• The Korean Journal of Physiology and Pharmacology
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• v.23 no.3
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• pp.191-201
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• 2019

The transient receptor potential canonical (TRPC) 5 channel, known as a nonselective cation channel, has a crucial role in calcium influx. TRPC5 has been reported to be activated by muscarinic receptor activation and extracellular pH change and inhibited by the protein kinase C pathway. Recent studies have also suggested that TRPC5 is extracellularly activated by englerin A (EA), but the mechanism remains unclear. The purpose of this study is to identify the EA-interaction sites in TRPC5 and thereby clarify the mechanism of TRPC5 activation. TRPC5 channels are over-expressed in human embryonic kidney (HEK293) cells. TRPC5 mutants were generated by site-directed mutagenesis. The whole-cell patch-clamp configuration was used to record TRPC5 currents. Western analysis was also performed to observe the expression of TRPC5 mutants. To identify the EA-interaction site in TRPC5, we first generated pore mutants. When screening the mutants with EA, we observed the EA-induced current increases of TRPC5 abolished in K554N, H594N, and E598Q mutants. The current increases of other mutants were reduced in different levels. We also examined the functional intactness of the mutants that had no effect by EA with TRPC5 agonists, such as carbachol or $GTP{\gamma}S$. Our results suggest that the three residues, Lys-554, His-594, and Glu-598, in TRPC5 might be responsible for direct interaction with EA, inducing the channel activation. We also suggest that although other pore residues are not critical, they could partly contribute to the EA-induced channel activation.

• Journal of the Daesoon Academy of Sciences
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• v.35
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• pp.509-539
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• 2020

Daesoon Jinrihoe makes use of The Canonical Scripture as the main body to explain their thinking regarding divine beings and humankind as it relates to doctrine, sacredness, religiousness and other such contents. The traditional meaning of divine beings and humankind through the interpretation of The Canonical Scripture, transcends ethics, tradition, sociality, and the ultimate concern of secularity. The analysis from the perspective of The Canonical Scripture can help readers to understand the purpose of Daesoon Jinrihoe's implementation of its policies and their future direction. The local church takes the Bible as its main body and connects God with man as an implantation of divine life and temperament that harmonizes itself with human life and nature. The divine life is constantly reconciled with one's human life to make one a holy person, or a humanistic diviner. This is the rationale of the 'God-Man,' those whose human lives become lives of God-men. This style of living enables divine nature to mingle with human nature as an explicit behavioral act, mode of character development, and lifestyle. Therefore, the expression "the Blending of God and man" is an interpretation of the relationship between God and man which focuses on their sacred connection. Engagement in this extends to the scope of the local church. The different divisions between Daesoon Jinrihoe and the local church appear on the basis of things such as history, culture, language, and religion, but both posit a theology of "Harmonious Union between Divine Beings and Human Beings" and "the Blending of God and man" according to a transcendent interpretation of God and man. Through dialogue, they can discover similarities and differences in this shared notion with both systems of theological thought.

• Safety and Health at Work
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• v.13 no.4
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• pp.394-400
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• 2022

Background: Impacts of exposure are generally monitored and recorded after injuries or illness occur. Yet, absence of conventional after-the-effect impacts (i.e., lagging indicators), tend to focus on physical health and injuries, and fail to inform if workers are not exposed to safety and health hazards. In contrast to lagging indicators, leading indicators are proactive, preventive, and predictive indexes that offer insights how effective safety and health. The present study is to validate an extended Voluntary Protection Programs (VPP) that consists of six leading indicators. Methods: Questionnaires were distributed to 13 organizations (response rate = 93.1%, 1,439 responses) in Taiwan. Cronbach α, multiple linear regression and canonical correlation were used to test the reliability of the extended Voluntary Protection Programs (VPP) which consists of six leading indicators (safe climate, transformational leadership, organizational justice, organizational support, hazard prevention and control, and training). Criteria-related validation strategy was applied to examine relationships of six leading indicators with six criteria (perceived health, burnout, depression, job satisfaction, job performance, and life satisfaction). Results: The results showed that the Cronbach's α of six leading indicators ranged from 0.87 to 0.92. The canonical correlation analysis indicated a positive correlation between the six leading indicators and criteria (1st canonical function: correlation = 0.647, square correlation = 0.419, p < 0.001). Conclusions: The present study validates the extended VPP framework that focuses on promoting safety and physical and mental health. Results further provides applications of the extended VPP framework to promote workers' safety and health.

