• Molecules and Cells
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• v.40 no.9
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• pp.613-620
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• 2017

The most common form of senile dementia is Alzheimer's disease (AD), which is characterized by the extracellular deposition of amyloid ${\beta}-peptide$ ($A{\beta}$) plaques and the intracellular formation of neurofibrillary tangles (NFTs) in the cerebral cortex. Tau abnormalities are commonly observed in many neurodegenerative diseases including AD, Parkinson's disease, and Pick's disease. Interestingly, tau-mediated formation of NFTs in AD brains shows better correlation with cognitive impairment than $A{\beta}$ plaque accumulation; pathological tau alone is sufficient to elicit frontotemporal dementia, but it does not cause AD. A growing amount of evidence suggests that soluble $A{\beta}$ oligomers in concert with hyperphosphorylated tau (pTau) serve as the major pathogenic drivers of neurodegeneration in AD. Increased $A{\beta}$ oligomers trigger neuronal dysfunction and network alternations in learning and memory circuitry prior to clinical onset of AD, leading to cognitive decline. Furthermore, accumulated damage to mitochondria in the course of aging, which is the best-known nongenetic risk factor for AD, may collaborate with soluble $A{\beta}$ and pTau to induce synapse loss and cognitive impairment in AD. In this review, I summarize and discuss the current knowledge of the molecular and cellular biology of AD and also the mechanisms that underlie $A{\beta}-mediated$ neurodegeneration.

• Journal of Korean Society of Transportation
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• v.9 no.2
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• pp.135-144
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• 1991

In recent years parking problems have been rapidly highlighted. Particularly on-street parking has become a very serious problem so an immediate action needs to be taken to resolve this problem. On-steet parking is attributable not only to insufficient capacity of parking lots but also to the facts that must of the parking lots are far away from the destinations to which drivers intend to go and that their locations are unclear. The effect of on-street parking is so great as to cause road traffic problems such as traffic jam and danger to road safety as well as to lead to obstructing business activities resulting in a decline of commercial areas. Therefore on-street parking is an important problem for a city as a whole. In this paper I have investigated a parking lot information and guiding system as one of the techniques to resolve the on-street parking problem and have clarified the effect of introducing this system and necessary conditions for implementing an optimum information and guiding system. Moreover I have pointed out the problems to be encountered in imp-lementing such system in areas not equipped with infrastructures taking into account the road conditions in these areas and have stated that it would be necessary to develop a new idea of information and guiding system in order to overcome these problems. I have suggested a Shot Gun Method as a proposal and have discussed extensibility of this method in the future.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2006.11a
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• pp.133-137
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• 2006

Can examine cause that the construction industry is faced in crisis of skill exhaustion in two sides. One is the tribe of actuality production manpower by entry evasion and graying of young man class specially new manpower to the tribe of skill manpower. Another is qualitative decline of skill manpower. Generally, problem of the systematic knowledge tribe and the picking up tribe about new technology etc, exists because learn skill for shoulder beyond in spot. In cutting phenomenon of skill that is depended on personal relationships availability with skilled worker in hereafter, problem that worker who is old or enter through rain skilled worker does not learn all life skill is detected. These problems institute entry of young man class and necessity of systematic vocational education training specially new human strength strongly. This study does presentation of way to promote construction industry entry of young man class and improvement way of vocational education training system that can do to train these by function manpower by purpose.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.20 no.7
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• pp.636-644
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• 2007

36,000lbs porcelain insulators of D-1995, D-1997 and D-2002 investigated mechanical and electrical qualities, where is process of using in the Korea 154 kV transmission lines. It analyzes the cause of the elapse of a year aging of the transmission insulators. Weibull distribution function, product quality and uniform quality, etc. investigated for prediction to extant life of insulator. It calculate change as statistical elapse of a year through product qualities of used insulator and new insulator, uniform equality and uniformity of insulator. In case of D-1995 year used insulator, it decided to badness decline index k by 0.0237, badness quality index by 1.0 and 3.0. Result of extant confidence life Ym was calculated that remain each 4 yens and 0.7 yens that uniformity index is considered. Extant life of D-1997 and D-2002 insulators Predicted by about 40 years.

• Journal of the Korean Society of Safety
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• v.5 no.1
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• pp.57-66
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• 1990

The purpose of this study is to investigate electrostatic charge condition and possibility of electrostatic hazards in case of putting on synthetic smocks and antistatic garments for the purpose of prevention of electrostatic hazards due to a human body electrical charge. It is shown in case of a synthetic smocks, electrostatic voltage by friction is about 2,900 (V), half life period is 12 second, and electrostatic charge is 1.4―1.8 ($\mu$ C). When putting on a synthetic smocks, electrostatic voltage is 2,500―2,800(V). When putting on a jumper of chemical fiber, electrostatic voltage is 8,000(V) . It is, therfore, possible to cause a electrostatic hazards. It is also shown in case of a antistatic garments, electrostatic voltage by friction is 87(V) ―280(V) (washing 90 times), half life period is 3―5 second, and electrostatic charge is 0.24―0.28($\mu$ C) which is much lower than 0.6($\mu$ C) limitation of fire and explosion occurance. When putting on a antistatic garments, electrostatic voltage is 10(V) ―125(V). In conclusion, it is shown when putting on a antistatic garments it is possible to prevent a electrostatic hazards such as fire or explosion due to human body, to prevent a destruction of semiconductor elements and capacity decline, and to prevent a misoperation of automation facilities and semiconductor electric and electronic products.

