• Title/Summary/Keyword: beta curve

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Estimation of heritability and genetic correlation of body weight gain and growth curve parameters in Korean native chicken

  • Manjula, Prabuddha;Park, Hee-Bok;Seo, Dongwon;Choi, Nuri;Jin, Shil;Ahn, Sung Jin;Heo, Kang Nyeong;Kang, Bo Seok;Lee, Jun-Heon
    • Asian-Australasian Journal of Animal Sciences
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    • v.31 no.1
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    • pp.26-31
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    • 2018
  • Objective: This study estimated the genetic parameters for body weight gain and growth curve parameter traits in Korean native chicken (KNC). Methods: A total of 585 $F_1$ chickens were used along with 88 of their $F_0$ birds. Body weights were measured every 2 weeks from hatching to 20 weeks of age to measure weight gain at 2-week intervals. For each individual, a logistic growth curve model was fitted to the longitudinal growth dataset to obtain three growth curve parameters (${\alpha}$, asymptotic final body weight; ${\beta}$, inflection point; and ${\gamma}$, constant scale that was proportional to the overall growth rate). Genetic parameters were estimated based on the linear-mixed model using a restricted maximum likelihood method. Results: Heritability estimates of body weight gain traits were low to high (0.057 to 0.458). Heritability estimates for ${\alpha}$, ${\beta}$, and ${\gamma}$ were $0.211{\pm}0.08$, $0.249{\pm}0.09$, and $0.095{\pm}0.06$, respectively. Both genetic and phenotypic correlations between weight gain traits ranged from -0.527 to 0.993. Genetic and phenotypic correlation between the growth curve parameters and weight gain traits ranged from -0.968 to 0.987. Conclusion: Based on the results of this study population, we suggest that the KNC could be used for selective breeding between 6 and 8 weeks of age to enhance the overall genetic improvement of growth traits. After validation of these results in independent studies, these findings will be useful for further optimization of breeding programs for KNC.

Prediction of The Course of Early Pregnancy after In Vitro Fertilization by Placental Proteins (체외수정 후 태반단백들을 이용한 초기임신의 예후 추정)

  • Kim, Hak-Soon;Moon, Shin-Yong;Chang, Yoon-Seok
    • Clinical and Experimental Reproductive Medicine
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    • v.17 no.1
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    • pp.45-56
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    • 1990
  • Maternal serum ${\beta}$-specific human chorionic gonadotropin(${\beta}$-hCG) and pregnancy-specific ${\beta}_1$-glycoprotein($SP_1$) levels were determined more than one per week during 11-41 days post embryo transfer(ET) in 21 consecutive pregnancies after in vitro fertilization(IVF), which included 8 normal singleton pregnancies, 3 twin pregnancies, 4 clinical abortions, 1 ectopic pregnancy, and 5 preclinical abortions. The sensitivity of serum ${\beta}$-hCG and $SP_1$ radioimmunoassays was 3mIU/ml and 0.7ng/ml relatively. At the 7th to 8th week of gestation, ultrasonographic confirmation of fetal pole and fetal heartbeat was performed. Both serm ${\beta}$-hCG and $SP_1$ levels showed logarithmic increase, but log[$SP_1$] had more steep rising curve and had wider variation than log[${\beta}$-hCG] in normal singleton pregnancies. In 3 twin pregnancies and one ectopic pregnancy, both serum ${\beta}$-hCG and $SP_1$ levels located within the 95% confidence interval of the mean levels of 8 normal singleton pregnancies(normal range). In 2 clinical abortions which had a fetal pole without heartbeat, serum ${\beta}$-hCG level showed lower limit of the normal range or just below, but all $SP_1$ levels showed within the normal range. In other 2 clinical abortions which were diagnosed as blighted ovum, both serum ${\beta}$-hCG levels from 11 days post-ET and serum $SP_1$ levels from later days compared with ${\beta}$-hCG were below the normal range. In 5 preclinical abortions, serum $SP_1$ levels were within the normal range but serum ${\beta}$-hCG levels were far below the normal range. In conclusion, both serum ${\beta}$-hCG and $SP_1$ levels increased exponentially with similar pattern in normally conceived pregancy after IVF-ET. Both serum ${\beta}$-hCG and $SP_1$ levels could predict outcome of early pregnancy to a certain degree, but log[${\beta}$-hCG] levels had more significant correlation with outcome of pregnancy compared with log[$SP_1$] levels. In addition, ultrasonographic examination of fetal poles and fetal heartbeats gives very important clinical information and prognosis.

