• The Korean Journal of Physiology and Pharmacology
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• v.1 no.1
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• pp.27-34
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• 1997

In the present study, it was aimed to further indentify the intracellular action mechansm of cromakalim and levcromakalim in the porcine coronary artery. In intact porcine coronary arterial strips loaded with fura-2/AM, acetylcholine caused an increase in intracellular free $Ca^{2+}$ $([Ca^{2+}]_i)$ in association with a contraction in a concentration-dependent manner. Cromakalim (1 ${\mu}M$) caused a reduction in acetylcholine-induced increased $[Ca^{2+}]_i$ not only in the mormal physiological salt solution (PSS) but also in $Ca^{2+}$-free PSS (containing 1 mM EGTA). In the skinned strips prepared by exposure of tissue to 20 .${\mu}M$ B-escin, inositol 1,4,5-trisphosphate ($IP_3$) evoked an increase in $[Ca^{2+}]_i$, but it was without effect on the intact strips. The $IP_3$-induced increase in $[Ca^{2+}]_i$ was inhibited by cromakalim by 78% and levcromakalim by 59% (1 .${\mu}M$, each). Pretreatment with glibenclamide (a blocker of ATP-sensitive $K^+$ channels, 10 .${\mu}M$) and apamin (a blocker of small conductance $Ca^{2+}$-activated $K^+$ channels, 1 .${\mu}M$) strongly blocked the effect of cromakalim and levcromakalim. However, charybdotoxin (a blocker of large conductance $Ca^{2+}$-activated $K^+$ channels, 1 .${\mu}M$) was without effect. In addition, cromakalim inhibited the $GTP{\gamma}S$ (100 .${\mu}M$, non-hydrolysable analogue of GTP)-induced increase in $[Ca^{2+}]_i$. Based on these results, it is suggested that cromakalim and levcromakalim exert a potent vasorelaxation, in part, by acting on the $K^+$ channels of the intracellular sites (e.g., sarcoplasmic reticulum membrane), thereby, resulting in decrease in release of $Ca^{2+}$ from the intracellular storage site.

• Science of Emotion and Sensibility
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• v.14 no.4
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• pp.525-530
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• 2011

Emotion is composed of various feelings such as pleasure, sorrow, comfortability, and so on. The complicated process of the measurement has long been recognized as a major hindrance for the studies of emotion. Previously, individuals' emotion has mainly been measured by means of self-report, interview, EEG (electroencephalogram), ECG (electrocardiogram), EOG (electroculography), and body temperature. With thanks to nano/micro technologies, the possibility in the development of emotion-on-a-chip (EOC) has begun to be proposed. EOC will make it possible to analyze one's psychological status by taking a drop of blood. Discovery of emotional biomarkers in body fluids, understanding of the correlation between those biomarkers and the results from brain science are prerequisites to validate the EOC technology. In this paper, paper microfluidics are introduced as a good candidate for the EOC. As paper microfluidics is cost-effective and easy to use it is expected to be a useful device for the emotion measurement. We present the design and fabrication process for the simple paper-based microfluidic device and discuss the possible application in the field of measuring the human emotion.

• The Journal of the Korea Contents Association
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• v.12 no.4
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• pp.60-68
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• 2012

In recent years, the requirements on the high quality environment monitoring by using the sensor nodes which can handle the multimedia data in WSN have been increased. However, because the volume of multimedia data is tremendous, the limited bandwidth of a wireless channel may incur the bottleneck of a system. To solve such a problem, most of the existing distributed multi-path routing protocols based on multimedia data just focused on overcoming the limited bandwidth in order to enhance the energy efficiency and the transmission rate. However, because the existing methods can not apply a key-based technique to encrypt the multimedia data, they are very weak for the security. In this paper, we propose a secure disjointed multipath routing scheme for multimedia data transmission. Since our proposed scheme divides multimedia data(eg. image) into pixels and sends them through disjointed multipath routing, it can provide security to the whole network without using the key-based method. Our experimental results show that our proposed scheme reduces about 10% the amount of the energy consumption and about 65% the amount of the missed data packets caused by malicious nodes over the existing methods on average.

• Journal of the Korean association of regional geographers
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• v.13 no.5
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• pp.509-525
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• 2007

The aim of this study is to evaluate the governance system involved in the policy of upgrading the Seongseo industrial complex in Daegu city. The governance system was evaluated by four indicators; social legitimacy, reliability, expertness, and transparency. The major findings of this study are summarized as follows. It is expected that the Seongseo industrial complex upgrading policy would accelerate to upgrade the industry structure and competitiveness of the cluster. However, the firms of the cluster have a Question of reliability to the actors of initiating the policy. In this context, to raise the trust level the policy needs to turn towards making the communication channel among the stake-holders of the cluster more democratically and horizontally. It is also problematic to reveal the low degree of expertness of the policy's decision makers, the fragmented system of policy operation and a lack of information. Consequently, the policy is required to improve the transparency on the policy-making process, and to activate the participation of professional groups and civil society.

