• Title/Summary/Keyword: biochip

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A Disposable BioChip for Single Cell Manipulation

  • Yoon, Euisik
    • Proceedings of the Korean Society Of Semiconductor Equipment Technology
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    • 2004.10a
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    • pp.1-15
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    • 2004
  • o Various microfluidic components including mixromixers and micropumps have been developed for disposable biochip applications. o Single cell capturing, positioning and nanoliter drug injection chip has been demostrated. o Multi-channel, two-dimensional micro-well array has been fabricated and cell capturing and specific reagent injection have been performed.

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최신특허 동향 바이오칩

  • 이한영
    • BT NEWS
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    • v.11 no.2
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    • pp.35-40
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    • 2004
  • ‘바이오칩(biochip)’ 이란 컴퓨터 칩(computer chip)에서 유래되어 바이오(bio)와 관련된 어떤 집적회로의 요소와 관련된 용어로 지칭되어 왔으나, 최근 몇년 동안 기술개발이 구체으로 이루어 지면서, DNA를 포함한 생체분자(biomolecule)에 대하여 생화학적 분석에 사용되는 프로브(probe)를 정렬(array)시킨 물질 및 장치라고 정의되고있다.(중략)

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Evaluation of Efficiency on Glass Precision Machining by using Abrasive Water-jet (연마재 워터젯 가공을 이용한 유리 미세 가공 성능 평가)

  • Bahk, Yeon-Kyoung;Park, Kang-Su;Kim, Hyung-Hoon;Shin, Bo-Sung;Ko, Jong-Soo;Go, Jeung-Sang
    • Journal of the Korean Society for Precision Engineering
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    • v.27 no.7
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    • pp.87-93
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    • 2010
  • This paper presents an evaluation of efficiency on glass precision machining by using abrasive water-jet machine. In this study, problems of conventional water-jet machining are examined experimentally and are analysized numerically. Especially, the reason of whitening on the machined surface of biochip glass is determined. It is found that the mass flow rate of abrasive input and transverse speed of water-jet are key parameters to control the direct machining of micro hole and channel on a glass substrate. Based on results of experimental analysis, possibility of direct fabrication of micro holes and channels on a glass substrate is successfully confirmed.

Enhancement of DNA Microarray Hybridization using Microfluidic Biochip (미세유체 바이오칩을 이용한 DNA 마이크로어레이 Hybridization 향상)

  • Lee, H.H.;Kim, Y.S.
    • KSBB Journal
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    • v.22 no.6
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    • pp.387-392
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    • 2007
  • Recently, microfluidic biochips for DNA microarray are providing a number of advantages such as, reduction in reagent volume, high-throughput parallel sample screening, automation of processing, and reduction in hybridization time. Particularly, the enhancement of target probe hybridization by decrease of hybridization time is an important aspect highlighting the advantage of microfluidic DNA microarray platform. Fundamental issues to overcome extremely slow diffusion-limited hybridization are based on physical, electrical or fluidic dynamical mixing technology. So far, there have been some reports on the enhancement of the hybridization with the microfluidic platforms. In this review, their principle, performance, and outreaching of the technology are overviewed and discussed for the implementation into many bio-applications.

Planar Hall Sensor Used for Microbead Detection and Biochip Application

  • Thanh, N.T.;Kim, D.Y.;Kim, C.G.
    • Journal of Magnetics
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    • v.12 no.1
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    • pp.40-44
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    • 2007
  • The Planar Hall effect in a spin valve structure has been applied as a biosensor being capable of detecting $Dynabeads^{(R)}$ M-280. The sensor performance was tested under the application of a DC magnetic field where the output signals were obtained from a nanovoltmeter. The sensor with the pattern size of $50{\times}100{\mu}m^2$ has produced high sensitivity; especially, the real-time profiles by using that sensor revealed significant performance at external applied magnetic field of around 7.0 Oe with the resolution of 0.04 beads per $\mu m^2$. Finally, a successful array including 24 patterns with the single sensor size of $3{\times}3{\mu}m^2$ has shown the uniform and stable signals for single magnetic bead detection. The comparison of this sensor signal with the others has proved feasibility for biosensor application. This, connecting with the advantages of more stable and high signal to noise of PHR sensor's behaviors, can be used to detect the biomolecules and provide a vehicle for detection and study of other molecular interaction.