• 한국가시화정보학회:학술대회논문집
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• 2004.11a
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• pp.84-85
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• 2004

Experimental study was conducted to characterize shear-induced lateral migration of $1.0-{\mu}m-diameter$ Brownian particles flowing through a rectangular microchannel which can be used to deliver small amount of liquids, drugs, biological agents and particles in microfluidic devices. Measurements were obtained by using a mercury lamp with a light of 532-nm wavelength, an inverted epi-fluorescence microscope, and a cooled CCD camera to record particle images. Peclet number was used as a parameter to assess the lateral distribution of the particles at a fixed volume fraction of $0.1\%$. It was shown that as Pe increased, particles were moved toward the centerline of the channel, which is in good agreement with previous studies.

• Journal of Photoscience
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• v.8 no.2
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• pp.43-53
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• 2001

a, a parameter that describes how effectively photoinactivated PS II units protect their functional neighbours; car, carotenoids; ΔpH, transthylakoid pH difference; D1 protein, psbA gene product in the PS II reaction centre; f, functional fraction of PS II: F$\_$v//F$\_$m/, the ratio of variable to maximum chlorophyll a fluorescence; k$\_$d/, rate coefficient for degradation of D1 protein; k$\_$i/ and k$\_$r/, rate coefficient for photoinactivation and repair of PS II, respectively; NADP+, oxidized nicontinamide adenine dinucleotide phosphate; P680, the primary electron donor in the PSII reaction centre; Ph, pheophytin; PS, photosystem; Q$\_$A/, first quinone acceptor of an electron in PS II; R$\_$s/, the gross rate of D1 protein synthesis.

• Korean Journal of Clinical Pharmacy
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• v.6 no.2
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• pp.14-18
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• 1996

This study was attempted to investigate the dissolution rate and the bioavailability after oral administration of commercially available norfloxacin tablets in rabbits. The dissolution test was conducted in artificial gastric juice using basket method with for norfloxacin preparations (A, B, C and D) which were chemically equivalent. The results were as follows ; The dissolution rate was increased in the order of four different brand A>D>B>C. Area under the plasma concentration curve and peak plasma concentration were increased in the order of brand A>D>B>C. Absorption rate constant and peak time were increased in the order of brand B>A>C>D, and there was a little difference in elimination rate constant and biological half-life. The correlation of the dissolution rate and relative bioavailability showed significant linear relationship. From the results of this experiment, the bioavailability of norfloxacin tablets in rabbits may be predicted from the results of dissolution rate studies.

• Proceedings of the KSME Conference
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• 2008.11a
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• pp.1455-1457
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• 2008

Cell adhesion is a coordinated process involving initial binding of integrin receptors to extracellular matrix (ECM), recruitment of adhesion proteins, and focal adhesion assembly. The formation of mechanically stable focal adhesion assembly of cells within surrounding ECM is a key parameter to direct numerous cellular functions including cell migration, differentiation, and apotosis. With current cell adhesion assays, it is difficult to understand contributions of each coordinated event on evolution of cell adhesion strengthening since cells spontaneously spread upon their adhesion to the substrate, thus remodeling their cytoskeletal structure. In this presentation, novel approaches for analysis of cell adhesion strengthening process based on the combination of mechanical device, micro-patterned substrates, and molecular biological techniques will be discussed.

• 전기의세계
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• v.26 no.1
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• pp.87-90
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• 1977

Various simulation techniques were developed in the modeling of biological system during the last decades. Mostly analog and hybrid simulation techniques have been used. The authors chose the Digital Analog Simulation (DAS) technique by using the MIMIC language to simulate the saccadic eye movement system performances on the digital computer. There have been various models presented by many investigators after Young & Stark's sampled-data model. The eye movement model chosen by the authors is Robinson's model III which shows the parallel information processing characteristics clearly to the double-step input stimuli. In the process of simulation, the parameter and constants used were based on the neurophysiological data of the human and animals. The analog model blocks were converted to the corresponding MIMIC block diagrams and programmed into the MIMIC statements. The program was run on the CDC Cyber 72-14 computer. The essential input stimulus was double-step of 5 and 10 degrees, and target durations chosen were 50,100 and 150 msec. The results obtained by the DAS technqiue were in good agreement with analog simulation carried out by other investigators as well as with the experimental human saccadic eye movement responses to double-step target movements.

