• Food Science and Biotechnology
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• 제15권4호
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• pp.494-498
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• 2006

An increase in variance (overdispersion) can occur when a binomial statistical analysis is applied to sensory difference test data in which replicate sensory evaluations (tastings) and multiple evaluators (judges) are combined to increase the sample size. Such a practice can cause extensive Type I errors, leading to serious misinterpretations of the data, especially when traditional simple binomial analysis is applied. Alternatively, the use of beta binomial analysis will circumvent the problem of overdispersion. This brief review discusses the uses and computation methodology of beta binomial analysis and in practice evidence for the occurrence of overdispersion.

• 한국신뢰성학회지:신뢰성응용연구
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• 제13권1호
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• pp.1-10
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• 2013

A Bayesian zero-failure reliability demonstration test method for products with exponential lifetime distribution is presented. Beta prior distribution for reliability of a product is used to design the Bayesian test plan and selecting a prior distribution using a prior test information is discussed. A test procedure with zero-failure acceptance criterion is developed that guarantees specified reliability of a product with given confidence level. An example is provided to illustrate the use of the developed Bayesian reliability demonstration test method.

• 산업경영시스템학회지
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• 제35권2호
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• pp.98-105
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• 2012

This paper describes the Bayesian approach for reliability demonstration test based on the samples from a finite population. The Bayesian approach involves the technical method about how to combine the prior distribution and the likelihood function to produce the posterior distribution. In this paper, the hypergeometric distribution is adopted as a likelihood function for a finite population. The conjugacy of the beta-binomial distribution and the hypergeometric distribution is shown and is used to make a decision about whether to accept or reject the finite population judging from a viewpoint of faulty goods. A numerical example is also given.

• 대한치과보철학회지
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• 제54권2호
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• pp.120-125
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• 2016

목적: 본 연구는 in-vitro 상에서 recombinant human transforming growth factor-beta (rhTGF-${\beta}2$)와 poly(D,L-lactide-co-glycolide) (PLGA) 의 복합체를 티타늄 디스크 표면에 코팅하여, 생물학적으로 간엽줄기세포 증식에 미치는 영향을 조사하기 위해 시행되었다. 재료 및 방법: 양극산화 디스크에 일렉트로스프레이 코팅법을 이용하여 anodized 된 티타늄 디스크를 대조군으로 설정하고, rhTGF-${\beta}2$를 125 ng/ml와 500 ng/ml 농도로 코팅한 것을 실험군으로 하였다. 티타늄 디스크 표면에 분사된 복합체가 균일하게 분사되었는지 field-emission scanning electron microscopy (FE-SEM)을 통해 확인하였으며, atomic force microscope (AFM) test를 이용하여 rhTGF-${\beta}2$로 코팅한 디스크와 양극산화 디스크의 거칠기 차이를 확인하였다. 디스크 위에 간엽줄기세포 배양 후 1, 4, 7일에 세포증식 양상을 MTT (3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl-tetrazolium bromide) assay 검사를 통해 확인하였다. 결과: AFM 결과 대조군과 실험군에서 거칠기의 유의할만한 차이가 없었다 (P>.05). MTT 결과 7일차 배양 결과에서 125 ng/ml와 500 ng/ml PLGA/TGF-${\beta}2$처리된 그룹은 각각 평균 0.45와 0.48이였으며, 대조군은 평균 0.33으로 PLGA/TGF-${\beta}2$처리된 그룹에서 세포 증식이 더 활성화 되는 것을 확인할 수 있었다 (P<.05). 결론: rhTGF-${\beta}2$ 복합체를 electrospray법으로 코팅한 티타늄 표면에서 7일차에서 줄기간엽세포의 빠른 증식을 확인하였다. 또한 복합체 처리군의 농도가 증가할수록 높은 세포 성장 수치를 보였다.

• 대한의생명과학회지
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• 제11권3호
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• pp.389-396
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• 2005

Resent studies have reported increased isolation of extended-spectrum $\beta-lactamase$ (ESBL) producing strains at several hospital in Korea. We studied to investigate the isolation rates of ESBL strains from clinical isolates of Klebsiella pneumoniae and to characterize differences in types using analyses of genotyping and antibiotic susceptibility test. Antibiotic susceptibility test with confirmation of ESBL by double disk synergy test was performed on the 54 ESBL strains of Klebsiella pneumoniae from a hospital in Busan. Transfer of resistant gene in ESBL strains resistant to 3rd generated antibiotics was confirmed by transconjugation test using E. coli $RG176^{nal(r)}$. blaTEM, blaSHV, blaCTX-M genes were detected by PCR. ESBL producing strains had 100% of resistant rate to ampicillin, azteronam, cefazolin, cefepime and ceftriaxone ($\beta-lactam$ antibiotics). Forty strains of bla TEM$(74\%)$, 41 strains of bla SHV $(76\%)$, 23 strains of bla CTX-M $(43\%)$ were found, respectively. The strains had one or more genes. They had high resistant rates to $\beta-lactam$ antibiotics including cephalosporin. The resistant rates of strains with multiple resistant genes were higher than those of strains with single resistant gene.