• Health Policy and Management
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• v.6 no.1
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• pp.59-84
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• 1996

It is generally believed that the medical profession in Korea is an well-paid field along with legal profession. In this vein, the nursing is regarded one of well-paid profession. The actual data, however, reveals that nurses belong to low income bracket. We carefully compare the nurse's earnings with those of other professions. We selected 58 professions, which are similar in vocational characteristics and education background to nurses and conduct a regression analysis to estimate earning functions. Using the estimated coefficients, we project an optimum salary level for nurse, and compare it with the actual salary level. The estimated results show that the nurses are underpaid : their actual salary is less than the optimum level. We provide several explanations for this phenomenon : a tradition based on Confucian value, wage discrimination for women, and wage inequality among hospitals. Undercompensation will result either ratard professional development, or block the motivation for high quality of nursing care. If the current underpaying situation is not improved, a shortage of nurses along with an noticeable decline in the quality of medical services are expected. Therefore an adequate compensation for nurses must be properly assessed and addresed not only be health care authorities but also by legislators. Further research is needed to explain why there is such as wide salary inequality among nurses, and to find what cause it.

• Korean journal of food and cookery science
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• v.26 no.6
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• pp.699-706
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• 2010

Since atopic dermatitis requires continuous care, the role of a patient's parents is important. However, the majority of parents cause even more serious situations by limiting allergy-inducing foods too much, causing an imbalance in nutrition and decline in immunity. Therefore, educating parents systematically and repeatedly via personal computer or smart phone could help to prevent and manage atopic dermatitis. In this study, 126 recipes of 4 seasons were developed for the parents of atophy students by using food with least chemical additives. After developing these recipes, a blog named "Atop" meaning "atophy stop" was made with these recipes and cooking step photos. In this blog, the visitors who used these recipes showed improvement responses of atopic dermatitis management. The results of this study show that further nutrition education programs such as this blog should be developed continuously and an effective evaluation tool must be also developed for the further prevention and management of atopic dermatitis.

• Journal of Korean Medical classics
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• v.36 no.4
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• pp.55-67
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• 2023

Objectives : Contents on causes of male infertility, reproductive health improvement, sexual tips were studied in classical texts of Korean Medicine, followed by representative formulas for male infertility treatment. Methods : Related texts from the Qiusimen chapters of the Yixuerumen, Yixuexinwu, Donguibogam, Nukejinglun, Jiaozhufurenliangfang, Jiyingandmu were collected, and their medical meaning discussed. Results : As immoderate libido and excessive mental consumption leads to sexual dysfunction causing male infertility, 'moderating sexual desire and accumulating Jing' should be the principle for improving reproductive health. Also, sufficient foreplay is recommended. In terms of formula, the Wuziyanzongwan with sufficient therapeutic evidence in both classical texts and contemporary Korean Medicine can be applied in cases of male infertility. Conclusions : Excessive sensual stimulation and immoderate sexual desire consumes the mind and results in decline in male reproductive health. While moderating sexual desire and accumulating Jing through controlling desire, not overworking, moderating anger, drinking in moderation, balanced eating should be the principle for improving reproductive health, having sexual intercourse 2~3 times per week rather than long-term abstinence is recommended. To improve the success rate in pregnancy, sufficient foreplay and time should be done and taken for intercourse. Wuziyanzongwan should be taken for at least three months or longer.

• Journal of Ginseng Research
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• v.26 no.3
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• pp.151-158
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• 2002

Ginseng (Panax quinquefolius L.) has become one of the most valuable herb crops grown in North America. However, traditional cropping practices are favourable to disease and significant losses due to root disease are common, despite frequent use of fungicides. Seedlots are often contaminated with pathogens, however, little is known about the causes of seed decay and the role of seed pathogens as incitants of root rots. It was shown that both Fusarium spp. and Cylindrocarpon destructans were able to rot seeds and that C. destructans was more virulent than Fusarium spp. on seedling roots. A modified rose bengal agar MRBA) medium (1 g KH$_2$PO$_4$; 0.5 g MgSO$_4$; 50 mg rose bengal; 10 g dextrose; 5 g Bacto peptone; 15 g Bacto agar; 30 mg streptomycin sulfate; 250 mg ampicillin; 10 mg rifampicin; 500mg pentachloronitrobenzene; 500 mg dicloran; and 1 L distilled water) was superior to potato dextrose agar in detecting C. destuctans in diseased roots. Isolation of C. destructans from diseased seedlings arising from seeds sown in replant soil supported the hypothesis that this pathogen is a cause of ginseng replant failure in North America.

• Journal of Pharmacopuncture
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• v.22 no.4
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• pp.279-283
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• 2019

Hominis placenta pharmacopuncture, a treatment that injects Hominis placenta extract into acupoints, has been suggested in the literature and researches that it could be used for cognitive decline. We experienced a case of mild neurocognitive disorder treated with Hominis placenta pharmacopuncture. Hominis placenta pharmacopuncture could be a possible treatment modality producing substantial clinical result in cognitive function which is assessed with Mini-Mental State Examination-Dementia Screening (MMSE-DS), Korean Version of Montreal Cognitive Assessment (MoCA-K), and Korean-Dementia Rating Scale (K-DRS). A 84-year-old man with mild neurocognitive disorder received Hominis placenta pharmacopuncture on GV20, CV12, and bilateral ST36 for a month. The results of neuropsychological examination showed increase in scores after treatment of Hominis placenta pharmacopuncture. Before treatment, they were 15 points for MoCA-K, and 120 points for K-DRS (7.6%), but after treatment, they elevated by 21 points for MoCA-K and 137 points for K-DRS (100%). MMSE-DS score was 28 points, unchanged before and after treatment. It did not cause any side-effect. Hominis placenta pharmacopuncture could be a safe option for treating mild neurocognitive disorder.