• 한국임상약학회지
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• 제29권2호
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• pp.133-137
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• 2019

Atorvastatin is one of the most widely prescribed medications for dyslipidemia treatment. In Korea, post combined therapy with ezetimibe, a 73-year-old woman was reported by a community pharmacy to have experienced visual field defect, which recovered after drug discontinuation. She had never experienced this symptom before, and several studies have reported an association between use of statins and visual disorders such as blurred vision, diplopia, and cataract. Blockage of cholesterol accumulation, oxidative stress, or myopathy is expected to be a cause of this symptom. Naranjo scale, Korean causality assessment algorithm (Ver.2), and World Health Organization-Uppsala Monitoring Center (WHO-UMC) criteria were the three tools used to determine causality between the visual disorder and atorvastatin. The results represent 'probable', 'certain', and 'probable/likely' causality, respectively. Our results, in combination with a review of literature, indicate that ocular adverse effects are highly likely related to atorvastatin.

• Journal of Information Processing Systems
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• 제18권3호
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• pp.319-331
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• 2022

The capability to examine an X-ray image is so far a challenging task. In this work, we suggest a practical and novel algorithm based on image fusion to inspect the issues such as background noise, blurriness, or sharpness, which curbs the quality of dual-energy X-ray images. The current technology exercised for the examination of bags and baggage is "X-ray"; however, the results of the incumbent technology used show blurred and low contrast level images. This paper aims to improve the quality of X-ray images for a clearer vision of illegitimate or volatile substances. A dataset of 40 images was taken for the experiment, but for clarity, the results of only 13 images have been shown. The results were evaluated using MSE and PSNR metrics, where the average PSNR value of the proposed system compared to single X-ray images was increased by 19.3%, and the MSE value decreased by 17.3%. The results show that the proposed framework will help discern threats and the entire scanning process.

• Journal of Dental Anesthesia and Pain Medicine
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• 제22권3호
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• pp.227-231
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• 2022

Although rare, complications can occur with anesthetic procedures. The posterior superior alveolar nerve (PSAN) block anesthetic technique has a high success rate, but positive aspiration can cause bruising, transient diplopia, blurred vision, and temporary blindness in approximately 3% cases. When edema occurs, it is occasionally massive, especially in the infratemporal fossa, and the resulting hematoma is usually unsightly. A 20-year-old woman presented with massive edema followed by hematoma in the upper right jaw immediately after PSAN block administration, which subsequently spread to the oral mucosa. The patient did not report any complications during the anesthetic procedure. However, after the injection was administered, the patient experienced anesthetic sensations, which rapidly evolved to facial edema. There was mild pain, but without intraoral or extraoral bleeding. The patient was prescribed medicines and instructed to perform contrast therapy. Although hematomas and edema are rare, they are difficult to prevent. The choice of local anesthetic and appropriate application of the anesthetic technique can minimize their occurrence.

• Journal of Preventive Medicine and Public Health
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• 제28권2호
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• pp.433-449
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• 1995

The study subjects in this study are 295 workers who work on one electronics industry, and they were composed of 93 VDT and 202 non-VDT workers. This study was carried out to obtain the prevalence of subjective symptoms and to compare psychological symptom scores from SCL-90-R between VDT and non-VDT work groups. And to verify the relationship between VDT work related symptoms and psychological symptoms, the author compared SCL-90-R T scores between symptom complaining and non-complaining groups. The results are summarized as follows : 1. Throughout the prevalence study of VDT work related symptoms according to VDT work state, the author could select the final 10 symptoms by sex;'eye fatigue', 'foggy vision', 'neck discomfort or pain', 'shoulder discomfort and pain', 'light headedness', 'dizziness', 'acne', 'itching sensation on face', 'difficulty in concentration', 'memory disturbance' in males, and 'blurred vision', 'foggy vision', 'neck discomfort or pain', 'shoulder discomfort and pain', 'abdominal distention', 'indigestion', 'acne', 'prickling sensation on face', 'difficulty in concentration', 'memory disturbance' in females. 2. Throughout comparison of psychological symptom scores from SCL-90-R between VDT and non-VDT workers, except 'Interpersonal sensitivity' in female, Mean T score were higher in VDT workers, but not significantly different between the two groups. These results indicate that the relation between VDT work status and psychological symptoms are not strongly correlated. 3. Because of the nonspecific characteristics of VDT work related symptoms, from the 40 subjective symptoms, the author selected the final 10 symptoms by sex, especially correlated to VDT, and divided the study subjects into symptom complaining and non-complaining groups. The mean SCL-90-R T scores between the two groups were compared. Except for the opthalmologic symptoms in females, the scores were significantly different between the two groups in all symptoms. And this indicates that the VDT work related symptoms strongly correlated with the present individual psychological conditions. 4. Due to understand that which of the 9 psychological symptom dimensions are strongly correlated with the subjective symptoms, the author excuted muliple logistic regression analysis, and the result were as follows; 'depression' and 'somatization', in male, and 'obsessive-compulsive' and 'somatization' in female.