• Asian Pacific Journal of Cancer Prevention
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• 제17권8호
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• pp.4089-4093
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• 2016

Purpose: This study aimed to explore the association of ${\beta}-catenin$ expression pattern with pathological response after neoadjuvant chemotherapy in breast cancer (BC) patients. Materials and Methods: In this retrospective exploratory study, data for 50 BC patients who received neoadjuvant chemotherapy were recorded. ${\beta}-catenin$ expression in tumours was assessed using immunohistochemistry and classified as either membranous or cytoplasmic according to the pattern of staining. Distributions of different clinico-pathological parameters according to ${\beta}-catenin$ expression were assessed using the Chi-square test. Logistic regression analysis was used to assess any relation of the pattern of ${\beta}-catenin$ expression with the pathological response. Results: Cytoplasmic ${\beta}-catenin$ expression was detected in 34% of BCs. Among our cases, 52% were hormonal receptor (HR)-positive, 24% were HER2-positive, 74% were clinical stage III and 74% received both anthracycline and taxane-based chemotherapy. Patients with cytoplasmic expression were more commonly younger than 40 years at diagnosis (cytoplasmic, 41.2% vs. no cytoplasmic expression, 12.1%, p=0.03). By doing t-test, cytoplasmic ${\beta}-catenin$ expression was linked with a higher body mass index compared to membranous-only expression ($mean{\pm}SD$ $33.0{\pm}4.47$ vs. $29.6{\pm}6.01$, respectively, p=0.046). No significant associations were found between ${\beta}-catenin$ expression and other parameters such as HR and HER2 status, or clinical stage. Complete pathological response (pCR) rate was twice as great in patients with membranous expression but without statistical significance (membranous-only, 33.3% vs. cytoplasmic, 17.6%, OR= 2.3, 95% CI= 0.55-9.87, p=0.24). Conclusions: This study suggests that cytoplasmic ${\beta}-catenin$ expression may be linked with lower probability of achieving pCR after neoadjuvant chemotherapy. These data need to be validated in a larger cohort of patients.

• Archives of Pharmacal Research
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• 제24권6호
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• pp.590-596
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• 2001

A new extended-spectrum ${\beta}-lactamase$ with an isoelectric point (pl) of 6.2 was detected in Klebsiella pneumoniae Fl 61 that was isolated from a patient with infection. This strain was highly resistant to the third or fourth generation cephalosporins such as cceftazidime ceftriaxone, cefoperzaone, and cefpirome. Analysis of this strain by the double disk diffusion test showed synergies between amoxicillin-clavulanate (AMX-CA) and cefotaxime, and AMX-CA and aztreonam, which suggested that this strain produced a extended-spectrum ${\beta}-lactamase$ (ESBL). Cenetic analysis revealed that the resistance was due to the presence of a 9.4-kb plasmic, designated as pkpl 61, encoding for new ${\beta}-lactamase$ gene (bla). Sequence analysis showed that a new bla gene of pkpl 61 differed from $bla_{TEM-1}$ by three mutations leading to the following amino acid substitutions: $Val_{84}{\rightarrow}lie,{\;}Ala_{184}{\rightarrow}Val,{\;}and{\;}Gly_{238}{\rightarrow}Ser$. These mutations have not been reported previously in the TIM type ${\beta}-lactamases$ produced by clinical strains. The novel ${\beta}-lactamase$ was overexpressed in E. coli and purified by ion exchange chromatography on Q-Sepharose and CM-Sepharose, and then further purified by gel filtration on Sehadex G-200. The catalytic activity of th8 purified ${\beta}-lactamase$ was confirmed by the nitrocefin disk.

