• International Journal of Naval Architecture and Ocean Engineering
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• v.13 no.1
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• pp.321-339
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• 2021

Response Surface Method (RSM) has been widely used for flammable cloud size prediction as it can reduce computational intensity for further Explosion Risk Analysis (ERA) especially during the early design phase of offshore platforms. However, RSM encounters the overfitting problem under very limited simulations. In order to overcome the disadvantage of RSM, Bayesian Regularization Artificial Neural (BRANN)-based model has been recently developed and its robustness and efficiency have been widely verified. However, for ERA during the early design phase, there seems to be room to further reduce the computational intensity while ensuring the model's acceptable accuracy. This study aims to develop an integrated method, namely the combination of Center Composite Design (CCD) method with Bayesian Regularization Artificial Neural Network (BRANN), for flammable cloud size prediction. A case study with constant and transient leakages is conducted to illustrate the feasibility and advantage of this hybrid method. Additionally, the performance of CCD-BRANN is compared with that of RSM. It is concluded that the newly developed hybrid method is more robust and computational efficient for ERAs during early design phase.

• Applied Chemistry for Engineering
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• v.29 no.6
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• pp.663-669
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• 2018

The process of extracting active ingredients from wheat sprout using ultrasound assisted method was optimized with a central composite design model. The response value of the central composite design model established the extraction yield and the total flavonoids content, main effects and interactive effects were analyzed depending on independent variables such as the extraction time, volume ratio of ethanol to ultrapure water, and ultrasonic irradiation power. The volume ratio of ethanol to ultrapure water and ultrasonic irradiation power were relatively large for the extraction yield and the extraction time was most significantly affected the total flavonoids, Considering both the extraction yield and total flavonoids content, the optimal extraction conditions were as follows: the extraction time of 17.00 min, volume ratio of ethanol to ultrapure water of 50.25 vol%, ultrasonic irradiation power of 551.70 W. In this case, the extraction yield and total flavonoids content were 28.43 wt% and $29.99{\mu}g\;QE/mL\;dw$, respectively. The actual experimental extraction yield and total flavonoids content under this condition were 8.73 wt% and $29.65{\mu}g\;QE/mL\;dw$, respectively with respective error rates of 1.05 and 1.13%.

• Journal of Ocean Engineering and Technology
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• v.27 no.2
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• pp.27-32
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• 2013

A valve is a marine structure that is subjected to multiple seawater loads. Therefore, it is necessary to define the kind of loads applied to it to confirm whether the structure has sufficient strength. In this research, we aimed to find the optimal solution for the stress and deformation of valves under various loads. We first selected design variables and implement a finite element analysis according to changes in the thickness of each component of a valve based on a central composite design. Next we developed a regression model of the response surface. Using this model, we calculated the optimal objective value based on NSGA-II. Finally, to confirm the correspondence between the optimal objective value and the real FEM value, we compared the optimal result and structural analysis result to verify the performance of NSGA-II.

• Applied Chemistry for Engineering
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• v.29 no.6
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• pp.682-689
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• 2018

In this paper, the stability criteria of cosmeceuticals emulsion containing Broussonetia kazinoki extracts was established using the central composite design model. As optimization conditions of the emulsification using the central composite design model, concentrations of the emulsifier and emulsion stabilizer were used as a quantitative factor while emulsion stability index (ESI) and polydispersity index (PDI) were used as a reaction value. The targeted values of ESI and PDI were estimated as over 60% and the minimum number, respectively. Optimized concentrations of the emulsifier and emulsion stabilizer were 3.73 and 3.07 wt%, respectively, from the emulsification optimization based on ESI and PDI values. The estimated reaction values of ESI and PDI were 60% and 0.585, respectively. As concentrations of the emulsifier and emulsion stabilizer increased, the stability of the emulsion prepared tended to increase. The emulsifier was one of the most influential factors for ESI than the emulsion stabilizer. On the other hand, the PDI value was similarly affected by both the emulsion and emulsion stabilizer. The ESI of the cosmeceuticals emulsion prepared under experimental conditions deduced from the central synthesis planning model showed at least about 45% of the stability. However, all of the emulsions were separated after 4 weeks from the initial preparation. When the concentration of the emulsifier was more than 3.72 wt%, the ESI value was over 60%. Also the layer separation rate decreased with increasing the emulsion stabilizer concentration.

