• Tuberculosis and Respiratory Diseases
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• v.42 no.4
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• pp.555-568
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• 1995

Background: It is most physiologic to measure the diffusing capacity of the lung by using oxygen, but it is so difficult to measure partial pressure of oxygen in the capillary blood of the lung that in clinical practice it is measured by using carbon monoxide, and single-breath diffusing capacity method is used most widely. However, since the process of withholding the breath for 10 seconds after inspiration to the total lung capacity is very hard to practice for patients who suffer from cough, dyspnea, etc, the intra-breath lung diffusing capacity method which requires a single exhalation of low-flow rate without such process was devised. In this study, we want to know whether or not there is any significant difference in the diffusing capacity of the lung measured by the single-breath and intra-breath methods, and if any, which factors have any influence. Methods: We chose randomly 73 persons without regarding specific disease, and after conducting 3 times the flow-volume curve test, we selected forced vital capacity(FVC), percent of predicted forced vital capacity, forced expiratory volume within 1 second($FEV_1$), percent of forced expiratory volume within 1 second, the ratio of forced expiratory volume within 1 second against forced vital capacity($FEV_1$/FVC) in test which the sum of FVC and $FEV_1$ is biggest. We measured the diffusing capacity of the lung 3 times in each of the single-breath and intra-breath methods at intervals of 5 minutes, and we evaluated which factors have any influence on the difference of the diffusing capacity of the lung between two methods[the mean values(ml/min/mmHg) of difference between two diffusing capacity measured by two methods] by means of the linear regression method, and obtained the following results: Results: 1) Intra-test reproducibility in the single-breath and intra-breath methods was excellent. 2) There was in general a good correlation between the diffusing capacity of the lung measured by a single-breath method and that measured by the intra-breath method, but there was a significant difference between values measured by both methods($1.01{\pm}0.35ml/min/mmHg$, p<0.01) 3) The difference between the diffusing capacity of the lung measured by both methods was not correlated to FVC, but was correlated to $FEV_1$, percent of $FEV_1$, $FEV_1$/FVC and the gradient of methane concentration which is an indicator of distribution of ventilation, and it was found as a result of the multiple regression test, that the effect of $FEV_1$/FVC was most strong(r=-0.4725, p<0.01) 4) In a graphic view of the difference of diffusing capacity measured by single-breath and intra-breath method and $FEV_1$/FVC, it was found that the former was divided into two groups in section where $FEV_1$/FVC is 50~60%, and that there was no significant difference between two methods in the section where $FEV_1$/FVC is equal or more than 60% ($0.05{\pm}0.24ml/min/mmHg$, p>0.1), but there was significant difference in the section, less than 60%($-4.5{\pm}0.34ml/min/mmHg$, p<0.01). 5. The diffusing capacity of the lung measured by the single-breath and intra-breath method was the same in value($24.3{\pm}0.68ml/min/mmHg$) within the normal range(2%/L) of the methane gas gradient, and there was no difference depending on the measuring method, but if the methane concentration gradients exceed 2%/L, the diffusing capacity of the lung measured by single-breath method became $15.0{\pm}0.44ml/min/mmHg$, and that measured by intra-breath method, $11.9{\pm}0.51ml/min/mmHg$, and there was a significant difference between them(p<0.01). Conclusion: Therefore, in case where $FEV_1$/FVC was less than 60%, the diffusing capacity of the lung measured by intra-breath method represented significantly lower value than that by single-breath method, and it was presumed to be caused largely by a defect of ventilation-distribution, but the possibility could not be excluded that the diffusing capacity of the lung might be overestimated in the single-breath method, or the actual reduction of the diffusing capacity of the lung appeared more sensitively in the intra-breath method.

• Journal of Environmental Science International
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• v.7 no.3
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• pp.301-310
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• 1998

Recently, bathes have been suspected to an Important source of indoor exposure to volatile organic compounds(VOCs). Two experiments were conducted to evaluate chloroform exposure and corresponding body burden by exposure routes while bathing. Another experiment was conducted to ekamine the chloro- form dose during dermal exposure and the chloroform decay In breath after dermal exposure. The chioroform dose was determined based on exhaled breath analysis. The ekamine breath concentration measured after normal baths (2.8 Vg/$m^3$) was approxidmately 13 tomes higher that measured prior to normal bathes (0.2 ug/$m^3$). Based on the means of the normalized post exposure chloroform breath concentration. the dermal exposure was estimated to contribute to 74% of total chloroform body burden while bathing. The Internal dose from bathing (Inhalation plus dermal) was comparable to the dose ostimated Srom dally water Ingestion. The rusk associated 10 a weekly, 30-min bath was estimated to be 1 x 10.5, while the rusk firom dally Ingestion of tap water was to be $0.5{\times}0^{-5} for 0.151 and 6.5{\times}10^{-5}$ for 2. 0 1. Chloroform breath concentration Increased gradually during the 60 minute dermal exposure. The breath decay after the dermal exposure showed two-phase mechanism, with early raped decay and the second slow decay. The mathematical model was developed to describe the relationship between water and air chloroform concentrations, with $R^2$ : 0.4 and p<0.02.

