• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.30 no.3
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• pp.280-291
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• 2020

Objectives: Hazard classification is a controversial issue in the new MSDS system in which chemical companies have to prepare and submit MSDS for chemicals that they manufacture or import to the competent authorities according to the amended Occupational Safety and Health Act. The aim of this study is to suggest how to apply and manage harmonized hazard classification criteria and results by investigating current hazard classification systems and trends. Methods: The domestic issues about different hazard classification criteria and results were investigated by reviewing the literature and business outcomes regarding KOSHA. We also checked official and unofficial reports from the UN to understand international discussion about the topic. Chemical hazard classification results from agencies providing chemical information were analyzed to compare a harmonized rate between classifications. Furthermore, a field survey of a few chemical companies was conducted. Results: Under the related competent authorities, an integrated standard proposal was developed to harmonize the domestic hazard classification criteria. Although harmonized chemical information is strongly needed, we recognized the uncertainty and difficulty of harmonized hazard classification from the UN global list project review. In practice the harmonization rate of the classification was generally low between the classification in KOSHA, MoE, and EU CLP. Among hazard classes, health hazards largely led the disharmony. The field survey revealed a change of perception that the main body of chemical information production is manufacturers. Approaches and solutions about hazard classification issues differed depending on business size, types of chemical handling, and other factors. Conclusions: We proposed reasonable ways by time and step to apply hazard classification in the new MSDS system. Chemical manufacturers should make and offer chemical information including responsible hazard classifications. The government should primarily accept these classifications, evaluate them by priority, and support or supervise workplaces in order to communicate reliable chemical information.

• Korean Journal of Materials Research
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• v.16 no.10
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• pp.633-638
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• 2006

Silica powders with spherical shape and narrow size distribution were prepared by large-scale ultrasonic spray pyrolysis applying the droplet classification apparatus. On the other hand, silica powders prepared by large-scale ultrasonic spray pyrolysis without droplet classification apparatus had broad size distribution. Droplet classification apparatus used in this paper applied the principles of cyclone and dispersion plate with small holes. The droplets formed from the ultrasonic spray generator applying the droplet classification apparatus had narrow size distribution. The droplets with fine and large sizes were eliminated by droplet classification apparatus. The optimum flow rate of the carrier gas and diameter of the hole of the dispersion plate were studied to reduce the size distribution of the silica powders prepared by large-scale ultrasonic spray pyrolysis. The size distribution of the silica powders prepared by large-scale ultrasonic spray pyrolysis at the optimum preparation conditions was 0.76.

• Bulletin of the Korean Chemical Society
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• v.32 no.4
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• pp.1237-1240
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• 2011

In this study, we have developed a ligand-based in-silico prediction model to classify chemical structures into hERG blockers using Bayesian and random forest modeling methods. These models were built based on patch clamp experimental results. The findings presented in this work indicate that Laplacian-modified naive Bayesian classification with diverse selection is useful for predicting hERG inhibitors when a large data set is not obtained.

• Environmental Analysis Health and Toxicology
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• v.21 no.2 s.53
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• pp.197-208
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• 2006

The hazards of chemicals can be classified using classification criteria that are based on physical, chemical and ecotoxicological endpoints. These criteria may be developed be iteratively, based on scientific or regulatory processes. A number of national and international schemes have been developed over the past 50 years, and some, such as the UN Dangerous Goods system or the EC system for hazardous substances, are in widespread use. However, the unnecessarily complicated multiplicity of existing hazard classifications created much unnecessary confusion at the user level, and a recommendation was made at the 1992 Rio Earth summit to develop a globally harmonized chemical hazard classification and compatible labelling system, including material safety data sheets and easily understandable symbols, that could be used for manufacture, transport, use and disposal of chemical substances. This became the globally harmonized system for the Classification and Labelling of Chemicals (GHS). The developmental phase of the GHS is largely complete. Consistent criteria for categorizing chemicals according to their toxic, physical, chemical and ecological hazards are now available. Consistent hazard communication tools such as labelling and material safety data sheets are also close to finalizations. The next phase is implementation of the GHS. The Intergovernmental Forum for Chemical Safety recommends that all countries implement the GHS as soon as possible with a view to have the system fully operational by 2008. When the GHS is in place, the world will finally have one system for classification of chemical hazards.

• Korean Chemical Engineering Research
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• v.58 no.3
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• pp.493-497
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• 2020

Hazardous area classification is designed to prevent chemical plant explosions in advance. Generally, the duration of the explosive atmosphere is used for zone type classification. Herein, IEC code, a quantitative zone type classification methodology, was used to achieve Zone 2 NE, which indicates a practical non-explosion condition. This study analyzed the operating pressure of a vessel handling propane to achieve Zone 2 NE by applying the IEC code via MATLAB. The resulting zone type and hazardous area grades were compared with the results from other design standards, namely API and EI codes. According to the IEC code, the operating pressure of vessels handling propane should be between 101325-116560.59 Pa. In contrast, the zone type classification criteria used by API and EI codes are abstract. Therefore, since these codes could interpret excessively explosive atmospheres, care is required while using them for hazardous area classification design.

