• Journal of Pharmacopuncture
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• v.25 no.3
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• pp.233-241
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• 2022

Objectives: Asthma is a chronic disease, and the demand for herbal medicines in this field has increased in recent years. The new findings highlight the role of the gut-lung axis in the pathophysiology of asthma. Hence, this study will evaluate the safety and efficacy of Glasthma syrup, an herbal formula based on Persian medicine, in improving asthma and regulating intestinal permeability. The formula consists of five herbal ingredients that have anti-inflammatory effects on the respiratory tract, also known as gut tonics. Methods: The study will be conducted as a placebo-controlled, triple-blind, randomized trial. It will consist of a 4-week intervention followed by a 4-week follow-up period. The target sample size is 20 patients with moderate asthma aged 18 to 60 years. Eligible participants will be randomly assigned to either the experimental group or the control group in equal numbers. Patients in the experimental group will take Glasthma syrup (7.5 mL, twice a day), while patients in the control group will take a matching placebo. Both groups will receive a 4-week combination of a long-acting beta2 agonist and a leukotriene modulator as standard of care. Inhaled corticosteroids can be used as rescue medication as needed. Results: The primary outcomes are asthma symptom scale, lung function, and intestinal permeability. Secondary outcomes include quality of life, symptom recurrence rates, and blood tests. A safety assessment will also be conducted during the trial. Conclusion: In this trial, the effects of Glasthma syrup in patients with moderate asthma will be examined. The study will also assess the effects of the formulation on the gut-lung axis by simultaneously monitoring the gut permeability index, asthma symptoms, and lung function.

• Journal of Chest Surgery
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• v.37 no.1
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• pp.35-42
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• 2004

Background: For the treatment of isolated left main coronary artery disease, twelve arterial revascularizations with Y-composite grafts using left internal thoracic artery and radial artery or right gastroepiploic artery were peformed. This study was performed to investigate whether V-composite graft can satisfy the blood flow required to make myocardium act properly or not. Borderline stenotic lesions on the left main coronary artery, which are very prone to remodel the bypassed vessels due to competitive flows, were also considered. Material and Method: Among 247 patients who underwent coronary artery bypass grafting from March 2000 to April 2003, 12 patients (4.7%) who had received total arterial revascularizations for the isolated left main coronary artery disease were studied retrospectively. Result: left anterior descending arteries were bypassed with left internal thoracic artery by off-pump technique in all patients, however, 2 cases of left obtuse marginal branches were bypassed under on-pump beating heart. Except for one patient, who did not have an obtuse marginal branch more than 1 mm in diameter, 11 patients had gone through complete arterial revascularizations by use of the Y shape arterial graft. Among five patients who had less than 75% stenosis, one patient showed string sign on left internal thoracic artery grafted to left anterior descending artery. However, two grafts to obtuse marginal blanches were completely obstructed and one showed slender sign. There were no graft-dominant flow in patients with stenotic lesion less than 75%. On the contrary to the result of patients with stenotic lesions less than 75%, all the patients with stenotic lesions more than 90% showed graft-dominant blood flow. Conclusion: In conclusion, it is assumed that, when stenotic lesions are over 90%, coronary artery bypass grafting with an Y shape arterial graft could possibly give enough help to the obstructed coronary arteries in blood supplying to myocardium, which needs massive quantity of blood to act well. However, when patients have borderline stenoses, through scrupulous examinations, more prudent and flexible decisions are required in choosing the treatment methods, such as, direct anastomosis of vein or artery to aorta, or adding supplementary treatment methods like percutaneous coronary intervention, rather than choosing a fixed treatment methods.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.3
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• pp.900-907
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• 2004

