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Ginsenoside Rh2 reduces depression in offspring of mice with maternal toxoplasma infection during pregnancy by inhibiting microglial activation via the HMGB1/TLR4/NF-κB signaling pathway

  • Xu, Xiang;Lu, Yu-Nan;Cheng, Jia-Hui;Lan, Hui-Wen;Lu, Jing-Mei;Jin, Guang-Nan;Xu, Guang-Hua;Jin, Cheng-Hua;Ma, Juan;Piao, Hu-Nan;Jin, Xuejun;Piao, Lian-Xun
    • Journal of Ginseng Research
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    • v.46 no.1
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    • pp.62-70
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    • 2022
  • Background: Maternal Toxoplasma gondii (T. gondii) infection during pregnancy has been associated with various mental illnesses in the offspring. Ginsenoside Rh2 (GRh2) is a major bioactive compound obtained from ginseng that has an anti-T. gondii effect and attenuates microglial activation through toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) signaling pathway. GRh2 also alleviated tumor-associated or lipopolysaccharide-induced depression. However, the effects and potential mechanisms of GRh2 on depression-like behavior in mouse offspring caused by maternal T. gondii infection during pregnancy have not been investigated. Methods: We examined GRh2 effects on the depression-like behavior in mouse offspring, caused by maternal T. gondii infection during pregnancy, by measuring depression-like behaviors and assaying parameters at the neuronal and molecular level. Results: We showed that GRh2 significantly improved behavioral measures: sucrose consumption, forced swim time and tail suspended immobility time of their offspring. These corresponded with increased tissue concentrations of 5-hydroxytryptamine and dopamine, and attenuated indoleamine 2,3-dioxygenase or enhanced tyrosine hydroxylase expression in the prefrontal cortex. GRh2 ameliorated neuronal damage in the prefrontal cortex. Molecular docking results revealed that GRh2 binds strongly to both TLR4 and high mobility group box 1 (HMGB1). Conclusion: This study demonstrated that GRh2 ameliorated the depression-like behavior in mouse offspring of maternal T. gondii infection during pregnancy by attenuating the excessive activation of microglia and neuroinflammation through the HMGB1/TLR4/NF-κB signaling pathway. It suggests that GRh2 could be considered a potential therapy in preventing and treating psychiatric disorders in the offspring mice of mothers with prenatal exposure to T. gondii infection.

Success Factors Analysis of Chinese Large Scenario Experience Drama:'You Jian Ping-yao' (중국 대형정경체험극 '우견평요'의 성공요인 분석)

  • Wang, Yilun;Jang, Hyewon
    • 지역과문화
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    • v.8 no.3
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    • pp.27-48
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    • 2021
  • In recent years, China's tourism performing art in a series of new completion of the project, increase the box office of tourism performing arts industry, higher economic income, at the same time led to the formation of brand of tourism performing arts and has a good reputation, with the regional culture, has a certain role in promoting economic development, including Large scenario experience drama is one of the key projects. Large scenario experience drama is a new form of drama that simulates the space design of real environment and enables the audience to have active experience in visual, auditory, smell, taste, touch and other senses with strong interactivity.Large scenario experience drama are adapted from traditional Chinese culture, regional culture and long-passed stories, and combine high technology such as lighting, sound effects, special effects and 3D effects to make the audience's experience more real.As the first Large scenario experience drama in China, 'You Jian Ping-yao' reflects the profound culture of Shanxi with new forms of expression and creative means, in the form of scene experience and make the audience more intuitive feel the 'Shanxi emotion', 'Shanxi sentiment' and 'Shanxi Morality', carry forward the traditional culture at the same time, also passed the Shanxi ancient and great values, strengthened the drama of China's movie village, impetus the development of the tourism industry in Shanxi, drive the Shanxi region of jingjing, gradually formed a complete industrial chain. However, there are also limitations such as improper plot connection and improper tourist management, which can improve the performance effect through more audience interaction and guidance. Therefore, it can be seen that large-scale situational experience dramas play a great role in promoting the dissemination of traditional culture and values, the development of tourism industry, the formation of regional brand characteristics and economic development. Through these, it can be seen that large-scale situational experience plays have enlightenments such as innovative thinking content, gradually forming an industrial chain closed-loop, and broadening publicity channels for the development of live-action performances.

