• Molecules and Cells
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• v.20 no.2
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• pp.271-279
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• 2005

Although macrophages are an important first line of cellular defense, they are unable to effectively kill phagocytosed C. albicans. To determine the physiological basis of this inability, we investigated the alterations of macrophage proteins caused by C. albicans infection. Since the formation of C. albicans hyphae caused cell death, proteins were prepared 3 h after infection and examined by two-dimensional gel electrophoresis (2-DE). The most prominent changes were in glycolytic enzymes, which could have caused energy depletion of the infected cells. Also changed were proteins involved in maintenance of cellular integrity and NO production. Treatment of the macrophages with either cytochalasin D or taxol did not alter their inability to kill C. albicans. Our results indicate that multiple factors contribute to cell death as the pathogenic form of C. albicans becomes fully active inside macrophage cells.

• ETRI Journal
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• v.45 no.3
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• pp.534-542
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• 2023

The large amount of secondary effects in complementary metal-oxide-semiconductor technology limits its application in the ultra-nanoscale region. Circuit designers explore a new technology for the ultra-nanoscale region, which is the quantum-dot cellular automata (QCA). Low-energy dissipation, high speed, and area efficiency are the key features of the QCA technology. This research proposes a novel, low-complexity, QCA-based one-bit digital comparator circuit for the ultra-nanoscale region. The performance of the proposed comparator circuit is presented in detail in this paper and compared with that of existing designs. The proposed QCA structure for the comparator circuit only consists of 19 QCA cells with two clock phases. QCA Designer-E and QCA Pro tools are applied to estimate the total energy dissipation. The proposed comparator saves 24.00% QCA cells, 25.00% cell area, 37.50% layout cost, and 78.11% energy dissipation compared with the best reported similar design.

• Steel and Composite Structures
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• v.49 no.4
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• pp.393-405
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• 2023

In this paper, the energy absorption capability of a novel cruciform composite lattice structure was evaluated through the simulation of compression tests. For this purpose, several test samples of Polylactic acid cellular reinforced with continuous glass fibers were prepared for compression testing using the additive manufacturing method of material extrusion. Using a conventional path design for material extrusion, multiple debonding is probable to be occurred at the joint regions of adjacent cells. Therefore, an innovative printing path design was proposed for the cruciform lattice structure. Afterwards, quasistatic compression tests were performed to evaluate the energy absorption behaviour of this structure. A finite element model based on local material property degradation was then developed to verify the experimental test and extend the virtual test method. Accordingly, different combinations of unit cells' dimensions using the design of the experiment were numerically proposed to obtain the optimal configuration in terms of the total absorbed energy. Having brilliant energy absorption properties, the studied cruciform lattice with its optimized unit cell dimensions can be used as an energy absorber in crashworthiness applications. Finally, a cellular structure will be suitable with optimal behavior in crush load efficiency and high energy absorption.

• Proceedings of the Korean Powder Metallurgy Institute Conference
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• 2006.09a
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• pp.99-100
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• 2006

Cellular metals based on Iron have been intensively investigated during the last two decades. Because of the significant decreasing of the structural density of Iron based cellular structures, numerous technologies have been developed for their manufacturing. Besides the tremendous weight reduction a combination with other properties like energy and noise absorption, heat insulation and mechanical damping can be achieved. This contribution will give an overview about the latest state in Iron based cellular materials, including technologies in manufacturing, properties and potential applications.

• Journal of Communications and Networks
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• v.17 no.5
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• pp.506-516
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• 2015

Wireless sensor networks (WSNs) are generally comprised of densely deployed sensor nodes, which results in highly redundant sensor data transmissions and energy waste. Since the sensor nodes depend on batteries for energy, previous studies have focused on designing energy-efficient medium access control (MAC) protocols to extend the network lifetime. However, the energy-efficient protocols induce an extra end-to-end delay, and therefore recent increase in focus on WSNs has led to timely and reliable communication protocols for mission-critical applications. In this paper, we propose an energy efficient and delay guaranteeing node scheduling scheme inspired by biological systems, which have gained considerable attention as a computing and problem solving technique.With the identification of analogies between cellular signaling systems and WSN systems, we formulate a new mathematical model that considers the networking challenges of WSNs. The proposed bio-inspired algorithm determines the state of the sensor node, as required by each application and as determined by the local environmental conditions and the states of the adjacent nodes. A control analysis shows that the proposed bio-inspired scheme guarantees the system stability by controlling the parameters of each node. Simulation results also indicate that the proposed scheme provides significant energy savings, as well as reliable delay guarantees by controlling the states of the sensor nodes.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.9
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• pp.4166-4182
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• 2018