• Journal of Korean Society of Forest Science
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• v.77 no.4
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• pp.429-444
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• 1988

Considering the recent trent toward the development of multiple-use of forest trees, investigations for comprehensive information on these young stands of Hinoki cypress are necessary for rational forest management. From this point of view, 83 sample trees were selected and cut down from 23-ear old stands of Hinoki cypress at Changsung-gun, Chonnam-do. Various stem growth factors of felled trees were measured and canonical correlaton analysis, principal component analysis and factor analysis were applied to investigate the stem growth characteristics, relationships among stem growth factors, and to get potential information and comprehensive information. The results are as follows ; Canonical correlation coefficient between stem volume and quality growth factor was 0.9877. Coefficient of canonical variates showed that DBH among diameter growth factors and height among height growth factors had important effects on stem volume. From the analysis of relationship between stem-volume and canonical variates, which were linearly combined DBH with height as one set, DBH had greater influence on volume growth than height. The 1st-2nd principal components here adopted to fit the effective value of 85% from the pincipal component analysis for 12 stem growth factors. The result showed that the 1st-2nd principal component had cumulative contribution rate of 88.10%. The 1st and the 2nd principal components were interpreted as "size factor" and "shape factor", respectively. From summed proportion of the efficient principal component fur each variate, information of variates except crown diameter, clear length and form height explained more than 87%. Two common factors were set by the eigen value obtained from SMC (squared multiple correlation) of diagonal elements of canonical matrix. There were 2 latent factors, $f_1$ and $f_2$. The former way interpreted as nature of diameter growth system. In inherent phenomenon of 12 growth factor, communalities except clear length and crown diameter had great explanatory poorer of 78.62-98.30%. Eighty three sample trees could he classified into 5 stem types as follows ; medium type within a radius of ${\pm}1$ standard deviation of factor scores, uniformity type in diameter and height growth in the 1st quadrant, slim type in the 2nd quadrant, dwarfish type in the 3rd quadrant, and fall-holed type in the 4 th quadrant.

• The Journal of Korean Medicine
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• v.24 no.1
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• pp.122-132
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• 2003

Objectives: To effectively improve the treatment of obesity through oriental medicine and to prepare basic material for proper classification of different types of obesity. Methods: After deciding on four types of obesity based on 'DongYiBaoJian', a questionnaire consisting of 38 items was constructed to decide to which type an individual belonged. 212 women were asked to the complete the questionnaire. To verify that the cluster of four types of obesity was acceptable, a cluster analysis and a factor analysis were conducted as well as an evaluation on the distinction of each type. Also, a canonical discriminant analysis was done to categorize the individuals into one of four types of obesity. Results: 1. Developed a reliable questionnaire consisting of 38 items for the purpose of classifying four types of obesity. 2. Obesity types were divided into four groups. Type I was designated as GanChengPi (肝乘脾類型), Type II as PiWeiJuWang(脾胃俱旺類型), Type III as PiWeiJuXu (脾胃俱虛類型), and Type IV as Tan TanYin(痰飮類型). These types were verified and classified through the use of a cluster analysis as well as a factor analysis (p<0.05). 3. By the use of a questionnaire, four types of obesity were correctly classified with a hit ratio of 87.3%, 40.64% higher than the maximum chance criteria (Cmax) in unselected grouped. The hit ratios for obesity types I, II, III and IV were 93.3%, 93.3%, 78.6% and 50%(p<0.05). Conclusion: Further clinical research is necessary into the four types of obesity explored. By analyzing various test results, characteristics these types should be further explored.

• Journal of the Korean Data and Information Science Society
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• v.21 no.6
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• pp.1071-1079
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• 2010

The decathlon is an athletic event consisting of ten track and field events. Events are held over two consecutive days and the winners are determined by the combined performance in all. We considered the best 200 decathletes who competed in the recent Olympics games and World Championship decathlon. We have used correspondence analysis to identify the relationship between ordered individual performance and the overall performance. Canonical correlation analysis of first day events versus second day events could shed light on the change of the level of performance between the two days. Correlation analysis was used to verify relation between cumulative event rank and final decathlon rank. Therefore, we conclude that the decathlon favors those atheletes who do well at the track events to become the best players. The best players in the decathlon performed relatively poorly in the 1,500 metres, but did well in the long jump, the 400 metres and the 110-metre hurdles. Decathletes in this study have a positive correlation between overall performance and maximal excellence in a particular discipline. Thus, to compete successfully at this level, a uniform, relatively high performance in all individual disciplines is required.