A modified U-net for crack segmentation by Self-Attention-Self-Adaption neuron and random elastic deformation

  • Zhao, Jin;Hu, Fangqiao;Qiao, Weidong;Zhai, Weida;Xu, Yang;Bao, Yuequan;Li, Hui
    • Smart Structures and Systems
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    • v.29 no.1
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    • pp.1-16
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    • 2022
  • Despite recent breakthroughs in deep learning and computer vision fields, the pixel-wise identification of tiny objects in high-resolution images with complex disturbances remains challenging. This study proposes a modified U-net for tiny crack segmentation in real-world steel-box-girder bridges. The modified U-net adopts the common U-net framework and a novel Self-Attention-Self-Adaption (SASA) neuron as the fundamental computing element. The Self-Attention module applies softmax and gate operations to obtain the attention vector. It enables the neuron to focus on the most significant receptive fields when processing large-scale feature maps. The Self-Adaption module consists of a multiplayer perceptron subnet and achieves deeper feature extraction inside a single neuron. For data augmentation, a grid-based crack random elastic deformation (CRED) algorithm is designed to enrich the diversities and irregular shapes of distributed cracks. Grid-based uniform control nodes are first set on both input images and binary labels, random offsets are then employed on these control nodes, and bilinear interpolation is performed for the rest pixels. The proposed SASA neuron and CRED algorithm are simultaneously deployed to train the modified U-net. 200 raw images with a high resolution of 4928 × 3264 are collected, 160 for training and the rest 40 for the test. 512 × 512 patches are generated from the original images by a sliding window with an overlap of 256 as inputs. Results show that the average IoU between the recognized and ground-truth cracks reaches 0.409, which is 29.8% higher than the regular U-net. A five-fold cross-validation study is performed to verify that the proposed method is robust to different training and test images. Ablation experiments further demonstrate the effectiveness of the proposed SASA neuron and CRED algorithm. Promotions of the average IoU individually utilizing the SASA and CRED module add up to the final promotion of the full model, indicating that the SASA and CRED modules contribute to the different stages of model and data in the training process.

Implementation of Air Pollutant Monitoring System using UAV with Automatic Navigation Flight

  • Shin, Sang-Hoon;Park, Myeong-Chul
    • Journal of the Korea Society of Computer and Information
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    • v.27 no.8
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    • pp.77-84
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    • 2022
  • In this paper, we propose a system for monitoring air pollutants such as fine dust using an unmanned aerial vehicle capable of autonomous navigation. The existing air quality management system used a method of collecting information through a fixed sensor box or through a measurement sensor of a drone using a control device. This has disadvantages in that additional procedures for data collection and transmission must be performed in a limited space and for monitoring. In this paper, to overcome this problem, a GPS module for location information and a PMS7003 module for fine dust measurement are embedded in an unmanned aerial vehicle capable of autonomous navigation through flight information designation, and the collected information is stored in the SD module, and after the flight is completed, press the transmit button. It configures a system of one-stop structure that is stored in a remote database through a smartphone app connected via Bluetooth. In addition, an HTML5-based web monitoring page for real-time monitoring is configured and provided to interested users. The results of this study can be utilized in an environmental monitoring system through an unmanned aerial vehicle, and in the future, various pollutants measuring sensors such as sulfur dioxide and carbon dioxide will be added to develop it into a total environmental control system.

Efficiency of Closed Cutting Propagation Affected by Closed Periods, Leaflet Number and Photoperiod in Rose (Rosa hybrida) (밀폐 기간, 소엽수 및 광주기에 따른 장미의 밀폐삽목 번식 효율)

  • Yang, Gyeong Rok;Jung, Hyun Hwan;Park, Ki Young;Song, Kwan Jeong
    • Journal of Bio-Environment Control
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    • v.31 no.3
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    • pp.212-220
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    • 2022
  • When it comes to single node leafy stem cuttings of rose (Rosa hybrida), environmental management such as air temperature, relative humidity, and light affect productivity. In order to investigate the effect of air temperature and relative humidity on the cutting success rate and rooted cuttings quality, a transparent airtight box was used to implement a closed system. We have also tried to find out the most effective photoperiod and the number of leaflets in closed system using artificial light (white LED, 104.0 µmol·m-2·s-1 photosynthetic photon flux density). The first experiment was conducted for a total of 6 weeks under 4 airtight period conditions. The number of roots and longest root length decreased as the airtight period increased. But there were no significant differences in the survival rate, shooting rate, and rooting rate according to airtight periods. In the second experiment the results indicated that survival and shooting rate were significantly affected by the photoperiod (0/24, 2/22, 4/20, 8/16, and 16/8 h), the number of leaflets (0, 2, and 4 leaflets) of the cuttings and their interaction. The survival rate was the highest in the 16-h day length and 4 leaflets. By considering survival rate and shooting rate with energy efficiency, the 8-h day length and 2 or 4 leaflets were judged to be the most effective.

