• Animal cells and systems
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• 제2권1호
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• pp.65-69
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• 1998

The hippocampus and prefrontal cortex are regarded as the highest-order association cortices. The hippocampus has been proposed to store "cognitive maps" of external environments, and the prefrontal cortex is known to be involved in the planning of behavior, among other functions. Considering the prominent functional roles played by these structures, it is not surprising to find direct monosynaptic projections from the hippocampus to the prefrontal cortex. Rhythmic stimulation of this projection patterned after the hippocampal EEG theta rhythm induced stable long-term potentiation of field potentials in the prefrontal cortex. Comparison of behavioral correlates of hippocampal and prefrontal cortical neurons during an a-arm radial maze, working memory task shows a striking contrast. Hippocampal neurons exhibit clear place-specific firing patterns, whereas prefrontal cortical neurons do not show spatial selectivity, but are correlated to different stages of the behavioral task. These data lead to the hypothesis that the role of hippocampal projection to the prefrontal cortex is not to impose spatial representations upon prefrontal activity, but to provide a mechanism for learning the spatial context in which particular behaviors are appropriate.propriate.

• Clinical and Experimental Pediatrics
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• 제54권6호
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• pp.241-245
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• 2011

Tuberous sclerosis complex (TSC) is a genetic multisystem disorder that results from mutations in the TSC1 or TSC2 genes, and is associated with hamartomas in several organs, including subependymal giant cell tumors. The neurological manifestations of TSC are particularly challenging and include infantile spasms, intractable epilepsy, cognitive disabilities, and autism. The TSC1- and TSC2-encoded proteins modulate cell function via the mammalian target of rapamycin (mTOR) signaling cascade, and are key factors in the regulation of cell growth and proliferation. The mTOR pathway provides an intersection for an intricate network of protein cascades that respond to cellular nutrition, energy levels, and growth factor stimulation. In the brain, TSC1 and TSC2 have been implicated in cell body size, dendritic arborization, axonal outgrowth and targeting, neuronal migration, cortical lamination, and spine formation. The mTOR pathway represents a logical candidate for drug targeting, because mTOR regulates multiple cellular functions that may contribute to epileptogenesis, including protein synthesis, cell growth and proliferation, and synaptic plasticity. Antagonism of the mTOR pathway with rapamycin and related compounds may provide new therapeutic options for TSC patients.

• Child Health Nursing Research
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• 제17권2호
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• pp.120-126
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• 2011

Purpose: The purpose of this study was to explore the concept of Mother-Child Interaction (MCI). Methods: The concept analysis method described by Walker & Avant (2005) was used. Results: The attributes of MCI were as follows; 1) MCI involves positive or negative affective and verbal communication. 2) MCI involves mother, child, and dyadic activity. 3) MCI involves sensitivity, responsiveness, and child developmental stimulation. 4) MCI is reciprocal, goal-oriented partnership process. The antecedents of MCI are need for goal attainment, relationship, and child development (cognitive, physical, emotional, and social). The consequences of MCI are goal attainment, promotion of mother-child relationship, and promotion of child development. Conclusion: MCI is a reciprocal, goal-oriented partnership process and is an important concept in child development and health. Appropriate instruments to operationalize the concept need to be developed.

• 한국정보전자통신기술학회논문지
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• 제8권1호
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• pp.75-78
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• 2015

Electric shock due to the increased use of power, equipment accidents, electrical accidents, such as electric fire and also continues to grow. To prevent electric shock accidents, an experience education is more effective than indoctrination education. But an electric shock experience education system required a proper physical stimulation on human body to experience electric shock. In this study, we conducted a study to take advantage of the realistic haptic interface using a low-frequency type experiential learning and prevention education. Results of this study could be applied to an electric shock experience education system.

• 만화애니메이션 연구
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• 통권33호
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• pp.99-126
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• 2013

