• Journal of Radiopharmaceuticals and Molecular Probes
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• v.1 no.1
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• pp.38-45
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• 2015

Most tumors are believed to overexpress several receptors, and small peptides targeting these receptors were developed for diagnosis and tumor therapy during past decade. Here we report that fibroadenoma can be visualized by bladder cancer specific peptide. A 9-mer bladder cancer specific peptide, which was discovered from the phage display method, was synthesized by peptide synthesizer, and additional tyrosine was conjugated at the N-terminal for radioiodination (Y-BP). Y-BP was radiolabeled with $^{131/124}I$ using Iodogen tube. The rat treated with N-butyl-N-(4-hydroxybutyl)nitrosamine for 8 weeks was allowed to grow until large size tumor was developed under axilla. The tumor model was microPET imaged sequentially using [$^{18}F$]FDG and radioiodinated $^{124}I-Y-BP$. The tumor was excised and examined by immunostaining studies. Radioiodinated $^{124}I-Y-BP$ was purified using fast protein liquid chromatography (FPLC) in > 90% radiochemical purity. The whole tumor was well visualized by [$^{18}F$]FDG with several intense focal uptake within tumor. The tumor was also clearly seen with $^{124}I-Y-BP$ at 4 h post-injection, and to our surprise the tumor uptake of $^{124}I-Y-BP$ lasted up to three days. The tumor was diagnosed histologically as a fibroadenoma derived from mammary gland. In conclusion, the bladder cancer specific peptide showed the good potential as a new radiotracer for the detection of breast fibroadenoma.

• Korean Journal of Food Science and Technology
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• v.29 no.3
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• pp.395-399
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• 1997

Meat model emulsions ware prepared with salt-soluble protein and soybean oil. Effects of water-soluble protein (WSP) on the meat model emulsion treated with/without BHT during 8 day storage $5^{\circ}C$ under both dark and light illumination were studied by measuring POV and TBA. An emulsion without BHA and WSP was used as a control. Under light storage, there was no significant difference in peroxide values between the control and the sample treated with BHA except the 2nd day of storage. However, TBA values of the sample treated with BHA were significantly (p<0.05) lower than those of control except the 4th day of storage. TBA and POV of the samples treated with WSP and WSP + BHA were higher than control after 4th day of storage under light. That is, water soluble protein, which was composed mainly of myoglobin, increased lipid oxidation under light storage. The similar trends were also shown in the samples stored under dark. These results suggested that acceleration of lipid oxidation of the meat model emulsions by water soluble protein (WSP) under both light and dark might not be due to the singlet oxygen formation, but due to superoxide anion formed.

• The Journal of Korean Academy of Sensory Integration
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• v.15 no.2
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• pp.22-34
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• 2017

Objective : The purpose of this study was to draw up sensory integration intervention competency model for occupational therapist and was to confirm a competency model through validation. Methods : We conducted literature review, expert opening survey, and expert focus meeting to draw up draft competency model. And then, we carried out Delphi survey twice and consulted an expert to confirm the sensory integration intervention competency model for occupational therapist. Results : The sensory integration intervention competency model for occupational therapist developed in this study was structured into 4 competency cluster, 15 competency, 60 competency indicators. 4 competency clusters had expertise, professionalism, interpersonal skills, and personal characteristics. Conclusion : The competency model revealed in this study can be used as basic critical data to foster development of competency based curriculum of Korean Academy of Sensory Integration (KASI).

• Journal of the Computational Structural Engineering Institute of Korea
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• v.29 no.4
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• pp.317-325
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• 2016

In this study, nonlinear earthquake responses of a soil-structure interaction(SSI) system which is subjected to a three-directional ground motion are examined. The structure and the near-field region of soil, where the geometry is irregular, the material properties are heterogeneous, and nonlinear dynamic responses are expected, are modeled by nonlinear finite elements. On the other hand, the infinite far-field region of soil, which has a regular geometry and homogeneous material properties and dynamic responses is assumed linearly elastic, is represented by three-dimensional perfectly matched discrete layers which can radiate elastic waves into infinity efficiently. Nonlinear earthquake responses of the system subjected to a three-directional ground motion are calculated with the numerical model. It is observed that the dynamic responses of a SSI system to a three-directional motion have a predominant direction according to the characteristics of the ground motion. The responses must be evaluated using precise analysis methods which can consider nonlinear behaviors of the system accurately. The the method employed in this study can be applied easily to boundary nonlinear problems as well as material nonlinear problems.

• Journal of The Korean Association of Information Education
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• v.14 no.3
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• pp.291-300
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• 2010

Group-based learning is known to be an effective means to improve scholastic achievement in online learning. Therefore, there are some previous researches for the group-based learning. A lot of previous researches define factors for grouping from the characteristics of classes, teacher's decision and students' preferences and then generate a group based on the defined factors. However, many algorithms proposed by previous researches depend on a specific class and is not a general approach since there exist several differences in terms of the need of courses, learners, and teachers. Moreover it is hard to find a automatic system for group generation. This paper proposes a grouping system which automatically generate a learner group according to characteristics of various classes. the proposed system automatically generates a learner group by using basic information for a class or additional factors inputted from a user. The proposed system defines a set of rules for learner grouping which enables automatic selection of a learner grouping algorithm tailored to the characteristics of a given class. This rule based approach allows the proposed system to accommodate various learner grouping algorithms for a later use. Also we show the usability of our system by serviceability evaluation.

