• Title/Summary/Keyword: center loss

Search Result 3,753, Processing Time 0.031 seconds

Monoterpenoid Loliolide Regulates Hair Follicle Inductivity of Human Dermal Papilla Cells by Activating the AKT/β-Catenin Signaling Pathway

  • Lee, Yu Rim;Bae, Seunghee;Kim, Ji Yea;Lee, Junwoo;Cho, Dae-Hyun;Kim, Hee-Sik;An, In-Sook;An, Sungkwan
    • Journal of Microbiology and Biotechnology
    • /
    • v.29 no.11
    • /
    • pp.1830-1840
    • /
    • 2019
  • Loliolide is one of the most ubiquitous monoterpenoid compounds found in algae, and its potential therapeutic effect on various dermatological conditions via agent-induced biological functions, including anti-oxidative and anti-apoptotic properties, was demonstrated. Here, we investigated the effects of loliolide on hair growth in dermal papilla (DP) cells, the main components regulating hair growth and loss conditions. For this purpose, we used a three-dimensional (3D) DP spheroid model that mimics the in vivo hair follicle system. Biochemical assays showed that low doses of loliolide increased the viability and size of 3D DP spheroids in a dose-dependent manner. This result correlated with increases in expression levels of hair growth-related autocrine factors including VEGF, IGF-1, and KGF. Immunoblotting and luciferase-reporter assays further revealed that loliolide induced AKT phosphorylation, and this effect led to stabilization of β-catenin, which plays a crucial role in the hair-inductive properties of DP cells. Further experiments showed that loliolide increased the expression levels of the DP signature genes, ALP, BMP2, VCAN, and HEY1. Furthermore, conditioned media from loliolide-treated DP spheroids significantly enhanced proliferation and the expression of hair growth regulatory genes in keratinocytes. These results suggested that loliolide could function in the hair growth inductivity of DP cells via the AKT/β-catenin signaling pathway.

Corrosion mitigation of photovoltaic ribbon using a sacrificial anode (희생양극을 이용한 태양광 리본의 부식 저감)

  • Oh, Wonwook;Chan, Sung-Il
    • Journal of the Korea Academia-Industrial cooperation Society
    • /
    • v.18 no.3
    • /
    • pp.681-686
    • /
    • 2017
  • Degradation is commonly observed in field-aged PV modules due to corrosion of the photovoltaic ribbon. The reduced performance is caused by a loss of fill factor due to the high series resistance in the PV ribbon. This study aimed to mitigate the degradation by corrosion using five sacrificial anodes - Al, Zn and their alloys - to identify the most effective material to mitigate the corrosion of the PV ribbon. The corrosion behavior of the five sacrificial anode materials were examined by open circuit potential measurements, potentiodynamic polarization tests, and galvanic current density and potential measurements using a zero resistance ammeter. Immersion tests for 120 hours were also conducted using materials and damp heat test tests were performed for 1500 hours using 4 cell mini modules. The Al-3Mg and Al-3Zn-1Mg sacrificial anodes had a low corrosion rate and reduced drop in power, making then suitable for long-term use.

Effect of Reverse Transformation Treatment on the Microstructure and Mechanical Properties of 0.15C-6Mn TRIP Steels (0.15C-6Mn TRIP강의 미세조직과 기계적 성질에 미치는 역변태 열처리의 영향)

  • Hong, H.;Lee, O.Y.;Song, K.H.
    • Korean Journal of Materials Research
    • /
    • v.13 no.7
    • /
    • pp.453-459
    • /
    • 2003
  • In this paper the effect of interstitial heat treatment on the microstructure and mechanical properties was examined both in the 0.15C-6Mn steels and 0.15C-6Mn steels added with Nb or Ti. This result will be applied into the development of a steel which has the properties of high strength and high ductility resulted from the transformation induced plasticity. The strength-elongation combination was increased as the holding time was increased when the temperature is at $625^{\circ}C$. However, the strength-elongation combination was decreased sharply as the holding time was increased when the temperature is at $675^{\circ}C$. The tensile strength and elongation of a reverse transformed steels added with Ti or Nb was 93 kg/$\textrm{mm}^2$ and 40%, respectively. This steel shows higher strength more than 10% of the 0.15C-6Mn steel without loss of ductility. The autenite formed from the reverse transformed treatment has a fine lath type, which has the width size of 0.1-0.3 $\mu\textrm{m}$. The TRIP sequence normally transforms the austenite to martensite, however, some of the sequence will produce retained austenite \longrightarrow deformation twin \longrightarrow martensite