• Safety and Health at Work
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• v.11 no.2
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• pp.152-158
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• 2020

Background: The Globally Harmonized System of Classification and Labeling of Chemicals (GHS) was developed to enhance chemical classification and hazard communication systems worldwide. However, some of the elements such as building blocks and data sources have the potential to cause "disharmony" to the GHS, particularly in its classification results. It is known that some countries have developed their own lists of classified chemicals in accordance with the GHS to "standardize" the classification results within their respective countries. However, the lists of classified chemicals may not be consistent among these countries. Method: In this study, the lists of classified chemicals developed by the European Union, Japan, Malaysia, and New Zealand were selected for comparison of classification results for carcinogenicity, germ cell mutagenicity, and reproductive toxicity. Results: The findings show that only 54%, 66%, and 37% of the classification results for each Carcinogen, Mutagen and Reproductive toxicants hazard classes, respectively are the same among the selected countries. This indicates a "moderate" level of consistency among the classified chemicals lists. Conclusion: By using classification results for the carcinogenicity, germ cell mutagenicity, and reproductive toxicity hazard classes, this study demonstrates the "disharmony" in the classification results among the selected countries. We believe that the findings of this study deserve the attention of the relevant international bodies.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.18 no.1
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• pp.62-71
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• 2008

The use of chemical products to enhance and improve life is a widespread practice worldwide. But alongside the benefits of these products, there is also the potential for adverse effects to people or the environment. As a result, a number of countries or organizations have developed laws or regulations over the years that require information to be prepared and transmitted to those using chemicals, through labels or Material Safety Data Sheets (MSDS). While these existing laws or regulations are similar in many respects, their differences are significant enough to result in different labels or MSDS for the same product in different countries. Given the reality of the extensive global trade in chemicals, and the need to develop national programs to ensure their safe use, transport, and disposal, it was recognized that a Globally harmonization system of classification and labeling of chemicals(GHS) would provide the foundation for such programs. This study offered complementary details of GHS classification criteria adopted in Korea by analyzing the differences in chemical classification system between UN and Korea Ministry of Labor. Also it is proposed that mutual agreement of information DB used is required by comparing classification results of chemicals in Korea, Japan, and EU. We offered the lists of information sources useful for chemical classification.

• Analytical Science and Technology
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• v.32 no.6
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• pp.233-242
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• 2019

Substance identification is the first step of the REACH registration. It is essential in terms of Classification, Labelling and Packaging (CLP) regulation and because even trace amounts of impurities or additives can affect the classification. In this study, a scheme for the screening, quantification, and interpretation of trace amounts of hazardous inorganic substances is proposed to detect the presence of more than 0.1% hazardous inorganic substances that have been affecting the hazard classification. An exemplary list of hazardous inorganic substances was created from the substances of very high concern (SVHCs) in REACH. Among 201 SVHCs, there were 67 inorganic SVHCs containing at least one or ~2-3 heavy metals, such as As, Cd, Co, Cr, Pb, Sb, and Sn, in their molecular formula. The inorganic SVHCs are listed in excel format with a search function for these heavy metals so that the hazardous inorganic substances, including each heavy metal and the calculated ratio of its atomic weight to molecular weight of the hazardous inorganic substance containing it, can be searched. The case study was conducted to confirm the validity of the established scheme with zinc oxide (ZnO). In a substance that is made of ZnO, Pb was screened by XRF analysis and measured to be 0.04% (w/w) by ICP-OES analysis. After referring to the list, the presence of Pb was interpreted just as an impurity, but not as an impurity relevant for the classification. Future studies are needed to expand on this exemplary list of hazardous inorganic substances using proper regulatory data sources.

• Journal of the Korean Society of Safety
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• v.34 no.3
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• pp.42-49
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• 2019

This study statistically analyzed the laboratory accidents by investigating 806 laboratory accident survey reports which were officially submitted to government from 2013 to June 2017. After comparing domestic and foreign accident classification criteria, the laboratory accidents were classified using KCD7(Korean Standard Classification of Diseases) and OIICS(Occupational Injury and Illness Classification System) criteria. For the type and part of injury, KCD7 classification criteria was adopted. And, for the cause and occurrence type of accidents, OIICS was adopted to analyze the laboratory accidents. Most of injuries happened to the wrist and hand caused by sharp materials or chemical materials. The analysis of accident cause showed that accidents resulted in medical practice and accidents from handtools and chemical materials such as acid and alkali frequently occurred. The major occurrence types of laboratory accidents was body exposure to the chemical materials such as hydrochloric acid and sulfuric acid. In addition, the accidents resulted in destroy of grasped object or falling object were frequently reported.

• Journal of Korean Library and Information Science Society
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• v.39 no.2
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• pp.249-266
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• 2008

This study investigated general problems concerning the subject Chemical Engineering in the KDC(Korean Decimal Classification) 4th edition based on the comparative analysis with DDC, NDC, and Disciplinary Classification System of Korean Research Foundation, and suggested on some ideas for the improvements of them. The subject of chemical Engineering in the KDC 4th edition had to be improved to use current terminology, to choose appropriate headings, and to subdivide the subjects more to introduce new topics.