• Parasites, Hosts and Diseases
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• 제50권1호
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• pp.73-78
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• 2012

We report a case of intraocular gnathostomiasis diagnosed by western blot assay in a patient with subretinal tracks. A 15-year-old male patient complained of blurred vision in the right eye, lasting for 2 weeks. Eight months earlier, he had traveled to Vietnam for 1 week and ate raw wild boar meat and lobster. His best-corrected visual acuity was 20/20 in both eyes and anterior chamber examination revealed no abnormalities. Fundus examination showed subretinal tracks in the right eye. Fluorescein angiography and indocyanine green angiography showed linear hyperfluorescence of the subretinal lesion observed on fundus in the right eye. Ultrasound examination revealed no abnormalities. Blood tests indicated mild eosinophilia (7.5%), and there was no abnormality found by systemic examinations. Two years later, the patient visited our department again for ophthalmologic evaluation. Visual acuity remained 20/20 in both eyes and the subretinal tracks in the right eye had not changed since the previous examination. Serologic examination was performed to provide a more accurate diagnosis, and the patient's serum reacted strongly to the $Gnathostoma$ $nipponicum$ antigen by western blot assay, which led to a diagnosis of intraocular gnathostomiasis. This is the first reported case of intraocular gnathostomiasis with subretinal tracks confirmed serologically using western blot in Korea.

• 한국정보통신학회논문지
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• 제15권4호
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• pp.957-964
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• 2011

영상 안정화(image stabilization)는 흔들림이 있는 영상을 영상처리 기법으로 안정화 시키는 과정을 말한다. PA(projection algorithm)기법을 이용한 디지털 영상 안정화는 쉽게 글로벌 모션을 얻을 수 있어 많이 연구가 되어 왔다. PA기법은 실현이 간단하고 속도가 빠른 장점이 있지만 고정된 탐색범위를 사용함으로 탐색범위를 초과한 떨림을 안정화 시킬 수 없고 또한 큰 떨림을 안정화 하기위하여 탐색범위를 크게 하면 모션 추적에 참여하는 블록이 작아져 적확한 글로벌 모션을 얻지 못하게 된다. 본 논문에서는 기존의 PA기법의 단점을 해결하기 위하여 여러 가지 흔들림의 크기에 절용할 수 있는 IPA(Iterative Projection Algorithm)기법을 제안하여, 차량에서 찍은 연속된 영상 1000프레임에 적용하였을 때 기존의 알고리즘을 사용하고 서로 다른 탐색범위를 사용한 결과보다 PSNR이 최저 6.8%, 최고 28.9% 향상 되었다.

• 한국안광학회지
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• 제3권1호
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• pp.75-86
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• 1998

18세에서 27세 사이의 남자 82명 여자 70명 총 152명을 대상으로 2시간 동안 쉬지 않고 VDT작업을 하도록 한 후, 안구 및 전신증상 등을 조사하고 시력, 타각적 굴절이상, 조절력 상위량 등을 측정한 결과, 안구증상으로는 눈의 피로를 느끼는 사항이 45.71%로 가장 많았고, 시기능 이상으로는 물체가 흐려 보이는 경우가 80.39%, 전신증상으로는 어깨가 아픈 사람이 33.33%로 가장 높게 나타났다. 시력변화는 평균나안시력 0.47에서 0.42로 약 10%가 저하했으며 타각적 굴절이상은 0.10D정도 근시도가 증가했다. 조절력은 7.46D에서 6.74D로 약 0.72D 정도 줄었고, 조절용이성은 2.27초에서 2.50초로 0.23초만큼 지연되었다. 실성상대조절량은 4.76D에서 4.16D로 0.50D만큼 감소했고 허성상대조절량은 2.46D에서 2.33D로 0.13D 만큼 줄었다. 사위량은 평균 $1.82{\Delta}$ B.O.에서 $3.24{\Delta}$ B.O.으로 내 사위량이 증가했다.

