• Journal of Microbiology and Biotechnology
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• v.12 no.6
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• pp.962-971
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• 2002

The current study proposes a simple monodimensional model to estimate the linear growth rate of photosynthetic microorganisms in flat-plate photobioreactors (FPPBRs) during batch cultivation. As a model microorganism, Chlorella kessleri was cultivated photoautotrophically in FPPBRs using light-emitting diodes (LEDs) as the light sources to provide unidirectional irradiation in the photobioreactors. Various conditions were simulated by adjusting both the intensity of the light and the height of the culture. The validity of the proposed model was examined by comparing the linear growth rates measured with the predicted ones obtained from the proposed model. Accordingly, the value of $\frac{K\cdot\mu m}{\alpha\cdot L}log(I_0\cdot{I_s}^{\varepsilon 1)\cdot {I_c}^{-\varepsilon})$ was proposed as an approximate index for strategies to obtain the maximal lightn yield under light-limiting conditions for high-density algal cultures and as a control parameter to improve the photosynthetic productivity and efficiency.

• KSBB Journal
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• v.32 no.2
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• pp.90-95
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• 2017

Mammalian cell cultures have been used extensively to produce proteins for therapeutic agent because of their ability to perform post-translational modification including glycosylation. To produce recombinant protein, many factors and parameter are considered such as media composition, host cell type, and culture process. In this study, recombinant human erythropoietin (rhEPO) producing cell line was established by using glutamine synthetase system. To reduce serum concentration in media, we compared direct adaptation with step adaptation. Cell growth was faster in step adaptation. In low-level serum media, there were insufficient glucose for cell growth. Thus, we added glucose in low-level serum media from 2 g/L to 4.5 g/L. Titer of rhEPO was higher than other conditions at 4.5 g/L of glucose. Additionally, N-methyl-D-aspartate (NMDA), 13-cis-retinal, and pluronic F-68 (PF-68) were added to enhance productivity in CHO cell cultures. In conclusion, we applied CHO cell producing rhEPO to low-level of serum in media using step-adaptation. Also, we confirmed positive effect of NMDA, 13-cis-retinal, and PF-68.

• Proceedings of the KOSOMBE Conference
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• v.1998 no.11
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• pp.201-202
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• 1998

In this paper we suggested an automated method for detecting and counting rapid eye movement(REM) using EOG during sleep. This method is formulated by two step fuzzy logic. At first step, the velocity and the distance of single channel eye movement are used for the fuzzy input to get the possibility of being REM at each EOG. At second step, the two possibility values of both EOG from the first step and the correlation coefficient of both eye movements are used for the fuzzy logic input, and the output is the final possibility of being Rapid Eye Movement. We applied this algorithm to the normal and narcoleptic sleep data and compared the difference. We found the possibility that the count of REM can be a parameter that has significant physiological meanings.

• Journal of Korean Society of Water and Wastewater
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• v.24 no.1
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• pp.5-14
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• 2010

A pilot-scale biological aerated filter (BAF) was operated with an anaerobic, anoxic and oxic zone at $23{\pm}1^{\circ}C$. The influent sCOD and total nitrogen concentrations in the feedwater were approximately 250 mg/L and 35 mg N/L, respectively. sCOD removal at optimum hydraulic retention time (HRT) of 3 hours with recirculation rates of 100, 200 and 300% in the column was more than 96%. Total nitrogen removal was consistently above 80% for 4 and 6 hours HRT at 300% recirculation. For 3 hours HRT and 300% recirculation, total nitrogen removal was approximately 79%. Based on fitting results, the kinetic parameter values on nitrification and denitrification show that as recirculation rates increased, the rate of ammonia and nitrate transformation increased. The ammonium loading rates for maximum ammonium removed were 0.15 and 0.19 kg $NH_3$-N/$m^3$-day for 100% and 200% recirculation, respectively. The experimental results demonstrated that the BAF can be operated at an HRT of 3 hours with 200 - 300% recirculation rates with more than 96 % removal of sCOD and ammonium, and at least 75% removal of total nitrogen.

