• Journal of Applied Biological Chemistry
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• 제63권1호
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• pp.69-74
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• 2020

The fruit, leaves, and roots of Elaeagnus multiflora Thunb. have been used in traditional Chinese medicine to treat cough, diarrhea, and itching. However, the anti-fatigue effects of E. multiflora fruit (EMF) extract have not been studied in detail. The aim of this study was to examine the effect of EMF on fatigue and exercise performance in BALB/c mice. EMF was orally administered to mice at four doses (10, 50, 100, and 200 mg/kg/day) for 2 weeks. The anti-fatigue activity was evaluated by determining the exhaustive swimming time. Blood lactate and glucose levels and serum lactate levels after a 10 min swimming time, as well as ammonia, creatine kinase (CK), blood urea nitrogen (BUN), lactate dehydrogenase (LDH), and glycogen contents after exhaustive swimming time were measured. The exhaustive swimming time of the EMF 200 group was significantly increased (p <0.01). The EMF groups showed significantly low levels of CK, BUN, LDH, and lactate compared with the control group (p <0.05). Increased liver glycogen was observed in the EMF 200 group (p <0.05). These results suggest that EMF can be utilized as an efficacious natural resource for its anti-fatigue effects.

• 대한한의학방제학회지
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• 제9권1호
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• pp.11-34
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• 2001

1. Crinical applicational of Sagoonjatang are frequently used in internal disease, G.I.T(Gastro Intestianl Tract) disease, chronical fatigue, athma, etc. 2. Sagoonjatang adjacent prescriptions in pathological organs are the stomach, the spleen, the kidneys, the heart, the lungs. 3. Sagoonjatang partake chronic fatigue disease, G.I.T disease, pulmonary disease, brain blood barrier disease, infertility, vomiting of pregnancy, sedation of brain, healing mechanism, sweating regulation, urination, peripheral blood ciraculation, electrolyte blance, etc.

• 한국전문물리치료학회지
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• 제12권2호
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• pp.90-97
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• 2005

By measuring changes in blood lactate and plasma enzyme (CPK, GOT, GPT) with electrical stimulation applied at two duty cycles, this study is intended to look into which type of duty cycle may have more effects on blood lactate and plasma enzyme constituents through animal experiment so as to determine any duty cycle appropriate for electrical treatment. In this study, electrical stimulation was applied to total 20 Korean house rabbits (weight: 3~3.5 kg) by means of an electrical therapeutic apparatus called TS6000 (made in Netherlands) at duty cycle of 50% and 20% respectively for 30 minutes. Here, 5 cc of blood was collected from their carotid artery before stimulation and in 30 minutes after stimulation respectively to carry out biochemical experiment and analysis. As determined through the above experiment, blood lactate rate was increased to 333.07% at 50% duty cycle after experiment and 185.71% at 20% duty cycle after experiment respectively. In both cases, blood lactate rate was significantly increased to higher level after electrical stimulation than before. Moreover, the rate of change in the average of blood lactate rate at both duty cycles also showed significant differences. CPK rate was boosted to 301.82% at 50% duty cycle after experiment and 321.35% at 20% duty cycle after experiment respectively. In both cases, CPK rate was remarkably boosted to higher level after stimulation than before (p<.05). However, there was not any significant difference in the rate of change in average CPK at both duty cycles (p<.05). GOT rate was significantly boosted up to 38.97% at 50% duty cycle after experiment (p<.05), while it was slightly increased to 1.68% at 20% duty cycle after experiment without any significant difference. Rather, GPT rate dropped slightly at both duty cycles after experiment, but there was not any significant difference. Although blood lactate and GOT were relatively less generated at 20% duty cycle after electrical stimulation than at 50% duty cycle, the change of duty cycle didn't have any significant influence on CPK rate. In this regard, this study failed to come any consistent conclusion about the association between change of duty cycle and muscle fatigue. Therefore, it is advisable that follow-up studies seek various ways to a little more effectively apply electrical stimulation to laboratory animals by avoiding their muscle fatigue. GOT rate was significantly boosted up to 38.97% at 50% duty cycle after experiment (p<.05), while it was slightly increased to 1.68% at 20% duty cycle after experiment without any significant difference. Rather, GPT rate dropped slightly at both duty cycles after experiment, but there was not any significant difference. Although blood lactate and GOT were relatively less generated at 20% duty cycle after electrical stimulation than at 50% duty cycle, the change of duty cycle didn't have any significant influence on CPK rate. In this regard, this study failed to come any consistent conclusion about the association between change of duty cycle and muscle fatigue. Therefore, it is advisable that follow-up studies seek various ways to a little more effectively apply electrical stimulation to laboratory animals by avoiding their muscle fatigue.