• The Korean Journal of Pain
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• 제18권2호
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• pp.218-221
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• 2005

This report describes a case of dizziness in a patient with trigeminal neuralgia that was caused by a vestibular schwannoma. A 60-year-old man with a history of pain on his left cheek, chin, molar and tongue for 5 months was diagnosed as suffering with trigeminal neuralgia of the left mandibular nerve, and this was caused by a left vestibular schwannoma. The diagnosis of the tumor was confirmed with magnetic resonance imaging (MRI), and so gamma knife surgery was performed 1 month later. At that time, the patient had been referred to the pain clinic due to allodynia on the tongue and gingival, and hypesthesia was also present on the left half of the face. Trigeminal nerve block with dehydrogenated alcohol and stellate ganglion block with 1% mepivacaine were performed and oral medication with diphenylhydantoin was started. The symptoms were alleviated after nerve block and oral medication. Dizziness, blurred vision and ataxia then developed from the 13th hospital day. We considered the symptoms as a side effect of diphenylhydantoin and we reduced the dose of diphenylhydantoin. However, the symptoms grew worse. Another brain MRI showed a slight increase of the tumor size and a mass effect with displacement of the adjacent organs, and hydrocephalus was also noted. This case shows the importance of considering the secondary symptoms that are due to brain tumor while treating trigeminal neuralgia. The changes of the brain tumors should also be considered along with the presence of new side effects.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1531-1533
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• 2016

Background: Polycythaemia rubra vera (PV) is a Philadelphia chromosome negative myeloproliferative neoplasm characterized by increased red cell production, independent of the mechanisms that regulate normal erythropoiesis. The aim of this study was to analyze the clinico-epidemiological profile of Pakistani patients with PV. Materials and Methods: In this retrospective cross sectional study, 26 patients with PV were enrolled from January 2010 to December 2014. They were diagnosed based on WHO criteria. Results: The mean age was $53.4{\pm}9.31years$ (range 36-72) and the male to female ratio was 2:1. Overall 30.7% of patients were asymptomatic. In symptomatic patients, major complaints were headache (30.8%), abdominal discomfort (23.1%), blurred vision (15.3%), pruritus (11.5%) and vascular incidents (11.5%). Physical examination revealed plethoric face and splenomegaly as predominant findings, detected in 34.6% and 30.7%, respectively, with the mean splenic span of $15.9{\pm}2.04cm$. The mean hemoglobin was $18.1{\pm}1.9g/dl$ with the mean hematocrit of $55.6{\pm}8.3%$. The mean total leukocyte count was $12.8{\pm}7.1{\times}10^9/l$ and the platelet count $511{\pm}341.9{\times}10^9/l$. Mean erythrocyte sedimentation rate was $3.5{\pm}1.22mm/hr$. Serum lactate dehydrogenase, serum creatinine and uric acid were $552.7{\pm}309.2$, $0.8{\pm}0.17$ and $6.60{\pm}1.89$ respectively. Conclusions: PV in Pakistani patients, unlike in the West, is seen in a moderately young population. The disease is frequently seen in male gender and primarily patients present with symptoms related to hyperviscosity.

• Journal of Korean Neurosurgical Society
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• 제53권5호
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• pp.312-315
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• 2013

Aspergillosis in the central nervous system (CNS) is a very rare disease in immune-competent patients. There was a case of a healthy man without a history of immune-compromised disease who had invasive aspergillosis with unusual radiologic findings. A 48-year-old healthy man with diabetes mellitus, presented with complaints of blurred vision that persisted for one month. Brain magnetic resonance imaging (MRI) showed multiple nodular enhancing lesions on the right cerebral hemisphere. The diffusion image appeared in a high-signal intensity in these areas. Cerebrospinal fluid examination did not show any infection signs. An open biopsy was done and intraoperative findings showed grayish inflammatory and necrotic tissue without a definitive mass lesion. The pathologic result was a brain abscess caused by fungal infection, morphologically aspergillus. Antifungal agents (Amphotericin B, Ambisome and Voriconazole) were used for treatment for 3 months. The visual symptoms improved. There was no recurrence or abscess pocket, but the remaining focal enhanced lesions were visible in the right temporal and occipital area at a one year follow-up MRI. This immune-competent patient showed multiple enhancing CNS aspergillosis in the cerebral hemisphere, which had a good outcome with antifungal agents.