The antiproliferative effect of the water extract of the branch and root bark of Ulmi Pumilae Cortex(WEUPC) was investigated on the p53-negative human leukemia cell line (HL-60). A dose- and time-dependent inhibition of cell growth was observed; this effect appears to be due to induction of apoptosis. Involvement of oxidative stress is indicated by a dose-dependent increase in intracellular reactive oxygen species levels. In addition. anti-apoptic effect was observed in the cells simultaneously treated with WEUPC and the anti-oxidant N-acetylcysteine. WEUPC did not affect the anti-apoptotic Bcl-2 and the pro-apoptotic Bax, whereas p21/sup WAF1/CIPl/ was enhanced in a dose- and time-dependent fashion; this effect was partially inhibited by N-acetylcysteine. The increase in p21/sup WAF1/CIPl/ was accompanied by a parallel accumulation of cells in the G1 phase of the cycle. These results suggest that the p53-independent induction of p21/sup WAF1/CIP/ and the induction of apoptosis may mediate the anti proliferative effect of WEUPC at least in this study; on the basis of this observation, WEUPC could be proposed as an useful adjunct to the treatment of p53-deficient tumors, which are often refractory to standard chemotherapy.

• Journal of Environmental Science International
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• v.21 no.8
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• pp.891-899
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• 2012

The chlorination pattern of naphthalene vapor when passed through a 1 cm particle bed of 0.5% (mass) copper (II) chloride ($CuCl_2$) mixed with silicon dioxide ($SiO_2$) was studied. Gas streams consisting of 92% (molar) $N_2$, 8% $O_2$ and 0.1% naphthalene vapor were introduced to an isothermal flow reactor containing the $CuCl_2/SiO_2$ particle bed. Chlorination of naphthalene was studied from 100 to $400^{\circ}C$ at a gas velocity of 2.7 cm/s. Mono through hexachlorinated naphthalene congeners were observed at $250^{\circ}C$ whereas a broader distribution of polychlorinated naphthalenes (PCNs) including hepta and octachlorinated naphthalenes was observed at $300^{\circ}C$. PCN production was peak at $250^{\circ}C$ with 3.07% (molar) yield, and monochloronaphthalene (MCN) congeners were the major products at two different temperatures. In order to assess the effect of a residence time on naphthalene chlorination, an experiment was also conducted at $300^{\circ}C$ with a gas velocity of 0.32 cm/s. The degree of naphthalene chlorination increased as a gas velocity decreased.

• Management & Information Systems Review
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• v.29 no.4
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• pp.109-121
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• 2010

In this study, we propose a solution procedure to solve travelling salesman problem(TSP) with special cost function, route dependent travelling salesman problem(RDTSP). First, we develop an integer programming model to describe the problem. In the model, a variable means a possible route. And, the number of variables in this model are extremely large. So, we develop a LP relaxation problem of the IP model and solve the relaxation problem by a column generation technique. The relaxation problem does not guarantee the optimal solution. If we get an integer solution in the ralaxation problem, then the solution is an optimal one. But, if not, we cannot get an optimal solution. So, we approach a branch and price technique. The overall solution procedure can be applied a printed circuit board(PCB) assembly process.

• Geomechanics and Engineering
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• v.13 no.4
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• pp.535-570
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• 2017

There are only few cases where cause and location of failure of a rock structure are limited to a single discontinuity. Usually several discontinuities of limited size interact and eventually form a combined shear plane where failure takes place. So, besides the discontinuities, the regions between adjacent discontinuities, which consist of strong rock and are called material or rock bridges, are of utmost importance for the shear strength of the compound failure plane. Shear behaviour of persistent and non-persistent joint are different from each other. Shear strength of rock mass containing non-persistent joints is highly affected by mechanical behavior and geometrical configuration of non-persistent joints located in a rock mass. Therefore investigation is essential to study the fundamental failures occurring in a rock bridge, for assessing anticipated and actual performances of the structures built on or in rock masses. The purpose of this review paper is to present techniques, progresses and the likely future development directions in experimental testing of non-persistent joint failure behaviour. Experimental results showed that the presence of rock bridges in not fully persistent natural discontinuity sets is a significant factor affecting the stability of rock structures. Compared with intact rocks, jointed rock masses are usually weaker, more deformable and highly anisotropic, depending upon the mechanical properties of each joint and the explicit joint positions. The joint spacing, joint persistency, number of rock joint, angle of rock joint, length of rock bridge, angle of rock bridge, normal load, scale effect and material mixture have important effect on the failure mechanism of a rock bridge.