• Animal Bioscience
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• 제36권2호
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• pp.307-314
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• 2023

Objective: Chicken essence and branched chain amino acid (BCAA) supplementation has been recognized to significantly relieve fatigue. To obtain chicken essence with high amounts of BCAA, spent hens herein was used to prepare dripped chicken essence (SCE) and compared with commercial dripped chicken essence (CCE) for in vivo anti-fatigue effect. Methods: To determine the effect on anti-fatigue by dripped chicken essence, the exhaustive swimming was performed. Thirty-two 7-week ICR mice were divided into four groups, which included the control group (CG), CCE, SCE-1X and SCE-2X. The mice were given daily oral administration (0.012 mL/g body weight/d). The fatigue index analysis was conducted weekly. Results: The results showed that SCE had a higher BCAA level as expected, and mice treated with dripped chicken essence (CCE and SCE) could significantly improve exercise performance. The lower blood lactate level, blood urea nitrogen level and creatine phosphokinase activity were found in the supplement of SCE group compared with the CCE group, which suggested that the SCE possessed strong anti-fatigue ability. This could possibly be due to the higher content of BCAA. Conclusion: In this study, SCE promoted recovery from physical fatigue in mice and elevated endurance ability. Among them, the double dose (SCE-2X) showed the strongest anti-fatigue ability. Taken together, spent chickens could be a good source of chicken essence to improve the effect of anti-fatigue.

• Journal of Korean Biological Nursing Science
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• 제20권3호
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• pp.187-195
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• 2018

Purpose: The purpose of this study was to identify associations among the sleep disturbance, fatigue, job stress, and blood and body fluid (BBF) exposure of shift-work nurses. Methods: A total of 299 shift-work nurses from two tertiary hospitals were enrolled in this study. We used the Insomnia Severity Index (ISI), and the Fatigue Severity Scale (FSS), and the Korean Occupational Stress Scale-Short Form (KOSS-SF) to evaluate sleep disturbance, fatigue, and job stress, respectively. The data were analyzed using t-test or chi-squared test and Logistic regression analysis using the SPSS 23.0 program. Results: We found that 43.8% of participants reported BBF exposure over the past year. Splash or exposure to broken skin of BBF were most frequent (56.9%), and followed by needlestick injuries (30.4%) and sharp injuries (12.8%). Age, hospital, working period, level of stress, sleep disturbance ($ISI{\geq}15$), fatigue (FSS $score{\geq}4$), job demand and organizational climate subset in KOSS-SF were significantly associated with BBF exposure in shift-work nurses. In multivariate analysis after adjusting age and hospital, the risk factors of BBF exposure in shift-work nurses were the level of stress and fatigue (FSS $score{\geq}4$). Conclusion: Fatigue and job stress were related to BBF exposure in shift-work nurses. Our results suggest that management of sleep disturbance, fatigue, and high job stress in shift-work nurses is needed to reduce risk of BBF exposure.

• 대한한의진단학회지
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• 제17권3호
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• pp.179-188
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• 2013

Objectives This study was designed to development the diagnosis indicators for the fatigue group without disease using analysis of questionnaire data. Methods The subjects were divided into three groups, the fatigue group with disease, the fatigue group without disease, non-fatigue group without disease. Thirteen kinds of questionnaire (Fatigue visual analogue scale, Fatigue severity scale, Pain visual analogue scale, Short-form McGill pain questionnaire score, Headache impact Test-6, Neck disability index, Oswestry low back pain disability questionnaire score, Blood stasis assessment scale, Physical activities questionnaire score, Beck depression inventory, Anger expression inventory score, Mood disability scale, Job stress scale) were carried out for the subjects. Results The results of this study are ; 1) The weight, the systolic and diastolic blood pressure were different among three groups. 2) Among nine questionnaires related to the physical or life conditions, the averages of eight questionnaires were not same one another. 3) Among four questionnaires related to the mental condition or autonomic nervous system, the averages of Beck depression inventory were not same one another. Conclusion The fatigue group without disease can be diagnosed through using the both the questionnaires related to the physical or life condition and the those related to the mental condition or autonomic nervous system.

