• BMB Reports
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• 제28권4호
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• pp.290-292
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• 1995

Existence of a binding site for choline esters with an acyl chain of various sizes was examined by comparing the inhibitory potency of the respective compound. In contrast to acetylcholine, which showed a pure competitive pattern of inhibition, choline esters with an acyl chain of a long size ($C{\geq}5$) expressed a mixed type of inhibition. Binding of choline esters containing a long chain ($C_7-C_{12}$) to the hydrophobic region in the active site is deduced from a linear relationship between the $K_{iE}$ value and the size of acyl moiety, and a good hydrophobicity relationship. In addition, the non-competitive component in the inhibition of acetylcholinesterase seems to be due to the interaction of choline esters with both the hydrophobic site and the trimethylammonium-binding site in the active center of the acetylated acetylcholinesterase.

• Industrial Engineering and Management Systems
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• 제13권1호
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• pp.29-42
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• 2014

Extensive research has been conducted on supplier evaluation and selection as a strategic and crucial component of supply chain management in recent years. However, few articles in the previous literature have been dedicated to the use of fuzzy inference systems as an aid in decision-making. Therefore, this essay attempts to demonstrate the application of this method in evaluating suppliers, based on a comprehensive framework of qualitative and quantitative factors besides the effect of gradual coverage distance. The purpose of this study is to investigate the applicability of the numerous measures and metrics in a multi-objective optimization problem of the supply chain network design with the aim of managing the allocation of orders by coordinating the production lines to satisfy customers' demand. This work presents a dynamic non-linear programming model that examines the important aspects of the strategic planning of the manufacturing in supply chain. The effectiveness of the configured network is illustrated using a sample, following which an exact method is used to solve this multi-objective problem and confirm the validity of the model, and finally the results will be discussed and analyzed.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2019년도 춘계 학술논문 발표대회
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• pp.127-128
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• 2019

The cost of procurement in construction projects varies depending on the type of project, but the proportion of the cost component is very large. Therefore, efficient procurement system operation affects the success of the project. However, difficulties arise in procurement management due to problems such as availability of data due to limited information, inaccurate scheduling and integration of costs. Therefore, the purpose of this study is to develop a procurement management system to help efficient communication decision by combining Big Data which can analyze a lot of information and Block Chain technology which can secure information and record reliability to satisfy the above requirements. The results of this study are used to develop a system to develop academically improved procurement management system and practically to develop a system to secure business competitiveness and to facilitate rapid communication among project participants.

• 항공우주시스템공학회지
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• 제15권6호
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• pp.26-32
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• 2021

The global aircraft-manufacturing industry ecosystem is characterized by the international division of labor through the worldwide supply chain and by the concentration of value added at the top of the supply chain. As a result, the competition for entry into the top supply chain and for order expansion is becoming increasingly intensive. To increase their orders, domestic aircraft manufacturing enterprises need to enhance their competitiveness by evaluating and analyzing it. However, most domestic aircraft manufacturing companies are unaware of the need to quantitatively evaluate their competitiveness. It is challenging to perform such an evaluation, and there are few research cases. In this study, we quantitatively evaluated and analyzed the competitiveness of domestic aircraft manufacturers by using data mining techniques. Thereby, implications for enhancing their competitiveness could be identified.

• Journal of Korea Trade
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• 제25권6호
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• pp.78-104
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• 2021

Purpose - Semiconductors are a significant export item for Korea that is expected to continue to contribute significantly to the Korean economy in the future. Thus, the semiconductor industry is a critical component in the 4th Industrial Revolution and is expected to continue growing as the non-face-to-face economy expands as a result of the COVID-19 pandemic. In this context, this paper aims to empirically investigate how semiconductors are imported and exported in Korea from a global supply chain perspective by analysing import and export data at the micro-level. Design/methodology - This study conducts a multifaceted analysis of the global supply chain for semiconductors and related equipment in Korea by examining semiconductor imports and exports by semiconductor type, year, target country, mode of transportation, airport/port, and domestic region, using import/export micro-data. The visualisation, flow analysis, and Bayesian Network methodologies were used to compensate for the limitations of each method. Findings - Korea is a major exporter of semiconductor memory and has the world's highest competitiveness but is relatively weak in the field of system semiconductors. The trade deficit in 'semiconductor equipment and parts' is clearly growing. As a result, continued investment in 'system semiconductors' and 'semiconductor equipment and parts' technology development is necessary to boost exports and ensure a stable supply chain. Originality/value - Few papers on semiconductor trade in Korea have been published from the perspective of the global supply chain or value chain. This study contributes to the literature in this area by focusing on import and export data for the global supply chain of the Korean semiconductor industry using a variety of approaches. It is our hope that the insights gained from this study will aid in the advancement of SCM research.

• 응용통계연구
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• 제11권2호
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• pp.377-387
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• 1998

컴퓨터의 발전에 따른 마코브체인 몬테카를로방법을 소프트웨어 신뢰확률모형에 이용하였다. 베이지안 추론에서 조건부분포를 가지고 사후분포를 결정하는데 있어서의 계산문제와 이론적인 정당성을 고려, 마코프연쇄와 메트로폴리스방법의 관계를 고찰하였으며, 특히 Mus-Okumoto와 Erlang(2)의 중첩모형에 대하여 깁스샘플링 알고리즘과 메트로폴리스 알고리즘을 활용하며 베이지안 계산과 예측 우도기준에 의 한 모형선택을 제안하고 Cox-Lewis에 의해 계시된 Thing method를 이용한 모의실험자료를 이용하여 수치적인 계산을 시행하고 그 결과가 제시되었다.

