• Journal of Periodontal and Implant Science
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• v.41 no.3
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• pp.157-163
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• 2011

Purpose: Curcumin is known to exert numerous biological effects including anti-inflammatory activity. In this study, we investigated the effects of curcumin on the production of interleukin-6 (IL-6) by murine macrophage-like RAW 264.7 cells stimulated with lipopolysaccharide (LPS) from Prevotella intermedia, a major cause of inflammatory periodontal disease, and sought to determine the underlying mechanisms of action. Methods: LPS was prepared from lyophilized P. intermedia ATCC 25611 cells by the standard hot phenol-water method. Culture supernatants were collected and assayed for IL-6. We used real-time polymerase chain reaction to detect IL-6 mRNA expression. $I{\kappa}B-{\alpha}$ degradation, nuclear translocation of NF-${\kappa}B$ subunits, and STAT1 phosphorylation were characterized via immunoblotting. DNA-binding of NF-${\kappa}B$ was also analyzed. Results: Curcumin strongly suppressed the production of IL-6 at both gene transcription and translation levels in P. intermedia LPS-activated RAW 264.7 cells. Curcumin did not inhibit the degradation of $I{\kappa}B-{\alpha}$ induced by P. intermedia LPS. Curcumin blocked NF-${\kappa}B$ signaling through the inhibition of nuclear translocation of NF-${\kappa}B$ p50 subunit. Curcumin also attenuated DNA binding activity of p50 and p65 subunits and suppressed STAT1 phosphorylation. Conclusions: Although further study is required to explore the detailed mechanism of action, curcumin may contribute to blockade of the host-destructive processes mediated by IL-6 and appears to have potential therapeutic values in the treatment of inflammatory periodontal disease.

• Molecules and Cells
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• v.19 no.3
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• pp.350-355
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• 2005

Selectins are carbohydrate-binding cell adhesion molecules that play a major role in the initiation of inflammatory responses. Heparin can bind to P-selectin, and its anti-inflammatory property is mainly due to inhibition of P-selectin. However, the strong anticoagulant activity of heparin limits its clinical use. We prepared periodate-oxidized, borohydride-reduced heparin (RO-heparin) by chemical modification and tested its anticoagulant and anti-inflammatory activities. Activated partial thromboplastin time (aPTT) assays showed that, compared with heparin, RO-heparin had greatly reduced anticoagulant activity. Intravenous administration of this compound led to reduction in the peritoneal infiltration of neutrophils in a mouse acute inflammation model. In vitro cell adhesion experiments demonstrated that the effect of RO-heparin on inflammatory responses was mainly due to inhibiting the interaction of P-selectin with its ligands. These results indicate that RO-heparin may be a safer treatment for inflammation than heparin, especially when selectin is targeted.

• KEPCO Journal on Electric Power and Energy
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• v.6 no.2
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• pp.119-122
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• 2020

With recent ESS (Energy Storage System) fire accident, the fault protection performance is becoming more important. However, there has never been any experiments with the protection performance on the faults in the ESS system level. In this study, the effect of AC ground fault and IGBT (Insulated Gate Bipolar mode Transistor) short-circuit failure on MW class ESS was performed experimentally for the first time in the world. First of all, the effect of the AC single line ground fault on battery was analyzed. Moreover, the transient voltage was investigated as a function of the battery capacity and the power level. Finally, the breaking capability and insulation performance of ESS were examined under PCS short-circuit fault condition. Through the tests, it was found that ESS protection system safely blocked the faulty current regardless of the faults, whereas the electronic parts such as IGBT and MC (Magnetic Contactor) were broken by the fault current. Also, the electrical breakdown in ESS resulted from the transient voltage during the protection process.

• The KIPS Transactions:PartD
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• v.10D no.6
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• pp.917-926
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• 2003

More views in data warehouse, can respond to the users more rapidly because the user's requests may be processed by utilizing only the materialized views with higher probabilities rather than accessing base relations. But, more views cause longer update duration of all the materialized views. During the update time, queries of users can not be processed because accesses to the datawarehouse are blocked. Thus, the update durations of the materialized views are necessary to be reduced. In this paper, we propose algorithm the update duration of the materialized views owing to managing by distinguishing insecton/deletion operations. Though there might overheads for distinguishing insertion/deletion, we concluded that the proposed algorithm could be excellent than others.

