The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지
DOI QR코드

DOI QR Code

Hepatic/Renal Safety Evaluation of Cheongsimyeonja-tang (Qīngxīn Liánzǎo Tāng), Dodam-tang (Táodàn Tāng), Hyeolbuchukso-tang (Xuè Fǔ Zhú Yū Tāng), and Boshiniknai-tang (Bǔ Shèn Yì Nǎo Tāng) for Cerebrovascular Diseases : A Retrospective Study

뇌혈관질환 환자에 대한 청심연자탕(淸心連子湯), 도담탕(導痰湯), 혈부축어탕(血府逐瘀湯), 보신익뇌탕(補腎益腦湯)의 간기능과 신기능 안전성 평가 : 후향적 연구

  • Min-hwa Kim (Dept. of Internal Medicine, Korean Medicine Hospital, Pusan National University) ;
  • Im-hak Cho (School of Korean Medicine, Pusan National University) ;
  • I-rang Nam (Dept. of Internal Medicine, Korean Medicine Hospital, Pusan National University) ;
  • Maria Kim (Dept. of Internal Medicine, Korean Medicine Hospital, Pusan National University) ;
  • Ki-beom Ku (Dept. of Internal Medicine, Korean Medicine Hospital, Pusan National University) ;
  • Se-yeon Lee (Dept. of Internal Medicine, Korean Medicine Hospital, Pusan National University) ;
  • Jung-nam Kwon (Dept. of Internal Medicine, Korean Medicine Hospital, Pusan National University) ;
  • In Lee (Dept. of Internal Medicine, Korean Medicine Hospital, Pusan National University) ;
  • Jin-woo Hong (Dept. of Internal Medicine, Korean Medicine Hospital, Pusan National University) ;
  • Young-ju Yun (Dept. of Internal Medicine, Korean Medicine Hospital, Pusan National University) ;
  • So-yeon Kim (Dept. of Internal Medicine, Korean Medicine Hospital, Pusan National University) ;
  • Chang-woo Han (Dept. of Internal Medicine, Korean Medicine Hospital, Pusan National University) ;
  • So-jung Park (Dept. of Internal Medicine, Korean Medicine Hospital, Pusan National University) ;
  • Jun-yong Choi (Dept. of Internal Medicine, Korean Medicine Hospital, Pusan National University) ;
  • Hyeun-kyoo Shin (KM Science Research Division, Korea Institute of Oriental Medicine)
  • 김민화 (부산대학교 한방병원 한방내과) ;
  • 조임학 (부산대학교 한의학전문대학원 한의학과) ;
  • 남이랑 (부산대학교 한방병원 한방내과) ;
  • 김마리아 (부산대학교 한방병원 한방내과) ;
  • 구기범 (부산대학교 한방병원 한방내과) ;
  • 이세연 (부산대학교 한방병원 한방내과) ;
  • 권정남 (부산대학교 한방병원 한방내과) ;
  • 이인 (부산대학교 한방병원 한방내과) ;
  • 홍진우 (부산대학교 한방병원 한방내과) ;
  • 윤영주 (부산대학교 한방병원 한방내과) ;
  • 김소연 (부산대학교 한방병원 한방내과) ;
  • 한창우 (부산대학교 한방병원 한방내과) ;
  • 박소정 (부산대학교 한방병원 한방내과) ;
  • 최준용 (부산대학교 한방병원 한방내과) ;
  • 신현규 (한국한의학연구원 한의과학연구부)
  • Received : 2023.05.24
  • Accepted : 2023.07.09
  • Published : 2023.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: As Korea transitions into an aging society, the incidence of cerebrovascular disease is expected to increase. Herbal medicine is commonly used in Oriental medicine to treat cerebrovascular disease. However, there is insufficient clinical evidence to actively support the safety of herbal medicine in clinical practice. Therefore, the aim of this study was to determine the toxicity and safety of four herbal medicines (Cheongsimyeonja-tang, Dodam-tang, Hyeolbuchukso-tang, and Boshiniknai-tang) in patients with cerebrovascular disease. Methods: This study used electronic medical records to analyze patients admitted to an oriental medicine hospital from April 1, 2017, to December 31, 2020. Liver and renal function values at the time of admission and discharge were compared. Results: A total of 25 patients were included in this study. We found no significant differences in various variables, such as complete blood count, liver-renal function test, and urine, before and after the administration of the four herbal medicines. Additionally, no significant adverse events related to herbal medicine were observed. Conclusions: This study confirmed the safety of the four herbal medicines in patients with cerebrovascular disease who were hospitalized in a single Oriental medicine hospital.

Keywords

Acknowledgement

본 연구는 한국한의학연구원 '한방의료기관 한약 처방의 안전성⋅유효성 구축 사업(KSN1823310, KSN1823311)'에 의해 수행되었으며, 이에 감사드립니다.