Study on Red and Black Heartwood Properties of Cryptomeria Japonica in Southern Region of Korea

  • Won, Kyung-Rok;Jung, Su-Young;Yoo, Byung-Oh;Hong, Nam-Euy;Byeon, Hee-Seop
    • Journal of the Korean Wood Science and Technology
    • /
    • v.45 no.6
    • /
    • pp.753-761
    • /
    • 2017
  • The heartwood (HW) of Japanese cedar (Cryptomeria japonica) has usually a reddish color. But some trees have black-colored heartwood (BHW). BHW of Japanese cedar has a low commercial value because of the appearance. Therefore, in this study, a comparative analysis was conducted to evaluate the differences in the physical, mechanical, and inorganic element properties, and decay resistance of red-colored heartwood tree (RHW) and BHW. The physical properties showed significant difference between sapwood (SW) and HW, but there was no significant difference between RHW and BHW. From the results of mechanical properties, no significant difference was recognized in SW of RHW, HW of RHW, SW of BHW, and HW of BHW. There were decay resistance differences between RHW and BHW in HW, and between HW and SW in both RHW and BHW, respectively. The magnesium (Mg), potassium (K), and calcium (Ca) contents had significant differences between SW and HW in both RHW and BHW. In this present study, the decay resistances and the contents of Mg and K were higher in HW than in SW both for RHW and BHW, while these measurements were lower in RHW than in BHW. Therefore, BHW was considered to be worthy as a high-quality material as RHW.

Frequency of different maxillary sinus septal patterns found on cone-beam computed tomography and predicting the associated risk of sinus membrane perforation during sinus lifting

  • Sigaroudi, Ali Khalighi;Kajan, Zahra Dalili;Rastgar, Shabnam;Asli, Hamid Neshandar
    • Imaging Science in Dentistry
    • /
    • v.47 no.4
    • /
    • pp.261-267
    • /
    • 2017
  • Purpose: Analyzing different patterns of maxillary sinus septa in cone-beam computed tomography (CBCT) images and predicting maxillary sinus membrane perforations. Materials and Methods: In this cross-sectional study, CBCT images of 222 patients ranging from 20 to 81 years old were evaluated. One hundred fifty-two patients (93 females and 59 males) who had maxillary sinus septa in axial views were included in this study. Cross-sectional images were used to determine classifications of sinus septa and the risk of membrane perforation using a method modified from Al-Faraje et al. Variables of sex, age, and dental status were considered. Chi-squared and Kruskal-Wallis tests were used for data analysis(P<.05). Results: In this study, 265 maxillary sinus septal patterns were found. The mean age of the patients was $44.1{\pm}14.7$ years old. The Class I and VII-div II patterns had the greatest and least prevalence, respectively. Furthermore, there was a significant relationship between the location of septa and the frequency of membrane perforation risk (P<.05). In this study, the relationship of different patterns of septa with dental status did not differ significantly (P>0.05). Conclusion: A higher prevalence of moderate risk of membrane perforation in the molar region relative to the premolar region was observed. Furthermore, maxillary sinus septa occur most frequently in the molar region, demonstrating the importance of paying attention to this region during sinus lift surgery. This study did not show any relationship between tooth loss and the presence of septa.