• YAKHAK HOEJI
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• v.31 no.6
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• pp.376-393
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• 1987

This study was performed in order to investigate the effect of nifedipine, a vasodilating drug which acts through calcium antagonism, on renal function using mongrel dog. Nifedipine, when given interavenously in doses ranging from 1.5 to 5.0$\mu\textrm{g}$/kg, elicited diuresis along with less changes of glomerular filtration rate and significant increases of renal plasma flow, so that the filtration fraction(FF) decreased significantly, at the same time both osmolar and free water clearances increased, and amount of sodium, potassium and calcium excreted in urine increased significantly. Nifedipine, when infused into a renal artery in doses from 0.05 to 0.15$\mu\textrm{g}$/kg/min, exhibited identical responses to the actions of intraveneous nifedipine except significant increase of glomerular filtration rate and no change of FF, which was confined only to the infused kidney. The renal action of nifedipine into a renal artery were not influenced by renal denervation, decreased significantly by ouabain, Na$^+$-K$^+$-ATPase inhibitor, which was given into a renal artery. Nifedipine infused into a renal artery in dog pretreated with propranolol i.v. produced diuresis associated with the increase of electrolytes excretion by reduction of electrolyte reabsorption and with no changes of glomerular filtration rate and renal plasma flow. Thus, it is concluded that nifedipine infused into a renal aretery produces diuretic action along with both improvement of hemodynamics and inhibition of electrolytes reabsorption, which may be related to sympathetic $\beta$-receptor or Na$^+$-K$^+$-ATPase activity because the action of nifedipine in kidney is blocked by propranolol or ouabain.

• Archives of Pharmacal Research
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• v.26 no.1
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• pp.64-69
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• 2003

To analyze vasopressin-induced $Ca^{2+}$ increase in liver cells, rat hepatocytes were isolated and attached to collagen-coated cover slips. Using fura-2, a $Ca^{2+}$-sensing dye, changes in intracellular $Ca^{2+}$ concentration by vasopressin were monitored. Results in this communication suggested that vasopressin-induced $Ca^{2+}$ increase were composed of both $Ca^{2+}$ release from internal $Ca^{2+}$ stores and influx from the plasma membrane. The $Ca^{2+}$ influx consisted of two distinguishable components. One was dependent on the presence of vasopressin and the other was not. SK＆F96365 blocked vasopressin-induced $Ca^{2+}$ influx in a dose-dependent manner. Vasopressin-induced $Ca^{2+}$ release from internal stores diminished in a primary culture of hepatocytes according to the culture time. However, changes in vasopressin-induced $Ca^{2+}$ influx across the plasma membrane differed from changes in the $Ca^{2+}$ release from internal stores, suggesting two separate signalings from receptor activation to internal stores and to the plasma membrane.

• Journal of electromagnetic engineering and science
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• v.11 no.3
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• pp.220-226
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• 2011

We have proposed a new method to accurately predict the resonance of Fabry-Perot Cavity (FPC) antennas enclosed with conducting side walls. When lateral directions of an FPC antenna are not blocked with metallic walls, the conventional technique is accurate enough to predict the resonance of the FPC antenna. However, when the FPC antenna has side walls, especially for case with only a short distance between the walls, the conventional prediction method yields an inaccurate result, inevitably requiring a tedious, time-consuming tuning process to determine the correct resonant height to provide the maximum antenna gain in a target frequency band using three-dimensional full-wave computer simulations. To solve that problem, we have proposed a new resonance prediction method to provide a more accurate resonant height calculation of FPC antennas by using the well-known resonance behavior of a rectangular resonant cavity. For a more physically insightful explanation of the new prediction formula, we have reinvestigated our proposal using a wave propagation characteristic in a hollow rectangular waveguide, which clearly confirms our approach. By applying the proposed technique to an FPC antenna covered with a partially reflecting superstrate consisting of continuously tapered meander loops, we have proved that our method is very accurate and readily applicable to various types of FPC antennas with lateral walls. Experimental result confirms the validness of our approach.

