• Title/Summary/Keyword: biomedical

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Soybean Peptides Induce Apoptosis in HeLa Cells by Increasing Oxidative Stress

  • Sung, Ho Joong;Jeong, Yu Jin;Kim, Jihyun;Jung, Eunsun;Jun, Jin Hyun
    • Biomedical Science Letters
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    • v.21 no.2
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    • pp.77-83
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    • 2015
  • Soy proteins have been extensively studied because of its multiple health benefits. However, the effects of soy proteins on human cervical cancer cells are still unclear. Therefore, this study investigated the effects of soy proteins on HeLa cells and human fibroblasts by using soybean peptides (SPs). SPs selectively increased the generation of reactive oxygen species and apoptosis in HeLa cells but not in fibroblasts. In addition, SPs suppressed the migration of HeLa cells. Although the molecular mechanisms underlying the effects of SPs on human cervical cancer cells need to be investigated further, our findings provide insights on the therapeutic effects of soy protein on cervical cancer.

PVC(Premature Ventricular Contraction) Arrhythmia Detection Using R-R Interval (R-R 간격 정보를 이용한 심실조기수축 부정맥 검출)

  • Lee, Sun-Ju;Yoon, Tae-Ho;Shin, Seung-Won;Lee, Seong-Taek;Kim, Kyeong-Seop;Lee, Jeong-Whan;Kim, Dong-Jun
    • Proceedings of the KIEE Conference
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    • 2008.10b
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    • pp.472-473
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    • 2008
  • 심실조기수축(PVC: Premature Ventricular Contraction)은 성인에게서 가장 흔하게 발생되는 심장 부정맥 증상 중의 하나이다. 심실조기수축 부정맥이 자주 발현되는 사람의 경우 관상 동맥질환, 고혈압 등의 심혈관계 질환이 진행되고 있을 가능성이 많고, 심실빈맥이나 심실세동으로 전이되는 경우 심정지 등을 유발하여 사망에 이르기 때문에 지속적으로 관찰이 필요한 증상이다. 따라서 본 연구에서는 R-R 간격 정보를 이용하여 심실조기수축 부정맥 증상을 실시간으로 검출할 수 있는 신호처리 알고리즘을 구현하고자 하였다.

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Ventricular Tachycardia Arrhythmia Detection Using R-R Interval (심전도 신호의 R-R 간격 정보를 이용한 심실빈맥 부정맥 검출)

  • Lee, Seong-Taek;Yoon, Tae-Ho;Shin, Seung-Won;Lee, Sun-Ju;Kim, Kyeong-Seop;Lee, Jeong-Whan
    • Proceedings of the KIEE Conference
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    • 2008.10b
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    • pp.474-475
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    • 2008
  • 심실 빈맥은 심실에서 비정상적인 전기자극 발생으로 인하여 심박수가 분당 $100{\sim}120$회를 초과하는 부정맥 증상을 일컫는다. 심실 빈맥이 발생하는 경우 심박출량이 감소하고, 폐에는 미처 나가지 못한 피가 고이는 경우도 발생하여 심부전증이 나타나거나 심실 세동으로 발전하여 사망에 이를 수 있는, 매우 위험한 부정맥 중의 하나이므로 심실 빈맥 검출은 매우 중요한 사안이다. 따라서 본 연구에서는 R-R 간격 정보를 이용하여 심실 빈맥 부정맥 신호를 실시간으로 검출할 수 있는 신호처리 알고리즘을 구현하고자 하였다.

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Implementation of Multi-threading Ambulatory Speech Audiometric System (멀티스레딩 기법을 이용한 휴대용 어음청력검사 시스템 구현)

  • Shin, Seung-Won;Kim, Kyeong-Seop;Yoon, Tae-Ho;Lee, Sun-Ju;Lee, Seong-Taek;Lee, Jeong-Whan
    • Proceedings of the KIEE Conference
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    • 2009.07a
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    • pp.1998_1999
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    • 2009
  • 본 연구에서는 단일 청력검사 모듈에서 여러 가지 작업들을 동시에 운용할 수 있는 멀티스레딩 기법의 구현을 통하여, 청력검사 시스템에서 피검사자가 검사가 진행되는 동안 언제든지 응답 결과를 확인하거나 또는 수정할 수 있도록 하는 휴대용 어음청력검사 시스템을 구현하고자 하였다.

