• 사상체질의학회지
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• 제26권3호
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• pp.328-337
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• 2014

Objectives The aim of this study was to report significant improvement of vertigo, tinnitus and aural fullness after treatment with Cheongsimyeonja-tang in a Taeeumin patient with Meniere's disease. Methods The patient was diagnosed with Taeeumin Dry-heat symptomatic pattern and treated with Cheongsimyeonja-tang and acupuncture. The patient's subjective symptoms of vertigo, tinnitus and aural fullness were observed using Global Assessment Scale (GAS) during the treatment period. Results & Conclusions The symptoms of vertigo, tinnitus and aural fullness decreased from GAS 100 to GAS 0 for seven weeks. Furthermore, the patient's symptoms of insomnia, urinary frequency, chest discomfort and fatigue were reported to be improved after treatment. In conclusion, this study shows that Sasang Constitutional Medicine can be effective treatment for Taeeumin patient with Meniere's disease diagnosed as Dry-heat symptomatic pattern.

• 사상체질의학회지
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• 제25권3호
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• pp.264-275
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• 2013

Objectives This study was designed to evaluate the effects of Korean medicine therapy(Cheongsimyeonja-tang) on Taeeumin patients diagnosed with Sj$\ddot{o}$gren's syndrome with arthritis. Methods The Sj$\ddot{o}$gren's syndrome with arthritis patient was treated with Cheongsimyeonja-tang. The progress was evaluated with the visual analogue scale and erythrocyte sedimentation rate on hematologic examination. Results There was improvement in the patient's Sj$\ddot{o}$gren's syndrome symptoms. The patient's symptoms of the alimentary system, dried fever and arthralgia evaluated with the visual analogue scale improved. Erythrocyte sedimentation rate was decreased on hematologic examination. Conclusions This study suggests that Korean medicine(Cheongsimyeonja-tang) is effective in the treatment of Sj$\ddot{o}$gren's syndrome on Taeumin patients.

• 사상체질의학회지
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• 제33권4호
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• pp.57-64
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• 2021

Objectives This study was aimed to report significant improvement of gastroesophageal reflux disease (GERD) treated by Cheongsimyeonja-tang and acupuncture treatment in Taeeumin. Methods Patient who has GERD was treated with herbal medicine and acupunture from June 15 to July 6. Gastrointestinal Symptom Rating Scale (GSRS) was used to observe changes of digestive symptoms. Results After treatment, the GSRS of the patient improved from 4.8 to 2.6. Also, the patient's symptoms of sore throat, cough, phlegm and bowel sound were reported to be improved after treatment. Conclusions This study shows that Cheongsimyeonja-tang might be effective in Taeeumin type patient's GERD.

• 사상체질의학회지
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• 제31권3호
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• pp.1-8
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• 2019

Objective This study was aimed to research how the recognition of Taeeumin's Mongsul disease was changed from the Gabo edition to the Sinchuk edition of Donguisusebowon, and to present reasonable explanation to the prescription suggested in the Sinchuk edition. Method The original text about Taeeumin Mongsul disease and corresponding prescription in Donguisusebowon Sinchuk edition written in 1901 and Donguisusebowon Gabo edition written in 1894 were compared and analyzed. Furthermore, the literature and articles which are relevant to the prescription and the difference of pathology between the Gabo edition and the Sinchuk edition of Donguisusebowon were searched. Results & Conclusion Sinchuk editon compared to Gabo edition differentiates prescriptions according to the condition of stool, which means that Mongsul disease can occur both in Lung-dryness of Esophagus-Cold pathology and that of Liver-Heat pathology. The prescriptions presented in Sinchuk edition are more specified and in agreement with pathology newly proposed in Sinchuk edition than the prescriptions in Gabo edition. Although Cheongsimyeonja-tang is not mentioned on the original text about Taeeumin Mongsul disease in Sinchuk edition, it can be prescribed for the disease with Lung-dryness of Liver-Heat pathology as Yuldahanso-tang can be. However, Yuldahanso-tang focuses more on Liver-Heat symptoms, while Cheongsimyeonja-tang focuses more on Lung-dryness.

• 대한한방내과학회지
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• 제38권6호
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• pp.971-979
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• 2017

Objectives: The aim of this study was to analyze the effects of Cheongsimyeonja-tang on the human body. Methods: This was a retrospective study, conducted using electronic medical records (EMR). Appropriate clinical cases were identified and databased through EMR. Changes of vital signs, blood tests, and functional tests before and after taking Cheongsimyeonja-tang were determined. Results: There were several significant changes after taking Cheongsimyeonja-tang. Hemoglobin, total blood proteins, and total bilirubin were increased. Eosinophil, aspartate aminotransferase, total cholesterol, and low-density lipoprotein cholesterol were decreased. Conclusions: Cheonseomyeonja-tang had significant effects, including improvement of blood cell count (increase of red blood cells and hemoglobin), improvement of blood lipid level (decrease of total cholesterol and LDL-cholesterol), and blood pressure control (reduction of systolic blood pressure).