• Proceedings of the KOSOMBE Conference
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• v.1991 no.11
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• pp.129-132
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• 1991

This paper describes the ECG pattern recognition using the syntatic pattern recognition algorithm. The algorithm uses the BNF rule wi th the semantic evaluation which has the structural Information of the ECG. This algorithm is constructed with (1) removing the baseline drift by the Cubic spline function and exract the significant point by the line-approximation algorithm, (2) syntatic peak recognition algorithm with the extracted significant point, (3) produce the token which is used pattern recognition, (4) pattern recognition of the ECG by the syntatic pattern recognition algorithm, (5) extract the parameter with the pattern recognized ECG signal.

• Proceedings of the KOSOMBE Conference
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• v.1991 no.11
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• pp.57-60
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• 1991

A new approach to texture classification for ultrasound liver diagnosis using run difference matrix was developed. The run difference matrix consists of the gray level difference along with distance. From this run difference matrix, we defined several parameters such as LDE, LDEL, NUF, SMO, SMG, SHP etc. and three vectors namely DOD, DGD and DAD. Each parameter value calculated in fatty cirrhotic, chronic hepatitic and normal liver mage was plotted in two dimensional plane. We compared our results with run length method. There are several advantages of run difference matrix method over the run lengths. 1) It is more sensitive to small difference of gray level distribution. 2) The parameters provide more statistically significant value. Images were classified with the extracted parameters to each diseases using neural networks. In preliminary clinical exprements, this approach showed satisfying results.

• Journal of Biomedical Engineering Research
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• v.11 no.2
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• pp.243-248
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• 1990

EMG (eleltromyographic) signals are generated by contracting muscle and detected in and out side of muscle in the form of random signals. In the measurement of muscle fatigue, the mean frequency of EMG signals using spectrum analysis is an important parameter in diagonosis of muscle disease and in sports medicine fields. In this study, the degree of spectral transfer to lower frequency caused by accumulation of Latic acid inside the muscle is estimated. The new spectral analysis method using 2"d order hAaximum Entropy Method was applied to estimate the mean frequency and we confirmed that this new method yields fast and reliable estimation.tion.

• Journal of Biomedical Engineering Research
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• v.11 no.2
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• pp.227-232
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• 1990

As a part of the study on ultrasonic tissue characterization, conventional ultrasonic imaging system is interfaced to the personal computer to acquire raw ultrasonic signal. One approach for tissue charaterization is performed using the attenuation map to the conventional images and the resulting attenuation map images are compared and inspected inside the region of interest from the viewpoint of pattern analysis. Currently, these methods are applied and modified to effectively find out the differences between the normal control and the patients with liver cirrhosis.

• Journal of Biomedical Engineering Research
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• v.11 no.1
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• pp.113-120
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• 1990

In this paper, the deconvolution method utilizing a modified Wiener filter is applied for the enhancement of lateral resolution of ultrasonic B-scan Images. For this purpose, a phantom composed of wires which are 0.6mm of diameter and apart in the range between 3 to 9mm is constructed. The modified Wiener filter with optimal parameter is applied to the phantom for the analysis of ultrasonic image. The results obtained are as follows'When all parameters of the modified Wiener filter are optimal, the resolution of B-scan images is enhanced by 50 percent : Othenrise, the images are blurred, spilt at peak points, or noises are strengthened severely. When the point-spread function representing the characteristic function of the system is determined, the selection ranges of op- timum parameters may be narrowed. It is expected that the proposed method may be able to apply to clinic situations for more accurate image analysis by means of reducing the loss of important information.