The Impact of Perception of Entrepreneurial Opportunity on the Entrepreneurial Intention: Focusing on Positive Psychological Capital (창업기회인식이 창업의도에 미치는 영향에 관한 탐색적 연구: 긍정심리자본의 매개효과를 중심으로)

  • Jang, Hyeon Cheol;Kim, Jong Sung
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
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    • v.16 no.6
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    • pp.43-55
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    • 2021
  • Recently, as the domestic job problem has become serious, government ministries are investing a lot of budgets to encourage startups by prospective entrepreneurs. What is important to the success of startups is the recognition of various startup opportunities before starting a startup, and the experience through trial. However, in reality, prospective entrepreneurs recognize and seek various startup opportunities through support such as startup education and initial commercialization funds through various government supported projects, but it is difficult to actually start a business. Previous studies have revealed that the recognition of entrepreneurial opportunities affects entrepreneurial intentions by various variables such as gender, but research is insufficient on what kind of black box exists between the recognition of entrepreneurial opportunities and entrepreneurial intentions. The purpose of this study is to emphasize the importance of positive psychological capital as a major method for improving the entrepreneurial intention, and to analyze exploratorily whether positive psychological capital plays a mediating role between the recognition of entrepreneurial opportunities and the entrepreneurial intention. As a result of the study, it was confirmed that the recognition of startup opportunities affects the intention to start a business, and positive psychological capital has a mediating effect between the recognition of the startup opportunity and the intention to start a business. This means that positive psychological capital is important in order to lead to actual entrepreneurial intentions after recognizing a startup opportunity. Therefore, in order to revitalize the startups of prospective entrepreneurs in the current startup ecosystem, it is necessary to prepare a plan to improve the recognition of startup opportunities and positive psychological capital.

Studies on the Differences of the Rice Tillering System and Yield Characteristics under the Different Cultivation Methods in Southern region of Korea I. Seedling Characteristics and Growth under the Different Nursing Methods and Time (남부지방에서 벼 재배형태별 분얼체계 및 수량구성형질의 차이에 관한 연구 I. 묘종류와 육묘시기에 따른 묘소질 및 본답 생육의 변화)

  • Kim, Yong-Jae;Shin-Hae-Ryong;Chang, Gang-Yeon
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.37 no.3
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    • pp.230-236
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    • 1992
  • To study the effects of different nursing methods and transplanting on the growth of the rice plant(Oriza sativa L.hn southern region of Korea, Kumo-byeo, Palgong-byeo and Dong-jinbyeo were transplanted from April 20 to July 20 with 15 days intervals as 8 days seedling (infant rice), 25 days box seedling for machine transplanting and 45 days conventional seedling, respectively. No. of leaves at transplanting were in order of 45 days seedling>25 days seedling>8 days seedling. In 25 days seedling, they were increased as transplanting dates were later from April 20 to June 5, and in 45 days seedling, it showed same tendency until June 5 with Dongjinbyeo, June 20 with Palgong-byeo and Kumo-byeo. Root activity according to the $\alpha$-naphthylamine oxidation activity and rooting activity were higher in order of 8 days seedling>25 days seedling>45days seedling. Panicle formation initiated after maximum tillering stage as transplanting at April 20 with 8 days seedling and 25 days seedling, but it intiated before maximum tillering stage as transplanting at July 20 in Kumo-byeo. and in Palgong-byeo intiations of panicle formation were shown after maximum tillering stage as transplanting until May 20, but June 5 in Dongjin-byeo. However, there was no significant tendency with 45 days seedling. Missing hill ratio were less than 5% as transplanting with 8 days seedling and 25 days seedlingregardless of transplanting periods or varieties.