• Journal of Science Education
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• v.39 no.3
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• pp.446-456
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• 2015

We have analyzed affecting factors of boiling point measurement and proposed to improve these after identifying errors of boiling point experiment in 7th grade science textbooks of 2009 revised curriculum. In the result of analyzing affecting factor of boiling point measurement for nine kinds of science textbooks, we have identified six affecting factors like as types of thermometer, heating instrument, sealing or not of stopper, position of thermometer, shape of container, and volume ratio of material and container. When performing experiment of boiling point measurement, we identified the best results when heating with a hot plate, positioning thermo sensor of MBL near neck branch after filling and sopping 10% volumes of material in round bottom flask. Based on this result, we have compared nine kinds of 7th grade science textbooks and found many errors that must be corrected in most of textbooks. Therefore it should be improved the experiment of science textbooks to enhance the understanding of students and to prevent from misconceptions for boiling point measurement.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.25 no.1
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• pp.13-19
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• 2015

Objectives: The purpose of this study was to assess excavator drivers in order to determine the proportion showing subjective symptoms of musculoskeletal disorders and to evaluate the association between the symptoms and characteristics of the subjects. Methods: A questionnaire survey was conducted to collect the information on participants' age, average working hours per day, duration of career (years), work-related musculoskeletal symptoms, and more. The final dataset included 141 excavator drivers. Frequency and percentage were summarized and then the associations between the characteristics of the subjects and symptoms were evaluated as odds ratios (ORs) and 95% confidence intervals (CIs) using multiple logistic regression analysis. Results: Seventy-six percent of the currently reported musculoskeletal symptoms. Those who have musculoskeletal symptoms attributed their symptoms to unstable posture at work, mental stress or vibrations. There was a significant association between symptoms of musculoskeletal disorders and career of excavator drivers (P for trend=0.04). Conclusions: The results of this study suggest that the prevalence of musculoskeletal disorders may be high among excavator drivers and warrants well-designed studies on work-related disorders among excavator drivers.

• Journal of the Korean Recycled Construction Resources Institute
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• v.2 no.4
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• pp.354-359
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• 2014

The objective of this study is to examine the fatigue behavior in compression of normal-weight and lightweight concrete mixtures with high volume supplementary cementitious material(SCM). The selected binder composition was 30% ordinary portland cement, 20% fly-ash, and 50% ground granulated blast-furnace slag. The targeted compressive strength of concrete was 40 MPa. For the cyclic loading, the constant maximum stress level varied to be 75%, 80%, and 90% of the static uniaxial compressive strength, whereas the constant minimum stress level was fixed at 10% of the static strength. The test results showed that fatigue life of high volume SCM lightweight concrete was lower than the companion normalweight concrete. The value of the fatigue strain at the maximum stress level intersected the descending branch of the monotonic stress-strain curve after approximately 90% of the fatigue life.

• Journal of the Korean Society of Safety
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• v.30 no.4
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• pp.159-167
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• 2015

The main purpose of this study is to evaluate the awareness survey on the experience of fire fighting safety education and living safety consciousness of college students in the department of noncommissioned officer. Additionally, making provision of basic references and the effective fire fighting safety education is another important purpose of this study. In order to evaluate the awareness, the survey consist of 43 queries based on 6 queries for general characters, 9 queries for experiences of fire fighting safety education and 30 queries for living safety consciousness. The collected data from survey was analyzed using SPSS 20.0 win program. The interrelationship for general characters was confirmed using analysis of frequency, percentage, independent T-tset, ANONVA analysis, and regression analysis. The results show that the experience of fire fighting safety education and living safety consciousness of students from the combatant branch and ordnance corps are higher than those students from quartermaster corps. This may be attributed to the presence or absence of safety relevant courses on a curriculum. Therefore, the presence of safety courses on a curriculum should be one of important points for improving the experience of fire fighting safety education and living safety consciousness of these college students.