• Korean Journal of Clinical Pharmacy
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• v.28 no.1
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• pp.24-29
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• 2018

Background: Cyclosporine is an immunosuppressive agent used to treat and prevent graft versus host reaction (GVHR)-a complication associated with stem cell transplantation. This study aimed to develop a population pharmacokinetic model of cyclosporine and investigate factors affecting cyclosporine clearance in pediatric hematopoietic stem cell transplant patients. Methods: A total of 650 cyclosporine concentrations recorded in 65 patients who underwent hematopoietic stem cell transplantation were used. Data including age, sex, weight, height, body surface area (BSA), type of disease, chemotherapy before stem cell transplantation, type of donor, serum creatinine levels, total bilirubin concentration, hematocrit value, and type of concomitant anti-fungal agents and methylprednisolone used were retrospectively collected. Data related to cyclosporine dosage, administration time, and blood concentration were also collected. All data were analyzed using the non-linear mixed effect model; a two-compartment model with first-order elimination was used. Results: The population pharmacokinetic model of cyclosporine using the NONMEM program was as follows: $CL(L/h)=5.9{\times}(BSA/1.2)^{0.9}$, V2 (L) = 54.5, Q (L/h) = 3.5, V3 (L) = 1080.0, $k_a(h^{-1})=0.000377$. BSA was selected as a covariate of cyclosporine clearance, which increased with an increase in BSA. Conclusion: A population pharmacokinetic model for Korean pediatric hematopoietic stem cell transplant patients was developed, and the important factor affecting cyclosporine clearance was found to be BSA. The model might contribute to the development of the most appropriate dosing regimen for cyclosporine. Further studies on population pharmacokinetics should be carried out, prospectively targeting pediatric patients.

• Journal of Korean Society of Transportation
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• v.28 no.1
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• pp.97-105
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• 2010

An All-red clearance interval(AR) has been operating with amber signal in order to avoid collision between vehicles which cannot come out of the intersections, vehicles coming in from the opposite direction, and pedestrians(bicycles) on the crosswalk during the signal conversion time at the intersections. Foreign nations have been analyzing AR's influences of traffic accidents. On the other hand, the similar research has not been conducted in the country. The objective of this paper, therefore, is to analyze the safety at the intersections with respect to the installation of AR through the hypothesis test. A before-and-after analysis has been performed for 10 intersections where applied AR. From the 95% of significance level, the results of Non-parametric Test show that the installation of AR improves a safety at the intersections. The results indicates that AR discharges vehicles passing through the intersections and control entering vehicles at the intersections.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.23 no.3
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• pp.266-275
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• 2020

Purpose: The outcome predictors of Kasai portoenterostomy (KPE) for biliary atresia (BA) are controversial. This study aimed to identify possible short-term outcome predictors of KPE for BA in infants. Methods: This retrospective study included infants with BA who underwent KPE between January 2015 and December 2017 and were followed up for at least 6 months after surgery at the Pediatric Hepatology Unit, Cairo University Pediatric Hospital, Egypt. The short-term outcome was jaundice clearance within 6 months following surgery. All data were compared between the jaundice free group and those with persistent jaundice to identify the predictors of jaundice clearance. Results: The study included 75 infants. The mean age at the time of surgery was 82.43±22.77 days (range, 37-150 days), and 28 (37.3%) infants cleared their jaundice within 6 months postoperative. Age at surgery did not significantly affect the outcome (p=0.518). Infants with persistent jaundice had significantly higher pre-operative levels of aspartate aminotransferase (AST) than those who were jaundice free (p=0.041). Receiver operating characteristic curve analysis showed that preoperative AST ≤180 IU/L was predictive of a successful KPE, with sensitivity 74.5% and specificity 60.7%. Infants with bile plugs in liver biopsy had a 6-fold higher risk of persistent jaundice than those without bile plugs (95% confidence interval: 1.59-20.75, p=0.008). Conclusion: Jaundice clearance after KPE for BA can be predicted using preoperative AST and presence of bile plugs in liver biopsy.

• The Korean Journal of Physiology and Pharmacology
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• v.28 no.2
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• pp.121-127
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• 2024

Vancomycin is a frequently used antibiotic in intensive care units, and the patient's renal clearance affects the pharmacokinetic characteristics of vancomycin. Several advantages have been reported for vancomycin continuous intravenous infusion, but studies on continuous dosing regimens based on patients' renal clearance are insufficient. The aim of this study was to develop a vancomycin serum concentration prediction model by factoring in a patient's renal clearance. Children admitted to our institution between July 1, 2021, and July 31, 2022 with records of continuous infusion of vancomycin were included in the study. Sex, age, height, weight, vancomycin dose by weight, interval from the start of vancomycin administration to the time of therapeutic drug monitoring sampling, and vancomycin serum concentrations were analyzed with the linear regression analysis of the mixed effect model. Univariable regression analysis was performed using the vancomycin serum concentration as a dependent variable. It showed that vancomycin dose (p < 0.001) and serum creatinine (p = 0.007) were factors that had the most impact on vancomycin serum concentration. Vancomycin serum concentration was affected by vancomycin dose (p < 0.001) and serum creatinine (p = 0.001) with statistical significance, and a multivariable regression model was obtained as follows: Vancomycin serum concentration (mg/l) = -1.296 + 0.281 × vancomycin dose (mg/kg) + 20.458 × serum creatinine (mg/dl) (adjusted coefficient of determination, R² = 0.66). This prediction model is expected to contribute to establishing an optimal continuous infusion regimen for vancomycin.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.67
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• pp.97-118
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• 2015

