• The Korean Journal of Physiology
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• 제6권1호
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• pp.27-31
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• 1972

The activity of Mg and Na-K activated ATPase of homogenate from rat brain cortex was measured in vitro under the variety of conditions. The effects of various hypnotic and tranquilizer such as phenobarbital, amobarbital, diazepam, promazine and chlorpromazine on the activities of both ATPase was investigated and the results was summarized as follows. 1. Na-K ATPase was slightly inhibited by phenobarbital and amobarbital while Mg ATPase was moderately activated by these drugs. 2. Both Mg and Na-K ATPase activities were markedly inhibited by diazepam. 3. Promazine and chlorpromazine markedly inhibited both Mg and Na-K ATPase activities. These findings indicate that remarkable correlation between hypnotic or tranquilizing potency and ATPase inhibition could be observed.

• 한국자기공명학회논문지
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• 제24권1호
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• pp.23-29
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• 2020

Mozart's music has been suggested to affect spatio-temporal reasoning of listeners, which has been called "Mozart effect". However, the effects of Mazart's music on human metabolism have not been known. We dissected Mozart's music into its compositional elements and studied their effects on metabolism of experimental animals. Mozart music significantly reduced cortisol level induced by stress. NMR metabolomic study revealed different urine metabolic profile according to the listening to Mozart's music. In addition, each element of music exhibited different metabolic profile. Functional MRI study also showed enhanced brain activity upon listening to Mozart's music. Taken together, Mozart's music seems to be related with brain activity, stress hormone and whole body metabolism.

• 동의생리병리학회지
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• 제16권5호
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• pp.881-887
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• 2002

This treatise is written in order to solve the important contradiction between the two theories; in oriental medicine psychological function is responsible for heart, but in western one it is responsible for brain. So we take the methods of studying in the aspects of morphological characteristics(MC) and visceral manifestation theory(VMT, 藏象論) and others about two organs-heart and brain. Brain(頭腦) is preferred to understand as a structure which is manifesting mental activity of heart. So the brain can be named with external heart(外心) corresponding to the relation of kidney(外 and external kidney. Saying conversely, the nutritional foundation of the mental function is the blood of heart, but the enlightening and insightful features of mentality make it's own residence move to the organ in the uppermost and positive site, that is head. And the close relationships on mental functions between heart and brain were discussed in various aspects, like investigation on east and west etymological literature, or Jiu gong and Taoist theory as well as Me and VMT, These understandings can make us know about the pathology of brain by itself. It has deep relations with heart fire and heart blood and kidney essence, and gastrointestinal function and liver with lung additionally. In another point, it makes the highly complicated psychological functions to be explained free from body relatively, and so can do a role in the complement of the strict 5 viscera theory.

• 동의신경정신과학회지
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• 제9궈1호
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• pp.73-82
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• 1998

Substantial evidence has accumulated that Alzheimer's disease is associated with a local inflammatory reaction in senile plaques which may be immunemediated, and includes extensive Brain Neuroglial invasion, lymphocytic infiltration, cytokine deposition. Tumor necrosis factor a (TNF-a) is a cytokine which plays an important immunoenhancing role in the local acute and chronic inflammatory response in response to a variety of stimuli. The neuropeptide, substance P, can stimulate secretion of TNF-a from Brain Neuroglial cells. Neuroglia have substance P receptors in the central nervous system. WQ investigated whether RADIX ASPARAGI inhibits secretion of TNF-a from primary cultures of Brain Neuroglial cells containing both astrocyte (∼90%) and microglia (∼10%). RADIX ASPARAGI dose-dependently inhibited the TNF-a secretion induced by substance P plus lipopolysaccharide (LPS). In cultures enriched for micoglia (>95% pure). LPS stimulated the secretion of TNF-a but substance P caused no enhancement. Because there was no synergism between substance P and LPS in the microglial cultures it is resonable to substance P madiated enhancement of TNF-a secretion. IL-1 is a modulator of TNF-a secretion in the immune system. Also IL-1 has been shown to elevate TNF- a secretion from LPS-stimulated Brain Neuroglial cells while having no effect on Brain Neuroglial cells in the absence of LPS. We therfore investigated whether IL-1 mediates the RADIX ASPARAGI inhibition of TNF-a secretion form primary Brain Neuroglial cells. Treatment of RADIX ASPARAGI to mixed cultures stimulated with both substance P and LPS decreased TNF-a secretion to the level observed with LPS alone. These results indicate that RADIX ASPARAGI possess strong antiinflammatory activity in the cental nervous system by inhibition of inflammatory cytokines secretion from Brain Neuroglial cells.