• Journal of the Korean Society of Physical Medicine
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• v.10 no.1
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• pp.107-113
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• 2015

PURPOSE: This study was to investigate the effect of stabilization exercise with abdominal breath on Balance and Oswestry Disability Index for Low Back Pain Patients. METHODS: The subjects were 18 low back pain patients in their twenties. The subjects were randomly assigned into experimental group and control group. Control group and experimental group both participated in 30 minutes of stabilization exercise for 8 weeks(5 times/week), and experimental group participated in stabilization exercise with abdominal breath. The subjects were tested balance and pain using BioRescue and Oswestry Diability Index respectively, before and after intervention. RESULTS: The experimental group showed a statistical significance in movement areas of the body's center(p<.05), but there was no significant differences between groups (p>.05). The experimental group showed a statistical significance in movement distances of the body's center with eyes open(p<.05), and there was significant differences between groups(p<.05). Both groups showed a statistical significance in ODI between pre and post test(p<.05) but there was no significant differences between groups(p>.05). CONCLUSION: As a result, the group participating in stabilization exercise with abdominal breath had a more effective improvement than the control group. Therefore, the stabilization exercise with abdominal breath may be used improving balance and pain in low back pain patients.

• Ceramist
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• v.22 no.1
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• pp.70-81
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• 2019

Breath analysis is rapidly evolving as a non-invasive disease recognition and diagnosis method. Metal oxide gas sensors are one of the most ideal platforms for realizing portable, hand-held breath analysis devices in the near future. This paper reviewed the recent developments in metal oxide gas sensors detecting exhaled biomarker gases such as nitric oxides, acetone, ammonia, hydrogen sulfide, and hydrocarbons. Emphasis was placed on strategies to tailor sensing materials/films capable of highly selective and sensitive detection of biomarker gases with negligible cross-response to ethanol, the major interfering breath gas. Specific examples were given to highlight the validity of the strategies, which include optimization of sensing temperature, doping additives, utilizing acid-base interaction, loading catalysts, and controlling gas reforming reaction. In addition, we briefly discussed the design and optimization method of gas sensor arrays for implementing the simultaneous assessment of multiple diseases. Breath analysis using high-performance metal oxide gas sensors/arrays will open new roads for point-of-care diagnosis of diseases such as asthma, diabetes, kidney dysfunction, halitosis, and lung cancer.

• Proceedings of the Korean Society of Food Science and Nutrition Conference
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• 2001.12a
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• pp.140-151
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• 2001

This study was performed to examine a possible application of the beverage as a bad breath controlling food. To achieve this objective, methods of gas chromatography, electronic nose, sensory analysis and halimeter were used to detect reduction in odor intensities of bad breath caused by the functional beverage as well as its active ingredients. According to results of GC and electronic nose, adding green tea and champignon extracts to bad breath indicators, methylmercaptan and trimethylamine, resulted in significant reduction in headspace concentrations of two indicators. GC results revealed that headspace concentrations of 5 ug/ml of methylmercaptan and 30 ug/ml of trimethylamine added to various concentrations of two extracts were reduced up to $100\%$ after incubating mixtures at $37^{\circ}C$ for 5min. When the functional beverage was properly formulated with green tea extract, champignon extract and $\alpha$-cyclodextrin and evaluated for its deodorizing effect systematically, it also showed distinctive deodorizing activities against bad breath indicators. Conclusively, results obtained from this study might encourage introduction of a new type of bad breath control food in near future.

• ETRI Journal
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• v.40 no.6
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• pp.802-812
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• 2018

Disease discrimination using an electronic nose is achieved by measuring the presence of a specific gas contained in the exhaled breath of patients. Many studies have reported the presence of acetone in the breath of diabetic patients. These studies suggest that acetone can be used as a biomarker of diabetes, enabling diagnoses to be made by measuring acetone levels in exhaled breath. In this study, we perform a chemical sensor array optimization to improve the performance of an electronic nose system using Wilks' lambda, sensor selection based on a principal component (B4), and a stepwise elimination (SE) technique to detect the presence of acetone gas in human breath. By applying five different temperatures to four sensors fabricated from different synthetic materials, a total of 20 sensing combinations are created, and three sensing combinations are selected for the sensor array using optimization techniques. The measurements and analyses of the exhaled breath using the electronic nose system together with the optimized sensor array show that diabetic patients and control groups can be easily differentiated. The results are confirmed using principal component analysis (PCA).

