• 한국임상약학회지
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• 제26권2호
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• pp.150-162
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• 2016

Objective: First-in-human dose estimation is an essential approach for successful clinical trials for drug development. In this study, we systematically compared first-in-human dose and human pharmacokinetic parameter estimation approaches. Methods: First-in-human dose estimation approaches divided into similar drug comparison approaches, regulatory guidance based approaches, and pharmacokinetic based approaches. Human clearance, volume of distribution and bioavailability were classified for human pharmacokinetic parameter estimation approaches. Results: Similar drug comparison approaches is simple and appropriate me-too drug. Regulatory guidance based approaches is recommended from US Food and Drug Administration (FDA) and European Medicines Agency (EMA) regarding no-observed-adverse-effect level (NOAEL) or minimum anticipated biological effect level (MABEL). Pharmacokinetic based approaches are 8 approaches for human clearance estimation, 5 approaches for human volume of distribution, and 4 approaches for human bioavailability. Conclusion: This study introduced and compared all methods for first-in-human dose estimation. It would be useful practically to estimate first-in-human dose for drug development.

• 대한의용생체공학회:의공학회지
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• 제21권2호
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• pp.219-224
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• 2000

본 연구는 몸통의 반복적인 flexion/extension 동작 수행시 근전도신호를 측정하고 이들 신호에서 나타난 EMG parameters(median frequency, median power, RMS) 와 피실험자의 주관적 불편도의 변화양상간의 정량적인 관계를 알아보고자 수행되었다. 피실험자별로 3-5회 정해진 업무를 수행하였고 주관적불편도와 근전도 신호를 측정하였다. 실험결과 반복횟수가 증가할수록 주관적 불편도는 증가하였으며 각 task 별로 EMG parameter와 불편도의 증감율 간의 회귀분석과 상관분석을 수행한 결과 실험과 EMG parameter에 따른 변이는 존재했지만 대체로 RMS에 비해 MF와 MP의 증감율이 불편도 증감율과 상관관계가 높은 것으로 나타났다.

• 대한의용생체공학회:의공학회지
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• 제18권2호
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• pp.133-146
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• 1997

In this paper, we describe the design methodology and specifications of the developed module-based bedside monitors for patient monitoring. The bedside monitor consists of a main unit and module cases with various parameter modules. The main unit includes a 12.1" TFT color LCD, a main CPU board, and peripherals such as a module controller, Ethernet LAN card, video card, rotate/push button controller, etc. The main unit can connect at maximum three module cases, each of which can accommodate up to 7 parameter modules. They include the modules for electrocardiograph, respiration, invasive blood pressure, noninvasive blood pressure, temperature, and SpO with plethysmograph.raph.

• 대한의용생체공학회:의공학회지
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• 제10권1호
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• pp.11-16
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• 1989

This paper describes the AR model of EMG signal during maximum voluntary contraction. By comparing the AR coefficients and the reflection coefficients of the AR model with the median frequency of power spectrum, it is proved that muscle fatigue can be measured by the AR and the reflection coefficients. In the estimation procedure of AR model parameter, the autocorrelation method is superior to the covariance method, and it is determined that the optimal order is six. As the muscle becomes fatigue, the median frequency of power spectrum is declined, and the AR coefficient [$a_1$] and the reflection coefficient [$k_1$] are also decreased. Therefore the muscle fatigue can be measured by the AR parameter.

• Journal of Microbiology and Biotechnology
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• 제18권5호
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• pp.889-896
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• 2008

A suitable simple model tested by experiments is required to address complex biological reactions like esterase synthesis by Saccharomyces cerevisiae. Such an approach might be the answer to a proper bioprocessing strategy. In this regard, a logistic model for esterase production from Saccharomyces cerevisiae has been developed, which predicts well the cell mass, the carbon source (glucose) consumption, and the esterase activity. The accuracy of the model has been statistically examined by using the Student's t-test. The parameter sensitivity analysis showed that all five parameters (${\mu}_m$, $K_a$, $X_m$, $Y_{x/s}$, and $Y_{p/x}$) have significant influence on the predicted values of esterase activity.