References

  1. Feigin VL, Forouzanfar MH, Krishnamurthi R, Mensah GA, Connor M, Bennett DA, et al. Global and regional burden of stroke during 1990-2010:findings from the Global Burden of Disease Study 2010. The Lancet 2014;383(9913):245-55.  https://doi.org/10.1016/S0140-6736(13)61953-4
  2. Clinical research center for stroke. Korean Clinical Practice Guidelines for Stroke(revisededition). Seoul: Clinical research center for stroke; 2013. 
  3. Lee WM, Senior JR. Recognizing drug-induced liver injury: Current problem, possible solution. Toxicol Pathol 2005;33(1):155-64.  https://doi.org/10.1080/01926230590522356
  4. Kim DM, Kim HK, Cho SY, Kim YS, Nam SS. Retrospective observation of liver function parameters for 101 patients using herbal drugs for one month. J Korean Oriental Med 2010;31(2):149-57. 
  5. Kim NH, Jung HY, Cho SY, Park SU, Park JM, Ko CN. Liver enzyme abnormalities during concurrent use of herbal and conventional medicines in Korea: a retrospective study. Phytomedicine. 2011 Nov 15;18(14):1208-13. doi: 10.1016/j.phymed.2011.06.026. 
  6. Kim JS, Jang WS. Safety of prescribed herbal medicines for hepatic and renal function of polypharmacy patients with stroke: A single-center retrospective study. Medicine (Baltimore) 2022;101(48):e32147. 
  7. Lee SH, Kim SY, Yang SB, Jin C, Kwon SW, Cho SY, et al. Safety of co-administration of herbal and conventional medicines on liver and kidney function in stroke patients: A single-center retrospective study. Phytomedicine 2021;81:153435. 
  8. Seo HJ, Shim SH, Kwon JN, Hong JW, Lee I. The Clinical Effectiveness of Frequently Used Herbal Medicines for Cerebrovascular Disease: A Retrospective Study. J Int Korean Med 2019;40(6):1063-80.  https://doi.org/10.22246/jikm.2019.40.6.1063
  9. Benichou C. Criteria of drug-induced liver disorders Report of an International Consensus Meeting. J Hepatol 1990;11(2):272-6  https://doi.org/10.1016/0168-8278(90)90124-A
  10. Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group (2012) KDIGO clinical practice guideline for acute kidney injury. Kidney Int 2012;2(Suppl 1):1-138.  https://doi.org/10.1038/kisup.2012.1
  11. Martino R, Foley N, Bhogal S, Diamant N, Speechley M, Teasell R. Dysphagia after stroke: incidence, diagnosis, and pulmonary complications. Stroke 2005;36(12):2756-63.  https://doi.org/10.1161/01.STR.0000190056.76543.eb
  12. Brown RD, Whisnant JP, Sicks JD, O'Fallon WM, Wiebers DO. Stroke incidence, prevalence, and survival: secular trends in Rochester, Minnesota, through 1989. Stroke 1996;27(3):373-80. 
  13. American Heart Association, Heart Disease and Stroke Statistics-2004 Update. Dallas, Tex American Heart Association. 2003. 
  14. WHO. Global Health Estimates 2016: Cause-specific mortality, 2000-2016. 2017. 
  15. Yang JM. Sung DM, Kim EG, Lee SD. Effects of Long-Term Intake of Korean Medicine on Gynecology Patients' Livers and Kidneys; Panel Study. J Korean Med 2020;41(1):84-92  https://doi.org/10.13048/jkm.20006
  16. Lee HU, Baek HK, Baek KM, Kim JH, Kim JW, Shim JC, et al. Comparison of Liver Function and Kidney Function Test Score by Administration Period of Herbal Medication. The Journal of Internal Korean Medicine 2006;fal. 
  17. Bae SH, Park SE, Kang CW, Hong SH. Safety of korean herbal medicine used with western medicine on liver function: prospective observational study. The Journal of Internal Korean Medicine 2013;34(2):192-203. 
  18. Yun YJ, Shin BC, Lee MS, Cho SI, Shin WJ, Park JH, et al. Korean Herbal Medicine on Liver Function : A Systematic Review in Korean Literature. Korean J Orient Int Med 2009;30(1):153-72. 
  19. Wang HL, Zeng H, Xu MB, Zhou XL, Rong PQ, Jin TY, et al. Efficacy and Safety of Chinese Herbal Medicine for Primary Intracerebral Hemorrhage: A Systematic Review of Randomized Controlled Trials. Front Pharmacol 2019;10:1139. 
  20. An DY, Han SZ, Yu JS. Review of experimental and clinical studies on Cheongsimyeonja-tang in Korea. Journal of Sasang Constitutional Medicine 2018;30(3):1-24.  https://doi.org/10.7730/JSCM.2018.30.3.1
  21. Jin SE, Ha HK, Shin HK. Effects of Yuldahanso -tang and Chungsimyonja-tang on Cytochrome P450 Activities. J Sasang Constitut Med 2012;24(4):84-91  https://doi.org/10.7730/JSCM.2012.24.4.84
  22. Ma JY, Huang DS, Seo CS, Lee SW, Kim JY, Sh HK. Acute toxicity study on Cheongsimyeonja-tang in mice. Journal of Sasang Constitutional Medicine 2010;22(1):59-65. 
  23. Kim YJ, Kim TW, Seo CS, Park SR, Ha HK, Shin HK, et al. Quatification of Flavonoid Contents in Chungsimyeonja-tang, a Multi-Herbal Decoction, and Its Protective Effect against Cisplatin-induced Nephrotoxicity. Natural Product Sciences 2014;20(4):251-7. 
  24. Han YH, Seo HJ, Lee I. Influence of Cheongsimyeonja-tang on the Liver Function of In patients at the Korean Medicine Hospital. J Int Korean Med 2019;40(6):1035-42.  https://doi.org/10.22246/jikm.2019.40.6.1035
  25. Lee BJ, Yun SY, Park HW, Jo IY, Lee JS, Lew JH. Effects of Concurrent Administration of Hyeolbuchukeo-tang and Aspirin on Atherosclerosis in the ApoE(-/-) Mouse. J Korean Oriental Med 2011;32(1):164-74. 
  26. Seo HB, Seo HJ, Shim SH, Cho IH, Han CW, Kim SY, et al. Effect of Herbal Medicine on Liver Function in Korean Medical Hospital In patients: A Retrospective Chart Review. J Int Korean Med 2019;40(6):1145-51. https://doi.org/10.22246/jikm.2019.40.6.1145