• Title/Summary/Keyword: choice properties

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Therapeutic radionuclides (치료용 방사성동위원소)

  • Choi, Sun-Ju;Hong, Young-Don;Lee, So-Young
    • Nuclear Medicine and Molecular Imaging
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    • v.40 no.2
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    • pp.58-65
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    • 2006
  • Since the development of sophisticated molecular carriers such as octereotides for peptide receptor targeting and monoclonal antibodies against various antigens associated with specific tumor types, radionuclide therapy (RNT) employing open sources of therapeutic agents is promising modality for treatment of tumors. furthermore, the emerging of new therapeutic regimes and new approaches for tumor treatment using radionuclide are anticipated in near future. In targeted radiotherapy using peptides and other receptor based tarrier molecules, the use of radionuclide with high specific activity in formulating the radiopharmaceutical is essential in order to deliver sufficient number of radionuclides to the target site without saturating the target. In order to develop effective radiopharmaceuticals for therapeutic applications, it is crucial to carefully consider the choice of appropriate radionuclides as well as the tarrier moiety with suitable pharmacokinetic properties that could result in good in vivo localization and desired excretion. Up to date, only a limited number of radionuclides have been applied in radiopharmaceutical development due to the constraints in compliance with their physical half-life, decay characteristics, cost and availability in therapeutic applications. In this review article, we intend to provide with the improved understanding of the factors of importance of appropriate radionuclide for therapy with respect to their physical properties and therapeutic applications.

Some properties of the Green's function of simplified elastodynamic problems

  • Sanchez-Sesma, Francisco J.;Rodriguez-Castellanos, Alejandro;Perez-Gavilan, Juan J.;Marengo-Mogollon, Humberto;Perez-Rocha, Luis E.;Luzon, Francisco
    • Earthquakes and Structures
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    • v.3 no.3_4
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    • pp.507-518
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    • 2012
  • It is now widely accepted that the resulting displacement field within elastic, inhomogeneous, anisotropic solids subjected to equipartitioned, uniform illumination from uncorrelated sources, has intensities that follow diffusion-like equations. Typically, coda waves are invoked to illustrate this concept. These waves arrive later as a consequence of multiple scattering and appear at "the tail" (coda, in Latin) of seismograms and are usually considered an example of diffuse field. It has been demonstrated that the average correlations of motions within a diffuse field, in frequency domain, is proportional to the imaginary part of Green's function tensor. If only one station is available, the average autocorrelation is equal to the average squared amplitudes or the average power spectrum and this gives the Green's function at the source itself. Several works address this point from theoretical and experimental point of view. However, a complete and explicit analytical description is lacking. In this work we study analytically some properties of the Green's function, specifically the imaginary part of Green's function for 2D antiplane problems. This choice is guided by the fact that these scalar problems have a closed analytical solution (Kausel 2006). We assume the diffusiveness of the field and explore its analytical consequences.

Comparison of Durability for PUA Type Resin using Wear and Nano-indentation Test (마모 및 나노 압입 시험을 이용한 PUA계 레진의 내구성 비교)

  • Choi, Hyun Min;Kwon, Sin;Jung, Yoon-Gyo;Cho, Young Tae
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.17 no.5
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    • pp.8-15
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    • 2018
  • Films with special properties (e.g., water-repellent films, optical films, anti-reflection films, and flexible films) are referred to as functional films. Recently, there has been interest in fine patterning methods for film fabrication. In particular there have been many studies that use a UV nanoimprint process involving a UV curing method. In this paper, a polymer film was fabricated by the UV nanoimprint process with a micro-pattern, and its durability was evaluated by a wear test and a nano-indentation test. The film mechanical properties (such as coefficient of friction, hardness, and modulus of elasticity) were measured. Moreover, the choice of PUA type resin used in the UV nanoimprint process was confirmed to impact the durability of the thin film. Despite making the polymer film samples using the same method and PUA type resin, different coefficient of friction, hardness, and modulus of elasticity values were obtained. PUA 4 resin had the most favorable coefficient of friction, hardness, and modulus of elasticity. This material is predicted to produce a high durability functional film.