• 한국운동역학회지
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• 제20권3호
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• pp.303-310
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• 2010

The purpose of this study was (a)to compare electromyographic (EMG) activities and physiological variables on the development of fatigue induced by ergometer test, (b)to determine investigate the differences in the stage of fatigue between the electromyographic characteristics and physiological variables. Nine male university students who have no musculoskeletal disorder were recruited as the subjects. The electromyographic characteristics(peak IEMG, average IEMG, median frequency, mean edge frequency) and physiological variables(HR, RPE, blood lactate) were determined for each stage(15, 30, 45, 60 minutes, all out). For each dependent variable, one-way analysis of variance(ANOVA) with repeated measures and correlation analysis were performed to test if significant difference existed(p<.05). The results showed that peak IEMG, average IEMG from low extremity and physiological variables were significantly increased during the all-out stage. EMG parameters in VL, VM show significantly correlation with physiological variables during whole stages. This indicated that IEMG values may be proper parameters to determine muscle fatigue rather than physiological variables.

• 생약학회지
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• 제47권3호
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• pp.258-263
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• 2016

In this study, we tested anti-fatigue effect of Kyung-Ok-Ko (KOK). We examined the exercise performance effects of KOK (600 mg/kg) at 2nd, 3rd and 4th week. The exercise performance of KOK treated group was significantly improved than that of vehicle control (VC) group on grip strength (2nd week), exhausted time of treadmill (3rd week) and exhausted time of weight loaded swimming (4th week). We also investigated the effects of KOK on the change of fatigue parameters in blood, skeletal muscle and liver after swimming exercise. KOK significantly reduced lactate level and enhanced glucose level in blood. Equally KOK significantly increased glycogen in skeletal muscle. However, the glycogen level of KOK in the liver was not significantly increased compared to VC group. These results show that supplementation of KOK may improve the anti-fatigue activity and exercise capacity.

• 대한물리치료과학회지
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• 제10권1호
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• pp.102-108
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• 2003

The purpose of this study was to determine the changes of skin temperature and subjective fatigue of the thoracic vertebrae by the chiropractic adjustments. Stimulation of the sympathetic nervous system will cause the changes in the skin blood flow which can be detected by measuring the skin surface temperature. This study was to see whether chiropractic adjustments could affect the activity of the sympathetic nervous system as reflected by changes in skin temperature of the thoracic. Skin temperature and subjective fatigue on 16 subjects was measured before, within 10 sec, 10min, 20min and 30 min after a thoracic adjustment with Digital Infrared Thermal Imaging(DITI) and Visual Analogue Scale(VAS). The adjustments consisted of a straight posterior-to-anterior high-speed, low-amplitude thrust to the transverse process of T3-T10 using a reinforced hypothenar contact. The average temperature and fatigue changed when the spine was considered as an entire unit. These results illustrate that the blood flow through the soft tissue can be affected by specific adjustments to the spine. This study might be served as an useful baseline data for the changes of the circulation and fatigue after the chiropractic adjustments.

• 생명과학회지
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• 제21권5호
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• pp.729-733
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• 2011

본 연구에서는 두 가지 투여그룹을 비교하여 ergogenic aid로서 D-ribose의 효과를 운동영양학적으로 규명하는데 그 목적이 있었고, 이를 위하여 2,000 m 조정운동 전, 운동종료 직후, 그리고 운동 종료 후 회복기 30분의 변화를 연구하였으며, 다음과 같은 결론을 얻었다. 첫째, 투여그룹에 따른 2,000 m 조정운동 수행력의 차이는 없었으며 둘째, 투여그룹에 따른 젖산과 암모니아 수치의 차이도 나타나지 않았다. 셋째, 회복 30분에서 무기인산은 PS에 비해서 RS투여그룹의 수치가 더 낮게 나타났으며, 마지막으로 회복 30분에서 hypoxanthine의 축적은 PS투여그룹에 비해 RS투여그룹의 수치가 더 낮게 나타났다. 따라서, 7-8분 정도의 고강도 운동 시 운동기록의 단축에 D-ribose 구강투여의 효과는 없었지만, 휴식 기 피로회복에 긍정적인 효과를 줄 수 있을 것이라 사료된다.