The purpose of this study was to investigate the self-resilience, professional self-concept, and major satisfaction on nursing students' adjustment to college life and to present the basic data to assist in healthy adaption of college life. The study included 310 students from two universities in Gwangju and Jeonnam. A questionnaire survey was conducted on the subjects to determine their self-resilience, professional self-concept, major satisfaction, and adjustment to college life with nursing as a major. The data were collected from 1, April, 2016 to 15, April using self-report, questionnaires and analyzed through descriptive statistics, percentage, mean, standard deviation, t-test, ANOVA, and Pearson correlation coefficient, using SPSS 20.0. As a result, self-esteem, professional self-concept, major satisfaction, and adjustment to college life averaged 3.80 (out of 4), 2.81 (4), 3.86 (5), and 2.75 (5) respectively. In terms of correlations, there was a significant positive correlation between adjustment to college life and self-resilience (r=.404, p<.001) and professional self-concept (r=.404, p<.001) and major satisfaction(r=.455, p<.001). In addition, self-resilience (${\beta}=.252$, p<.001) and major satisfaction (${\beta}=.309$, p<.001) of variance in adjustment to college life and the explanatory power of the model was 27.2%. Based on these results, improvement programs are necessary to help nursing students get adjusted to college life.