Effect of the Electrode Type on the Dielectric and Piezoelectric Properties of Piezoelectric PMN-PZT Single Crystals (압전 PMN-PZT 단결정의 유전 및 압전 특성에 미치는 전극 종류의 영향)

  • Lee, Jong-Yeb;Oh, Hyun-Taek;Choi, Kyoon;Lee, Ho-Yong
    • Journal of the Korean Ceramic Society
    • /
    • v.52 no.1
    • /
    • pp.77-82
    • /
    • 2015
  • The effect of the electrode type on the dielectric and piezoelectric properties of $Pb(Mg_{1/3}Nb_{2/3})O_3-PbZrO_3-PbTiO_3$ (PMN-PZT) single crystals was investigated in an effort to improve their properties for various piezoelectric applications. First, three different types of PMN-PZT single crystals [PMN-PZT-A (piezoelectrically soft type; dielectric constant ~ 10,000), PMN-PZT-B (piezoelectrically soft type; phase-transition temperature between the rhombohedral and tetragonal phases ($T_{RT}$) ~ $145^{\circ}C$), PMN-PZT-C (piezoelectrically hard type; high mechanical quality factor ($Q_m$) ~ 1,000)] were fabricated using the solid-state single crystal growth (SSCG) method. Then, four different types of electrodes [sputtered Au, sputtered Cr/Au, sputtered Ti/Au, and fired Ag] were formed on the single crystals, and their dielectric and piezoelectric properties were measured. The single crystals with a sputtered Ti/Au electrode showed the highest dielectric and piezoelectric constants but the lowest coercive electric field ($E_C$). The single crystals with a fired Ag electrode showed the lowest dielectric and piezoelectric constants but the highest coercive electric field ($E_C$). This dependence on the type of electrode was most significant in the piezoelectrically hard PMN-PZT-C single crystals. However, the effects of the electrode type on the phase transition temperatures ($T_C$, $T_{RT}$) and dielectric loss were negligible. These results clearly demonstrate that it is important to select an appropriate electrode so as to maximize the dielectric and piezoelectric properties of single crystals in each type of piezoelectric application.

Design of Wideband Small Antenna for UWB Communication (UWB 통신용 광대역 소형 안테나 설계)

  • Ko Ji-Whan;Shin In-Ho;Lee Young-Soon;Cho Young-Ki
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
    • /
    • v.16 no.11 s.102
    • /
    • pp.1086-1098
    • /
    • 2005
  • Two types of small wideband antennas are proposed for UWB application. One type is small biconical structure fed by coaxial probe, which is easy to be installed on the circuit board. The other type is of planar bow-tie type fed by coplanar transmission line. Generally, the bandwidth of the latter type is significantly narrower than that of the former type. It is shown, however that the bandwidth of the latter type can be made to be comparable to that of the former, if some series inductive component is introduced in the center conductor line in the CPW transmission line by replacing some part of center line with narrower line of higher characteristic impedance. The series inductance component play an important role of neutralizing the capacitive component of the small bow-tie antenna, thereby making broadband impedance matching possible. The small planar bow-tie antenna was fabricated and experimented. The experimental results for return loss are observed to be in good agreement with simulated results. The radiation pattern is also investigated experimentally.

Thermal Comfort of the Sports/Leisure Clothing with the Heat Storage/Reflection Function - Wearing Evaluation under the Condition of 0x00B1;1℃ and 50±5% RH - (축열/체열반사기능을 가진 스포츠 레저복의 온열쾌적성 - 0±1℃, 50±5% RH 환경에서의 착의평가 -)

