• The Journal of Art Theory & Practice
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• no.13
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• pp.157-184
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• 2012

This essay examines Jacques Callot's Les Grandes Mis$\grave{e}$res et Malheurs de la Guerre (1633) as a moral meditation on war as catastrophe. It also uses Callot's Miseries to reflect on the nature of catastrophe as such, particularly as "An event producing a subversion of the order or system of things." As such, catastrophe refers less to nature or the natural gone awry, than it does to the abnegation or suspension of moral aspects of human nature. More than a reflection on war as catastrophe, and catastrophe as fundamentally moral, Callot's Miseries are a timeless meditation on aspects of the human condition; or on human beings in what amounts to state of nature-as evidenced in times of disaster. Such reflection, again, does not by itself imply that all war-even when catastrophic-is unnecessary, let alone necessarily unjust. But it does suggest that artistic engagement with war understood as catastrophic, may yield insights into human nature that are as important to human self-understanding as those represented in artistic subject matter that is more quotidian.

• Computers and Concrete
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• v.25 no.6
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• pp.517-523
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• 2020

An experimental system on three point bending notched beams was established to study the fracture process of concrete. In this system, the acoustic emission (AE) was used to build the cumulative generation order (AGO) and dynamically track the process of microcrack evolution in concrete. A grey-cusp catastrophe model was built based on AE parameters. The results show that the concrete beams have significant catastrophe characteristic. The developed grey-cusp catastrophe model, based on AGO, can well describe the catastrophe characteristic of concrete fracture process. This study also provides a theoretical and technical support for the application of AE in concrete fracture prediction.

• Journal of Life Science
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• v.20 no.4
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• pp.519-527
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• 2010

Paclitaxel is known as a potent inhibitor of microtubule depolymerization. It leads to mitotic arrest and cell death by stabilizing the spindle in various cell types. Here, we investigated the effects of paclitaxel on the proliferation and cell death of rabbit articular chondrocytes. Paclitaxel inhibited proliferation in a dose- and time- dependent manner, determined by MTT assay in rabbit articular chondrocytes. We also established paclitaxel-induced G2/M arrest by fluorescent activated cell sorter (FACS) analysis. Paclitaxel increased expression of cyclin B, p53 and p21, while reducing expression of cdc2 and cdc25C in chondrocytes, as detected by Western blot analysis. Interestingly, paclitaxel showed the mitotic catastrophe that leads to abnormal nucleus division and cell death without DNA fragmentation through activation of caspase. Cell death by mitotic catastrophe in cells treated with paclitaxel was suppressed by inhibiting G1/S arrest with 2 mM thymidine. These results demonstrate that paclitaxel induces cell death via mitotic catastrophe without activation of casepase in rabbit articular chondrocytes.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 1998.06a
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• pp.343-346
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• 1998

This paper deals with the decision in vague knowledge, One method is a classic theory. That is to say, constraints and goals in the vague knowledge. Another method is the fuzzy catastrophe. If there exist two fuzzy variables, there may be a discontinuity which plays an important role in decision.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.7 no.2
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• pp.308-326
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• 2013

Mobility Model has drawn more and more attentions since its critical role in Mobile Wireless Networks performance evaluation. This paper analyzes the mobility patterns in the catastrophe rescue scenario, and proposes the Random Waypoint with Base Point mobility model to model these characteristics. We mathematically analyze the speed and spatial stationary distributions of the nodes and derive explicit expressions for the one dimensional case. In order to keep the stationary distribution through the entire simulation procedure, we provide strategies to initialize the speed, location and destination of the nodes at the beginning of the simulation. The simulation results verify the derivations and the proposed methods in this paper. This work gives a deep understanding of the properties of the Random Waypoint with Base Point mobility model and such understanding is necessary to avoid misinterpretation of the simulation results. The conclusions are of practical value for performance analysis of mobile wireless networks, especially for the catastrophe rescue scenario.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.5
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• pp.2140-2149
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• 2013

Managing uncertainty or discontinuity in an innovation is still a challenge to most companies. For sustainable corporate survival over the long term, one of the problems caused by discontinuous innovation is the innovator's dilemma. In specific, the dynamics between discontinuous innovation and incumbents inspires the interestof researchers and managers. This paper employs catastrophe theory as a theoretical basis to explain the driving force of new discontinuous change. In other words, we extract the control variables overcoming innovation dilemma by interpreting the dynamics of corporate strategy for discontinuous innovation from the perspective of catastrophe theory. First, we define four types of discontinuity such as technology discontinuity, product discontinuity, business discontinuity, and consumer preference discontinuity. Second, we analyze the dynamics of the competition between companies by interpreting the cases of discontinuous innovation. This analyzing process enables us to identify the control variable which can, in advance, respond to the discontinuous situation.