• 한국산학기술학회논문지
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• 제17권9호
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• pp.628-640
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• 2016

본 연구는 간호대학생의 감성지능이 진로결정 자기효능감과 진로결정수준에 미치는 영향요인을 파악하고자 실시된 서술적 조사연구이다. 대상자는 대구 경북지역 간호 대학생 3,4학년 223명이며, 구조화된 설문지를 이용하여 2015년 10월 19일부터 10월 30일까지 편의표집 하였다. 본 연구에서 수집된 자료는 SPSS 22.0 통계 프로그램을 이용하여, 인구사회학적 특성, 감성지능, 진로결정자기효능감, 진로결정수준은 기술통계(빈도, 백분율, 평균, 표준편차)를 실시하고, 측정도구의 신뢰도는 Cronbach's ${\alpha}$값을 구하였다. 일반적인 특성에 따른 감성지능, 진로결정자기효능감, 진로결정수준의 차이는 t-test와 ANOVA를 하였고, 사후검정은 Scheffe test를 실시하였다. 또한 주요변인 간의 상관관계는 Pearson's correlation coefficients를 산출하여 분석하였다. 대상자의 일반적 특성과 감성지능이 진로결정자기효능감과 진로결정수준에 미치는 영향을 살펴보기 위하여 다중회귀분석을 실시하였다. 분석결과 감성지능과 진로결정 자기효능감, 진로결정수준은 정(+)적 상관성을 보였다. 진로결정 자기효능감에 미치는 영향요인은 성별(${\beta}=-.155$), 취업률 동기(${\beta}=-.145$), 감성 활용(${\beta}=.236$), 감성조절(${\beta}=.197$), 타인 감성이해(${\beta}=.157$)가 유의미하였다. 진로결정수준에 미치는 영향요인은 학년(${\beta}=.273$), 취업률 동기(${\beta}=-.145$), 주위의 권유동기(${\beta}=-.138$), 감성조절(${\beta}=.223$)이 유의미하였다. 따라서 간호학과 선택 시 자신의 의지로 선택할 수 있도록 학교나 가정에서 간호사의 역할이나 임무 등에 대하여 충분하게 조언할 필요가 있다. 또한 학사과정에서 정서적 교육 등의 비중을 높이면 감성지능을 향상시킬 수 있을 것이다.

• 대한간호학회지
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• 제44권5호
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• pp.515-524
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• 2014

Purpose: The purpose of this study was to identify whether the couple perceived breast cancer as a traumatic event, to evaluate the association among posttraumatic growth, dyadic adjustment, and quality of life and to explore the predictors affecting quality of life of the couple. Methods: A cross-sectional comparative survey design was utilized. Participants were 57 couples recruited from a national cancer center in Korea. Data were analyzed using paired t-test, McNemar test and independent t-test. On the basis of variables found to be significantly associated with quality of life, multiple regression was used to examine the simultaneous influence of multiple predictors. Results: Breast cancers survivors and spouses perceived breast cancer as a traumatic event (43.9% and 24.6%, respectively). The global quality of life was explained by perception as trauma (${\beta}$= -19.79) and posttraumatic growth (${\beta}$=0.46) in survivors, and perception as trauma (${\beta}$= -18.81) and dyadic adjustment (${\beta}$=0.53) in spouses. Conclusion: Results suggest that future research should use qualitative methods to evaluate why contemplating reasons for cancer contributed to posttraumatic growth, examine other potential predictors of quality of life such as dyadic adjustment and intimacy, and identify links between posttraumatic growth and other psychological outcomes such as distress and well-being, using prospective analyses.

• 한국컴퓨터정보학회논문지
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• 제22권10호
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• pp.145-150
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• 2017

This study aims to analyze panel data using OECD Health data of 34 years to examine how significant the inequality of income is to the inequality of health. The data was from OECD's pooled Health data of 32 countries from 1980 to 2013. The process of determining analysis model was as follows; First, through the descriptive statistics, we examined averages and standard deviation of variables. Second, Lagrange multiplier test has done. Third, through the F-test, we compared Least squares method and Fixed effect model. Lastly, by Hausman test, we determined proper model and examined effective factor using the model. As a result, rather than Pooled OLS Model, Fixed Effect Model was shown as effective in order to consider the characteristics of individual in the panel. The results are as follows: First, as relative poverty rate(${\beta}=-19.264$, p<.01) grows, people's life expectancy decreases. Second, as the rate of smoking(${\beta}=-.125$, p<.05) and the rate of unemployment (${\beta}=-.081$, p<.01) grows, people's life expectancy decreases. Third, as health expenditure(${\beta}=.414$, p<.01) shares more amount of GDP and as the number of hospital beds(${\beta}=-.190$, p<.05) grows, people's life expectancy increases.