• Journal of Ginseng Research
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• v.43 no.3
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• pp.361-367
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• 2019

Panax ginseng, known as Koran ginseng, one of the most commonly used traditional plants, has been demonstrated to show a wide range of pharmacological applications. Ginsenosides are the major active ingredients found in ginseng and are responsible for the biological and pharmacological activities, such as antioxidation, antiinflammation, vasorelaxation, and anticancer actions. Existing studies have mostly focused on identifying and purifying single ginsenosides and investigating pharmacological activities and molecular mechanisms in cells and animal models. However, ginsenoside studies based on clinical trials have been very limited. Therefore, this review aimed to discuss the currently available clinical trials on ginsenosides and provide insights and future directions for developing ginsenosides as efficacious and safe drugs for human disease.

• Structural Engineering and Mechanics
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• v.71 no.1
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• pp.77-87
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• 2019

In this paper, the interaction between two neighboring tunnel has been investigated using PFC2D. For this purpose, firstly calibration of PFC was performed using Brazilian experimental test. Secondly, various configuration of two neighboring tunnel was prepared and tested by biaxial test. The maximum and minimum principle stresses were 0.2 and 30 MPa respectively. The modeling results show that in most cases, the tensile cracks are dominant mode of cracks that occurred in the model. With increasing the diameter of internal circle, number of cracks decreases in rock pillar also number of total cracks decreases in the model. The rock pillar was heavily broken when its width was too small. In fixed quarter size of tunnel, the crack initiation stress decreases with increasing the central tunnel diameter. In fixed central tunnel size, the crack initiation stress decreases with increasing the quarter size of tunnel.

• Steel and Composite Structures
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• v.47 no.1
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• pp.71-77
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• 2023

This paper presents a study on the wave propagation of functionally graded material (FGM) sandwich nanoplates with soft core resting on a Winkler foundation. The structure is modelled by classical theory. Motion equations are derived by the assumption of nonlocal Eringen theory and energy method. Then, the equations are solved using an exact method for finding phase velocity responses. The effects of Winkler foundation, nonlocal parameters, thickness and mode number on the dispersion of elastic waves are shown. With the increase of spring constant, the speed of wave propagation increases and reaches a uniform state at a higher wave number.

• Korean Journal of Veterinary Service
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• v.34 no.3
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• pp.235-243
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• 2011

Probiotics have many effects such as antihypertensive, prevention of cancer, antioxidation, reduction of dermatitis symptoms, improvement of mineral absorption, reduction of allergic symptoms, and decrease of cholesterol, However, the main role of probiotics is that they balance intestinal microbials proportion. L. acidophilus is one of probiotics and microflora in intestine. It has an acidification activity, aroma production, texture formation and probiotics properties. We studied on the roles of L. acidophilus in mice. In this study, body weights of mice were decreased when administration of L. acidophilus ($1{\times}10^{10}$ CFU) and swimming ability has been raised than a normal group after feeding on L. acidophilus ($1{\times}10^{10}$ CFU). After taking L. acidophilus ($1{\times}10^{10}$ CFU), total white cells were increased than a normal group; hemoglobin and thrombocytes were increased. The level of cholesterol and triglyceride were decreased in blood analysis. We knew L. acidophilus is related to innate immune system. We found out the secretion of cationic peptide was increased in the Lysoplate assays as a result of L. acidophilus ($1{\times}10^{10}$ CFU) administration. Appearance rate of lysozyme was also increased than the normal group on an immunohistochemistry stain. We confirmed L. acidophilus contributes to host health through innate immune system stimulation. L. acidophilus more than $1{\times}10^{10}$ CFU are thought to be beneficial for the host health and prevention of intestinal diseases in field condition.

• The Journal of Sustainable Design and Educational Environment Research
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• v.2 no.2
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• pp.15-33
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• 2002

This study purpose is extract on the architectural principles and architectural planning direction for existing school facility renovation. therefore, This study is occur to renovation from change factor and change direction of the school facility under prerequisite, school facility change direction is with a pedagogy side and it classified with the social side which it bites and it presented. School facility renovation extracted a plan principles with the base which will reach. Was extracted renovation plan Principles to analyze the interrelationship of necessary condition of school facility, It follows in renovation principle presented the renovation plan direction 61 branch.

• Journal of Korean Society for Atmospheric Environment
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• v.18 no.6
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• pp.539-546
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• 2002

The physicochemical properties of solid wastes generated from seven highway service areas, four branch offices, and one construction site were analyzed in concert with air pollutants including heavy metals emitted from near-by small-scale incinerators. The amount of solid wastes generated from highway areas has been increasing with recent increases in the number of highways and passengers. Twelve incinerators examined in this study generally had capacity smaller than 100 kg/hr, most of which were equipped with cyclone for dust removal. It was seen that the concentrations of the gas-phase air pollutants (e.g., SO$_2$, NO$_{x}$, HCl and H$_2$S) were above the acceptable emission standards except one or two sites. CO concentrations at all incinerators were also higher due to incomplete combustion. In addition, particulate matters showed concentration six times higher at their maximum. The results of heavy metal analysis showed that the concentrations of Cu, Cd, and Ni satisfied the emission standards. whereas Pb at one site and Zn at five sites exceeded the standards. Cr measurement results indicated that 9 of 12 incinerators had higher values than the standard; especially one branch office showed nine times higher than normal concentration. In order to satisfy more stringent emission standards in the near future, it is necessary to install air pollution control system and to develop an intensified management plan.n.

