• 미술이론과 현장
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• 제13호
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• pp.157-184
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• 2012

This essay examines Jacques Callot's Les Grandes Mis$\grave{e}$res et Malheurs de la Guerre (1633) as a moral meditation on war as catastrophe. It also uses Callot's Miseries to reflect on the nature of catastrophe as such, particularly as "An event producing a subversion of the order or system of things." As such, catastrophe refers less to nature or the natural gone awry, than it does to the abnegation or suspension of moral aspects of human nature. More than a reflection on war as catastrophe, and catastrophe as fundamentally moral, Callot's Miseries are a timeless meditation on aspects of the human condition; or on human beings in what amounts to state of nature-as evidenced in times of disaster. Such reflection, again, does not by itself imply that all war-even when catastrophic-is unnecessary, let alone necessarily unjust. But it does suggest that artistic engagement with war understood as catastrophic, may yield insights into human nature that are as important to human self-understanding as those represented in artistic subject matter that is more quotidian.

• Computers and Concrete
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• 제25권6호
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• pp.517-523
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• 2020

An experimental system on three point bending notched beams was established to study the fracture process of concrete. In this system, the acoustic emission (AE) was used to build the cumulative generation order (AGO) and dynamically track the process of microcrack evolution in concrete. A grey-cusp catastrophe model was built based on AE parameters. The results show that the concrete beams have significant catastrophe characteristic. The developed grey-cusp catastrophe model, based on AGO, can well describe the catastrophe characteristic of concrete fracture process. This study also provides a theoretical and technical support for the application of AE in concrete fracture prediction.

• 생명과학회지
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• 제20권4호
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• pp.519-527
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• 2010

Paclitaxel은 미세소관의 탈중합을 억제하는 시약으로 알려져 있다. Paclitaxel은 다양한 세포에서 세포 내 방추체를 안정화시킴으로써 유사분열 억제 및 세포사멸을 유도한다. 본 실험에서는 토끼 관절 연골세포에서 paclitaxel이 연골세포의 증식과 사멸에 미치는 효과에 대한 연구를 수행하였다. MTT assay를 수행한 결과 paclitaxel은 연골세포에서 농도 의존적으로 세포 증식을 억제한다는 것을 확인 할 수 있었으며, FACS analysis와 Western blot analysis를 수행한 결과, paclitaxel이 G2/M 정지를 유도하는 것을 확인하였다. 또한, paclitaxel이 비정상적인 세포 분열유도와 핵 단편분절 유도없이 일어나는 mitotic catastrophe 즉, caspase-3 비의존적인 세포사멸을 유도하였다. Paclitaxel을 처리한 세포에서 일어나는 이러한 mitotic catastrophe에 의한 세포 죽음은 G1/S기의 진행을 억제하는 시약인 thymidine을 처리하는 것에 의해 억제되는 것을 확인할 수 있었다. 이러한 결과를 종합해 볼 때, paclitaxel에 의한 토끼 관절 연골 세포에서의 세포 죽음은 caspase-3 비의존적인 mitotic catastrophe에 의해 일어나는 것으로 사료되어진다.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 1998년도 The Third Asian Fuzzy Systems Symposium
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• pp.343-346
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• 1998

This paper deals with the decision in vague knowledge, One method is a classic theory. That is to say, constraints and goals in the vague knowledge. Another method is the fuzzy catastrophe. If there exist two fuzzy variables, there may be a discontinuity which plays an important role in decision.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제7권2호
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• pp.308-326
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• 2013

Mobility Model has drawn more and more attentions since its critical role in Mobile Wireless Networks performance evaluation. This paper analyzes the mobility patterns in the catastrophe rescue scenario, and proposes the Random Waypoint with Base Point mobility model to model these characteristics. We mathematically analyze the speed and spatial stationary distributions of the nodes and derive explicit expressions for the one dimensional case. In order to keep the stationary distribution through the entire simulation procedure, we provide strategies to initialize the speed, location and destination of the nodes at the beginning of the simulation. The simulation results verify the derivations and the proposed methods in this paper. This work gives a deep understanding of the properties of the Random Waypoint with Base Point mobility model and such understanding is necessary to avoid misinterpretation of the simulation results. The conclusions are of practical value for performance analysis of mobile wireless networks, especially for the catastrophe rescue scenario.

