined preparation of crude drugs and mitomycin C(MMC). The combined effects on the proliferation of Molt-4 cells and activation of human lymphocytes were estimated by MTT colorimetric assays. The drugs itself enhanced the proliferation of Molt-4, but the inhibitory action of MMC was not affected by the combined treatment of the drugs and MMC. Among 9 kinds of the drugs, Sip Jeon Dae Bo Tang(SDT), Saeng Maek San(SMS) and Kwi Bi Tang(KBT) did not inhibit the action of MMC, but activated lymphocytes. When the mice were treated by MMC, the number of leukocytes was decreased significantly at the 1st day, but recovered at the 7th day. In the groups of MMC treated with SDT or KBT, the number of leukocytes was increased significantly than the group of MMC treated only at the 3rd day. The combined treatment of SDT, SMS and MMC retained the body weight of mice at the level of normal mice. The SDT, SMS and KBT did not change the number of plaque forming cells(PFC) and the proliferation of T cells. The combined treatment of SDT and MMC increased the number of PFC significantly than the MMC treated group. The combined treatment of SDT, SMS, KBT and MMC increased the T cell proliferation significantly than the MMC treated group. In conclusion, it is suggested that SDT, SMS and KBT can recover the side effects of MMC, such as weight loss, leukopenia and immunosuppression, without any intercalating the anti-proliferative action of MMC in vivo.

• Radiation Oncology Journal
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• 제7권1호
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• pp.1-13
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• 1989

Effects of ionizing radiation alone and combined with chemotherapy on tumor growth and it's clonal specificity monitored by changes in distribution of chromosome number were studies in A549 ceil line originated from human adenocarcinoma of the lung. Radiation (300 rad, 600 rad and 900 rad) were delivered with or without 5-FU. Forty eight hours later, 57.5% of growth inhibition of cell w8s seen in cells treated with 5-FU concentration of $0.4{\mu}g/ml$ for 24hr exposure. Cell survival curves after radiation with and without 5-FU were made. Chromosomal analysis of cells in metaphase in control, and in cells treated with 300 rad of radiation, or $0.4{\mu}g/ml$ of 5-FU treatment, and combined treatment of both were done to examine the changes in ploidy and number of chromosome. Radiation combined with S-FU enhanced growth inhibition of A549 cells. However, no evidence of synergegic effects in growth. inhibition was observed in the cells treated with the combination therapy. Pattern of chromosomal distribution of survived cells were shifted from hyperploidy to hypoploidy by single dose of radiation (300 rad). As radiation dose increased a large number of hypoploidy cells were observed. Following treatment of cells with 5-FU, chomosomal distribution of survived cells were also shifted to hypodiploidy which were seen in cells treated with radiation, The ceil treated with 5-FU and fellowed by radiation within 24 hrs had cell with increased number of hypodiploidy cells. Almost same type of chromosomal changes were reproduced in cells treated with combined treatment with radiation and 5-FU. Minor differences were that cells with fewer number of chromosome were more frequent in cells treated with combined therapy. Further increase in cells of hypoploidy (93%) having 1-10 chromosome were induced by additional radiation. Therefore, the enhanced therapeutic effect of 5-FU combined with radiation of A549 cells appeared to be additive rather than synergistic.