• The korean journal of orthodontics
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• v.12 no.1
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• pp.61-68
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• 1982

Tooth Positioner는 band를 제거한 후 가능한 빨리 장착시켜야 susceptible하며 무엇보다도 환자의 생리학적 jaw movement를 설정해서 제작해야 하고 적어도 hingeaxis relation은 찾아서 제작해야한다. Positioner의 장착시간은 하루에 $3\~4$시간의 active biting exercise와 수안시간동안 사용하게 한다. 처음 장착시에 가장 tight하고 이 tightness 는 치아가 요망되는 위치로 근접함에 따라서 점차 감소되고 이 tightness의 감소가 작용효과의 가장 좋은 지침이 되며 자는 하루 하루 그 변화를 느껴야 한다. Positioner가 느슨하게 적합되고 좋은 교합관계를 보이면 장착을 수안시간동안으로 제한시키거나 혹은 깨어 있을 동안 한 두시간 장착하게 한아. 대개 $3\~4$주 후에 predetermined pattern과 유사하게 되며, 일반적으로 장착 후 $8\~10$주 후에 더 장착할 것인가를 결정하고 필요성이 없다면 conventional retainer로 바꾸어 준다. Tooth Positioner는 기능적인 구호흡, thumb sucking, snoring을 해소시켜 줄 수 있으며 jaw relationship이나 overbite문제를 해결할 수 있다. 그리고 chair time을 감소시켜 줄 수 있으며 tissue tone을 자극해서 치아위치를 증진시키는데 끊임없이 작용한다. 그러나 제작에 많은 시간이 걸리고 치아를 배열하는 술자의 능력에 따라 치료효과가 많이 좌우되며 너무 bulky하므로 이물감이 커서 유용하게 장착할 수 있는 시간이 제한적이고 natural muscle balance에 대해 간헐적인 교정력을 가함으로써 치아를 loosening 시킬 수 있다. 이 장치물은 다른 removable appliance와 같이 환자의 협조가 무엇보다 중요하므로 환자에게 장착동기를 유발시켜 주는 것이 좋으며 True Blocked Nasal Airway가 있는 환자에게는 금기증이 된다.

• Advances in Traditional Medicine
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• v.9 no.2
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• pp.135-141
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• 2009

The purpose of this study was to characterize the putative anxiolytic-like effects of the 70% ethanol extract of Portulaca oleracea (EPO) using an elevated plus maze (EPM) in mice. The EPO was orally administered at 50, 100, 200 or 400 mg/kg to ICR mice, 1 h before the behavioral evaluation in the EPM, respectively. Control mice were treated with an equal volume of 10% tween 80, and positive control mice with diazepam (1 mg/kg). Single treatments of the EPO significantly increased the percentage of time spent and arm entries into the open arms of the EPM versus controls (P < 0.05). Moreover, there were no changes in the locomotor activity and myorelaxant effects in any group compared with the saline controls. In addition, the anxiolytic-like effects of the EPO were blocked by flumazenil (10 mg/kg, i.p), a $GABA_A$ antagonist not by WAY 100635 (0.3 mg/kg, i.p), a 5-$HT_{1A}$ receptor antagonist. These results indicate that P. oleracea is an effective anxiolytic agent, and suggest that the anxiolytic-like effects of P. oleracea is mediated via the GABAergic nervous system.

• Nuclear Engineering and Technology
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• v.48 no.1
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• pp.98-113
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• 2016

A reactor vessel level monitoring system measures the water level in a reactor during normal operation and abnormal conditions. A drop in the water level can expose nuclear fuel, which may lead to fuel meltdown and radiation spread in accident conditions. A level monitoring system mainly consists of a sensing line and pressure transmitter. Over a period of time boron sediments or other impurities can clog the line which may degrade the accuracy of the monitoring system. The aim of this study is to determine blockage in a sensing line using the energy of the composite signal. An equivalent Pi circuit model is used to simulate blockages in the sensing line and the system's response is examined under different blockage levels. Composite signals obtained from the model and plant's unblocked and blocked channels are decomposed into six levels of details and approximations using a wavelet filter bank. The percentage of energy is calculated at each level for approximations. It is observed that the percentage of energy reduces as the blockage level in the sensing line increases. The results of the model and operational data are well correlated. Thus, in our opinion variation in the energy levels of approximations can be used as an index to determine the presence and degree of blockage in a sensing line.