• 생명과학회지
• /
• 제25권7호
• /
• pp.819-825
• /
• 2015

본 연구는 과당 위주의 스포츠음료 투여가 최대운동부하시 심폐기능과 젖산 및 염증반응에 미치는 영향에 대해 비교 분석하기 위해 실시되었다. 연구대상자는 D 대학교 체육학과 학생 8명으로 구성하였으며 실험시기를 2차로 나누어 스포츠 음료 투여 전과 투여 후 시기에 심폐기능과 젖산 및 염증반응 등을 비교 분석하였다. 본 연구의 결과 스포츠 음료 섭취 전과 섭취후 운동시간과 V0₂max, AT HRmax가 유의하게 증가하였고(p<0.05), 스포츠 음료 투여 후 회복기 20분에서 젖산 농도가 유의하게 감소되었다(p<0.05). 따라서 고강도 최대운동 전 과당위주의 스포츠 음료 투여는 운동지속시간을 늘려주고 VO₂max를 높여주며, 운동 후 피로물질인 젖산축적의 빠른회복에 도움을 줄 수 있는 것으로 사료된다. 비록 본 연구에서 염증 반응에 대한 효과를 완벽하게 규명하지는 못했지만 스포츠 음료 투여시 CRP의 농도가 감소하는 경향이 나타나 염증반응 개선에도 어느 정도 영향을 미칠 수 있을 것이라 생각된다. 추후 과당위주의 스포츠 음료투여시 염증 반응에 대한 다양한 운동 강도와 상황에서의 기전적 연구가 수행되어져야 할 것이다.

• 동의생리병리학회지
• /
• 제19권2호
• /
• pp.544-548
• /
• 2005

I studied on the influence of BUDDEUMI(moxa and cupping a boil) in the live blood condition and the favorable turn up a subjective symptom of chronic irritable bowel syndrome patient. The results are as follows : After the perform of BUDDEUMI, in the Erythrocyte Aggregation, the efficiency is 87%(3persons decrease and 10 persons destroy/15 persons). In the Rouleau, the efficiency is 78%(2persons decrease and 5 persons destroy/9 persons). In the Target Cells, the efficiency is 90%(3persons decrease and 6 persons destroy/10 persons). In the Ovalocytes, the efficiency is 88%(3persons decrease and 4 persons destroy/8 persons). In the Poikilocytes, the efficiency is 76%(1persons decrease and 2 persons destroy/4 persons). After the perform of BUDDEUMI, in the Cholesterol Crystals, the efficiency is 82%(3persons decrease and 6 persons destroy/11 persons). In the Atherosclerotic Plaque, the efficiency is 80%(2persons decrease and 2 persons destroy/5 persons). In the Chylous, the efficiency is 86%(3persons decrease and 9 persons destroy/14 persons). On the favorable turn up a subjective symptom, the efficiency of symptom of appetite and digestion is 91%(5persons turn up exceedingly favorable, 9 persons turn up favorable, 7 persons turn up good, 2 persons turn up invalid / 23persons). In the efficiency of symptom of fatigue and feeble is 85%(3persons turn up exceedingly favorable, 6 persons turn up favorable, 8 persons turn up good, 3 persons turn up invalid / 20persons). And the efficiency of symptom of abdominal swelling and displeasure is 88%(2persons turn up exceedingly favorable, 10 persons turn up favorable, 8 persons turn up good, 3 persons turn up invalid / 24persons). In the efficiency of symptom of abdominal pain is 88%(4persons turn up exceedingly favorable, 10 persons turn up favorable, 8 persons turn up good, 3 persons turn up invalid / 25persons). The efficiency of symptom of constipation and diarrhoea is 90%(5persons turn up exceedingly favorable, 9 persons turn up favorable, 6 persons turn up good, 2 persons turn up invalid / 22persons).

