• 대한한의진단학회지
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• 제15권2호
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• pp.175-190
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• 2011

Objectives: Even though there has been no consensus on the concept of viscera organ between the oriental and western medicine, we tried to investigate the correlation between clinical biomarkers of five Jang and chronological age and develop the models for predicting five Jang biological ages by statistical analysis. Methods: We obtained data from about 120,000 subjects who visited health promotion centers for health promotion and disease prevention from January 2004 to June 2009. Participants were included if they were over 20 years old, and excluded if reported to have cardiovascular disease or other serious medical illness such as cancer, malignant hypertension, uncontrolled diabetes, cardiopulmonary insufficiency, liver disease, pancreatic disease or renal disease. Among the clinical biomarkers obtained, we selected the biomarkers which were associated with the function of 5 Jang in previous studies, or showed statistically significant correlation with age. Multiple regression models were used for building prediction models of biological age after adjusting for potential confounders for men and women, respectively. Pearson correlation coefficient was calculated to examine the linear relationship between age and various biomarkers, and multiple regression analysis was used for building the prediction models of five Jang biological ages for men and women, respectively. All statistical data analysis was performed by using SPSS Version 12.0 software and statistical significance was obtained if p<0.05. Results: For males, the best models were developed using 12, 2, 8, 3, and 4 biomarkers for predicting biological ages of heart, lung, liver, pancreas, and kidney, respectively (R2 = 0.57, 0.43, 0.11, 0.24, and 0.93, respectively). Similar to males, for the females, 10, 2, 8, 3, and 4 biomarkers were selected as the models respectively (R2 = 0.76, 0.44, 0.14, 0.38, and 0.89, respectively). Conclusions: As we have developed for the first time the models for predicting five Jang biological ages with common clinical biomarkers, it is expected that these models may be used as clinical supplementary tools in the evaluation of aging status and functional decline of five Jang according to age in health promotion centers and private clinics. At the same time, it is considered that the use as objective tools to evaluate aging status and functional decline of each Jang.

• 한국환경보건학회지
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• 제9권2호
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• pp.1-10
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• 1983

The purpose of this study was to analyze general ingredient of bean cured on the market and to examine its exposure to bacterial contamination. For this study, 17 samples (each 9 samples for general bean curd, soft bean curd, and uncurdled bean curd) were randomly collected from nine areas in Seoul from the beginning of April, 1983 to the beginning of June, 1983. The result of ingredient analysis of moisture, ash, and protein of bean curd was compared with the standard set by the Ministry of Health & Social Affairs. In order to find out exposure of bean curd on the market to bacterial contamination, total biological bacteria and coliform group were examined. Experimental results were shown as follows 1) Results of ingredient analysis of moisture, ash, and protein of general bean curd showed that total samples in both moisture and protein met the standard set by the Ministry of Health & Social Affairs but 44.4% of the samples in ash was below the above standard, indicating average 82.0%, 0.9% and 9.6% in moisture, ash, and protein order. 2) Experimental results of moisture, ash, and protein of soft bean curd demonstrated 90.2%, 0.5% and 4.3% respectively total samples in both moisture and protein satisfied the self-criteria set by the Soft Food Co-operative Association of Seoul City but 11.1% of the samples in ash didn't meet the self-criteria. 3) Total samples of uncurdled bean curd satisfied the self-criteria set by the above association, indicating average 92.0%, 0.4%, and 3.5% in moisture, ash, and protein order. 4) Total biological bacteria and coliform group detected in general bean curd showed that more than 10$^5$/g in total biological bacteria accounted for 88.8% of the samples and that 10$^4$/g or more in coliform group accounted for 77.7% of the samples. The result proves that general bean curd has been exposured to a severe bacterial contamination. 5) Result of total biological bacteria and coliform group detected in such packed bean curd as uncurdled bean curd and soft bean curd showed that 61.6% of the samples exceeded 10$^6$/g in total biological bacteria and 27.7% of the samples exceeded 10$^3$/g in coliform group. 6) According to the change with time and temperatures in total biological bacteria and coliform group of general bean curd, general bean curd began to decay around 72 hours at 4$\circ$C and around 48 hours at 23$\circ$C and around 24 hours at 37$\circ$C and, at that time, total biological bacteria approached 10$^6$/g while coliform group did 10$^6$/g. The result indicates that temperature has a great effect on bacteria counts and decay.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 춘계학술대회
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• pp.453-456
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• 1997

In this paper, we present the developement of Biofeedback system. Biofeedback is a method for learned control of physiological response of the body. It can be used to control certain biological response that cause health problems. Over the past 2 decades, biofeedback has received much attention from medicine as a cure-all for a variety of disease. It has been heralded as a technique that can provide normalization of disturbed physiology without the need for drugs or surgery and their attendant negative side effects. Biofeedback system has been implemented by using PIC microprocessor. We have displayed 5-channel value on PC and managed patient information by using Delphi.