• Journal of Distribution Research
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• v.12 no.4
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• pp.49-77
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• 2007

The purpose of this study is to examine a relationship between the headquarters and the sales offices of a car manufacturing company by comparing their channel types. It examines how the level of communication and commitment of sales offices on their headquarters differently affects some mediating effects between participation and relationship performance. It also tries to find out what kind of mechanisms are needed in order to improve the relationship. Through the data analysis of a total of 200 sales offices which are directly managed stores and agency stores by a domestic car manufacturing company, the following conclusions were reached: Participation, one of the variables in bureaucratic structuring, influences all dimensions of communication. Also, it has found that communication dimensions influence commitment dimensions differently by the type of channels, and commitment dimensions influence relationship performance by the type of channels. Recently, import car makers are accelerating their moves in the domestic market, and the importance of a customer-oriented retail innovation and a relationship management in an auto manufacturing industry is increasing. This study will give an useful suggestion on how to improve a long term relationship of distributors through an enhancement of communication and commitment.

• Journal of Distribution Science
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• v.15 no.2
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• pp.79-90
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• 2017

Purpose - Cargo Distribution O2O Business Model is the form of business that connects the cargo and empty cargo-truck based on mobile online platform. In Korean cargo distribution market, FIN(Freight Information Network) is the only model that represents O2O Business Model. The purpose of this paper is investigating the recognition of driver who is the only source of income toward cargo distribution O2O Business Model, and based on the investigated recognition of trucker, suggesting strategic implication. Research design, data, and methodology - PESTLE methodology which is massive environment analysis, and 5 Forces Model when analyze the present and future of cargo distribution O2O business market of industrial structure analysis were used as investigation methodology. Also structured questionnaire was used for trucker's recognition investigation. Based on collected 196 structured effective questionnaires organized with 26 questions were analyzed using statistics package. Results - 51.3% of responded driver is non-differentiated, deprofessionalize form that transport all types of cargo. 95.4% recognize cargo distribution O2O Business Model, FIN is needed, especially during back-hall(94.7%). As a payment method, monthly due is preferred(73%), but it is also needed to pay annual due and pay whenever cargo and cargo-truck are connected(24.5%). Trucker prefer FIN operation corporation which has rich supply(85.2%), and is liberal in supply in any domestic area(75.5%). Conclusions - First, 91% was the member of FIN, and 95% of non-member recognized FIN is needed. 83% of them has the intent to be the member of FIN. Second, besides of monthly due as payment method of FIN, 25% has positive recognition toward new payment method. The new payment method means paying annual due and pay whenever cargo and cargo-truck are connected. Third, because of information imbalance about the cargo and cargo-truck among, operators whose business goal is FIN, it was investigated that transportation fee is low and commission charge of broker is high. The core of Korean Cargo Distribution O2O Business Model, FIN, is online platform that matches cargo and cargo-truck. Therefore, FIN operator should minimize the amount of single transportation of trucker. This study suggests the development of shipper using FIN, diversify distribution channel, suggesting backhaul toward trucker as solution to FIN operator.

• Journal of Satellite, Information and Communications
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• v.4 no.1
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• pp.1-7
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• 2009

As the information age comes out, the aspect of future war brings about the many changes in terms of war-fighting environment. Accordingly, information superiority and intelligence-centric warfare have been important and new war-fighting concept such as NCW(network centric warfare) have been turned up. This paper proposed all-weather core-strategy communications systems guaranteeing not only the real-time transmission of the information collected in a battlefield and expansion, automation, and rapidity of a battlefield but also broadband, mobility, survivability, and flexibility. The proposed military satellite communications system is classified into wideband mass capacity link, survivability, and the system supporting OTM(on the move) communication for the real-time transmission of battlefield information. This paper analyzed the essential operation concepts and core schemes of the U.S. Army's next generation system, TSAT(Transformational Satellite Communication System). Base on the analysis results, this paper proposed that the architecture of next generation military satellite communications systems for NCW have to provide the data rate, anti-jamming capability, network control and management capability which are optimally adaptable for the wireless channel environments such as jamming and interference and to support the variety of platforms like high-speed mobile vehicles, micromini devices, super-high speed unmanned aerial vehicles. Finally, this paper also proposed that next generation military satellite communications systems need the technologies such as the adaptable multi-antenna, laser link, and next-generation anti-jamming waveform.