• 동의생리병리학회지
• /
• 제20권6호
• /
• pp.1678-1727
• /
• 2006

This study was perfromed to develop the assessment guideline and endpoints for clinical trial with anticancer herbal medicine. The botanical products used to humans for long time may be applied to phase 3 clinical trial after submitting the evidences for safety and efficacy of them or completion of basic requirement of phase 1 and phase 2 for safety confirmation and dose determination. Syndrome improvement was chiefly evaluated by Zubrod and karnofsky(%) methods. We suggest the general clinical trial assessment with botanical products, by following assessment points, that is, tumor size for 50 points, survival fate for 10 points, major syndromes for 40 points. It is recommendable that the each symptom of Qi deficiency syndrome, blood deficiency syndrome and Qi stagnation syndrome was allocated by assessment points, Similarly, the each symptom was given the assessment points according to the severity of symptom, for example, slight for 3 points, moderate for 2 points and severe for 1 point in hepatocelluar carcinoma and lung cancer. Then, the efficacy of botanical products was evaluated by the difference between pre-treatment and post-treatment. Asking the neoplastic patients of questionnaire on physical, emotional, cognitive, social and role subjects availability, three more syndromes (Fatigue, Pain and Nausea/Vomit), quality of life(QOL) will be evaluated by GLM statistics. In addition, in case of lung cancer, 13 questions will be asked by the EORTC QLQ-C13 forms. As the assessment of endpoints for efficacy to reduce side effects induced by chemotherapy and radiotherapy, the data of image scanning and hemato-urinalysis can be usefully applied on immune response, weight loss, indigestion, hemopoietic damage and injury of liver and kidney, while the changes of syndromes of side effect can be evaluated by differentiation methods of Qi and blood and five viscera. However, it is still necessary to determine the ratio between scientific analytical method and Oriental differentiation method as well as confirm the Oriental assessment endpoints by clinical trial. In addition, we suggest the continuous development of assessment endpoints on other carcinomas except of hepatocelluar carcinoma and lung cancer in future.

• 한방비만학회지
• /
• 제13권1호
• /
• pp.33-45
• /
• 2013

Objectives: This study was aimed to find out the characteristics of ordinary symptoms between the control and patient groups, diagnosed as overweight or obesity, in Soyang, Taeeum, and Soeum Constitutions and among those 3 groups. Methods: As a prospective cross-sectional study based on medical records, 9213 patients, who visited Kyung Hee University Medical Center from May in 2007 to June in 2010, were included. To diagnose the constitution, Revised Questionnaire for the Sasang Constitution Classification II and examinations by oriental medical doctors who majored in Sasang Constitution Medicine were performed. Based on the World Health Organization criteria for Asian obesity assessment, body mass index (BMI) was classified into 3 groups; more than 25 as obesity, 23 to 25 as overweight, and less than 23 as normal. Ordinary symptoms questionnaire, which consists of 46 questions in 8 categories, were given to the subjects. One-way ANOVA test in continuous variables and chi-square test in categorical variables were carried out to analyze statistical significance. Results and Conclusions: 1) In general characteristics, we could find out the significant differences in age, sex, height, weight, BMI, waist circumference, blood pressure, total cholesterol, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, fasting blood sugar, and hemoglobin A1c among the 3 Constitutional groups. 2) Soyang Constitution of overweight and obesity has tendency to have higher appetite, like cool or cold water, defecate more, swear more, dislike heat, and have warmer or hotter extremities in the ordinary symptoms, compared with the control group. 3) Taeeum Constitution of overweight and obesity has tendency to have higher appetite, like cool or cold water, defecate more, swear more, dislike heat, and have warmer or hotter extremities in the ordinary symptoms, compared with the control group. 4) Soeum Constitution of overweight and obesity has tendency to have higher appetite and less fatigue in the ordinary symptoms, compared with the control group. 5) Soeum Constitution showed the slightest increase in appetite, preference about room temperature water, less number of feces, and feeling of chill and warmer extremities in ordinary symptoms, compared with Soyang and Taeeum Constitutions. Taeeum Constitution showed the distinct increase in appetite and sweating in ordinary symptoms, compared with Soyang and Soeum Constitutions.