• Phonetics and Speech Sciences
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• v.11 no.4
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• pp.109-116
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• 2019

This study was conducted to identify the characteristics of pauses and breath groups made by normal adults and patients with voice disorders while reading a paragraph. Forty normal female adults and forty female patients with a functional voice disorder (18-45 yrs.) read the "Gaeul" paragraph with the "Running Speech" protocol of the Phonatory Aerodynamic System (PAS), by which the pauses with or without inspiration and between or within syntactic words and breath groups were analyzed. The number of pauses with inspiration was found to be higher in the patient group, but the number of pauses without inspiration was higher in the normal group. The rate of syntactic word boundaries with pauses with inspiration was higher in the patient group, while the number of syllables per breath group was higher in the normal group. As these results can be explained by patients' poor breath support due to glottal insufficiency, the question of whether voice disorder patients use their pauses and breath groups properly should be considered carefully in evaluation and intervention.

• Journal of Environmental Science International
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• v.1 no.1
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• pp.47-51
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• 1992

Volatile organic rompounds(VOCs) present in the VOCs-contaminated water are released to air while showering and their air concentrations depend on the shower parameters, resulting in the variation of the VOCs breath concentration. The present study evaluated the key shower parameters(water temperature and inhalation duration) that affect the inhalation exposure to air chloroform while showering, by determining chloroform breath concentration. The chloroform breath concentrations increased with water temperature and inhalation duration increase. The two inhalation exposure conditions which resulted in the greatest chloroform breath contentration difference were a 5 min-inhalation exposure with warm water and a 15 min-inhalation exposure with hot water. The chloroform breath concentration was almost three times higher after later exposure. The mathematical model analyzing the relationship between two key shower parameters and breath concentration normalized to water concentration fits quite Ivell with the experimental data at a probability of p : 0.0001.

• Journal of Korean Society of Transportation
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• v.26 no.6
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• pp.49-60
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• 2008

The aim of this study was to evaluate the variability of the blood.breath ratio (BBR) value and to rationalize the determination of ethanol in breath for evidential sobriety testing. In the experiment forty eight healthy persons, 24 men and 24 women, took part. The experiment included the experimental condition such as sex(2),the type of alcoholic beverage(2; soju, whisky), the type of food(2;kimchi stew, pork belly) and the amount of ethanol consumed(2; 0.35g/kg, 0.70g/kg, based on body weight ) according to 24 factorial design by orthogonal arrays. Breath and blood sample were taken each 8 times and 5 times after the end of drinking. The blood and breath alcohol measurements were highly correlated (r = 0.973). The Results of four way analyses of variance revealed a significant 'the type of food' effect for maximum BrAC (F (1, 43) =5.1, pp<.029), but no significant effect in the type of alcoholic beverage and sex. The overall blood/breath ratio (${\pm}$ SD) was 2295${\pm}$403 and the 95% confidence interval were 1489 and 3101. In spite of these variations, at this time, it seems to be reasonable that apply 2100:1 conversion factor to breathalyzers, because most of the subjects showed the blood.breath ratio of over 2100:1 at least 30 minutes or more passed from the time of drinking as shown in this study.

• Phonetics and Speech Sciences
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• v.12 no.1
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• pp.19-31
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• 2020

The purpose of this study is to observe the realization of pause and breath groups from adult speakers and to examine how gender, generation, and tasks can affect this realization. For this purpose, we analyzed forty-eight male or female speakers. Their generation was divided into two groups: young, old. Task and gender affected both the realization of pause and breath groups. The length of the pause groups was longer in the read speech than in the spontaneous speech and female speech. On the other hand, the length of the breath group was longer in the spontaneous speech and the male speech. In the spontaneous speech, which requires planning, the speaker produced shorter length of pause group. The short sentence length of the reading material influenced the reason for which the length of the breath group was shorter in the reading speech. Gender difference resulted from difference in pause patterns between genders. In the case of the breath groups, the male speaker produced longer duration of pause than the female speaker did, which may be due to difference in lung capacity between genders. On the other hand, generation did not affect either the pause groups or the breath groups. The generation factor only influenced the number of syllables and the eojeols, which can be interpreted as the result of the difference in speech rate between generations.