• Physical Therapy Korea
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• v.16 no.4
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• pp.31-36
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• 2009

Hemiplegia-induced immobilizatoin and reduction of mechanical loading in chronic stroke limbs are common cause of disuse osteoporosis. The purpose of this study was to investigate the effects of asymmetrical weight bearing on the loss of bone mineral in the individual with chronic stroke. Sixteen hemiplegic patients with strokes were evaluated. The measurements of bone mineral density (BMD) were evaluated with the quantitative ultrasound system on the calcaneus region of the paretic and non-paretic side. Plantar pressure was measured using the Mat-Scan system. The paretic side showed significantly smaller values in the T-score of BMD, and peak value of plantar pressure, which included forefoot, midfoot, and hindfoot, than the non-paretic side (p<.05). Results from the pearson correlation analysis showed statistically significant correlation between the BMD difference and the peak-pressure difference of midfoot pressure (p<.05). This finding indicated that BMD loss depended on decrease of body weight born on the paretic leg.

• Korean Journal of Community Nutrition
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• v.15 no.3
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• pp.403-414
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• 2010

Reducing women's bone mineral density (BMD) has close relationship to risk in osteoporosis. This study was carried out to identify bone density risk factors affecting women's BMD, and to analyze the relationship of age, between BMD and menopause, BMI, blood pressure lifestyle and dietary habits for bone health by physical measurement and questionnaires. The study subjects, 128 women living in Seoul, were divided into 4 age group; 30~39 years (17), 40~49 years (54) and 50~59 years (36) and 60~69 years (21). There were significant differences in mean height, BMI, systolic blood pressure, menache and menopause age and menopause ratio and BMD T-score among the 4 age groups. BHD was significantly decreased according to increasing age and BMI and menopause. The rate of BMD risk subjects was significantly different increasing with age and BMI. The rate of risk group were 0%, 13%, 22.2% and 71.4%, by age groups and 0%, 16.2%, 33.3% and 52.9% by BMI respectively. BMD of menopause groups was significantly decreased from 1.23 (40 years) to 1.34 (60 years). p < 0.001. Also systolic blood pressure were significantly increased from 116.5 mmHg (30 years) to 130.81 mmHg (60 years). The T-score of normal group also decreased significantly from 1.27 to 0.13 (60years) with age. There were significant negative correlation between BMD and age (r = -0.409) menopause (r = -0.346), BMI (r = -0.218) systolic blood pressure (r = -0.193), salty taste eating out (r = -0.185) (p < 0.05). There were significant positive correlation between BMD and meat fish and walking time. In conclusion, bone density decreased with age. Most of the 50 years' subjects were in risk group. BMI, menopause, systolic blood pressure, frequency alcohol consuming. To prevent osteoporosis, over 40 years needed to be educated to maintain normal weight and the improvement of eating and living habits.

• Journal of Yeungnam Medical Science
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• v.14 no.2
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• pp.383-392
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• 1997

To study the differences of bone mineral density according to the gestational ages and the birth weight and get a reference data for the diagnosis of metabolic bone diseases in the newborn infants, bone mineral densities of the lumbar vertebrae were measured in fifty-three newborn infants born at Yeungnam University Hospital from March 1, 1995 to February 28, 1997, whore gestational ages were between $28^{+3}$ and $41^{+3}$ weeks and who had no intrauterine growth retardation, using dual energy X-ray absorptiometry (X-R 26, Norland, USA) within seven days of life. 1. There was no sexual difference in bone mineral density. The bone density increased significantly as gestational age increased from $0.149{\pm}0.009g/cm^2$ at 28-30wks to $0.229{\pm}0.034g/cm^2$ at 39-41wks of gestational age (p<0.05), but there was no significant difference between bone mineral densities at 33-34 wks and 35-36wks. There was positive linear correlation between gestational age and bone mineral density ($Y=7.5{\times}10^{-3}X-0.082$, r=0.7018, p<0.001). 2. The bone mineral density increased significantly as the birth weight increased from $0.158{\pm}0.020g/cm^2$ in 1,000-1,499 g to $0.251{\pm}0.021g/cm^2$ in 3,500-4,000 g of the birth weight (p<0.05), but there was no significant difference between bone mineral densities in 1,000-1,499 g and 1,500-1,999 g of the birth weight. There was positive linear correlation between the birth weight and the bone mineral density ($Y=3.9{\times}10^{-5}X+0.093$, r=0.7296, p<0.001). There were positive correlations between the bone mineral density and gestational age, and between the bone mineral density and the birth weight. It can be used as a reference data for the further study on the bone mineral metabolism in the newborn infants including preterm babies.

• The Korean Journal of Food And Nutrition
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• v.18 no.1
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• pp.72-80
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• 2005

To prevent and treat the osteoporosis, diverse therapies have been applied, which is still need to solve negative side effects. We investigated the effects of the extract from alternative medicine(AM) on the progress of bone loss in ovariectomized-rats fed with Ca-deficient diet for 7 or 14 weeks. Ovariectomy(OVX) concomitant with Ca-deficiency caused bone loss evidently decreased in bone mineral density and bone strength of femoral epiphysis and vertebrae, which were ameliorated with administration of AM extract. Also, the effect of AM extract on the biochemical markers were measured. The increased serum alkaline phosphatase caused by OVX and Ca-deficiency were observed, which were not affected by administration of AM extract. Administration of AM extract may have preventive effect on the elevated serum acid phosphatase concentrations caused by OVX and Ca-deficiency at 14 wks, implicating that AM extract possibly acts toward reducing born resorption, even though the results were not statistically significant. Serum osteocalcin and urinary deoxypyridinoline, the markers of bone turn over, were not changed by estrogen deficiency or AM extract. We concluded that the AM extract treatment had potently preventive effects on the decreased bone density and bone strength induced by OVX and Ca-deficiency. The changes of biochemical markers related to the effect of AM extract were not manifested but it still suggest that AM extract may inhibit the bone resorption derived from OVX and Ca-deficiency.

• Korean Journal of Pharmacognosy
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• v.44 no.3
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• pp.257-262
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• 2013

Osteoporosis is a disease of bones that leads to an increased risk of fracture. In osteoporosis, the bone mineral density is reduced, bone microarchitecture deteriorates, and the amount and variety of proteins in bone are altered. $It^{\circ}{\emptyset}s$ caused by the imbalance between born resorption and born formation. Recently natural products from plants have been extensively studied as therapeutic drugs to treat and prevent various diseases. Wheat bran is the hard outer layers of wheat grain and produced as a by-product of milling in the production of refined grains. In oriental medicines, Bu So Maek (Tritici Immaturi Semen) with wheat bran has been used as bronchitis, sedatives and anti-sweating effects. However effects of wheat bran butanol fraction (WBB, 50 ${\mu}g/ml$) in osteoclast differentiation remains unknown yet. Thus we investigated the effects of WBB on RANKL induced osteoclast differentiation. WBB inhibited osteoclast differentiation by downregulating the RANKL-induced activations of MAP kinases. Moreover mRNA expression of osteoclast-mediating molecules such as c-Fos, NFATc1 and DC-STAMP were attenuated by WBB during osteoclast differentiation. The finding of this study show that WBB and its components might prevent osteoclast-related bone loss.