• 문화기술의 융합
• /
• 제5권3호
• /
• pp.359-367
• /
• 2019

본 연구는 알코올 분해 및 간 손상 보호, 피로회복, 체력증진 등의 효과가 있는 헛개과병추출물과 인삼열매 복합추출물의 섭취가 숙취해소에 미치는 효과를 규명하는데 목적이 있다. 20세 이상 자발적으로 참여한 64명을 대상으로 무작위배정과 반복측정설계방법을 이용하여 블록무작위배정을 통해 집단 별 인원을 구성하였다. 집단 구성은 헛개과 병추출물+인삼열매 복합추출물(ARI 1000) 투여군, 헛개과병추출물투여군, 인삼열매추출물 투여군, 위약군을 각각 16명을 구성하였다. 호흡기알콜농도 변화결과 ARI 1000 투여군이 음주 1시간에서 헛개과병추출물투여군, 인삼열매추출물 투여군, 위약군에 비해 유의하게 낮았으며, 음주 2시간, 3시간에는 위약군에 비해 유의하게 낮았다(p<0.05). 혈중 알코올 농도결과 음주 2시간, 3시간 후에 ARI 1000 투여군이 헛개과병추출물투여군, 인삼열매추출물 투여군, 위약군에 비해 유의하게 낮았다(p<0.05). 결론적으로 음주 전 ARI 1000 섭취는 호흡기와 혈중 알코올 농도를 유의하게 감소시켜 숙취효과에 효능이 있는 것으로 생각된다.

• 대한본초학회지
• /
• 제34권6호
• /
• pp.45-55
• /
• 2019

Objective : Diabetic gastroparesis is a complication that is defined as delayed gastric emptying and upper gastrointestinal symptoms and often occurs in long-standing diabetic patients. Bojungikgi-tang (BJT) is a traditional oriental herbal formula that has long been used for the treatment of digestive disorders. The purpose of this study was to investigate the effects of BJT on streptozotocin (STZ)-induced diabetic gastroparesis rat model. Methods : Sprague-Dawley (SD) male rats (250-270g) were divided into 13 groups including normal group, STZ-induced diabetic control group, BJT diet (7 various concentrations), and insulin-, glibenclamide-, metformin-treated group were used for the experiments for the comparison. Diabetic gastroparesis was induced by intraperitoneal injection of STZ. The water intake, food intake, body weights and fasting blood glucose levels were measured. After 4 weeks the animals were sacrificed and gastrin, leptin, insulin, hemoglobin A1C (HbA1c), lactate, lactate dehydrogenase (LDH), bilirubin, creatinine, albumin and lipid levels were evaluated. Results : Intraperitoneal injection of BJT for 4 weeks resulted in increased levels of gastrin in blood and decreased leptin and lactate concentration in STZ-induced diabetic gastroparesis rat model. BJT did not affect insulin, fasting glucose, HbA1c, and lipid levels in STZ-induced diabetic gastroparesis rat model. Conclusion : These results indicated that BJT would have protect effect on diabetic gastroparesis through the improvement effect of gastric motility and fatigue syndrome in STZ-induced diabetic rats. This study shows that BJT might be effective for treatment of diabetes and its complications such as gastroparesis.

• 한방비만학회지
• /
• 제16권1호
• /
• pp.70-77
• /
• 2016

고혈압으로 진단된 비만환자 6예에 10일간 감로수 절식요법을 시행한 결과 절식기 후 혈압은 평균 148/89 mmHg에서 119/79 mmHg로 수축기 혈압은 28.7 mmHg 감소(-19.39%) 하였고, 이완기 혈압은 10.3 mmHg 감소(-11.57%)하였다. 절식기 후 체중, 체질량지수, 체지방량, 체지방률은 각각 평균 -6.65%, -6.10%, -7.76%, -1.42% 감소하였다. 위의 증례결과로 보았을 때 감로수 절식요법은 비만, 고혈압환자에 적용하였을 때 체중감량과 더불어 혈압강하효과를 가져올 것으로 기대된다. 감로수는 절식요법을 진행할 때 생길 수 있는 문제점의 발생을 줄여 10일간 절식요법이 안정되게 진행할 수 있게 도움으로써 혈압강하효과를 증가시킨다.

