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Comparative Study of the Nucleotide Bias Between the Novel H1N1 and H5N1 Subtypes of Influenza A Viruses Using Bioinformatics Techniques

  • Ahn, In-Sung;Son, Hyeon-Seok
    • Journal of Microbiology and Biotechnology
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    • v.20 no.1
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    • pp.63-70
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    • 2010
  • Novel influenza A (H1N1) is a newly emerged flu virus that was first detected in April 2009. Unlike the avian influenza (H5N1), this virus has been known to be able to spread from human to human directly. Although it is uncertain how severe this novel H1N1 virus will be in terms of human illness, the illness may be more widespread because most people will not have immunity to it. In this study, we compared the codon usage bias between the novel H1N1 influenza A viruses and other viruses such as H1N1 and H5N1 subtypes to investigate the genomic patterns of novel influenza A (H1N1). Totally, 1,675 nucleotide sequences of the hemagglutinin (HA) and neuraminidase (NA) genes of influenza A virus, including H1N1 and H5N1 subtypes occurring from 2004 to 2009, were used. As a result, we found that the novel H1N1 influenza A viruses showed the most close correlations with the swine-origin H1N1 subtypes than other H1N1 viruses, in the result from not only the analysis of nucleotide compositions, but also the phylogenetic analysis. Although the genetic sequences of novel H1N1 subtypes were not exactly the same as the other H1N1 subtypes, the HA and NA genes of novel H1N1s showed very similar codon usage patterns with other H1N1 subtypes, especially with the swine-origin H1N1 influenza A viruses. Our findings strongly suggested that those novel H1N1 viruses seemed to be originated from the swine-host H1N1 viruses in terms of the codon usage patterns.

A Positive Analysis of Housing Price Model in Seoul: Applications of Structural Equation Modeling

  • Kim, Kyong-Hoon;Lee, Yoon-Sun;Ahn, Byung-Ju;Kim, Jae-Jun
    • Architectural research
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    • v.9 no.2
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    • pp.27-35
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    • 2007
  • Our nation has a problem with discrimination of income distribution and inefficient of resources distribution caused by real estate price rising from a sudden economy growth and industrialization. Specially, in recent years, there is a great disparity of apartment price between the north and south of the Han river. Because the housing price is decided by the immanent value of a house and neighborhood effects of the regional where the house is situated, the housing price is occurred difference. The purpose of study was to analyze the influence of various factors of housing price. Also, this study tried to predict real estate market and to establish previous effective real estate policy. In this study, we analyzed the differences of housing price determinants about apartment developments between the north and south of the Han river, and found the important factors that affect the housing price using Structural Equation Modeling(SEM). As a result of this study, the older the buildings are, the more the housing price and the housing price rising ratio have increased, in Gang Nam area. This reason is that these have large possibility to be reconstructed and many convenient facilities, in this area. In the case of Kang Buk area, the increase rate of housing price are so low that they couldn't take effect on the housing price and they were declined. So to speak, constructing the infrastructure which takes effect on the increase rate of housing price is very urgent.

Relationship among Types of Nursing Organizational Culture, Self-leadership and Burnout as Perceived by Perioperative Nurses (수술실 간호사가 지각하는 간호조직문화 유형, 셀프리더십 및 소진 간의 관계)

  • Im, Minkyung;Sung, Young-Hee;Jung, Junghee
    • Journal of Korean Academy of Nursing Administration
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    • v.23 no.2
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    • pp.170-180
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    • 2017
  • Purpose: This study was designed to assess the types of nursing organizational culture, and degree of self-leadership and burnout as perceived by perioperative nurses, and to identify correlations between these variables. Methods: Participants were 155 nurses from 3 tertiary hospitals in Seoul and data were analyzed using descriptive statistics, ANOVA, Scheffe, and Pearson correlation coefficient. Results: In the types of nursing organizational culture, the mean score for hierarchy-oriented culture was 3.57, and for self-leadership, 3.61 and for burnout, 2.87. In the relationship between the types of nursing organizational culture, self-leadership and burnout, relation-oriented culture (r=.24, p<.01), innovation-oriented culture (r=.23, p<.01) and task-oriented culture (r=.22, p<.01) had a slight positive correlation with self-leadership in that order. The innovation-oriented culture (r=-.29, p<.01) and relation-oriented culture (r=-.42, p<.01) among the types of nursing organizational culture showed a negative correlation with burnout while the hierarchy-oriented culture (r=.28, p<.01) showed a positive correlation with burnout. Self-leadership showed a negative correlation with burnout (r=-.42, p<.01). Conclusion: The results show that nurses in operating rooms have a high awareness of hierarchy-oriented culture that affects burnout in a negative way while having a low awareness of relation-oriented culture that has a positive influence on burnout.