• Journal of Digital Convergence
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• v.11 no.10
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• pp.639-651
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• 2013

This study aims to improve caregiver's labor conditions, to provide a high-quality care service and to offer basic research information for developing a standardized job content of caregiver. The study establishes basic principles for a standardized job content with a literature review and then collects basic information of caregiver's task with an observation technique. The study based on the observation technique develops 11 job categories and 72 duty categories expected to do by the caregiver. The study examines acute care hospitals that provide joint care services in Seoul and Gyeonggi province. Sixty caregivers who work at these hospitals are carried out a survey regarding a specific task of caregiver, an importance of task and a frequency of task. Collected data is analyzed using statistical package SPSS 18.0, and descriptive statistics (frequency, percentage, average, standard deviation) is reported. An analysis of frequency is used to analyze target for research. From the collected information, tasks of caregiver are sorted into 10 job categories and 60 duty categories. As a result of the study, tasks of caregiver are sorted into 10 job categories and 68 duty categories based on the observations technique. One job category and four duty categories are added to the final survey based on an interview with professionals and officials in the field of care service but, one additional job category and four duty categories based on the interview are excepted from the result of the analysis. The interview with professionals and officials is nothing meaningful on the task analysis of caregiver.

• Korean Journal of Optics and Photonics
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• v.19 no.3
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• pp.199-207
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• 2008

Wavelength converting devices with a ridge-type waveguide in periodically poled $MgO:LiNbO_3$ are made and characterized. The experimental results are compared with theoretical analysis on the effects of waveguide dimension and duty ratio of the periodically poled structure. To show the relationship of the conversion efficiency to those factors, a new measurement system is configured. That experimental results show that the center wavelength, normalized conversion efficiency and full width half maximum of the conversion efficiency curve are 1067.45 nm, 90.7%/$Wcm^2$ and 0.17 nm, respectively. Also, the estimated results of the duty period and full width half maximum of the conversion efficiency from theoretical calculations agreed well with experimental results with the errors of 0.016 ${\mu}m$ and 0.01 nm.

• Journal of the Korean Chemical Society
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• v.18 no.2
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• pp.85-96
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• 1974

Extended H ckel Theory and CNDO/2 MO calculation methods have been applied to $C_6H_5YCH_2Cl$(Y = None, -$CH_2$-, -O-, -S-, -CO-, -$SO_2$-). It has been shown that charge distributions in molecules are mainly controlled by the migration of valence inactive electron, giving the order of ${\sigma}$-acceptor and ${\pi}$-donor effects -O- > -S- > -$CH_2$- > -$SO_2$-. The -CO- group exceptionally acts as ${\sigma}$-donor and ${\pi}$-acceptor. It was also predicted that, $S_N2$ reactivities of C$C_6H_5YCH_2Cl$ would be in the order of -O-${\thickapprox}$-CO- >>-S-${\thickapprox}$None > -$CH_2$-, neglecting solvent effect. From the results of our studies, we conclude that the structural factors influencing 의 $S_N$ reactivities will be: (1) positive charge developments on reaction center carbon atom (2) energy level of ${\sigma}$-antibonding unoccupied MO with respect to C-Cl bond. (3) ${\sigma}$-antibonding strength of C-Cl bond at that level.

• Journal of the Society of Disaster Information
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• v.10 no.2
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• pp.288-293
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• 2014

The purpose of this study was to provide response plans against acts of suicide bomb using utilize unmanned aircrafts to prevent large losses of lives such as the terrorist attacks of September 11. As the result, First, this research suggests revising the definition and categorization of utilizing unmanned aircrafts and legislating the Anti-terrorism law. Second, it is needed to establish the proper social safety network through terrorism response management integrated system against the terror of related organization. Third, suicide bomb using utilizing unmanned aircrafts can be occurred because it is possible to make bomb and open web site for terrorism without connection with terrorist organization because of universal use of Internet. In response to this, it is needed to make a law which can block the use and open of illegal site and contents. Forth, the increasing number of foreigners and immigrants can make conflicts, and cause the foreigner's anti-korea feeling and the citizen's anti-cultural diffusion. Therefore, it is needed for the citizen to change and improve the awareness of them, and the change of social politics.

• The Korean Journal of Pesticide Science
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• v.4 no.3
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• pp.7-14
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• 2000

Methanol extracts from 21 grains were tested for fungicidal activities against six phytopathogenic fungi and for insecticidal activities toward five insect pests in a greenhouse. The efficacy varied with both the plant pathogen/insect pest and grain species used. Potent fungicidal activity at 5 mg/pot, were produced from extracts of Elymus sibiricus and Hordeum vulgare var. nudum against Pyricularia grisea and Erysiphe graminis and these of Sesamum indicum (W) and Triticum aestivum against Puccinia recondita and Erysiphe graminis. At 2,500 ppm, potent insecticidal activities were exhibited from the extracts of Fagopyrum esculentum against Myzus persicae and Ischaemum crassipes, and these of Oryzo sativa var. glutinosa, Panicum miliaceum, Setaria italica, Sorghum bicolor, and T. aestivum against Tetranychus urticae. All grain extracts revealed weak or no fungicidal and insecticidal effect against Phytophthora infestans, Plutella xylostella and Spodoptera litura. As a naturally occurring fungicide and insecticide, grain-derived materials described could be useful as new fungicidal and insecticidal products against phytopathogenic fungi and insect pests.