• Proceedings of the KSAR Conference
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• 2002.06a
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• pp.15-15
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• 2002

Telomere erosion is the earliest chromatin modification in cells entering the apoptotic regime. The purpose of this investigation was to demonstrate that loss of telomeric DNA was involved in the induction of mitotic catastrophe and cell death of Chinese hamster Don cells that were grown continuously without subculturing for several days. Don, which is a diploid male Chinese hamster-derived cell line, was grown without sub-culturing for one to four days at 37℃ and then harvested for cytological preparations. (omitted)

• Atmosphere
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• v.15 no.1
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• pp.69-74
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• 2005

In this short article, oceanic processes that could have strong effect on the climate have been explained while focusing on the oceanic thermohaline circulation (THC). First, the structure of THC is explained using a simple scaling law. Then, the thermohaline catastrophe, which is believed to be a cause of a rapid climate changes observed in paleoclimate records, and interdecadal variations in THC are explained. The interactions between the oceans and $CO_2$ are also mentioned briefly.

• Geomechanics and Engineering
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• v.15 no.1
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• pp.621-630
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• 2018

In the note a comprehensive and optimal passive-active mode for describing the limit failure of circular shallow tunnel with settlement is put forward to predict the catastrophic stability during the geotechnical construction. Since the surrounding soil mass around tunnel roof is not homogeneous, with tools of variation calculus, several different curve functions which depict several failure shapes in different soil layers are obtained using virtual work formulae. By making reference to the simple-form of Power-law failure criteria based on numerous experiments, a numerical procedure with consideration of combination of upper bound theorem and stochastic medium theory is applied to the optimal analysis of shallow-buried tunnel failure. With help of functional catastrophe theory, this work presented a more accurate and optimal failure profile compared with previous work. Lastly the note discusses different effects of parameters in new yield rule and soil mechanical coefficients on failure mechanisms. The scope of failure block becomes smaller with increase of the parameter A and the range of failure soil mass tends to decrease with decrease of unit weight of the soil and tunnel radius, which verifies the geomechanics and practical case in engineering.

• Journal of Microbiology and Biotechnology
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• v.30 no.2
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• pp.279-286
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• 2020

A novel compound named 'kanakugiol' was recently isolated from Lindera erythrocarpa and showed free radical-scavenging and antifungal activities. However, the details of the anti-cancer effect of kanakugiol on breast cancer cells remain unclear. We investigated the effect of kanakugiol on the growth of MCF-7 human breast cancer cells. Kanakugiol affected cell cycle progression, and decreased cell viability in MCF-7 cells in a dose-dependent manner. It also enhanced PARP cleavage (50 kDa), whereas DNA laddering was not induced. FACS analysis with annexin V-FITC/PI staining showed necrosis induction in kanakugiol-treated cells. Caspase-9 cleavage was also induced. Expression of death receptors was not altered. However, Bcl-2 expression was suppressed, and mitochondrial membrane potential collapsed, indicating limited apoptosis induction by kanakugiol. Immunofluorescence analysis using α-tubulin staining revealed mitotic exit without cytokinesis (4N cells with two nuclei) due to kanakugiol treatment, suggesting that mitotic catastrophe may have been induced via microtubule destabilization. Furthermore, cell cycle analysis results also indicated mitotic catastrophe after cell cycle arrest in MCF-7 cells due to kanakugiol treatment. These findings suggest that kanakugiol inhibits cell proliferation and promotes cell death by inducing mitotic catastrophe after cell cycle arrest. Thus, kanakugiol shows potential for use as a drug in the treatment of human breast cancer.