A Preliminary study on the Direction of Design and Designer in the Era of 4th Industrial Revolution (제4차 산업혁명 시대의 디자인과 디자이너 방향성에 관한 기초연구)

  • Gong, Hoe-Jeong
    • Journal of Digital Convergence
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    • v.16 no.4
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    • pp.307-312
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    • 2018
  • This paper deals with the role and direction of design in the era of 4th industrial revolution. In addition to understanding the whole of science and technology such as Artificial Intelligence, Internet of Things, Cyber Physical System, 3D printer and Bio which are leading technology of the $4^{th}$ industrial revolution, this thesis is seeking direction of design that makes human life and society comfortable and convenient. The design in the 4th Industrial Revolution must be at the center of society and human being. Therefore, the design using ICT technology is also applied to the emotional design that stimulates human emotion warmly through in-depth study on society and human culture and environment. Through the above research, the design that has continued to evolve along with the development of technology continues to play a role as a design in which human emotion is alive.

The Statistically and Economically Significant Clustering Method for Economic Clusters in an Urban Region (통계적 및 경제적 유의성을 가진 경제 클러스터 탐식방법에 대한 연구)

  • Shin Jungyeop
    • Journal of the Korean Geographical Society
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    • v.40 no.2 s.107
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    • pp.187-201
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    • 2005
  • With the trend of urban polynucleation, the issue of detecting economic clusters or urban employment centers has been considered as crucial. However, the prior researches had some limitations in detecting economic clusters in the empirical analysis: i.e. inherent inefficiency of density-based clustering methods, difficulty in detecting linear types of spatial clusters and lacks of consideration of economic significance. The purpose of this paper is to propose the clustering method with the procedure of testing statistical and economic significance named as VCEC (Variable Clumping method for Economic Clusters) and to apply it to a case analysis of Erie County, New York, in order to test its validity. By applying a search radius and a total employment as an economic threshold, 'the both statistically and economically significant clusters' were detected in the Erie County, and proved to be efficient.

A Study On Legal Delay Before Divorce Program in Korea (이혼숙려제도 활성화를 위한 기초연구 - 자발적으로 이혼관련상담기관을 내방한 기혼남녀를 중심으로 -)

  • Park, Sang-Jin;Kim, Yang-Hee;Auh, Seong-Yeon;Park, Jeong-Yun;Chang, Young-Eun;Jung, Jin-Hee
    • Journal of Family Resource Management and Policy Review
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    • v.13 no.3
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    • pp.157-180
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    • 2009
  • The purposes of this study were (a) to examine perceptions of the Legal Delay Before Divorce Program (LDBDP) in Korea among individuals, (b)to predict the need for the LDBDP, and (c) to predict the needs for psychological counseling with predicting variables. Two hundred questionnaires were completed by the clients of a legal aid center in Seoul. The majority of participants knew about and expressed their need for the LDBDP. Participants agreed to the LDBDP because it could prevent impulsive divorce, provide time to prepare for post-divorce life, provide support with counseling, and protect the children in families of divorce. Participants disagreed to the LDBDP because it only delayed the time to divorce, prolonged emotional suffering, and intruded on personal privacy. In the model test, the need for the LDBDP was significantly predicted by marital instability scale, age, education, occupation, the period of living apart, and the status of voluntary divorce. The need for psychological counseling was significantly predicted by age, having at least one child, having at least one minor child, marital period, and need for family life counseling in the suggested model.

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A Study on the Methodology of Excavated-Costumes - With a Focus on the Cases of Excavated Costumes from the Grave of Nor Su-ham(1516~1573)'s Family - (출토복식 보수방법에 관한 고찰 - 경주노씨 수함(1516~1573)공(公) 일가(一家) 출토복식 사례를 중심으로 -)

  • Chung, Young-Ran;Song, Mi-Kyung
    • Journal of the Korean Society of Costume
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    • v.63 no.7
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    • pp.65-78
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    • 2013
  • This study aims to suggest the methodology for conservation of excavated costumes especially repair and restoration process. Early excavated costumes had not attracted attention from the field of academia and the public. So not many scholars, organization and society participated in the excavations but as its value has gotten more recognition, there has been a reversal in trend. And so many organizations have taken part in it. Excavating includes conservation processes such as washing, repair and restoring, and then it is published by reports or books after the process is complete. However the method of conservation has varied depending on the institution. In particular, repair and restore methods do not include anything specific details, and often times, only has descriptions of the before and after state, and so a more unified method needs to be suggested and shared. This study defined 'Conservation', 'Repair' and 'Restoration' and then applied it to the short history of Korean excavated-costumes. Then it suggested ways to repair and restore excavated-costumes in terms of construction, textile, and damage by the unpublished cases of excavated-costumes of Noh Su-ham(1516~1573)'s Family. It was also referred to repair and restoration process such as shaping correction, dyeing, supporting, sewing and after treatment by texts and pictures. Other contents such as a list of relics and its details, will be published through a report or a book. The whole process of conservation was in progress based on the ethical guidelines of conservation, 'Minimum intervention' and 'Reversibility'.