• 사상체질의학회지
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• 제24권4호
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• pp.51-61
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• 2012

Objectives : The purpose of this study was to investigate the anti-atherosclerotic effects of 4 herbal formulas for Sasang constitutional medicine (Yeoldahanso-tang: YDHST, Yanggyeoksanhwa-tang: YGSHT, Cheongsimyeonja-tang: CSYJT and Taeeumjowi-tang: TEJWT). Methods : The antioxidant activities of herbal formulas were studied by measuring free radical scavenging activities on ABTS and DPPH. The inhibitory effects on LDL oxidation was evaluated by the formation of TBARS, REM and fragmentation of apolipoprotein B-100 (ApoB). Effects of herbal formulas on macrophage lipid accumulation were determined in native LDL and LPS co-incubated macrophages using Oil Red O staining. Results : The scavenging activities on ABTS and DPPH of herbal formulas were increased in dose-dependent manner (YDHST>YGSHT>CSYJT>TEJWT). Herbal formulas reduced the oxidation properties of LDL induced by $CuSO_4$. YDHST, YGSHT and CSYJT showed strong suppressive effect on LDL oxidation than TEJWT. In addition, YDHST, YGSHT and CSYJT significantly inhibited foam cell formation in LDL/LPS stimulated RAW 264.7 cells. Conclusions : These results demonstrate that YDHST, YGSHT and CSYJT have potentials on anti-atherosclerosis by antioxidative effect and suppressive effect on LDL oxidation.

• 사상체질의학회지
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• 제16권1호
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• pp.130-147
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• 2004

To investigate the antioxidant capacity of traditional Korean herb medicines, water extracts from 42 species which has been used for the Taeum constitution of Sasang Medicine, were tested on their antioxidant activity using radical scavenging effects against ABTS. Some Of them showed strong antioxidant capacities at $50{\mu}g$ concentration. And, antioxidant capacities of 2 prescriptions extract of Sasang Medicine, Cheongsimyeonja-tang and Yeoldahanso-tang, in the different concentration ($10{\mu}g$, $50{\mu}g$, and $100{\mu}g$) were determined. At the same time, the antiperoxidation effects of these 2 prescriptions extract were determined. Lipid peroxidation in brain homogenates induced by NADPH and $ADF-Fe^{2+}$ was strongly inhibited by Cheongsimyeonja-tang in vitro. The above-mentioned 2 prescriptions are a potent antioxidant capacity and antiperoxidation activity, further investigation into the in vivo antioxidant therapeutic potential for treatment of human disorders in brain tissue.

• 대한한방내과학회지
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• 제44권3호
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• pp.439-454
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• 2023

Objectives: As Korea transitions into an aging society, the incidence of cerebrovascular disease is expected to increase. Herbal medicine is commonly used in Oriental medicine to treat cerebrovascular disease. However, there is insufficient clinical evidence to actively support the safety of herbal medicine in clinical practice. Therefore, the aim of this study was to determine the toxicity and safety of four herbal medicines (Cheongsimyeonja-tang, Dodam-tang, Hyeolbuchukso-tang, and Boshiniknai-tang) in patients with cerebrovascular disease. Methods: This study used electronic medical records to analyze patients admitted to an oriental medicine hospital from April 1, 2017, to December 31, 2020. Liver and renal function values at the time of admission and discharge were compared. Results: A total of 25 patients were included in this study. We found no significant differences in various variables, such as complete blood count, liver-renal function test, and urine, before and after the administration of the four herbal medicines. Additionally, no significant adverse events related to herbal medicine were observed. Conclusions: This study confirmed the safety of the four herbal medicines in patients with cerebrovascular disease who were hospitalized in a single Oriental medicine hospital.

• 사상체질의학회지
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• 제25권1호
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• pp.51-61
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• 2013

Objectives We performed the simultaneous analysis for three compounds in Cheongsimyeonja-tang (CSYJT) and evaluated its anti-obesity effect. Methods The column for separation of three compounds was used Gemini $C_{18}$ column and maintained at $40^{\circ}C$. The mobile phase for gradient elution consisted of two solvent systems. The analysis was carried out at a flow rate of 1.0 mL/min with PDA detection at 275 nm. The injection volume was $10{\mu}L$. 3T3-L1 preadipocytes were differentiated into adipocytes by adding insulin, dexamethasone and 3-isobutyl-1-methylxanthine (IBMX) for 8 days in the absence or presence of CSYJT. Anti-obesity effects of CSYJT were evaluated by Oil Red O staining, glycerol-3-phosphate dehydrogenase (GPDH) activity, triglyceride contents, and leptin production. Results Calibration curves were acquired with $r^2$ >0.9999. The contents of baicalin, wogonoside and baicalein in CSYJT were 14.54-14.65 mg/g, 5.24-5.27 mg/g and 0.01-0.02 mg/g, respectively. CSYJT showed inhibitory effect on lipid accumulation and GPDH activity in the differentiated 3T3-L1 cells. Furthermore, CSYJT significantly decreased contents of triglyceride and leptin production in 3T3-L1 adipocytes. Conclusions These results will be helpful to improve quality control and anti-obesity effect of Taeeumin CSYJT.

• 대한한의학방제학회지
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• 제31권3호
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• pp.203-213
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• 2023

본 증례는 그레이브스병에 의한 갑상선기능항진증으로 진단된 환자에서 메티마졸 단독 투여에도 계속된 갑상선기능항진증의 증상치료를 위하여 한의 변증진단(辨證診斷) 과정을 통하여 심담허겁(心膽虛㥘)과 심화상염(心火上炎) 변증형(辨證形)을 도출하고 가미온담탕(加味溫膽湯)에 청심연자음(淸心蓮子飮)을 합방(合方)한 한약을 메티마졸과 병행투여 한 사례이다. 본 증례에서 한약이 메티마졸의 갑상선 호르몬 억제 효과는 계속 유지하면서 갑상선기능항진증 환자의 증상을 완화한 효과를 보여준 결과는 갑상선기능항진증 치료에 있어서 한약이 베타 차단제를 대체하여 메티마졸과 병행투여할 수 있는 약물로써 가능성이 있다는 것을 보여준다.