We consider the Device-to-Device (D2D) communications in cellular networks where each cellular user (CU) shares the same resource with multiple D2D users (DUs). In this paper, we aim to maximize the energy efficiency (EE) of the D2D networks, subject to an interference constraint required by the CU. Since the cellular and D2D communications belong to different networks, we consider to incentivize base station (BS) while assisting the DUs. To this end, we propose a Stackelberg game based interference pricing framework for the considered D2D communications in cellular networks. Unlike most of the existing methods, we use interference pricing framework to jointly address the EE resource allocation problem and the interference management in our networks rather than only improve the EE of the DUs or protect cellular networks. In particular, BS and all the users do not need all channel state information, which is more realistic in practice. In addition, two different pricing strategies are also proposed. Based on the two strategies, we analyze the equilibrium of the game. Moreover, in the first strategy, the upper and lower boundaries of the interference price are obtained. The closed-form expression is gained with a backward induction for the second strategy. Both offer valuable insights to the considered scenarios. Finally, compared with the existing work, the EE of the D2D communications is significantly improved. The advantageous performance of our scheme are demonstrated by the simulation results.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.11
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• pp.5209-5228
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• 2016

Device-to-device (D2D) communication underlaying cellular networks can bring significate benefits for improving the performance of mobile services. However, it hinges on elaborate resource sharing scheme to coordinate interference between cellular users and D2D pairs. We formulate a joint mode selection, link allocation and power control optimization problem for D2D communication sharing uplink resources in a multi-user cellular network and consider the efficiency and the fairness simultaneously. Due to the non-convex difficulty, we propose a three-step scheme: firstly, we conduct mode selection for D2D pairs based on a minimum distance metric after an admission control and obtain some cellular candidates for them. And then, a cellular candidate will be paired to each D2D pair based on fairness. Finally, we use Lagrangian Algorithm to formulate a joint power control strategy for D2D pairs and their reused cellular users and a closed-form of solution is derived. Simulation results demonstrate that our proposed algorithms converge in a short time. Moreover, both the sum rate of D2D pairs and the energy efficiency of cellular users are improved.

• BMB Reports
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• v.56 no.12
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• pp.651-656
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• 2023

Senescence, a cellular process through which damaged or dysfunctional cells suppress the cell cycle, contributes to aging or age-related functional decline. Cell metabolism has been closely correlated with aging processes, and it has been widely recognized that metabolic changes underlie the cellular alterations that occur with aging. Here, we report that fatty acid oxidation (FAO) serves as a critical regulator of cellular senescence and uncover the underlying mechanism by which FAO inhibition induces senescence. Pharmacological or genetic ablation of FAO results in a p53-dependent induction of cellular senescence in human fibroblasts, whereas enhancing FAO suppresses replicative senescence. We found that FAO inhibition promotes cellular senescence through acetyl-CoA, independent of energy depletion. Mechanistically, increased formation of autophagosomes following FAO inhibition leads to a reduction in SIRT1 protein levels, thereby contributing to senescence induction. Finally, we found that inhibition of autophagy or enforced expression of SIRT1 can rescue the induction of senescence as a result of FAO inhibition. Collectively, our study reveals a distinctive role for the FAO-autophagy-SIRT1 axis in the regulation of cellular senescence.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.1
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• pp.114-130
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• 2021

With the drastic growth of Information and Communication Technology (ICT) industry, global energy consumption is exponentially increased by mobile communications. The huge energy consumption and increased environmental awareness have triggered great interests on the research of dynamic distribution of cell user and traffic, and then designing the energy efficient cellular network. In this paper, we explore the temporal and spatial characteristics of human mobility and traffic distribution using real data set. The analysis results of cell traffic illustrate the tidal effect in temporal and spatial dimensions and obvious periodic characteristics which can be used to design Base Station (BS) dynamic with sleeping or shut-down strategy. At the same time, we designed a new Cell Zooming and BS cooperation mode. Through simulation experiments, we found that running in this mode can save about 35% of energy consumption and guarantee the required quality of service.

• Journal of the Korean Institute of Telematics and Electronics B
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• v.33B no.3
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• pp.126-132
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• 1996

In this paper, the complexity reduction method for QCELP speech coder (IS-96) without any perfomrance degradation is proposed for the vecoder of CDMA digital cellular system. The energy terms in pitch parameter search and codebook search routines that require large computations are calculated recursively by utilizing the overlapped structure of code vectors in adaptive codebook and excitation codebook. The additional complexity reduction in the codebook search routine can be achieved by using a simple form in calculation of the energy term when the initial codebook value is zero. In the case of lower transmission rates such as 4,2,1 kbps, the complexity reduction by recursive calulations of energy term is increased.