Relationship between Visceral Adipose Tissue and Self-Esteem in Korean Pre-menopausal Obese Women (폐경전 비만여성에서 내장지방과 자존감의 연관성)

  • Hwang, Mi-Ja;Lee, A-Ra;Hwang, Deok-Sang;Chung, Won-Suk;Song, Mi-Yeon
    • Journal of Korean Medicine for Obesity Research
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    • v.8 no.1
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    • pp.89-99
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    • 2008
  • Objectives Obesity is not only a matter of accumulation of adipose tissue but also a projection of self-cognition. This study examined the association between low self-esteem and visceral obesity; visceral adipose tissue (VAT) and visceral adipose tissue /subcutaneous adipose tissue ratio (VSR). Methods This cross-sectional study was performed in pre-menopausal obese(BMI $\geq\;25\;kg/m^2$) women in Seoul, from 2007 to 2008 (n=54). Simple anthropometry including BMI and waist circumference and Computed Tomography (CT) including VAT and VSR were done. To measure self-esteem, Rosenberg self-esteem scale (SES) questionnaire was administered. Subjects were given written consent and this study was performed under the permission of institutional review board of Kyung-Hee East-west Neo Medical Center. Results There was a significant relationship self esteem (SES score) with visceral obesity (VAT and VSR). 1. SES was correlated with VAT (r=-0.377, p<0.01) and VSR (r= -0.400, p<0.01) significantly by Pearson Correlation. 2. VAT and VSR could be predicted from SES by Simple linear regression. VAT = -1.701 ${\times}$ (SES score) +161.191 ($R^2$=0.142) VSR = -1.09${\times}$$10^{-2}$ ${\times}$ (SES score) +0.858 ($R^2$=0.160) Conclusions This study proves that low self-esteem might contribute to visceral obesity in Korean pre-menopausal obese women. Self-esteem and psychological factor should be considered in treatment of visceral obesity in adult-women.

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Variation of Eupatilin and Jaceosidin Content of Mugwort (약쑥의 Eupatilin과 Jaceosidin 함량변이)

  • Ryu Su-Noh;Han Sang-Suk;Yang Jong-Jin;Jeong Hae-Gon;Kang Sam-Sik
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.50 no.spc1
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    • pp.204-207
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    • 2005
  • This study was carried out to select the high eupatilin and jaceosidin containing species and suppose the crop value of Mugwort (Artemisia sp.) investigating plant characteristics. Among the twelve collected mugworts, only one's of Ganghwa and Baekryeongdo contained the eupatilin and jaceosidin and the highest eupatilin and jaceosidin contents weye obtained from the Ssajuarissuk collected in Ganghwa. The result of seasonal variation in eupatilin content indicated the highest contents from May 23 to June 10. Eupatilin content of leaves in upper was higher than in lower leaves and content of middle leaves was not higher than in upper leaves. And the highest eupatilin content found in the leaves of the upper part of the plant, almost 2 times higher than those of the lower of the plant.

Effects of Social Support, Ego-resilience, and Subjective Wellbeing on Suicidal Ideation in Nursing Students (간호대학생의 사회적 지지, 자아탄력성, 주관적 안녕감이 자살생각에 미치는 영향)

  • Park, Soonjoo;Bak, Eunyeong;Lee, Songiee;Jang, Ahhyun;Cho, Seowon
    • Journal of Korean Academy of Fundamentals of Nursing
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    • v.23 no.3
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    • pp.310-319
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    • 2016
  • Purpose: This study was done to examine whether risk of suicidal ideation in nursing students as related to social support and ego-resilience, and whether subjective wellbeing mediated the relationships. Methods: Structural equation modeling was applied to test the model in which ego-resilience and social support from family, friends, and others were considered as exogenous variables and subjective wellbeing as a mediating variable. The participants were 285 nursing students who completed self-report measures including the Suicidal Ideation Questionnaire, the Multidimensional Scale of Perceived Social Support, the Ego-Resiliency Scale, and the Index of Wellbeing. Results: Results show that higher scores on family support and ego-resilience were positively associated with subjective wellbeing and negatively with suicidal ideation. Subjective wellbeing mediated the relationships between family support and suicidal ideation, and also ego-resilience and suicidal ideation. Among the three social supports, only family social support had both direct and indirect effects on suicidal ideation. Conclusion: Findings suggest that family support is a useful resource in the prevention of suicidal ideation in nursing students and building supportive relationship with family should be considered as the first step in suicide prevention strategies. Also enhancing ego-resilience could play an important role to reduce suicide risk through promoting well-being.