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Rice Seedling Establishment for Machine Transplanting V. Effect on Endosperm Weight Change on the Seedling Growth and Regrowth After Transplanting (수도기계이앙 육묘에 관한 연구 -제5보 상자육묘시 배유양분의 소모가 묘생육 및 활착에 미치는 영향-)

  • Yun, Yong-Dae;Park, Seok-Hong
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.29 no.1
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    • pp.25-30
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    • 1984
  • Rice seedlings were raised in seedling box for rice transplanter at the temperatures of 32$^{\circ}C$ (day/1$0^{\circ}C$(night) and $25^{\circ}C$/1$0^{\circ}C$ in a phytotron. The endosperm materials were consumed more rapidly at the high temperature (32/1$0^{\circ}C$) than at the low temperature (25/1$0^{\circ}C$) and thus the leaf development was proloted at the high temperature for 15 days from the sowing. But at 35 days after sowing more leaves were developed at the low temperature than the high temperature. The short cotyledon length(5mm) before sowing was more available for the leaf development than the long cotyledon(20mm) because the endosperm materials of the former were consumed slowly. The residual of 10% endsoperm materials, when seedling age was of 2.0 to 2.1, promoted the regrowth of seedlings after machine transplanting.

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Simulation-based Design Validation and Alternatives Analysis of Release Process of Logistics Automation Warehouse (시뮬레이션을 활용한 물류 자동화 창고의 출고 프로세스 설계 검증 및 대안 분석)

  • Moon-Gi Jeong;JongPil Kim;JinSung Park;Kyung-Min Seo
    • Journal of the Korea Society for Simulation
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    • v.32 no.3
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    • pp.75-91
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    • 2023
  • As the business-to-customer (B2C) online market expands after the COVID-19 pandemic, the logistics industry has been constructing automated warehouses to handle multi-product, low-volume logistics. When constructing a logistics automation warehouse, it is crucial to validate that the facility's performance and operational logic are designed to meet the required throughput of the automated warehouse from the system design phase. This study proposes simulation-based validation and optimal alternatives for an H logistics automation warehouse in Iksan, Jeollabuk-do. Firstly, we focused on the box supply and packing processes, which are related to the release process, among the entire logistic processes. Then, we analyzed the potential bottlenecks in the target process and designed and implemented a discrete-event simulation model based on the analysis results. The simulation experiments showed that the facility parameters and operational logic identified in the system design phase did not satisfy the performance requirements of the entire automated warehouse. Additional experiments were conducted to suggest alternatives to meet the system performance requirements by changing the facility parameters and operational logic. We expect that the proposed study will be utilized in the future, not only in the system design phase but also in the system construction phase, for verification purposes to ensure that the construction proceeds according to the design.

Matching Analysis between Actress Son Ye-jin's Core Persona and Audience Responses to Her Starring Works (배우 손예진의 코어 페르소나와 주연 작품에 대한 수용자 반응과의 정합성 분석)

  • Kim, Jeong-Seob
    • Journal of Korea Entertainment Industry Association
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    • v.13 no.4
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    • pp.93-106
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    • 2019
  • Persona is an actor's external ego constructed by playing various roles, and his/her another self-portrait in the eyes of the audience. This study was conducted to analyze persona identity containing core persona(CP) and to gain implications for the growth strategy of the actress Son Ye-jin called "melo queen" by verifying consistency between the CP and audience responses to her starring works of the past. According to the related theories and models, the persona was firstly set as image, visuality, personality and consistency, and it was used to extract and sort descriptive texts about Son related news articles in the last 5 years of the six major Korean newspapers using the content analysis method. After that, we analyzed the number of viewers of her movies and the audience share of her dramas by genre. As a result, Son's persona components were found to have a proportion for 54.2% images (34.0% for melo and romance images, 20.2% for non-melo and romance images), 25.6% for visibility, 13.8% for consistency, and 6.4% for personality. Her CP was derived from a melo and romance image. Comparing this with the audience reaction, the melo romance genre dominated and showed consistency in the drama, but in the case of the film, the non-melo romance was dominant and did not match each other. The results were attributed to a wide gap between dramas and movies in terms of key viewers, box office factors, degree of genre hybridity and experimentality. Therefore, Son should actively use her CP in the drama and challenge the various roles in order to expand her persona spectrum in the film.