• 대한간호학회지
• /
• 제26권4호
• /
• pp.903-916
• /
• 1996

The purpose of this study was to discover practical health problems which hemodialysis clients experienced so as to present basic data for development of a health assessment tool. The research subjects were 70 clients receiving hemodialysis in Seoul and Inchon from Mar. 1996 to Sep. 1996. Data were collected by researcher's informal indepth interview and nurses' open ended question. Content analysis was applied to collect similar contents and common experiences in order to derivate concepts and categories for better understanding of hemodialysis clients' experiences. As a result, 9 categories derivated to identify the health problems of clients receiving hemodialysis were as follows : 1) They experienced 'the decreased digestive function' which contained the changed appetite, nausea, vomiting, constipation and diarrhea. 2) They experienced 'the decreased respiratory and circulatory function' which contained dyspnea, changed blood pressure, tingling sensation and the fear of aggrevated vascular condition. 3) They experienced 'the aggrevated oral condition' which contained dry mouth and destruction of teeth and their soft tissue. 4) They experienced 'the decreased sensory function' which contained visual disturbances, sensation difficulty, and hearing loss. 5) They experienced 'the aggrevated skin condition' which contained dark brown skin color, dry skin (and hyperpigmentatic freckle, seborrheric keratosis, scale), itching sense, and alopethia. 6) They experienced 'the decreased urinary reproductive function' which contained anuria or oliguria, dysmenorrhea, sterility and decreased libido. 7) They experienced 'the restricted activity' which contained decreased activity, muscle cramp and stiffness of joint. 8) They experienced 'the changed mental status' which contained memory disturbance, decreased cognition, disorientation, neurosis and psychosis. 9) They experienced 'the aggrevated general condition' which contained kyphosis, weight loss, fatigue, sleep disturbance, bleeding tendency, inflammation, generalized edema and foul oder of uremia.

• 대한지역사회영양학회지
• /
• 제12권1호
• /
• pp.68-79
• /
• 2007

Iron deficiency is the most common nutritional problem that affects people of all ages in both industrialized and developing countries. Especially, college women are the target population for dietary iron deficiency. Recent study showed that the nutritional status of college women was poor because of insufficient food consumption and repeatabled weight reduction. The purpose of this study was to investigate the effects of nutrition counseling on the diet quality, nutritional status of iron and hematic parameters in college women who have self-recognized anemic symptoms. Anthropometric and dietary assessments as well as blood analysis, were carried out before and after the 8 weeks of nutrition counseling. During the experimental period, the 31 subjects were given nutrition education by a clinical dietitian. Nutrition counseling consisted of pathology of anemia, nutrition information for iron deficient anemia, diet information of balanced meals and menu choices for eating out. As a result, the frequencies of consumption of legumen and vegetables significantly increased after nutrition counseling(p<0.05). Daily intakes of protein, especially animal protein, vitamin E, niacin, heme iron, and zinc significantly increased(p<0.05). After nutrition counseling, some self-reported clinical symptoms such as 'dizziness', 'fatigue', 'short of breath', 'headache', 'sleeplessness', and 'beating heart' were significantly improved. Serum levels of transferrin(p<0.01) and total iron binding capacity levels(p<0.05) significantly increased. It could be concluded that the 8 weeks of nutrition counseling might be effective on quality of diet as well as iron status and it might also improve the some hematic parameters in college women who have self-recognized anemic symptoms.

• 대한한방부인과학회지
• /
• 제19권4호
• /
• pp.225-244
• /
• 2006

Purpose : This study was performed to assess the clinical effect of Daejo-hwan(DJH) on climacteric syndrome, not only common symptoms such as hot flushes, anxiety, palpitation and so on, but also urogenital tract disturbances like vaginal dryness and sexual problems. Methods : We randomly divided 120 women with the climacteric syndrome into two groups. One group received only DJH 2 pills(4g) a time, three times a day for 8 weeks and the other group didn't get any treatment for the same period. We evaluated sonography, DXA, blood test, female hormone test and questionnaires in the beginning as well as after 8 weeks of the treatment. Symptoms were measured by Kupperman's index, Menopausal Rating Scale and the Greene Climacteric Scale. Results : In this study, DJH was innoxious on liver and kidney. And DJH in the treated group reduced climacteric symptoms significantly as compared to the control group without enlargement of uterus myoma and the change of estradiol. In Kupperman's index and MRS, DJH in the treated group especially had effects on fatigue, shoulder pain. anxiety, headache, hot flushes as well as sexual problems. Conclusion : These results suggest that DJH can be useful in treating various climacteric symptoms including sexual problems without influences on the size of uterus myoma and estradiol.