• 한국신뢰성학회지:신뢰성응용연구
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• 제17권4호
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• pp.332-342
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• 2017

Purpose: In this study, the lifetime distribution of a k-out-of-n system with heterogeneous components is suggested as Markov model, and the time-to-failure (TTF) distribution of each component is considered as phase-type distribution (PHD). Furthermore, based on the model, a redundancy allocation problem with a mix of components (RAPMC) is proposed. Methods: The lifetime distribution model for the system is formulated by the structured Markov chain. From the model, the various information on the system lifetime can be ascertained by the matrix-analytic (or-geometric) method. Conclusion: By the generalization of TTF distribution (PHD) and the consideration of heterogeneous components, the lifetime distribution model can delineate many real systems and be exploited for developing system operation policies such as preventive maintenance, warranty. Moreover, the effectiveness of the proposed RAPMC is verified by numerical experiments. That is, under the equivalent design conditions, it presented a system with higher reliability than RAP without component mixing (RAPCM).

• 농업과학연구
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• 제22권1호
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• pp.82-95
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• 1995

본(本) 연구(硏究)는 한국인(韓國人) 산모(産母)로 부터 수집한 초유(初乳) 및 Holstein종(種)으로 부터 수집한 초유(初乳) 중에 존재하는 Secretory immunoglobulin A의 분리방법(分離方法)을 검토하고 분리(分離)된 분획들의 면역화학적(免疫化學的) 특성을 비교 검토하여 향후 인공영양(人工營養)에 대한 시험(試驗) 자료를 얻고자 하였으며 그 결과(結果)는 다음과 같다. 1. 인유(人乳) 초유(初乳) 중의 SIgA는 Sephadex G-200과 Sepharose 6B를 통한 gel-filtration 만으로도 순수한 상태로 분리(分離) 정제할 수 있었으나, 우유(牛乳) 초유(初乳) 중의 SIgA는 gel-filtration을 반복하는 방법(方法)으로는 순수한 상태로 분리(分離) 및 정제할 수 없었으며, gel-filtration으로 얻어진 SIgA rich fraction을 모아서 DEAE를 실시한 결과(結果) 또한 마찬가지로 SIgA를 순수한 상태로 분리(分離)할 수는 없었다. 2. 인유(人乳) 초유(初乳)로 부터 gel-filtration을 통하여 분리(分離)한 분획들을 Immunoelectrophoresis 및 Double immunodiffusion 방법(方法)으로 면역화학적(免疫化學的) 특성을 살펴본 결과(結果), 첫번째 peak의 분획에서 IgM이 존재하고 있음을 확인할수 있었으며 두번째 peak의 분획에서 SIgA가 순수한 상태로 존재하고 있음을 확인할수 있었다. 반면에 우유(牛乳) 초유(初乳)로 부터 gel filtration 및 DEAE를 통하여 분리(分離)한 분획들을 같은 방법(方法)으로 면역화학적(免疫化學的) 특성을 살펴본 결과(結果), SIgA rich fraction 중에는 IgG가 다량(多量)으로 혼재(混在)되어 있음을 확인할 수 있었다. 3. 우유(牛乳) 초유(初乳)에서 분리(分離)한 SIgA rich fraction의 Fragment를 SDS-PAGE로 분자량을 측정해 본 결과(結果), Secretory component가 77,000-80,000, Heavy chain이 50,000-60,000, Light chain이 25,000-27,000 dalton으로 나타났으며 J-chain은 Light chain과 중복되어 분자량 측정이 어려웠다. 이와같은 결과(結果)는 인유(人乳) 초유(初乳) 중에 존재하는 SIgA Fragment 분자량과 유사한 결과(結果)를 보여주었다.

• 한국자기공명학회논문지
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• 제19권3호
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• pp.149-155
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• 2015

Acyl carrier protein is related with fatty acid biosynthesis in which specific enzymes are involved. Especially, acyl carrier protein (ACP) is the key component in the growing of fatty acid chain. ACP is the small, very acidic protein that covalently binds various intermediates of fatty acyl chain. Acylation of ACP is mediated by holo-acyl carrier protein synthase (ACPS), which transfers the 4'PP-moiety of CoA to the 36th residue Ser of apo ACP. Acyl carrier protein P (ACPP) is one of ACPs from Helicobacter plyori. The NMR structure of ACPP consists of four helices, which were reported previously. Here we show how acylation of ACPP can affect the overall structure of ACPP and figured out the contact surface of ACPP to acyl chain attached during expression of ACPP in E. coli. Based on the chemical shift perturbation data, the acylation of ACCP seems to affect the conformation of the long loop connecting helix I and helix II as well as the second short loop connecting helix II and helix III. The significant chemical shift change of Ile 54 upon acylation supports the contact of acyl chain and the second loop.

• Molecules and Cells
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• 제46권7호
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• pp.430-440
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• 2023

Linear ubiquitin chain assembly complex (LUBAC) is a ubiquitin E3 ligase complex composed of HOIP, HOIL-1L, and SHARPIN that catalyzes the formation of linear/M1-linked ubiquitin chain. It has been shown to play a pivotal role in the nuclear factor (NF)-κB signaling induced by proinflammatory stimuli. Here, we found that tumor susceptibility gene (TSG101) physically interacts with HOIP, a catalytic component of LUBAC, and potentiates LUBAC activity. Depletion of TSG101 expression by RNA interference decreased TNFα-induced linear ubiquitination and the formation of TNFα receptor 1 signaling complex (TNF-RSC). Furthermore, TSG101 facilitated the TNFα-induced stimulation of the NF-κB pathway. Thus, we suggest that TSG101 functions as a positive modulator of HOIP that mediates TNFα-induced NF-κB signaling pathway.