• 대한핵의학회지
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• 제26권2호
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• pp.360-364
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• 1992

Treatment for the brain tumors consist of surgery, chemotherapy, and a variety of methods of irradiation. Therapy is aimed to destroy the tumor, but necrosis and edema occur concurrently. Conventional structural imaging techniques such as CT or MRI are unable to reliably distinguish persistent and recurrent tumor from necrosis or edema. T1-201 has been shown to be useful in the evaluation of the myocardial viability by comparing the early uptake and redistribution image. The aim of this study is to evaluate the clinical usefulness of the early uptake and delayed washout images of the T1-201 brain SPECT in the brain tumors. In the pathologically diagnosed various brain tumor patients, brain SPECT was done with rotating gamma camera 15 minutes and 3 hours after T1-201 injection, and the T1-201 uptake in the tumor was compared with the skull and scalp activity. In the glioblastoma multiforme, meningioma and metastatic tumor, the T1-201 uptake was higher than low grade glioma in both 15 minute and 3 hour images (p<0.02). In the low grade glioma,3 hour T1-201 uptake was significantly lower than 15 minute uptake (p<0.05) but in the glioblastoma, meningioma and metastatic tumor there was no significant difference. There was no significant difference in the T1-201 uptake among the glioblastoma, meningioma and metastatic tumors. In one matastatic tumor, T1-201 uptake was decreased after radiation therapy. T1-201 brain SPECT could distinguish the benign and malignancy, and seems to be useful in the follow-up after treatment. But one of the early or delayed SPECT seems not to be necessary for these purposes.

• 디지털콘텐츠학회 논문지
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• 제7권1호
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• pp.15-23
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• 2006

뇌의 조화로운 개발은 시대를 막론한 고유의 목표였고 이를 위한 다양한 훈련 프로그램들이 교육현장에서 그리고 상업적 시장에서 선보여 왔다. 그러나 이러한 훈련방법들은 뇌 생리적(neurophysiology) 견지에서 그리고 뇌 개발의 방법론적인 견지에서 바라본다면, 다소 편협되고 뇌의 전인격적인 개발에 반하는 요소들이 내재되어 있다는 점을 지적하고 싶다. 그럼으로 뇌로 하여금 전인격적인 다양한 자극에 반응하여 스스로 학습하고 생성을 계속하게 하며 하며, 뇌세포 간 무수한 시냅스(synapse)를 창조 강화케 하며, 그로 인해 뇌신경회로를 형성케 하는 것이 바람직한 뇌 훈련 프로그램이다. 본 연구는 특정한 목적에 맞게 제작된 multimedia를 이용한 두뇌 훈련 프로그램을 사용하였을 때 실제로 두뇌개발 효과가 있는지의 여부를 뇌파를 직접 측정함으로써 훈련효과의 여부를 보다 객관적으로 정량적으로 분석한 것이다.

• 환경생물
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• 제29권4호
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• pp.305-311
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• 2011

$Lactobacillus$ $jensenii$ YW-33이 생산하는 생물응집제의 활성본체를 규명하고자 응집물질을 분리, 정제하고 그 특성을 검토하고자 하였다. 생물응집제의 활성 본체를 조사하기 위하여 배양액을 원심분리하여 균체 자체와 균체를 제거한 상등액을 비교한 결과 균체를 제거한 상등액이 86%로 높은 응집활성을 나타냈다. 또한 pronase 처리와 periodate 산화를 행한 결과 pronase로 처리한 시료는 무처리군과 비교하여 차이가 없었던 반면 periodate로 산화시킨 시료는 응집활성이 크게 감소함에 따라 다당에 기인되는 것으로 추정되었다. 균체가 제거된 상등액을 감압, 농축하여 EtOH 60~80%의 농도로 분획한 결과 LJ-80을 얻었다. 분리된 LJ-80을 DEAE-Toyopearl 650C chromatography, Sepharose CL-6B chromatography을 이용하여 최종 정제된 LJ-80-II-1을 분리하였으며 HPLC 분석에 의해 순도를 확인했다. 정제된 LJ-80-II-1의 분자량은 약 800,000 이상이며 총당이 98.4%, 단백질이 0.6%으로 mannose : galactose : glucose가 1.61 : 0.25 : 1.00의 molecule ratio을 가지고 있었다.

• Korean Journal of Acupuncture
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• 제19권1호
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• pp.25-33
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• 2002

Substantial evidence suggests that behavioral and reinforcing effects of cocaine can be mediated by the mesolimbic dopaminergic system. Injections of cocaine can produce one of the immediate-early gene, c-fos expression in the brain and behavioral activation. Acupuncture as a therapeutic intervention is widely used for the treatment of many mental disorders such as drugs of abuse. In order to investigate whether acupuncture has an influence on cocaine-induced reinforcing and behavioral effects, we examined the effect of acupuncture on cocaine-induced locomotor activity and c-Fos expression in the nucleus accumbens and the striatum using Fos-like-immunoreactivity(FLI). Male SD rats received acupuncture for 1 min after injection of cocaine hydrochloride(1 mg/kg, i.v.). The employed acupuncture point, Shenmen$(HT_7)$, has been clinically used to treat mental and psychosomatic disorders. Injections of cocaine produced a marked increase in locomotor activity and FLI in the nucleus accumbens and the striatum. Acupuncture at $HT_7$, but not at control points($PC_6,\;TE_4$ or tail), significantly attenuated cocaine-induced increase in locomotor activity and Fos-like immunoreactivity. These results demonstrated that reduction in locomotor activity by acupuncture may be reflected by reduction of postsynaptic neuronal activity in the nucleus accumbens and the striatum. Our results suggest that acupuncture may have a therapeutic effect on cocaine addiction.

• 정보과학회지
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• 제27권4호
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• pp.43-49
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• 2009

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 2001년도 제40차 추계학술대회 및 총회
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• pp.33.1-33.1
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• 2001