• 대한의용생체공학회:의공학회지
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• 제17권4호
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• pp.545-552
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• 1996

Researches on chromosome are very significant in cytogenetics since a gene of the chromosome controls revelation of the inheritance plasma The human chromosome analysis is widely used to diagnose genetic disease and various congenital anomalies. Many researches on automated chromosome karyotype analysis has been carried out, some of which produced commercial systems. However, there still remains much room for improving the accuracy of chromosome classification. In this paper, we propose an algorithm for reconstruction of the chromosDme image to improve the chromosome classification accuracy. Morphological feature parameters are extracted from the reconstructed chromosome images. The reconstruction method from chromosome image is the 32 direction line algorithm. We extract three morphological feature parameters, centromeric index(C.I.), relative length ratio(R.L.), and relative area ratio(R.A.), by preprocessing ten human chromosDme images. The experimental results show that proposed algorithm is better than that of other researchers'comparing by feature parameter errors.

• 대한의용생체공학회:의공학회지
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• 제29권3호
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• pp.222-230
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• 2008

This paper introduces a method of estimating the knee joint moment developed during MVC. By combining the Hill-type muscle model and analytic results on moment arm and musculotendon length change as a function of hip and knee joint angle, the knee joint moment at a specific knee joint angle during MVC is determined. Many differences between the estimated results and the experimental data are noted. It is believed that these differences originate from inaccurate information on the muscle-tendon parameters. The establishment of exact values for the subject's muscle parameters is almost impossible task. However, sensitivity analysis shows that the tendon slack length is the most critical parameter when applying the Hill-type muscle model. The effect of a change of this parameter on the muscle length force relationship is analyzed in detail.

• Korean Journal of Chemical Engineering
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• 제36권3호
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• pp.356-367
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• 2019

This work presents an advanced and systematic approach to analytically design the optimal parameters of a two parameter second-order internal model control (IMC) filter that satisfies operational constraints on the output process, the manipulated variable as well as rate of change of the manipulated variable, for a first-order plus dead time (FOPDT) process. The IMC parameters are designed to minimize a control objective function composed of the weighted sum of the error between the process variable and the set point, and the rate of change of the manipulated variable, and to satisfy the desired constraints. The feasible region of the constrained IMC control parameters was graphically analyzed, as the process parameters and the constraints varied. The resulting constrained IMC control parameters were also used to find the corresponding industrial proportional-integral controller parameters of a Smith predictor structure.

• 대한의생명과학회지
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• 제28권2호
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• pp.120-126
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• 2022

Natural products are important sources for drug development because they have a wide variety of useful biological properties. Angelica gigas Nakai (AGN) has been used as an herbal medicine. The present study was designed to evaluate the immune-enhancing effect of AGN in the cyclophosphamide (CP) induced immune-suppressed mice. As the result, we found that CP induced the reductions of body ratio, spleen weights, hematopoietic parameter and cytokine productions in mice. However, AGN recovered immunosuppression-mediated decreased body ratio, spleen and thymus weights as well as regulation of hematopoietic parameter including white blood cell, lymphocyte, and neutrophil. According to histological study, AGN regenerated on CP-mediated injured spleen. Moreover, AGN increased the CP-induced reduction of cytokine expression in spleen tissue. Collectively, the findings provide experimental evidence that AGN may be a candidate for health-improving herbs.

• 대한의용생체공학회:의공학회지
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• 제43권2호
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• pp.71-80
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• 2022

The interaction between dual-ligand decorated particle-based delivery system and target cell under shear flow is predicted using probability model developed. We assumed the two kinds of ligand are decorated on the surface of the particle with 10% length difference. Fixed with other biophysical parameters, a study on the particle-cell interaction for the different non-specific interaction parameter is performed. To induce the firm adhesion, short ligand-receptor should be engaged. Also, it is shown that the rational design of ligand-receptor interaction, including receptor number, specific interaction parameter, kinds of ligand-receptor, etc., should be considered.