이 연구는 애니메이션의 재미가 어떻게 구성되는지를 이론적으로 검토하고 조작화 한 후, 애니메이션의 재미를 강화시켜 줄 수 있는 구조를 제안한다. 그리고 제안한 재미모델을 검증하여 애니메이션의 재미가 어떠한 방식으로 작동하고 있는지를 살펴보는데 의미가 있다. 재미에 대해 이론적으로 검토한 결과 애니메이션의 재미는 감각적 재미, 인지적 재미, 심리적 재미로 구성된다고 조작화할 수 있었다. 감각적 재미는 시각, 청각등의 감각적 정보를 통해 유발되는 재미로, 감각적 재미에 직접 영향을 주는 요소로는 이미지, 사운드, 움직임이 있다. 인지적 재미는 감각적으로 지각된 자극을 자신이 가지고 있는 지식을 동원하여 능동적으로 추론하고 해석하여 얻어지는 재미로 스토리를 인지적 재미의 요소로 보았다. 심리적 재미는 관객이 애니메이션을 관람할 때 발생하는 심리적 정체를 해소함으로써 재미를 경험하는 심리적 감정 상태로 동일시나 낯섦의 재미로 구성된다. 애니메이션의 재미를 구성하는 감각적 재미, 인지적 재미, 심리적 재미가 서로 어떠한 영향을 미치는 가에 대해 연구모델을 검증한 결과, 감각적 재미가 인지적 재미와 심리적 재미를 강화시킨다는 것을 알 수 있었다. 물론 인지적 재미도 심리적 재미를 강화시키는 것으로 나타났으나, 감각적 재미가 인지적 재미보다 두 배 이상 심리적 재미를 강화시키는 것으로 나타났다. 또한 감각적 재미가 심리적 재미에 영향을 미칠 때 인지적 재미가 매개변수로서 간접효과를 나타내고 있음을 알 수 있었다. 따라서 감각적 재미는 심리적 재미에 직접적으로도 영향을 주지만 인지적 재미를 통해서 더욱 강화된다는 것을 보여주고 있다. 애니메이션의 재미란 감각적 재미와 인지적 재미, 심리적 재미가 하나로 융합되어 작용할 때 경험되어지는 것이다. 따라서 어느 한 재미요소만을 부각시킨 애니메이션은 관객에게 사랑받기 어렵다. 애니메이션의 재미요소인 스토리, 이미지, 사운드, 움직임의 조화로운 결합을 통해 재미감정을 유발시켜 심리적으로 재미있게 만드는 일이 중요하다.

• Journal of Acupuncture Research
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• 제24권3호
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• pp.215-229
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• 2007

Objectives : Placebo phenomena have been considered as a confounding factor of clinical trial. Expectancy and belief of acupuncture have not been evaluated quantitatively. The present study was performed to analyze the emotional and cognitive factor .of acupuncture and investigate whether the expectancy of acupuncture treatment is associated with the cognition of acupuncture. Methods : The expectancy and the perception of bodily sensation (PBS) of 22 participants were assessed using self-reported questionnaire. The subjects used the self assessment manikin (SAM) to rate each of the standard affective image of the international affective picture system (lAPS) and other acupuncture-related image. Based on the degree of expectancy, the high expectant (HE) and the low expectant (LE) group were classified. The thermal and pressure pain threshold was objectively evaluated using radiant-heat device and algometer. The degree of expected pain of acupuncture and the actual pain of painful stimulation was subjectively evaluated using facial pain scales (FPS). Results : Using SAlVI analysis, we identified the negative correlation between hedonic valence and arousal dimension on acupuncture-related visual cue. The degree of the PBS and general pain threshold did not show any significant difference between the HE and the LE group. The HE group rated the acupuncture images as more pleasant, more arousing, than the LE group. In addition, we also found that the higher expectancy marked the lower FPS of the expected pain of acupuncture, but not of the actual pain of painful stimulation. Conclusions : Our preliminary study identified the psychological dimensions of acupuncture-related visual cue. These findings indicate that the expectancy of acupuncture could affect the cognition of acupuncture.

• Journal of Korean Neurosurgical Society
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• 제61권4호
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• pp.427-433
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• 2018

Obsessive compulsive disorder is a debilitating condition characterized by recurrent obsessive thoughts and compulsive reactions. A great portion of the obsessive compulsive disorder (OCD) patients are managed successfully with psychiatric treatment such as selective serotonin-reuptake inhibitor and cognitive behavioral psychotherapy, but more than 10% of patients are remained as non-responder who needs neurosurgical treatments. These patients are potential candidates for the neurosurgical management. There had been various kind of operation, lesioning such as leucotomy or cingulotomy or capsulotomy or limbic leucotomy, and with advent of stereotaxic approach and technical advances, deep brain stimulation was more chosen by neurosurgeon due to its characteristic of reversibility and adjustability. Gamma knife radiosurgery are also applied to make lesion targeting based on magnetic resonance (MR) imaging, but the complication of adverse radiation effect is not predictable. In the neurosurgical field, MR guided focused ultrasound has advantage of less invasiveness, real-time monitored procedure which is now growing to attempt to apply for various brain disorder. In this review, the neurosurgical treatment modalities for the treatment of OCD will be briefly reviewed and the current state of MR guided focused ultrasound for OCD will be suggested.

