• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2008.06a
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• pp.261-262
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• 2008

분산제의 종류와 함량이 무기물-유기물 복합재료의 레올로지 특성 및 유전특성에 미치는 영향에 대하여 고찰하였다. 먼저 Multiple light scattering 방법을 통하여 용액의 입자 이동속도와 용액의 맑은층의 두께변화를 살펴보았으며 이를 통해 적정한 분산제의 선정 및 선정된 분산제의 함량비에 따른 무기물 분말의 분산 특성을 고찰하였다. 그리고 테이프 캐스팅을 통하여 테이프를 제작한 후 1GHz에서 유전특성을 측정하였다. 위 결과들을 통하여 분산제의 종류와 함량비에 따라 용액 및 슬러리의 특성이 다르며 적정한 분산제를 사용하여 유전상수 16.5에 유전손실 0.0058의 복합재료를 제작할 수 있었다.

• Journal of the Ergonomics Society of Korea
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• v.29 no.6
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• pp.915-924
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• 2010

Muscular strength in the elderly is important factors deciding on functional state in daily lives, and functional state shows a health condition. Resistance training to prevent loss of muscle mass and muscle fiber atrophy due to aging can increase muscle mass and strength. Recently, resistance training to improve muscular strength and endurance has been actively researched. Resistance training increases activities of daily living and ability of the elderly, which makes healthy senescent. ADL/IADL is suitable for measuring health condition of the elderly. In this study, target muscles of resistance training were chosen through a correlation analysis between ADLs and elementary motion, and we presented a procedure to select target muscles and exercise equipments. This procedure consist of a survey method that were described detailed motion of ADL/IADL. So we should be to extract resistance training machine to improve functions of regarding fundamental motion. Result of study may improve daily life activities of the elderly through objectives and scientific approaches. Furthermore, it will be helpful to studies about various fields of the elderly.

• Archives of Pharmacal Research
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• v.29 no.8
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• pp.645-650
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• 2006

Tributyltin chloride (TBTC) at concentrations of $0.5-1.0\;{\mu}M$ inhibits dopamine biosynthesis in PC12 cells. In this study, the effects of TBTC on L-3,4-dihydroxyphenylalanine (L-DOPA)-induced cytotoxicity in PC12 cells were investigated. TBTC at concentrations up to $1.0\;{\mu}M$ neither affected cell viability, nor induced apoptosis after 24 or 48 h in PC12 cells. However, TBTC at concentrations higher than $2.0\;{\mu}M$ caused cytotoxicity through an apoptotic process. In addition, exposure of PC12 cells to non-cytotoxic (0.5 and $1.0\;{\mu}M$) or cytotoxic $(2.0\;{\mu}M)$ concentrations of TBTC in combination with L-DOPA (20, 50 and $100\;{\mu}M$) resulted in a significant increase in cell loss and the percentage of apoptotic cells after 24 or 48 h compared with TBTC or L-DOPA alone. The enhancing effects of TBTC on L-DOPA-induced cytotoxicity were concentration- and treatment time-dependent. These data demonstrate that TBTC enhances L-DOPA-induced cytotoxicity in PC 12 cells.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2004.05b
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• pp.19-22
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• 2004

The resonant planar transformer, which had power capacity of 300 W, input voltage of 220 V, output voltage of 15 V, and switching frequency of 500 kHz, was designed and manufactured by using the planar core with large effective area and the flat copper lead frames for miniaturization and high efficiency of the switching mode power supply (SMPS). As well as, a resonant converter equipped with the above mentioned planar transformer was manufactured and electromagnetic characteristics were investigated. The numerical value of turns for 1st and 2nd winding were 12 and 2 respectively. The self inductance of 1st winding was 33.2 ${\mu}H$, very low leakage inductance of 1.27 ${\mu}H$, and the coupling factor of 0.98 were obtained at switching frequency of 300 kHz. The high efficiency of 88.21 % for the SMPS equipped with planar transformer was obtained at power capacity of 300 W.

• Journal of the Korean Magnetic Resonance Society
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• v.9 no.2
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• pp.122-137
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• 2005

The hepatitis B virus X protein (HBx) is highly linked with liver diseases and the development of hepatocellular carcinoma. HBx-interacting protein (XIP) has been shown to abolish the transactivation functions of HBx. Here, we define the structural characteristics and HBx binding properties of XIP. Under physiological conditions, XIP was composed mainly of random-coils but significant helicity was induced in the hydrophobic condition. NMR spectroscopy defined the secondary structure of XIP in the presence of sodium dodecyl sulfate. Four putative helices were mapped to the amino acids 8-12, 32-38, 42-54 and 82-91. Any deletion of defined putative helices in XIP led to loss of binding to HBx, and truncated mutant lacking last putative helix decreased helicity more than that it could. Our results suggest that XIP requires its entire sequence for HBx binding and it may be under drastic conformational change when binds to HBx.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.46 no.1
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• pp.43-47
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• 2020

A novel series of adamantyl derivatives of N-aryl amides as androgen receptor antagonists were synthesized and their anti-androgenic activities were evaluated. The N-aryl amides containing adamantyl derivatives had more activity than those lacking adamantyl substitutions. The synergistic effect of bulkiness of the adamantyl group and modulation of electron density on the aromatic ring by pendant groups was crucial to the potent antagonism. Molecular modeling studies were performed to elucidate the interactions between ligands and receptors.