• Journal of Biomedical Engineering Research
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• v.16 no.3
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• pp.345-352
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• 1995

The LPC cepstrum coefficients, which are an acoustic features of speech signal, have been widely used as the feature parameter for various speech recognition systems and showed good performance. The vocal tract area function is a kind of articulatory feature, which is related with the physiological mechanism of speech production. This paper proposes the vocal tract area function as an alternative feature parameter for speech recognition. The linear predictive analysis using Burg algorithm and the vector quantization are performed. Then, recognition experiments for 5 Korean vowels and 10 digits are executed using the conventional LPC cepstrum coefficients and the vocal tract area function. The recognitions using the area function showed the slightly better results than those using the conventional LPC cepstrum coefficients.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2001.05a
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• pp.1-5
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• 2001

시각제시에 의한 감성반응 생체신호 추출 실험시 시각 제시물 선정에 주관적 방식을 사용하였다. 시각제시 영상물로는 감성반응도가 가장 큰 인물얼굴 영상자료를 선정하였다. 피검자군 스스로 자신이 극도로 선호하고 혐오하는 양극단의 얼굴영상물을 선호도 특성조사를 통해 선택케 하였다. 외부와의 영상잡음이 차폐된 모니터 제시 장치를 구성하여 선호와 혐오의 양극단 영상물을 교차 제시하며 설문조사와 뇌파를 측정하였다. 피검자로는 남녀 대학생 20명을 선발하였으며 영상매체 선정을 비롯한 뇌파측정에 과정에 참여시켰다. 뇌파신호 분석 방법으로는 대역별 적분값, 반응구간 변화 미분값을 파라미터로 사용하였다. 분석결과, 교차제시에 따른 반응민감도가 향상되었으며 동일 시각 반복제시에 따라 민감도가 둔화됨을 밝혔다.

• Science of Emotion and Sensibility
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• v.4 no.1
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• pp.61-67
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• 2001

This paper described the effect of subjective approach in case of the human sensibility experiments. The procedure is proceeded subjectively. Human faces are selected as the image presentation media. Pleasant and unpleasant images are selected directly by examiner, And also the image presentation system, which is executed with a computer and has the square-type black box monitor equipment, is manufactured. Images are presented with the step-variation time interval technique. questionnaire test and EEG signal detection data are analyzed. The analysis parameters are a “frequency band integral value” and a “band differential variation ratio”. he results show the high sensibility and fast response. The fact that image presenting repetition alleviates is verified.

• Journal of Biomedical Engineering Research
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• v.13 no.4
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• pp.269-274
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• 1992

In this paper, we describe the design methodology and specifications of the developed module-based bedside monitors for patient monitoring. The bedside monitor consists of a main unit and module cases with various parameter modules. The main unit includes a 12.1" TFT color LCD, a main CPU board, and peripherals such as a module controller, Ethernet LAN card, video card, rotate/push button controller, etc. The main unit can connect at maximum three module cases each of which can accommodate up to 7 parameter modules. They include the modules for electrocardiograph, respiration, invasive blood pressure, noninvasive blood pressure, temperature, and SpO2 with Plethysmograph.raph.

• Journal of Biomedical Engineering Research
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• v.10 no.2
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• pp.185-190
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• 1989

In this paper, the discriminant analysis was performed on parameter for detection of cardiac arrythmia. The parameters used for discriminant analysis was two group. One group consist of 05 width and Heart rate, and the other Morphology and Heart Rate. For this study, we designed data acquisition system for EKG signals. The parameters pre-processed by this system was heart rate, 05 width and Morphology. And then, we analyzed the discriminancy of two group and extracted the quantity of discriminancy. The analysis results showed first that the group with morphology and heart rate is better discriminant than with 05 width and heart rate : next, that it can quantify the discriminany of each group of diseases.

• Journal of Biomedical Engineering Research
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• v.2 no.1
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• pp.31-38
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• 1981

The objective of the present study was to develop an equivalent circuit model of glucose kinetics including the hepatic glucose balance functions which were neglected in the previous compartmental models. Using this circuit model, the insulin resistivity parameter and hepatic glucose sensitivity parameter were estimated in optimal fitting of the model based data of glucose and insulin concentration to the reported clinical intravenous glucose tolerance test(IVGTT) data in normal and diabetic subjects. The addition of the hepatic function in the model has improved the overall performance of the simulation. Also, the computed tissue insulin resistivity and the hepatic glucose sensitivity are shown to be significant in distinguishin four clinical groups of normal and diabetic groups.