• 한국산학기술학회논문지
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• 제14권5호
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• pp.2140-2149
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• 2013

혁신에서 불확실성이나 불연속을 경영한다는 것은 대부분의 기업에게 어려운 과제이다. 기업의 지속 가능한 장기적인 생존을 위해 불연속 혁신이 내포하고 있는 문제 중 하나는 혁신가의 딜레마이다. 특히 불연속 혁신과 기존 사업자간의 동태적인 상황은 연구자들과 기업 경영자들에게 큰 관심사항이다. 본 논문은 불연속 혁신이라는 현상을 설명하는 이론적 배경으로 격변이론을 도입한다. 즉, 불연속 혁신에 대한 기업전략의 동태적인 현상을 격변이론의 틀에서 해석함으로써 혁신딜레마를 극복하는 제어인자를 도출한다. 이를 위해 본 논문은 불연속 혁신의 네 가지 유형으로 기술 불연속, 제품 불연속, 사업 불연속, 그리고 소비자 선호도 불연속을 정의하고, 각각의 유형별로 불연속 혁신 실사례를 격변이론의 관점에서 해석함으로써 불연속 혁신을 중심으로 한 기업간 경쟁의 동태적인 상황을 분석하였다. 이러한 분석 과정은 기업 간 경쟁 속에서 예측이 떨어지는 불연속적인 상황에 미리 대처할 수 있는 제어인자를 발굴할 수 있도록 해준다.

• 한국동물번식학회:학술대회논문집
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• 한국동물번식학회 2002년도 춘계학술발표대회 발표논문초록집
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• pp.15-15
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• 2002

Telomere erosion is the earliest chromatin modification in cells entering the apoptotic regime. The purpose of this investigation was to demonstrate that loss of telomeric DNA was involved in the induction of mitotic catastrophe and cell death of Chinese hamster Don cells that were grown continuously without subculturing for several days. Don, which is a diploid male Chinese hamster-derived cell line, was grown without sub-culturing for one to four days at 37℃ and then harvested for cytological preparations. (omitted)

• 대기
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• 제15권1호
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• pp.69-74
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• 2005

In this short article, oceanic processes that could have strong effect on the climate have been explained while focusing on the oceanic thermohaline circulation (THC). First, the structure of THC is explained using a simple scaling law. Then, the thermohaline catastrophe, which is believed to be a cause of a rapid climate changes observed in paleoclimate records, and interdecadal variations in THC are explained. The interactions between the oceans and $CO_2$ are also mentioned briefly.

• Geomechanics and Engineering
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• 제15권1호
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• pp.621-630
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• 2018

In the note a comprehensive and optimal passive-active mode for describing the limit failure of circular shallow tunnel with settlement is put forward to predict the catastrophic stability during the geotechnical construction. Since the surrounding soil mass around tunnel roof is not homogeneous, with tools of variation calculus, several different curve functions which depict several failure shapes in different soil layers are obtained using virtual work formulae. By making reference to the simple-form of Power-law failure criteria based on numerous experiments, a numerical procedure with consideration of combination of upper bound theorem and stochastic medium theory is applied to the optimal analysis of shallow-buried tunnel failure. With help of functional catastrophe theory, this work presented a more accurate and optimal failure profile compared with previous work. Lastly the note discusses different effects of parameters in new yield rule and soil mechanical coefficients on failure mechanisms. The scope of failure block becomes smaller with increase of the parameter A and the range of failure soil mass tends to decrease with decrease of unit weight of the soil and tunnel radius, which verifies the geomechanics and practical case in engineering.

• Journal of Microbiology and Biotechnology
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• 제30권2호
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• pp.279-286
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• 2020

A novel compound named 'kanakugiol' was recently isolated from Lindera erythrocarpa and showed free radical-scavenging and antifungal activities. However, the details of the anti-cancer effect of kanakugiol on breast cancer cells remain unclear. We investigated the effect of kanakugiol on the growth of MCF-7 human breast cancer cells. Kanakugiol affected cell cycle progression, and decreased cell viability in MCF-7 cells in a dose-dependent manner. It also enhanced PARP cleavage (50 kDa), whereas DNA laddering was not induced. FACS analysis with annexin V-FITC/PI staining showed necrosis induction in kanakugiol-treated cells. Caspase-9 cleavage was also induced. Expression of death receptors was not altered. However, Bcl-2 expression was suppressed, and mitochondrial membrane potential collapsed, indicating limited apoptosis induction by kanakugiol. Immunofluorescence analysis using α-tubulin staining revealed mitotic exit without cytokinesis (4N cells with two nuclei) due to kanakugiol treatment, suggesting that mitotic catastrophe may have been induced via microtubule destabilization. Furthermore, cell cycle analysis results also indicated mitotic catastrophe after cell cycle arrest in MCF-7 cells due to kanakugiol treatment. These findings suggest that kanakugiol inhibits cell proliferation and promotes cell death by inducing mitotic catastrophe after cell cycle arrest. Thus, kanakugiol shows potential for use as a drug in the treatment of human breast cancer.