This study reviews the judgements by the Korean Supreme Court on the time of delivery of goods, as it depends on which bonded place the goods are kept for the purpose of the customs clearance. Thereafter, this study analyzes the Ocean Carrier's liability, when the cargoes are mis-delivered without the presentation of bill of lading in relation to the specific bonded place such as an independent bonded warehouse or a self-use bonded warehouse. Furthermore, considering that voyage charter is a kind of marine transport, this study also reviews whether or not the Court's judgements, which has been developed in respect of the carriage of affreightment, could be applied to voyage charter in respect of the time of delivery goods and the Ocean Carrier's liability for mis-delivery. Lastly, in the case that the substantial importer takes the goods from the independent bonded warehouse without the presentation of bill of lading after the customs clearance, it is noted that the Court has made the Ocean Carrier liable for the mis-delivery through the application of theory of double deposit contract. The position of the Court would be understandable in terms of the protection for the bona-fide holder of bill of lading, but this study reviews the limitation of liability as the device for the protection of the Ocean Carrier, considering the situation where the Ocean Carrier is somewhat unreasonably sacrificed under the bonded system provided for the convenience of substantial importer.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.28 no.12
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• pp.1864-1870
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• 2004

A spot welded structures have an influence on a diverse climatic situation, for instance temperature, humidity and precipitation. In addition factors of environmental pollution such as acid rain, that courses corrosion, have the tendency to increase. But spot welded structures strength is affected by humidity and environment temperature. Therefore, it is important to evaluate effect of temperature and water immersion on strength properties of spot welded part. In this study, the strength distribution of spot welded plates is evaluated the environmental temperature of zinc coated steel plates. Test is conducted with welded part immersed in distilled and synthetic sea water. Specimens are immersed into water for 10, 100, 500 and 1000 hours to evaluate the offsets of water immersion time on tensile-shear strength under the conditions of -40, 0, 20 and 5$0^{\circ}C$. From this result, spot welded specimens with 5 mm clearance have lower tensile-shear strength in the distilled water or synthetic sea water than without clearance. And they have lower tensile-shear strength under -4$0^{\circ}C$ and over 5$0^{\circ}C$.

• Transactions of the Korean Society of Mechanical Engineers
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• v.15 no.1
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• pp.120-126
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• 1991

An expanded scheme of a direct numerical solution method for solving the Navier-Stokes equation considering the modified boundary conditions for gas lubrication with ultra low clearance at high .LAMBDA. region is presented. Many examples are calculated by this scheme and their results are compared to the previous solutions using P$^{2}$H$^{[-992]}$ . This scheme has the advantages of fast calculation time and stable convergence in high .LAMBDA. region, and gives very good results in the case of fluid film thickness discontinuity.

• Tribology and Lubricants
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• v.25 no.5
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• pp.324-329
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• 2009

In this study a complex design fitness analysis of journal bearings is carried out for the LPLi rotary-vane fuel pump application, as an external and horizontal installation, in LPG vehicles. Bearings considered in the analyses are plain and 3-axial groove journal bearings. Upon reflecting the fact that the primary failure mode of bearings in the application is a premature friction and wear failure of bearing metal due to a very low viscosity of liquid fuel LPG as a bearing lubricant, the performance factors of bearings used in an evaluation process of design fitness are a load carrying capacity and vibration suppression ability relative to a rated speed. At this time the design variables of bearings are a radial clearance and length. Results show that, in terms of both of the load carrying capacity and vibration suppression ability, the plain journal bearings are superior to the 3-axial groove journal bearings and among the plain bearings the smaller the bearing clearance (5>10>$15\;{\mu}m$) is and the longer the bearing length (6<8<10<12<14 mm) is, the better the bearing performance is.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.43 no.4
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• pp.341-348
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• 2015

This paper addresses Monte-Carlo simulation analyses for the stage separation of the general launch vehicle. The stage separation event of the launch vehicle occurs during a very short time and is related with many dynamic parameters. The stage separation is a critical event in that the launch fails if there is a collision during the stage separation. The stage separation analyses was conducted for the general launch vehicle to confirm the separation without collision within the designed clearance in case of the random input parameters. This paper presents the stochastic results of the stage separation of the launch vehicle using the Monte-Carlo simulation.

• Journal of Aerospace System Engineering
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• v.14 no.1
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• pp.1-7
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• 2020

This paper discusses a series of procedures and results for designing the gear part of a fuel transfer pump for an aircraft, developed as an independent technology for the first time in Korea. A gear pump type is selected because the design requirements of the fuel transfer pump are met by a gear pump with a characteristics of less leakage inside than a vane pump with superior overall performance. The gear housing is designed with suitable clearance, considering the outer diameter of the gear, which is the main factor on which the flow can be determined. Additionally, the calculation of the required hydraulic and axial force for the motor to drive the fuel transfer pump was performed.