Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Inhibition of Osteoclast Differentiation by Wheat Bran Butanol Fraction

밀기울 부탄올 분획물이 파골세포의 분화억제에 미치는 효과

  • Moon, Jung Sun (Department of Pharmacy, College of Pharmacy, Sahm Yook University) ;
  • Moon, Seung-Hee (Laboratory of Translational Therapeutics, Pharmacology Research Center, Division of Drug Discovery Research, Korea Research Institute of Chemical Technology) ;
  • Shim, Bo Won (Department of Pharmacy, College of Pharmacy, Sahm Yook University) ;
  • Kang, Tae Jin (Department of Pharmacy, College of Pharmacy, Sahm Yook University) ;
  • Lee, Sookyeon (Korea Re-Creation Institute of Phytochemicals, College of Pharmacy, Sahm Yook University) ;
  • Yim, Dongsool (Department of Pharmacy, College of Pharmacy, Sahm Yook University)
  • 문정선 (삼육대학교 약학대학 약학과) ;
  • 문성희 (한국화학연구원 신약연구본부) ;
  • 심보원 (삼육대학교 약학대학 약학과) ;
  • 강태진 (삼육대학교 약학대학 약학과) ;
  • 이숙연 (삼육대학교 약학대학 한국약식동원연구소) ;
  • 임동술 (삼육대학교 약학대학 약학과)
  • Received : 2013.08.01
  • Accepted : 2013.09.10
  • Published : 2013.09.30
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Abstract

Osteoporosis is a disease of bones that leads to an increased risk of fracture. In osteoporosis, the bone mineral density is reduced, bone microarchitecture deteriorates, and the amount and variety of proteins in bone are altered. $It^{\circ}{\emptyset}s$ caused by the imbalance between born resorption and born formation. Recently natural products from plants have been extensively studied as therapeutic drugs to treat and prevent various diseases. Wheat bran is the hard outer layers of wheat grain and produced as a by-product of milling in the production of refined grains. In oriental medicines, Bu So Maek (Tritici Immaturi Semen) with wheat bran has been used as bronchitis, sedatives and anti-sweating effects. However effects of wheat bran butanol fraction (WBB, 50 ${\mu}g/ml$) in osteoclast differentiation remains unknown yet. Thus we investigated the effects of WBB on RANKL induced osteoclast differentiation. WBB inhibited osteoclast differentiation by downregulating the RANKL-induced activations of MAP kinases. Moreover mRNA expression of osteoclast-mediating molecules such as c-Fos, NFATc1 and DC-STAMP were attenuated by WBB during osteoclast differentiation. The finding of this study show that WBB and its components might prevent osteoclast-related bone loss.

Keywords

References

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