Horizon-AGN virtual observatory: SED-fitting performance and forecasts for future imaging surveys

  • Laigle, Clotilde;Davidzon, I.;Ilbert, O.;Devriendt, J.;Kashino, D.;Capak, P.;Arnouts, S.;De la Torre, S.;Dubois, Y.;Gozaliasl, G.;Leborgne, D.;McCracken, H.J.;Pichon, C.
    • The Bulletin of The Korean Astronomical Society
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    • v.43 no.2
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    • pp.32.3-32.3
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    • 2018
  • We use the synthetic light-cone from the cosmological hydrodynamical simulation Horizon-AGN to produce a mock photometric galaxy catalogue on the redshift range 0

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"Cohesiveness of Hyaluronic Acid Fillers": Evaluation Using Multiple Cohesion Tests

  • Kyun Tae Kim;Won Lee;Eun-Jung Yang
    • Archives of Plastic Surgery
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    • v.51 no.1
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    • pp.14-19
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    • 2024
  • Background Hyaluronic acid fillers can be manufactured using various processes. They have multiple properties, including their concentration, degree of modification, and rheological data. Cohesion is one such property to evaluate gel integrity; however, there is no standardized method for calculating this parameter. This study aimed to evaluate different tests for calculating hyaluronic acid cohesion and discuss the importance of hyaluronic acid cohesion as a consideration when selecting fillers. Methods The cohesion levels of five different hyaluronic acid fillers with different rheological properties were evaluated and compared using the drop weight, compression, tack, and dispersion time tests. Results The cohesion tests yielded different results in the samples. Samples 2 and 4 showed approximately two times the number of droplets when compared with Sample 5 in drop weight test. Samples 1, 2, 3, and 4 were superior to Sample 5 in tack test. Samples 1, 2, and 3 showed cohesive appearances at 95 seconds in most cases in dispersion test. Rheological test results did not reflect the measures of cohesion. Conclusion Although there are no definite standardized tests to evaluate the cohesion of hyaluronic acid fillers, our proposed tests showed similar results for different hyaluronic acid filler products. Further studies are needed to evaluate the cohesion of hyaluronic acid fillers and determine the clinical use of this distinguishing characteristic for clinicians selecting the product of choice. Level of evidence statement: These data are Level IV evidence.

Effect of Shock Wave Exposure on Structural, Optical and Magnetic Properties of Lead Sulfide Nanoparticles (충격파 유동노출에 따른 황화납 나노소재의 미세구조 및 자기광학적 특성 분석에 관한 실험적 연구)

  • Kiwon Kim;Surendhar Sakthivel;J. Sahadevan;P. Sivaprakash;Ikhyun Kim
    • Journal of the Korean Society of Visualization
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    • v.22 no.1
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    • pp.18-27
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    • 2024
  • A series of shock wave pulses with Mach number 2.2 of 100, 200, and 300 shocks were applied to lead sulfide (PbS) nanomaterials at intervals of 5 sec per shock pulse. To investigate the crystallographic, electronic, and magnetic phase stabilities, powder X-ray diffractometry (XRD), diffused reflectance spectroscopy (DRS), and vibrating-sample magnetometry (VSM) were employed. The material exhibited a rock salt structure (NaCl-type structure); XRD results indicated that material is monoclinic with space group C121 (5). Further, XRD results showed shifts due to lattice contraction and expansion when material was subjected to shock wave pulses, indicating stable material structure. Based on the data obtained, we believe that the PbS material is a good choice for high-pressure, high-temperature, and aerospace applications due to its superior shock resistance characteristics.

A Study about the Improvement of State-Owned Properties Management - With a Focus on State-Owned Land - (국유재산관리제도의 개선방안에 관한 연구(국유지를 중심으로))

  • Lee, Kwi-Taek;Min, Guy-Sik
    • The Journal of the Korea institute of electronic communication sciences
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    • v.6 no.5
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    • pp.739-748
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    • 2011
  • As of 2010, the state owns $24,086km^2$ of land, which accounts for 24% of the nations total land area of $24,086km^2$. In the meantime, the state-owned national property management policies enacted laws changed since the variety has been showing up but still a problem. Also recently, on April 1, 2011 amendment, the state-owned property law enforcement in the front and relieve the problem somewhat, but still state-owned estates efficiently and economically as well as management and operation of the state not be public purpose and welfare of the people in order for there not being used as a reasonable choice still remains to be improved is Free.

Solving Social Dilemmas for Natural Recreation Resource Management (자연휴양자원관리(自然休養資源管理)를 위한 Social Dilemma 해소방안(解消方案))

  • Kim, Yong-Geun
    • Journal of Korean Society of Forest Science
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    • v.80 no.3
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    • pp.287-295
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    • 1991
  • Overuse and damage to natural resources from inappropriate visitor behavior is a type of social dilemmas faced by many recreation areas. Social dilemmas in natural recreation resource management are the conflict between the individual's own benefit and that of the collectivity. Social dilemmas may be defined by two properties : (1) Each individual in a group receives a higher payoff for a socially defecting choice than for a cooperative choice, regardless of others' choices, and (2) each individual receives a higher payoff if all group members cooperate than if all defect. There are two approaches to solve the social dilemmas in National Parks, the structural solutions and the individual solutions. Establishment of superordinate authority, selective incentives, and privatization of common resources are included in the structural approaches, while face-to-face interaction and communication among group members in the individual approaches. To aid in generalizing from specific results to other situation, data from laboratory and field experiments are interpreted in the light of social dilemma theory.