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ORGANOPHOSPHATE-INDUCED BRAIN DAMAGE: NECROSIS, APOPTOSIS AND GFAP EXPRESSION

  • Kim, Yun-Bae;Hur, Gyeung-Baeng;Phi, Taek-San;Cheon, Ki-Cheol;Kim, Wang-Soo;Yeon, Gyu-Baek
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.05a
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    • pp.123-123
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    • 2001
  • The distribution of necrotic and apoptotic neural cells, and expression of astrocytic glial fibrillary acidic protein (GFAP) in the brain of rats poisoned intraperitoneally with diisopropylfluorophosphate were investigated. Pyridostigmine bromide (0.1 mg/kg) and atropine methylnitrate (20 mg/kg), which are centrally inactive, were treated intramuscularly 30 min and 10 min, respectively, before diisopropylfluorophosphate (4 - 10 mg/kg) poisoning to reduce the mortality.(omitted)

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Analysis of Criteria Regarding Frontal and Side Impacts of Wheelchair Occupant in Vehicle by Computer Simulation Method (컴퓨터 시뮬레이션 방법을 이용한 휠체어 탑재 차량의 전방/측방충돌 시 휠체어 탑승자의 위험도 분석)

  • Kim, S.M.;Lee, M.P.;Park, S.Y.
    • Journal of Biomedical Engineering Research
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    • v.27 no.6
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    • pp.365-369
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    • 2006
  • According to the IIHS (Insurance Institute fur Highway Safety), side impacts are made up 30% of all accidents (reported 1998). In the case of auto accidents, head and neck injuries were most common as 58%, injuries to the body's trunk equaled 32%, and injuries to the abdomen were 21%. Therefore in this study, injury of wheelchair occupant in frontal and side impact of wheelchair loaded vehicle was analyzed using computer simulation method. The occupant was restrained at the rear of wheelchair by the lap belt. The detailed fixation and restrain conditions of the wheelchair occupant are referred to SAR J2249's recommendation. We estimated HIC(Head Injury Criteria) and HNIC (Head and Neck Injury Criteria) based on measured data.

Detection of Gastric Contraction by Vector Analysis in Electrogastrography (위전도신호의 벡터분석에 의한 위수축 측정)

  • Han, Wan-Tack;Kim, In-Young;Kim, Won-Ky
    • Proceedings of the KOSOMBE Conference
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    • v.1997 no.05
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    • pp.387-390
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    • 1997
  • Electrogastrography(EGG), the cutaneous recording of the myoelectrical activity of the stomach using surface electrodes, is attractive due to its non-invasiveness. We propose feasible methods to detect tile gastric contraction by vector analysis of the surface EGG signals obtained from three paired electrodes. The amplitude and direction of the calculated EGG vector were analyzed and compared with the gastric contraction signals such as the strain gauge signal from the gastric serosa in dog. From the vector analysis of the EGG signal, we found a typical change of the amplitude and direction of the EGG vector, which can indicate occurrences of the gastric contraction.

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High-performance Digital Hearing Aid Processor Chip with Nonlinear Multiband Loudness Correction (비선형 다중채널 Loudness 교정을 위한 고성능 보청기 칩)

  • Park, Young-Cheol;Kim, Dong-Wook;Kim, Won-Ky;Park, Sang-Il
    • Proceedings of the KOSOMBE Conference
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    • v.1997 no.05
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    • pp.342-344
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    • 1997
  • Owing to technical advances in very large-scale integrated circuits (VLSI), high-speed digital signal processing (DSP) chips become fast enough to allow for real-time implementation of hearing aid algorithms in units small enough to be wearable. In this paper, we present a digital hearing aid processor (DHAP) chip built around a general-purpose 16-bit DSP core. The designed DHAP performs a nonlinear loudness correction of 8 octave frequency bands based on audiometric measurements. By employing a programmable DSP, the DHAP provides all the flexibility needed to implement audiological algorithms. In addition, the has a low power feature and $5.410\times5.720mm^2$ dimensions that fit for wearable devices.

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