• Korean Journal of Veterinary Research
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• v.46 no.3
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• pp.235-248
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• 2006

The VP2 full gene of Korean infectious bursal disease virus(IBDV) strain, SH/92, three attenuated vaccine strains, Bur706, Bursine-2 and CEV/AC strains, were amplified by reverse transcriptase-polymerase chain reaction and sequenced and compared with published VP2 gene sequences of IBDVs. The VP2 nucleotide sequence similarity between SH/92 and three vaccine stains was 95.6~96.5% whereas the nucleic acid similarity among three vaccine strains was 97.5~98.5%. The amino acid sequence similarity of VP2 of SH/92 compared with three vaccine strains was between 94.4 and 97.6% while the amino acid similarity among three vaccine strains was between 97.4 and 98.4%. The amino acid similarity between SH/92 and classical virulent strain, 52/70 and STC strain was 96.4 and 96.5%, respectively. The serine-rich heptapeptide was conserved in CEVAC and Bursine-2 as well as SH/92 but not in Bur706. The phylogenetic tree developed from amino acid sequences showed that SH/92 was categorized with vv IBDVs(HK46, OKYM, KKI, UPM94/273, SH95) in one branch while three vaccine strains were catagorized with STC strain in the other branch.

• Journal of Periodontal and Implant Science
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• v.44 no.3
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• pp.141-146
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• 2014

Purpose: Peri-implantitis and periodontitis are inflammatory and infectious diseases of implant and tooth-supporting tissues. Recently, the role of gene polymorphisms of immune response components in the relevant pathogenesis has been investigated. The present study was the first to evaluate the relationship between two known single nucleotide polymorphisms (SNPs) of the receptor activator of nuclear factor kappa-${\beta}$ (RANK) gene (rs3018362 and rs35211496) in chronic periodontitis and peri-implantitis patients in an Iranian population. Methods: Eighty-one periodontally healthy patients, 38 patients with peri-implantitis, and 74 patients with chronic periodontitis were enrolled in this study. DNA was extracted from blood arm vein samples by using Miller's salting out technique according to the manufacturer's instructions given in the extraction kit. The concentration of DNA samples was measured using a spectrophotometer. The genetic polymorphisms of the RANK gene were evaluated using a competitive allele specific polymerase chain reaction (KBioscience allele specific PCR) technique. Differences in the frequencies of genotypes and alleles in the diseased and healthy groups were analyzed using chi-squared statistical tests (P<0.05). Results: Analysis of rs35211496 revealed statistically significant differences in the expression of the TT, TC, and CC genotypes among the three groups (P=0.00). No statistically significant difference was detected in this respect between the control group and the chronic periodontitis group. The expression of the GG, GA, and AA genotypes and allele frequencies (rs3018362) showed no statistically significant difference among the three groups (P=0.21). Conclusions: The results of this study indicate that the CC genotype of the rs35211496 RANK gene polymorphism was significantly associated with peri-implantitis and may be considered a genetic determinant for peri-implantitis, but this needs to be confirmed by further studies in other populations.

• Steel and Composite Structures
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• v.33 no.3
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• pp.319-332
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• 2019

This study is aimed to predict the behaviour of channel shear connectors in composite floor systems at different temperatures. For this purpose, a soft computing approach is adopted. Two novel intelligence methods, including an Extreme Learning Machine (ELM) and a Genetic Programming (GP), are developed. In order to generate the required data for the intelligence methods, several push-out tests were conducted on various channel connectors at different temperatures. The dimension of the channel connectors, temperature, and slip are considered as the inputs of the models, and the strength of the connector is predicted as the output. Next, the performance of the ELM and GP is evaluated by developing an Artificial Neural Network (ANN). Finally, the performance of the ELM, GP, and ANN is compared with each other. Results show that ELM is capable of achieving superior performance indices in comparison with GP and ANN in the case of load prediction. Also, it is found that ELM is not only a very fast algorithm but also a more reliable model.

• Journal of the Korean Society of School Health
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• v.28 no.2
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• pp.120-126
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• 2015

Purpose: The purpose of this study was to understand interpersonal dispositions and social support among high school students and identify factors associated with depression. Methods: A total of 604 students (320 males and 284 females) from four high schools conveniently sampled from high schools in the Incheon area participated in a self-administered survey. Results: According to hierarchical multiple regression analysis, the following factors significantly affected the participants' depression levels with the explanatory power of 30.6%: grade, perceived health status, sympathetic-acceptable personality, sociable-friendly personality, rebellious-distrustful personality, parent support, peer support, and the support from community. Conclusion: In this study, interpersonal dispositions and social support were positively associated with depression. These results suggest that strengthening personal relations and social support can help high school students in terms of mental health and suicide prevention.