• Journal of Korean Biological Nursing Science
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• 제13권3호
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• pp.262-268
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• 2011

Purpose: The purpose of this study was to identify the relationship between health behaviors and musculoskeletal disease in adults. Methods: The data of 7,421 adults applied in this study were collected from health behaviors (smoking, drinking, exercise, weight, sleeping, stress) and related with musculoskeletal disease form 2009 Korea National Health and Nutrition Examination Survey. Date were collected through self-report questionnaires from January to December, 2009. Data were analyzed using chi-square test, Multivariate logistic regression with SPSS/WIN 17.0. Results: The prevalence rate of musculoskeletal disease was 30.6%. In multivariate analyses, the sex, age, BMI, stress and education were statistically strongly associated with most of musculoskeletal disease among adults. Conclusion: The results of this study suggest that musculoskeletal disease prevention and nursing intervention programs should be necessarily established and continuously managed in order to treat with the musculoskeletal disease.

• 한국환경보건학회지
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• 제36권5호
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• pp.418-434
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• 2010

As concerns regarding water pollution grow, the need increases for a fast and accurate assessment of ecological risk. In this context, many studies have been conducted to identify biomarkers which can sensitively indicate exposure to and effects of various contaminants in a water environment. However, the utility of most such biomarkers in the real water environment is not yet validated. In this paper, we conducted a thorough review of publications that were related to developing or evaluating molecular and biochemical biomarkers of freshwater fish in ecological risk assessment, and evaluated whether these biomarkers of interest could link to the effects on higher biological levels, such as histopathology and above. Biomarkers of interest included those associated with metabolism, oxidative stress, reproduction and endocrine disruption, genotoxicity, and defense against heavy metal exposure. We found that, when used alone, most molecular and biochemical biomarkers are not sufficient to understand the effects of toxic substances in higher biological levels, due to defense or acclimation mechanisms of organisms. Moreover, some biomarkers respond not only to hazardous substances but also to the changes in water quality and disease outbreak. Molecular and biochemical biomarkers may be most useful in understanding the potential biological effects of toxic compounds when used in parallel with relevant endpoints of higher biological levels.

• 한국산업보건학회지
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• 제20권4호
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• pp.274-281
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• 2010

The objectives of this study are (a) to investigate the distribution patterns and exposure concentrations of biological agents in sawmill industries and (b) to compare sampling methods of biological agents. The representative processes of 5 sawmills were selected to measure total airborne bacteria, fungi, endotoxin as well as dust. Airborne bacteria and fungi were measured with one stage impactor, six stage impactor and gelatin filteration methods. Endotoxin was collected with polycarbonate filters and analysed by kinetic chromogenic Limulus Amebocyte Lysate method. Geometric mean levels of airborne bacteria, fungi, endotoxin and dust were 1,864 CFU/$m^3$, 2,252 CFU/$m^3$, 31.5 EU/$m^3$ and 2.4 mg/$m^3$. The ratios of indoor/outdoor concentrations were 3.7 for bacteria, 4.1 for fungi, 3.3 for endotoxin and 9.7 for dust. The respiratory fractions of bacteria were 68.0, 50.9, 49.2 and 45.1% in band-saw, table-saw, rip-saw process and outdoor air. The respiratory fractions of fungi were 78.7, 90.8, 87.5 and 84.8% in band-saw, table-saw, rip-saw process and outdoor air, respectively. There was no significant differences in bacterial concentrations among single stage, six stage impaction and filteration methods. But, fungal concentrations measured with filtration methods were significantly higher than those with impaction methods. Geometric mean levels of airborne bacteria and fungi were higher than the OSHA guideline values of 1,000 CFU/$m^3$. The respiratory fractions of fungi were above 75%. The concentrations of biological agents were significantly different among culture-based sampling methods. In the exposure assessments of biological agents, further studies are needed for the comparisons of diverse sampling methods and the investigations of environmental factors.

