• Perspectives in Nursing Science
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• v.12 no.1
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• pp.50-59
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• 2015

Purpose: The purpose of this study was to investigate the influencing factors on the quality of life of elders. Methods: Data were collected from August 25, September 1, 2014, and participants were 300 elders who were using senior welfare centers. Descriptive statistics, t-test, one-way ANOVA, Pearson correlation coefficient, and stepwise multiple regression were used for data analysis. Results: Elders who were more painful, highly perceived health status, self-esteem and social support, and lower depression showed relatively higher quality of life. Also, there were strong correlations between quality of life and depression (r=-.737) /perceived health status (r=.709). Factors predicted quality of life of elders were perceived health status (${\beta}=.349$), depression (${\beta}=-.267$), social support (${\beta}=.172$), self-esteem (${\beta}=.170$), pain (${\beta}=-.130$), income (${\beta}=.113$), and level of education (${\beta}=.064$). These 7 factors explained 78.2% of the variance in quality of life of elders (F=154.49, p<.001). Conclusion: Therefore, in order to improve the quality of life of elders, a systematic approach is necessary through multilateral cooperation among comprehensive sectors.

• Molecules and Cells
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• v.41 no.9
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• pp.853-867
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• 2018

As the most common type of endocrine malignancy, papillary thyroid cancer (PTC) accounts for 85-90% of all thyroid cancers. In this study, we presented the hypothesis that SDC4 gene silencing could effectively attenuate epithelial mesenchymal transition (EMT), and promote cell apoptosis via the $Wnt/{\beta}-catenin$ signaling pathway in human PTC cells. Bioinformatics methods were employed to screen the determined differential expression levels of SDC4 in PTC and adjacent normal samples. PTC tissues and adjacent normal tissues were prepared and their respective levels of SDC4 protein positive expression, in addition to the mRNA and protein levels of SDC4, $Wnt/{\beta}-catenin$ signaling pathway, EMT and apoptosis related genes were all detected accordingly. Flow cytometry was applied in order to detect cell cycle entry and apoptosis. Finally, analyses of PTC migration and invasion abilities were assessed by using a Transwell assay and scratch test. In PTC tissues, activated $Wnt/{\beta}-catenin$ signaling pathway, increased EMT and repressed cell apoptosis were determined. Moreover, the PTC K1 and TPC-1 cell lines exhibiting the highest SDC4 expression were selected for further experiments. In vitro experiments revealed that SDC4 gene silencing could suppress cell migration, invasion and EMT, while acting to promote the apoptosis of PTC cells by inhibiting the activation of the $Wnt/{\beta}-catenin$ signaling pathway. Besides, $si-{\beta}-catenin$ was observed to inhibit the promotion of PTC cell migration and invasion caused by SDC4 overexpression. Our study revealed that SDC4 gene silencing represses EMT, and enhances cell apoptosis by suppressing the activation of the $Wnt/{\beta}-catenin$ signaling pathway in human PTC.

• Archives of Pharmacal Research
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• v.28 no.2
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• pp.227-231
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• 2005

We examined the effect of the subcutaneous (s.c.) pretreatment of formalin into both hind paws of mice on the antinociception induced by the intracerebroventricularly (i.c.v.) or intrathecally (i.t.) administration of ${\beta}$-endorphin using the tail-flick test. Pretreatment with formalin ($5\%$) for 5 h had no affect on the i.c.v. administered ${\beta}$-endorphin-induced tail-flick response. However, pretreatment with formalin for 40 h attenuated the tail-flick inhibition induced by i.c.v. administered ${\beta}$-endorphin. This antinociceptive tolerance to i.c.v. ${\beta}$-endorphin continued up to 1 week, but to a lesser extent. Pretreatment with formalin for 5 and 40 h significantly reduced the i.t. ${\beta}$-endorphin-induced inhibition of the tail-flick response, which continued up to 1 week. The s.c. formalin treatment increased the hypothalamic pro-opiomelanocortin (POMC) mRNA level at 2 h, but this returned to the basal level after 40 h. Our results suggest that the increase in the POMC mRNA level in the hypothalamus appears to be involved in the supraspinal or spinal ${\beta}$-endorphin-induced antinociceptive tolerance in formalin-induced inflammatory pain.

