Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
권호 표지

Effect of Acupuncture$(HT_7)$ on Acute Cocaine-induced locomotor Activity and Fos-like Immunoreactivity in the Brain of the Rats

신문(神門) 침 자극이 급성 코카인 투여로 인한 보행성 활동량과 뇌내 c-Fos 발현에 미치는 효과

  • Lee Bom-Bi (Dept. of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Yang Che-Ha (Dept. of Physiology, College of Oriental Medicine, Kyungan University) ;
  • Lee Hak-In (Dept. of Physiology, College of Oriental Medicine, Kyungan University) ;
  • Hahm Dae-Hyun (Dept. of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Lee Hae-Jeong (Dept. of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Shim In-Sup (Dept. of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung Hee University)
  • 이봄비 (경희대학교 동서의학대학원 한의과학과 침구경락학교실) ;
  • 양재하 (경산대학교 한의과대학 생리학교실) ;
  • 이학인 (경산대학교 한의과대학 생리학교실) ;
  • 함대현 (경희대학교 동서의학대학원 한의과학과 침구경락학교실) ;
  • 이혜정 (경희대학교 동서의학대학원 한의과학과 침구경락학교실) ;
  • 심인섭 (경희대학교 동서의학대학원 한의과학과 침구경락학교실)
  • Published : 2002.03.27
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Abstract

Substantial evidence suggests that behavioral and reinforcing effects of cocaine can be mediated by the mesolimbic dopaminergic system. Injections of cocaine can produce one of the immediate-early gene, c-fos expression in the brain and behavioral activation. Acupuncture as a therapeutic intervention is widely used for the treatment of many mental disorders such as drugs of abuse. In order to investigate whether acupuncture has an influence on cocaine-induced reinforcing and behavioral effects, we examined the effect of acupuncture on cocaine-induced locomotor activity and c-Fos expression in the nucleus accumbens and the striatum using Fos-like-immunoreactivity(FLI). Male SD rats received acupuncture for 1 min after injection of cocaine hydrochloride(1 mg/kg, i.v.). The employed acupuncture point, Shenmen$(HT_7)$, has been clinically used to treat mental and psychosomatic disorders. Injections of cocaine produced a marked increase in locomotor activity and FLI in the nucleus accumbens and the striatum. Acupuncture at $HT_7$, but not at control points($PC_6,\;TE_4$ or tail), significantly attenuated cocaine-induced increase in locomotor activity and Fos-like immunoreactivity. These results demonstrated that reduction in locomotor activity by acupuncture may be reflected by reduction of postsynaptic neuronal activity in the nucleus accumbens and the striatum. Our results suggest that acupuncture may have a therapeutic effect on cocaine addiction.

Keywords

References

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