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Systematic Reviews of Current Domestic Studies of Herbaceous Plants on Anti-diabetes - since 2000 (국내 천연물 항 당뇨 실험연구의 체계적 논문 고찰 - 2000년 ~ 2010년)

  • Choi, You-Kyung
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.25 no.3
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    • pp.389-397
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    • 2011
  • This study tried to integrate the traditional oriental medical theories and results of experimental studies of herbaceous plants on anti-diabetes. And I tried to analyze recent experimental study trend on the anti-diabetic herb. I searched anti-diabetic herb studies on 4 korean databases and 10 korean journals by keywords, 'diabetes', 'blood glucose', 'glycometabolism', 'pancreatic ${\beta}$-cell', etc. In order to see detail review, searching was performed from 2000 to 2010. And I searched 125 study cases concerning anti-diabetic herb and 72 varieties herbaceous plants used in study of anti-diabetes. and I analyzed the choice motives of each herb for anti-diabetic study, the extract methods and anti-diabetic evaluation contents. And I analyzed anti-diabetic herbs from a traditional oriental medical point of view. When the researchers chose herb for anti-diabetic experiment, just 8.8% of the choice was based on the oriental medical evidences. I found that 60.6% of the herb shown to be effective in diabetes experimentally had oriental medical theory-based Properties(性). There were studies with whole plants(16.8%), aqueous extract(45.6%), methanol extract(8.0%), ethanol extract(8.0%) and comparative studies of more than 2 types of extracts or various fractions(18.4%). The most frequent experimental diabetic models was diabetic mouse induced by streptozotocin(STZ)(87.8%). And there were db/db mouse(6.7%), ob/ob mouse(1.1%), etc. 33.6% of all studies just measured hematological indices of diabetes, and 66.4% researches analyzed details. To improve herbaceous plants study on diabetes, we oriental medical scientists have to integrate the oriental medical theories and results of experimental studies.

A comparative review of epinephrine and phenylephrine as vasoconstrictors in dental anesthesia: exploring the factors behind epinephrine's prevalence in the US

  • Navkiran Deol;Gerardo Alvarez;Omar Elrabi;Gavin Chen;Nalton Ferraro
    • Journal of Dental Anesthesia and Pain Medicine
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    • v.23 no.6
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    • pp.293-302
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    • 2023
  • This review paper delves into the comparative study of epinephrine and phenylephrine as vasoconstrictors in dental anesthesia, exploring their histories, pharmacological properties, and clinical applications. The study involved a comprehensive literature search, focusing on articles that directly compared the two agents in terms of efficacy, safety, and prevalence in dental anesthesia. Epinephrine, with its broad receptor profile, has been a predominant choice, slightly outperforming in the context of prolonging dental anesthesia and providing superior hemostasis, which is crucial for various dental procedures. However, the stimulation of beta-adrenergic receptors caused by epinephrine poses risks, especially to patients with cardiovascular conditions. Phenylephrine, a selective alpha-1 adrenergic agonist, emerges as a safer alternative for such patients, avoiding the cardiovascular risks associated with epinephrine. Moreover, its vasoconstrictive effect may not be as deleterious as that of epinephrine, due to its selective action. This review reveals that despite the potential benefits of phenylephrine, epinephrine continues to dominate in clinical settings, due to its historical familiarity, availability, and cost-effectiveness. The lack of commercially available pre-made phenylephrine dental carpules in most countries, except Brazil, and a knowledge gap within dental academia regarding phenylephrine, contribute to its limited use. This review concludes that while both agents are effective, the choice between them should be based on individual patient conditions, availability, and the practitioner's knowledge and familiarity with the agents. The underuse of other vasoconstrictors like levonordefrin and the unavailability of phenylephrine in pre-mixed dental cartridges in many countries highlights the need for further exploration and research in this field. Furthermore, we also delve into the role of levonordefrin and examine the rationale behind the exclusion of phenylephrine from commercially available pre-mixed local anesthetic carpules, suggesting a need for a responsive approach from pharmaceutical manufacturers to the distinct needs of the dental community.