• Journal of Korean Academy of Nursing
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• v.16 no.2
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• pp.63-69
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• 1986

The main purpose of this study was to find out variables relevant to self-care activities of physically disabled person. The subjects of this analysis were 1277 person which is between 15~64 years, the data came from the 1985 National Interview Survey on Disabled Person in Korea. For this analysis, Breakdown, Oneway and Discriminant Analysis were used. The finding of the analysis can be summarized as follows: First, the mean of self care activities was 2.57 (SD: 0.69, range: 1-3). The relevance for the self-care activities by several variables is as follows. 1. The relevance for the self-care activities by socioeconomic status is significant at age, education level, occupation of household members variables. Especially, in the case of high age, low education level, the self-care activities are shown low score. 2. The relevance by impairment characteristics is shown high significance at all input variables. When disabled person have double impairment. paralysis, late occurance age, and is due to diseases the self-care activities score is lowered. 3. The relevance by health care services variables. is not shown significant at all input variables. Second, the relevance for social activities by sev-eral variables was conducted by discriminant analysis. The relative importance of social activities discriminant function is 0.344 of eigenvalue. The-canonical correlation between the social activities discriminant function and 9 dummy variables is 0.51, total variance of dummy variables for social activities is shown 26 persent. The self-care activities variable represents the highest contribution of its associated variable to the function (canonical coefficient: -.56). The occurance age, the occupation of household members, the education level variables are shown comparatively high contribution to the function. To sum up, this analysis suggests that the self-care activities variable is the highest contributed to the social activities. In relation to self-care concept, this finding will be useful in rehabilitation nursing care.

• Proceedings of the KIEE Conference
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• 2001.11c
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• pp.76-79
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• 2001

This paper is concerned with a stability analysis of Madam Type fuzzy systems. It Introduces the canonical form of an unforced fuzzy system and its stability theorem suggested in the previous study. Then it gives new simplified stability conditions based on the Lyapunov function method. A common positive definite matrix in the stability conditions is searched by the LMI method.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.5D
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• pp.885-894
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• 2006

The purpose of this study is focused on the development of the effective classification technique using ultra multiband of hyperspectral image. This study suggests the classification technique using canonical correlation analysis, one of multivariate statistical analysis in hyperspectral image classification. High accuracy of classification result is expected for this classification technique as the number of bands increase. This technique is compared with Maximum Likelihood Classification(MLC). The hyperspectral image is the EO1-hyperion image acquired on September 2, 2001, and the number of bands for the experiment were chosen at 30, considering the band scope except the thermal band of Landsat TM. We chose the comparing base map as Ground Truth Data. We evaluate the accuracy by comparing this base map with the classification result image and performing overlay analysis visually. The result showed us that in MLC's case, it can't classify except water, and in case of water, it only classifies big lakes. But Canonical Correlation Classification (CCC) classifies the golf lawn exactly, and it classifies the highway line in the urban area well. In case of water, the ponds that are in golf ground area, the ponds in university, and pools are also classified well. As a result, although the training areas are selected without any trial and error, it was possible to get the exact classification result. Also, the ability to distinguish golf lawn from other vegetations in classification classes, and the ability to classify water was better than MLC technique. Conclusively, this CCC technique for hyperspectral image will be very useful for estimating harvest and detecting surface water. In advance, it will do an important role in the construction of GIS database using the spectral high resolution image, hyperspectral data.

• Korean Journal of Ecology and Environment
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• v.45 no.4
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• pp.490-498
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• 2012

This study demonstrates the investigation of zooplankton communities (e.g. rotifers, cladocerans and copepods) and environmentally related driving factors (e.g. elevation, area size, water depth, types of dike construction, and bottom substrates). We hypothesized that zooplankton community structure and composition would be influenced by ambient driving forces in different scales of the irrigation ponds (Dumbeong). A total of 66 zooplankton species/groups (56 rotifers, 9 cladocerans, 1 copepods) were found and identified at 45 Dumbeong of Goseong region (i.e. Goseong-gun) in 2011. The rotifers occupied 84.9% of the total zooplankton abundance. We could categorize a clear separation of zooplankton communities into 4 different patterns based on cluster analysis. Zooplankton diversities in Dumbeongs were lower than those in natural ponds or wetlands. In addition, community structure of zooplankton was also simpler and had a broken stick distribution based on SHE analysis. Species composition in each Dumbeong was not significantly discriminated each other. The result of canonical correspondence analysis (CCA) pinpointed that significant influential variables upon zooplankton community were dissolved oxygen percent saturation, pH, and Dumbeong's material. This study indicated that morphological type of the Dumbeong and its water quality could determine the community structure of zooplankton. Furthermore, the connectivity between ambient habitats and materials could be necessary to be rigorously considered in respect to producing the Dumbeongs to subsidize alternative habitats for wetland ecosystem in freshwater landscape.