• Journal of Microbiology and Biotechnology
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• v.16 no.9
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• pp.1338-1346
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• 2006

Ansamitocin P-3 is a potent antitumor agent produced by A. pretiosum. A deletion mutant of A. pretiosum was constructed by deleting the asm2 gene, a putative transcriptional repressor. The deletion mutant showed a 9-fold enhanced ansamitocin P-3 productivity. The response surface method with central composite design was employed to further optimize the culture medium composition for ansamitocin P-3 production by the deletion mutant. The concentrations of four medium ingredients, dextrin, maltose, cotton seed flour, and yeast extract, which have been reported as major components for ansamitocin production, were optimized through a series of flask culture experiments. The optimum concentrations of the selected factors were found to be dextrin 6.0%; maltose 3.0%; cotton seed flour 0.53%; and yeast extract 0.45%. The maximum titer of ansamitocin P-3 was 78.3 mg/l with the optimized composition, about 15-folds higher than the unoptimized titer of 5.0 mg/l obtained with YMG medium.

• Food Science and Biotechnology
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• v.18 no.4
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• pp.959-964
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• 2009

Production of the antioxidant substances by Bacillus polyfermenticus SCD was investigated using shake-flask fermentation. The one-factor-at-a-time method was first employed to determine the key ingredients for optimal medium composition, then further investigation of the medium composition was performed using response surface methodology (RSM). The antioxidant activity was measured using 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) assays. After screening various elements, fructose, tryptone, and $MgSO_4\;7H_2O$ were chosen as the main factors for study in the statistical experimental design. Central composite design (CCD) was then used to determine the optimal concentrations of these 3 components. Under the proposed optimized medium containing 2.8% fructose, 1.34% tryptone, 0.015% $MgSO_4\;7H_2O$), 0.5% NaCl, and 0.25% $K_2HPO_4$, the model predicted an antioxidant activity of 80.5% ($R^2=0.9421$. The actual experimental results were in agreement with the prediction.

• Composites Research
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• v.12 no.6
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• pp.31-42
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• 1999

In aerospace industry, the improvement of structural performance of fight structure without increasing weight has great advantage. In this study. an innovative design method to increase the buckling load and tension failure load at the same time without increasing the weight of composite plates was investigated. By using the curvilinear fiber format a method to increase the buckling load and tension failure load simultaneously was investigated for composite plates with central hole with finite element method. It was investigated how much gain can be obtained with curvilinear fiber format for the plates with different hole size and different stacking sequence. And, for the cases studied, the failure mechanism was also investigated. For the manufacturing of the curvilinear fiber format, smoothly and continuously changing fiber path is necessary. In this study, a simple method to find the smoothly changing fiber path by using the fiber angles obtained with finite element method was presented.

• Journal of the Korean institute of surface engineering
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• v.51 no.5
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• pp.303-308
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• 2018

Currently hydrofluoric acid (HF) based glass etch method is widely used for anti-glare (AG) surface treatment since it can effectively alleviate the specular reflection problem with relatively low processing cost. However, due to the environmental regulation and safety problem, it is essential to develop alternative technology to replace this method. For this, in this paper, we propose sand blasting based AG surface treatment method for display glass. To characterize the sand blasting process, surface roughness, haze, surface durability, and flatness are considered as process outputs and central composite design (CCD) method and response surface model (RSM) method are applied to model each process output. Models for surface roughness and haze showed 96.44% and 97.24% of R-squared values, respectively and they can be applied to optimize AG surface treatment process for various haze level requirements of display industries.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.39 no.5
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• pp.535-541
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• 2015

In this study, an approximate multi-objective optimization of a wall-mounted monitor bracket arm was performed. The rotation angle of the bracket arm was determined considering the inplane degree of freedom. We then formulated an optimization problem on maximum stress and deflection. Analyses of mean and design parameters were conducted for sensitivity regarding performance with orthogonal array and response surface method (RSM). RSM models of objective and constraint functions were generated using central composite (CCD) and D-optimal design. The accuracy of approximate models was evaluated through $R^2$ value. The obtained optimal solutions by non-dominant sorting genetic algorithm (NSGA-II) were validated through the finite element analysis and we compared the obtained optimal solution by CCD and D-optimal design.

• Transactions of Materials Processing
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• v.10 no.6
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• pp.493-499
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• 2001

An optimal robust design methodology has been developed to minimize warpage in injection-molded pats. The response surface methodology was applied to obtain a functional relationship between design variables and warpage value, and the modified complex method was used as an optimization tool to search for an optimal design solution over prescribed design region. To attain robustness against process variations, Taguchi's SN ratio was introduced as the design metric. The proposed optimal design procedure was applied to an actual part, the Guide-ASF model of a fax machine, and the usefulness of the methodology was shown through the CAE simulation using a commercial injection molding software package.