• Journal of the Korean association of regional geographers
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• v.15 no.2
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• pp.226-249
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• 2009

This study aims to establish the regional mix types and models of place marketing strategy. For this purpose, eighty seven cases of place marketing in Gwangju-Jeonnam region during the last two years are reviewed, Twenty seven types of regional mix are abstracted according to space, theme, subject, target, and factor. There are five spatial types(urban mix, zoning mix, zoning urban mix, package urban mix, zoning mix, and space package mix), eight thematic types(culture mix, history mix, tourism mix, industry mix, administration mix, environment mix, transportation mix, and PR mix), five subject types(central government led public mix, local government led public mix, enterprise led private mix, civil society led private mix, and private public partnership mix), four target types(resident mix, tourist mix, enterprise mix, and common mix), and five factor types (organization mix, image mix, point mix, target mix, and channel mix). In the basis of these types, the twenty two primary model of regional mix, and the one hundred twenty six secondary model of regional mix are established.

• The Korean Journal of Physiology and Pharmacology
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• v.8 no.4
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• pp.201-206
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• 2004

Mitochondrial ATP-sensitive potassium $(mitoK_{ATP})$ channels play a role in early and late ischemic preconditioning. Nevertheless, the subunit composition of $mitoK_{ATP}$ channels remains unclear. In this study, we investigated the subunit composition of $mitoK_{ATP}$ channels in mitochondria isolated from rat cardiac myocytes. Mitochondria were visualized using the red fluorescence probe, Mitrotracker Red, while $mitoK_{ATP}$ channels were visualized using the green fluorescence probe, glibenclamide-BODIPY. The immunofluorescence confocal microscopy revealed the presence of Kir6.1, Kir6.2 and SUR2 present in the cardiac mitochondria. Western blot analysis was carried to further investigate the nature of $mitoK_{ATP}$ channels. For SUR proteins, a 140-kDa immunoreactive band that corresponded to SUR2, but no SUR1 was detected. For Kir6.2, three bands $({\sim}44,\;{\sim}46,\;and\;{\sim}30\;kDa)$ were detected, and a specific ${\sim}46-kDa$ immunoreactive band corresponding to Kir6.1 was also observed. These observations suggest that the subunits of $mitoK_{ATP}$ channels in rat myocytes include Kir6.1, Kir6.2, and a SUR2-related sulfonylurea-binding protein.

• The Korean Journal of Physiology and Pharmacology
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• v.12 no.4
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• pp.155-164
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• 2008

Resveratrol has been known to possess various potent cardiovascular effects in animal, but there is little information on its functional effect on the secretion of catecholamines (CA) from the perfused model of the adrenal medulla. Therefore, the aim of the present study was to determine the effect of resveratrol on the CA secretion from the isolated perfused model of the normotensive rat adrenal gland, and to elucidate its mechanism of action. Resveratrol (10${\sim}100{\mu}$M) during perfusion into an adrenal vein for 90 min inhibited the CA secretory responses evoked by ACh (5.32 mM), high $K^+$ (a direct membrane-depolarizer, 56 mM), DMPP (a selective neuronal nicotinic $N_n$ receptor agonist, 100${\mu}$M) and McN-A-343 (a selective muscarinic $M_1$ receptor agonist, 100${\mu}$M) in both a time- and dose- dependent fashion. Also, in the presence of resveratrol (30${\mu}$M), the secretory responses of CA evoked by veratridine 8644 (an activator of voltage-dependent$Na^+$ channels, 100${\mu}$M), Bay-K-8644 (a L-type dihydropyridine $Ca^{2+}$ channel activator, 10${\mu}$M), and cyc1opiazonic acid (a cytoplasmic $Ca^{2+}$-ATPase inhibitor, 10${\mu}$M) were significantly reduced. In the simultaneous presence of resveratrol (30${\mu}$M) and L-NAME (an inhibitor of NO synthase, 30${\mu}$M), the CA secretory evoked by ACh, high $K^+$, DMPP, McN-A-343, Bay-K-8644 and cyc1opiazonic acid were recovered to a considerable extent of the corresponding control secretion compared with the inhibitory effect of resveratrol alone. Interestingly, the amount of nitric oxide (NO) released from the adrenal medulla was greatly increased in comparison to its basal release. Taken together, these experimental results demonstrate that resveratrol can inhibit the CA secretory responses evoked by stimulation of cholinergic nicotinic receptors, as well as by direct membrane-depolarization in the isolated perfused model of the rat adrenal gland. It seems that this inhibitory effect of resveratrol is exerted by inhibiting an influx of both ions through $Na^+$ and $Ca^{2+}$ channels into the adrenomedullary cells as well as by blocking the release of $Ca^{2+}$ from the cytoplasmic calcium store, which are mediated at least partly by the increased NO production due to the activation of NO synthase.