• 감성과학
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• 제13권4호
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• pp.703-710
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• 2010

본 연구에서는 선행 연구에서 개발된 촉각 자극 시스템의 시스템적인 문제, 자극 제어에 관한 문제, 기타 부가적인 문제들을 보완할 수 있는 촉각 자극기를 개발하였다. 개발된 장치는 제어부(control unit), 구동부(drive unit), 진동부(vibrator)의 세부분으로 구성된다. 제어부는 E-Prime 소프트웨어로부터 명령을 전송받고 진동 자극 신호를 발생한다. 구동부는 촉각 자극기가 효과적으로 진동 자극을 발생할 수 있도록 충분한 전류를 공급한다. 진동부는 작은 동전(coin) 형 진동기(vibrator)와 벨크로(velcro)로 구성되며 피험자의 손에 쉽게 고정 할 수 있도록 제작하였다. 개발된 장치는 소형, 경량, 저전력 구동, 간단한 구조, 최대 35개의 자극 채널, 시각 및 청각과의 다양한 자극 조합을 지연시간 없이 제시할 수 있도록 설계 되어 시스템적인 문제들을 보완하였다. 자극의 크기와 시간을 10단계로 조절할 수 있도록 하고, 넓은 동작주파수 범위를 확보하여 자극 제어에 관한 문제들을 보완하였다. 저전압 구동으로 인체에 대한 안정성을 확보하고, 손가락 이외에 신체의 어느 부분이든 자극 제시가 가능하도록 제작하였다. 특히 본 시스템은 인지과학 연구에서 범용으로 사용되는 소프트웨어인 E-Prime을 기반으로 개발되었기 때문에 활용성이 매우 높을 것으로 판단된다.

• 인지과학
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• 제31권3호
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• pp.55-76
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• 2020

사회성은 인간 삶의 고유 영역이자 종합적인 능력으로서 중요한 가치를 지닌다. 일반 통념상 사회성 부족이 게임 이용의 대표적인 문제점으로 지적되는 가운데, 본 문헌 고찰에서는 비디오 게임 중 온라인 비디오 게임을 대상으로 사회적 역량과의 관계를 살펴본 연구들을 분석했다. 해당 분야에는 현재 온라인 게임 안의 관계가 실제 관계를 대체하거나 보완하여 사회성 발달을 저해할 것이라는 견해와 온라인 비디오 게임이 직접적으로 사회성에 악영향을 미치지 않으며 오히려 사회적 학습의 공간을 제공함으로써 유익한 결과를 낼 수 있다는 주장이 팽팽하게 맞서고 있다. 또한 온라인 게임 이용과 심리특성 및 사회적 역량을 측정한 대규모 설문 조사에서도 게임 이용과 사회성 저하 간의 뚜렷한 관계성이 관찰되지 않았다. 이에 본 문헌 고찰 연구를 통해 온라인 게임 플레이가 사회성 저하를 초래한다는 고정관념에서 벗어날 것과 관련 연구의 타당성을 높이기 위한 노력이 필요함을 제안한다.

• The Korean Journal of Pain
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• 제31권3호
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• pp.155-173
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• 2018

Chronic postsurgical pain (CPSP) is an unwanted adverse event in any operation. It leads to functional limitations and psychological trauma for patients, and leaves the operative team with feelings of failure and humiliation. Therefore, it is crucial that preventive strategies for CPSP are considered in high-risk operations. Various techniques have been implemented to reduce the risk with variable success. Identifying the risk factors for each patient and applying a timely preventive strategy may help patients avoid the distress of chronic pain. The preventive strategies include modification of the surgical technique, good pain control throughout the perioperative period, and preoperative psychological intervention focusing on the psychosocial and cognitive risk factors. Appropriate management of CPSP patients is also necessary to reduce their suffering. CPSP usually has a neuropathic pain component; therefore, the current recommendations are based on data on chronic neuropathic pain. Hence, voltage-dependent calcium channel antagonists, antidepressants, topical lidocaine and topical capsaicin are the main pharmacological treatments. Paracetamol, NSAIDs and weak opioids can be used according to symptom severity, but strong opioids should be used with great caution and are not recommended. Other drugs that may be helpful are ketamine, clonidine, and intravenous lidocaine infusion. For patients with failed pharmacological treatment, consideration should be given to pain interventions; examples include transcutaneous electrical nerve stimulation, botulinum toxin injections, pulsed radiofrequency, nerve blocks, nerve ablation, neuromodulation and surgical management. Physical therapy, cognitive behavioral therapy and lifestyle modifications are also useful for relieving the pain and distress experienced by CPSP patients.