• Journal of Ecology and Environment
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• 제39권1호
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• pp.61-70
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• 2016

Major objectives of the study were to analyze chemical and biological influences of the river ecosystem on the artificial weir construction at three regions of Sejong-Weir (S_j-W), Gongju-Weir (G_j-W), and Baekje-Weir (B_j-W) during 2008-2012. After the weir construction, the discharge volume increased up to 2.9 times, and biological oxygen demand (BOD) and electrical conductivity (EC) significantly decreased (p < 0.05). Also, the decrease of total phosphorus (TP) was also evident after the weir construction, but still hyper-eutrophic conditions, based on criteria by , were maintained. Multi-metric model of Index of Biological Integrity (IBI) showed that IBI values averaged 21.0 (range: 20-22; fair condition) in the B_wc, and 14.3 (range: 12-18; poor condition) in the A_wc. The model values of IBI in S_j-W and G_j-W were significantly decreased after the weir construction. The model of Self-Organizing Map (SOM) showed that two groups (cluster I and cluster II) of B_wc and A_wc were divided in the analysis based on the clustering map trained by the SOM. Principal Component Analysis (PCA) was similar to the results of the SOM analysis. Taken together, this research suggests that the weir construction on the river modified the discharge volume and the physical habitat structures along with distinct changes of some chemical water quality. These physical and chemical factors influenced the ecosystem health, measured as a model value of IBI.

• Molecules and Cells
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• 제38권5호
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• pp.457-465
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• 2015

The 15-kDa selenoprotein (Sep15) is a selenoprotein residing in the lumen of the endoplasmic reticulum (ER) and implicated in quality control of protein folding. Herein, we established an inducible RNAi cell line that targets Sep15 mRNA in Chang liver cells. RNAi-induced Sep15 deficiency led to inhibition of cell proliferation, whereas cell growth was resumed after removal of the knockdown inducer. Sep15-deficient cells were arrested at the G1 phase by upregulating p21 and p27, and these cells were also characterized by ER stress. In addition, Sep15 deficiency led to the relocation of focal adhesions to the periphery of the cell basement and to the decrease of the migratory and invasive ability. All these changes were reversible depending on Sep15 status. Rescuing the knockdown state by expressing a silent mutant Sep15 mRNA that is resistant to siRNA also reversed the phenotypic changes. Our results suggest that SEP15 plays important roles in the regulation of the G1 phase during the cell cycle as well as in cell motility in Chang liver cells, and that this selenoprotein offers a novel functional link between the cell cycle and cell motility.

• Journal of Korean Biological Nursing Science
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• 제17권1호
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• pp.50-59
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• 2015

Purpose: The purpose of this study was to determine the relationship among concepts of the salutogenic model - sense of coherence, occupational stress, and health status in clinical nurses. Methods: Participants were recruited from a hospital in Seoul using a stratified random sampling. A total of 349 nurses participated in the study and data were collected using a self-administered questionnaire. The structural equation model was used to assess the relationships among the variables. Results: The results of the study showed that occupational stress and health behavior were significant factors, directly explaining the health status of nurses. Factors explaining occupational stress were: sense of coherence, and social support. Sense of coherence showed higher effects on occupational stress than those of social support. Sense of coherence and the work conditions (work experience and shift work) of nurses had a significant and direct effect on health behavior. Sense of coherence and social support had a significant and indirect effect on health status through occupational stress and health behavior. Conclusion: Strategies to enhance sense of coherence and social support are necessary for successful health promotion programs for nurses.

• Journal of Korean Biological Nursing Science
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• 제24권2호
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• pp.113-121
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• 2022

Purpose: The purpose of this study was to identify influence of health behavior in patients with coronary artery disease. Methods: A cross-sectional descriptive design included 150 patients treated with percutaneous coronary intervention in S hospital in S city. Data were collected by using self-questionnaires July 5-August 26, 2021 and were analyzed by descriptive statistics, t-test, ANOVA, Scheffé test, Pearson's correlation coefficients, and multiple regression with SPSS 23.0. Results: Factors significantly influencing health behavior in patients with coronary artery disease were health empowerment (β = .48, p< .001), and post-traumatic growth (β = .20, p= .013). The explanatory power of related variables was 39%. Conclusion: Based on the this study, it was found that health empowerment and post-traumatic growth had a significant effect on the health behavior of patients with coronary artery disease. Thus, it is necessary to promote the health behavior of patients with coronary artery disease through the development of intervention programs to improve health empowerment and post-traumatic growth.