  • Kim, Tae-Gyou;Song, Min Kyu;Lee, Chang Min;Kwon, Oh Kyung
    • Fashion & Textile Research Journal
    • /
    • v.20 no.4
    • /
    • pp.474-481
    • /
    • 2018
  • For this study, we developed clothing in which textile materials that were excellent weather control function for the cold environment and we performed the human subject test with developed clothing to determine the thermal comfort. We used 2 clothing samples developed (A and B, hollow yarn+moisture absorption/quick drying yarn, 3 layers, high stretchable, heat reflection film and lamination treated) and a control sample (Ctrl.) for the human subject test and 8 adult males were used as a human subjects and environmental conditions of chamber were $0{\pm}1^{\circ}C$. $50{\pm}5%RH$, 0.3m/sec. The results were as follows: The average skin temperature and hand, thigh temperature of B were higher than B and Ctrl. (p<.05). The micro-climates of B were near to thermal comfort range which is $32{\pm}1^{\circ}C$ and $50{\pm}10%\;RH$. The chest temperature of B was significantly higher than others (p<.05). The relative humidity of B was lower than others and kept stable rather than others. The thermal sensation of B was near the "neutral" and was significantly different from Ctrl. (p<.01) and the weight loss of B was lower than Ctrl. (p<.05). The counting task and hand temperature was positively related and the counting task value of B and A is bigger than Ctrl. and that of A was bigger than Ctrl. (p<.05).

A Case of Mycoplasma haemofelis Infection in a Korean Domestic Shorthair Cat (한국 토종 단모종 고양이에서 Mycoplasma Haemofelis 감염 증례)

  • Kim, Mi-Ryung;Lee, Seung-Jin;Lee, Keun-Woo
    • Journal of Veterinary Clinics
    • /
    • v.31 no.1
    • /
    • pp.57-60
    • /
    • 2014
  • A six-months-old male Korean domestic shorthair cat was presented with fever, tachypnea, anorexia, and weight loss and admitted to Lee Seung Jin Animal Medical Center. During the routine physical examination, clinical signs such as mild dehydration and jaundice in the sclera were present. The complete blood count (CBC) and serum chemistry result showed anemia, thrombocytopenia, neutrophilia, and hyperbilirubinemia. Radiography revealed hepatomegaly and splenomegaly. Blood smear and microscopic examination showed severe hemolysis and anisocytosis. We sent the blood sample to the Neodin Veterinary Laboratory for PCR analysis to conduct a test to find out Ehlichia, feline hemoplasmas (haemobartonella), feline leukemia virus (FeLV), feline immunodeficiency virus (FIV) and anaplasma infection. According to PCR examination, the blood of this cat was positive for feline hemoplasmas (Mycoplasma haemofelis), but negative for other pathogens. The patient was prescribed doxycycline for 4 weeks and prednisolone for 1 week. The free of feline hemoplasmas infection was confirmed by PCR recheck after six months.

Study on Association between Risk of Eating Disorder and Self-Esteem on Body Image (일부 대학생의 체형 만족 정도와 식사 장애 위험 정도의 관계 연구)

  • Nam Hee-Jung;Kim Young-Soon
    • The Korean Journal of Food And Nutrition
    • /
    • v.18 no.2
    • /
    • pp.115-126
    • /
    • 2005
  • This Quantitative study was investigated to examine the relationship between self-esteem on body image and disordered eating patterns in some university students. This study used a cross-sectional study design. Total 347 students participated in this study (88 male and 259 female) among three universities. The assessment of eating disorder was conducted by Eating Attitudes Test (EAT-26), a score of >or=20 identified individuals likely have an eating disorder, including anorexia nervosa and bulimia nervosa. Ideal body weight and current body weight were completed with self-evaluation. A distorted body image was independently related to the eating problem in the Logistic regression analysis. There were stronger relationships between their EAT-26 scores and their expected weight changes and weight control behaviors. Compared with the men, women showed highly wishful to loss for current body weight. In the relationship between score of EAT-26 and BMI distance by sex, levels of eating disorder showed linearly elevated toward increased BMI distance (Ideal BMI-Current BMI) (F-value=18.794, p<0.0001) in women, but there were not significant in men (F-value=2.028, p>0.05). In estimate on state-trait anxiety inventory according to quartile of BMI distance by sex, levels of state-trait anxiety were not significant difference by degree of body dissatisfaction in all sex. In addition, higher distorted body image was significantly increased numbers of weight control method and experience of side effects in female, but there were not showed significant relation between two variables in male.