Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Ginsenosides: the need to move forward from bench to clinical trials

  • Yu, Seung Eun (Biomarker Branch, Research Institute, National Cancer Center) ;
  • Mwesige, Benjamin (Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center) ;
  • Yi, Young-Su (Department of Pharmaceutical and Biomedical Engineering, Cheongju University) ;
  • Yoo, Byong Chul (Biomarker Branch, Research Institute, National Cancer Center)
  • Received : 2018.07.26
  • Accepted : 2018.09.04
  • Published : 2019.07.15
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Abstract

Panax ginseng, known as Koran ginseng, one of the most commonly used traditional plants, has been demonstrated to show a wide range of pharmacological applications. Ginsenosides are the major active ingredients found in ginseng and are responsible for the biological and pharmacological activities, such as antioxidation, antiinflammation, vasorelaxation, and anticancer actions. Existing studies have mostly focused on identifying and purifying single ginsenosides and investigating pharmacological activities and molecular mechanisms in cells and animal models. However, ginsenoside studies based on clinical trials have been very limited. Therefore, this review aimed to discuss the currently available clinical trials on ginsenosides and provide insights and future directions for developing ginsenosides as efficacious and safe drugs for human disease.

Keywords

References

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