• Journal of Korean Academy of Nursing
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• v.46 no.3
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• pp.327-337
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• 2016

Purpose: The purpose of this study was to construct and test a structural equation model on resilience of breast cancer patients receiving chemotherapy. Methods: Participants were 204 patients with breast cancer who received chemotherapy treatment. They participated in a structured interview, which included social support, depression, symptom experience, self-efficacy, hope, resilience, and infection prevention behaviors. Data were analyzed using SPSS/WIN 20.0 and AMOS 18.0. Results: Lower depression (${\gamma}=-.33$, p=.020) and symptom experience (${\gamma}=-.31$, p=.012) and higher self-efficacy (${\gamma}=.32$, p=.005) and hope (${\gamma}=.48$, p=.016) were influenced by higher social support. Greater resilience was influenced by lower symptom experience (${\beta}=-.18$, p=.016), higher self-efficacy (${\beta}=.49$, p=.023), and higher hope (${\beta}=.46$, p=.012), and these predictors explained 66.7% of variance in resilience. Greater resilience (${\beta}=.54$, p =.009) made an impact on greater infection prevention behaviors. Resilience mediated the relations of symptom experience (${\beta}=-.10$ p=.013), self-efficacy (${\beta}=.27$, p=.006) and hope (${\beta}=.25$, p=.009) with infection prevention behaviors. These predictors explained 24.9% of variance in infection prevention behaviors. Conclusion: The findings of the study suggest that breast cancer patients with greater resilience who are receiving chemotherapy participate in increased infection prevention behaviors. Further research should be conducted to seek intervention strategies that improve breast cancer patients' resilience.

• Nutrition Research and Practice
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• v.9 no.5
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• pp.480-488
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• 2015

BACKGROUND/OBJECTIVES: Alzheimer's disease (AD) is characterized by deficits in memory and cognitive functions. The accumulation of amyloid beta peptide ($A{\beta}$) and oxidative stress in the brain are the most common causes of AD. MATERIALS/METHODS: Caffeic acid (CA) is an active phenolic compound that has a variety of pharmacological actions. We studied the protective abilities of CA in an $A{\beta}_{25-35}$-injected AD mouse model. CA was administered at an oral dose of 10 or 50 mg/kg/day for 2 weeks. Behavioral tests including T-maze, object recognition, and Morris water maze were carried out to assess cognitive abilities. In addition, lipid peroxidation and nitric oxide (NO) production in the brain were measured to investigate the protective effect of CA in oxidative stress. RESULTS: In the T-maze and object recognition tests, novel route awareness and novel object recognition were improved by oral administration of CA compared with the $A{\beta}_{25-35}$-injected control group. These results indicate that administration of CA improved spatial cognitive and memory functions. The Morris water maze test showed that memory function was enhanced by administration of CA. In addition, CA inhibited lipid peroxidation and NO formation in the liver, kidney, and brain compared with the $A{\beta}_{25-35}$-injected control group. In particular, CA 50 mg/kg/day showed the stronger protective effect from cognitive impairment than CA 10 mg/kg/day. CONCLUSIONS: The present results suggest that CA improves $A{\beta}_{25-35}$-induced memory deficits and cognitive impairment through inhibition of lipid peroxidation and NO production.

• Journal of Korean Academy of Nursing
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• v.49 no.4
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• pp.375-385
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• 2019

Purpose: This study aimed to develop and test a structural model for chemotherapy-related cognitive impairment of breast cancer patients based on a literature review and Hess and Insel's chemotherapy-related cognitive change model. Methods: The Participants consisted of 250 patients who were ${\geq}19$ years of age. The assessment tools included the Menopause Rating Scale, Symptom Experience Scale, Hospital Anxiety and Depression Scale, Everyday Cognition, and Functional Assessment of Cancer Therapy-Breast Cancer. Data were analyzed using the SPSS 21.0 and AMOS 21.0 programs. Results: The modified model was a good fit for the data. The model fit indices were ${\chi}^2=423.18$ (p<.001), ${\chi}^2/df=3.38$, CFI=.91, NFI=.91, TLI=.89, SRMR=.05, RMSEA=.09, and AIC=515.18. Chemotherapy-related cognitive impairment was directly influenced by menopausal symptoms (${\beta}=.38$, p=.002), depression and anxiety (${\beta}=.25$, p=.002), and symptom experiences (${\beta}=.19$, p=.012). These predictors explained 47.7% of the variance in chemotherapy-related cognitive impairment. Depression and anxiety mediated the relations among menopausal symptoms, symptom experiences, and with chemotherapy related cognitive impairment. Depression and anxiety (${\beta}=-.51$, p=.001), symptom experiences (${\beta}=-.27$, p=.001), menopausal symptoms (${\beta}=-.22$, p=.008), and chemotherapy-related cognitive impairment (${\beta}=-.15$, p=.024) had direct effects on the quality of life and these variables explained 91.3%. Conclusion: These results suggest that chemotherapy-related toxicity is highly associated with cognitive decline and quality of life in women with breast cancer. Depression and anxiety increased vulnerability to cognitive impairment after chemotherapy. Nursing intervention is needed to relieve chemotherapy-related toxicity and psychological factor as well as cognitive decline for quality of life in patients undergoing chemotherapy.