• Annals of Pediatric Endocrinology and Metabolism
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• v.23 no.4
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• pp.229-234
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• 2018

X-linked hypophosphatemic rickets is caused by loss-of-function mutations in PHEX, which encodes a phosphate-regulating endopeptidase homolog. We report a 26-year-old man with X-linked hypophosphatemic rickets who showed decreased serum phosphate accompanied by bilateral genu valgum and short stature. He had received medical treatment with vitamin D (alfacalcidol) and phosphate from the age of 3 to 20 years. He underwent surgery due to valgus deformity at the age of 14 and 15. Targeted gene panel sequencing for Mendelian genes identified a nonsense mutation in PHEX (c.589C>T; p.Gln197Ter) and a mosaic pattern where only 38% of sequence reads showed the variant allele. This mutation was not found in his mother, who had a normal phenotype. This is a case of a sporadic nonsense mutation in PHEX and up to date, this is the first case of a mosaic mutation in PHEX in Korea.

• Journal of the Korea Society of Computer and Information
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• v.24 no.3
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• pp.29-39
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• 2019

In this study, we introduce a model that satisfies energy efficiency and economical efficiency by introducing and demonstrating cogeneration generators in industrial complexes using various actual data collected at the site. The proposed model is composed of three scenarios, ie, full - time operation, scenario operated according to demand, and a fusion type. In this study, the power generation profit and surplus thermal energy are measured according to the operation of the generator, and the thermal energy is traded according to the demand of the customer to calculate the profit and loss including the heat and evaluate the economic efficiency. As a result of the study, it is relatively profitable to reduce the generation of the generator under the condition that the electricity rate is low and the gas rate is high, while the basic charge is not increased. On the contrary, if the electricity rate is high and the gas rate is low, The more you start up, the more profit you can see. These results show that even a cogeneration power plant with a low economic efficiency due to a low "spark spread" has sufficient economic value if it can sell more than a certain amount of heat energy from a nearby customer and adjust the applied power through peak management.

• Journal of the Korean Wood Science and Technology
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• v.47 no.4
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• pp.451-458
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• 2019

Jabon (Anthocephalus cadamba Miq.) is a fast-growing species that exhibits a lower natural resistance than that exhibited by the timber sourced from natural forests. Jabon's resistance to termite attack can be improved by impregnating its wood structure with poisonous organic materials. This study examined jabon's resistance to termite attack when impregnated with wood vinegar and an animal adhesive. The wood specimens were impregnated using sengon wood vinegar and an animal adhesive (8% and 10%, respectively) using a vacuum pressure machine. The specimens were tested for their resistance to subterranean and dry-wood termites according to Indonesian National Standard (SNI 7207-2014). The results denoted that jabon impregnated with wood vinegar and an animal adhesive concentration of at least 8% with the addition of 4% borate was effective to resist termite attacks. The impregnated jabon exhibited a lower weight loss and higher termite mortality when compared with those exhibited by the control specimens. Thus, the resistance class improved from class IV to class I.

• Journal of Genetic Medicine
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• v.17 no.2
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• pp.83-88
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• 2020

Silver-Russell syndrome (SRS) is a rare genetic disorder characterized by intrauterine growth restriction, poor postnatal growth, relative macrocephaly, a triangular face, body asymmetry, and feeding difficulties. It is primarily diagnosed according to a clinical scoring system; however, the clinical diagnosis is confirmed with molecular testing, and the disease is stratified into the specific molecular subtypes. SRS is a genetically heterogeneous condition. The major molecular changes are hypomethylation of imprinting control region 1 in 11p15.5 and maternal uniparental disomy of chromosome 7 (UPD(7)mat). Therefore, first-line molecular testing should include methylation-specific approaches for these regions. Here, we report an extremely low birth weight (ELBW) infant with intrauterine growth retardation, postnatal growth retardation, and dysmorphic facial appearance-characteristics consistent with the clinical diagnostic criteria of SRS. Methylation-specific molecular genetic analysis revealed UPD(7)mat, while the loss of heterozygosity was not detected on chromosomal microarray analysis. We present a case of SRS with suspected uniparental heterodisomy of chromosome 7 in an ELBW infant.