• Korean journal of applied entomology
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• v.24 no.4 s.65
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• pp.209-218
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• 1986

This study was performed to evaluate the differences in resistance of rice varieties to biotypes of the brown planthopper (BPH), capable of surving on the Milyang 30 and Milyang 63 varieties which have Bph 1 and bph 2 gene for resistance, respectively. The rice varieties tested were Milyang 30, Cheongcheong, Milyang 63 and Gaya which have been reported as having resistant genes for the BPH. The check varieties were Chucheong and Sangpoong which have no resistant gene. The degree of resistance to the BPH biotypes indicated that Milyang 30, Cheongcheong, Milyang 63 and Gaya varieties were highly resistant to the biotype 1. But their reactions against biotype 2 and 3 were variable, namely Milyang 30 and Cheongcheong were susceptible to biotype 2, and Milyang 63 was susceptible to biotype 3. In the esterase isozyme patterns of brown rice the bands of ${\beta}-1,\;{\beta}-3\;and\;{\beta}-5$ were detected in Chucheong and Sangpoong, while the bands of ${\alpha}-1,\;{\beta}-2\;and\;{\beta}-5$ were detected in the test varieties which have genes for resistance. However, the bands of ${\beta}-5$ in Milyang 63 and Gaya were stronger than those of Milyang 30 and Cheongcheong varieties. In the root of 10-days seedling, the esterase bands of ${\alpha}-2,\;{\beta}-2\;{\beta}-4\;and\;{\beta}-5$ were detected in Chucheong and Sangpoong, while the bands of ${\alpha}-1,\;{\beta}-1\;{\beta}-3\;and\;{\beta}-5$ were detected in the tested different varieties. But the bands of ${\alpha}-1\;and\;{\beta}-5$ in Milyang 63 and Gaya were stronger than those of Milyang 30 and Cheongcheong varieties.

• Proceedings of the KSR Conference
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• 2011.05a
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• pp.1799-1810
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• 2011

Origin-Destination(OD) trip survey being used in travel demand forecasting has been obtained through totalizing process with direct sample survey techniques such as plate license survey, roadside interview, household travel survey, and cordon line counts. However, the OD survey has many discrepancies in sampling, totalizing process, and such discrepancies contains problems of difference between forecasted traffic volume and observed data. On the other hand, transit smart card data recently collected has credible resource of obtaining travel information for bus and metro. This paper presents parameter estimation of gravity model by using transit smart card data. Through the parameter estimation method, we estimated =0.57, ${\beta}$=0.14 of gravity model for bus, and ${\alpha}$=-0.21, ${\beta}$=0.05 for metro. The statistical test such as T-test, coefficient of correlation, Theil`s inequality coefficient showed no difference between observed volume and estimated volume. Elasticities of bus and metro derived in this paper are also reasonable.

• Journal of Korean Biological Nursing Science
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• v.19 no.3
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• pp.170-177
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• 2017

Purpose: This study was to identify factors influencing the quality of sleep in elderly women with urinary incontinence and examine the relationship among the factors. Methods: The study investigated 113 elderly women with urinary incontinence who were subject to the visiting care program at health centers in D-gu, D-si, South Korea. The collected data were analyzed using IBM SPSS version 19.0 along with ${\chi}^2-test$, t-test, ANOVA, Pearson's correlation, and multiple regression. Results: The total Pittsburgh Sleep Quality Index (PSQI) of the participants was found to be $11.41{\pm}4.34$. As a result of the correlation analysis, PSQI was found to have significant correlations with Female Lower Urinary Tract Symptoms (BFLUTS) (r= .32, p< .001). The Korean version of Physical Activity Scale for Elderly (K-PASE) was (r= -.34, p< .001) and the Geriatric Depression Scale Short Form (GDS-SF) was (r= .23, p= .012). Multiple regression analysis found sleeping pill use (${\beta}=-.35$, p< .001) had the strongest influence on PSQI, followed by physical activity (${\beta}=-.20$, p< .001), depression (${\beta}=.20$, p< .001), and lower urinary tract symptoms (${\beta}=.19$, p< .001). The total model explanatory power was 28.3% (F= 12.07, p< .001). Conclusion: The study findings are expected to be useful for enhanced understanding of the quality of sleep in elderly women with urinary incontinence.

• The Journal of the Convergence on Culture Technology
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• v.4 no.2
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• pp.17-25
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• 2018

The purpose of this study was to investigate the relationship among the variables and the influence of academic self-efficacy and self-directed learning ability on the life satisfaction of nursing students. Method : The participants were 340 nursing students in K city, who were surveyed between October 10 and October 17, 2017, using self-report questionnaire. Result: There were positive correlation between academic self-efficacy and self-directed learning ability life satisfaction for nursing students. The variables for life satisfaction addiction where "Self-directed learning ability" (${\beta}=.143$, p=.029) and "Class concentration" (${\beta}=.099$, p=.048), with a coefficient of determination ($R^2$) of 37.0%. Based on these results, it will be necessary to develop educational programs and strategies related with the self-directed learning ability and class concentration disposition to improve life satisfaction of nursing students.