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Molecular Theory of Superplastic Deformation (초소성변형의 분자론)

  • Chang Hong Kim;Taikyue Lee
    • Journal of the Korean Chemical Society
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    • v.23 no.4
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    • pp.217-236
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    • 1979
  • The author's theory for plastic deformation was applied to superplastic alloys (Zn-Al eutectoid, Al-Cu, Pb-Sn, Sn-Bi, Mg-Al eutectics). The plastic deformation of the superplastic alloys could be described by two Maxwell models connected in parallel which represent two grain boundary flow units. The flow units are characterized by the two parameters $X_{gj}/{\alpha}_{gj}\;and\;{\beta}_{gj}$ (j=l or 2, g signifies the grain boundary) the values of which were obtained by applying our flow equation [Eq. (5)] to experiment. We confirmed that our flow equation describes the superplasticity very well. The curve of strain rate sensitivity m (=${\partial}\;In\;f/{\partial}\;In\;\dot{s})\;vs.\;-In\dot{s}$, where f and s are stress and strain rate, respectively, showed two peaks corresponding to flow unit gl and g2, the separation of the two peaks is determined by the difference between ${\beta}_{g1}\;and\;{\beta}_{g2}$. The condition of superplasticity is also determined by ${\beta}_{gj}$, which satisfies $\dot{s}_{mj}{\leqslant}1.53}{\beta}_{gj}$ [Eq.(13)], where $\dot{s}_{mj}$ is the s of the jth unit at the peak. The grain size dependence of ${\beta}_{gj}$ is described by $ln({\beta}_{gj})^{-1}$=alnx+b [Eq. (16)], where x is the grain size, and a and b are constants. The activation enthalpy for each flow unit, ${\Delta}H_{gj}^{\neq}$ was also determined from the temperature dependence of ${\beta}_{gj}$ which is proportional to the relaxation time of the j th unit. Since the superplasticity is determined by Eq. (13), and since ${\beta}_{gj}$ and ${\Delta}H_{gj}^{\neq}$ are related, we obtained the conclusion that superplasticity occurs in the system having small ${\Delta}H_{gj}^{\neq}$ values. The Aej values were equal to the activation enthalpies of grain boundary self-diffusion of the component atoms of the alloys, this accords with our proposed flow mechanism. The ${\Delta}H_{gj}^{\neq}$ value increases with grain size as expected from Eq. (16).

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S100ß, Matrix Metalloproteinase-9, D-dimer, and Heat Shock Protein 70 Are Serologic Biomarkers of Acute Cerebral Infarction in a Mouse Model of Transient MCA Occlusion

  • Choi, Jong-Il;Ha, Sung-Kon;Lim, Dong-Jun;Kim, Sang-Dae;Kim, Se-Hoon
    • Journal of Korean Neurosurgical Society
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    • v.61 no.5
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    • pp.548-558
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    • 2018
  • Objective : Diagnosing acute cerebral infarction is crucial in determining prognosis of stroke patients. Although many serologic tests for prompt diagnosis are available, the clinical application of serologic tests is currently limited. We investigated whether $S100{\beta}$, matrix metalloproteinase-9 (MMP-9), D-dimer, and heat shock protein 70 (HSP70) can be used as biomarkers for acute cerebral infarction. Methods : Focal cerebral ischemia was induced using the modified intraluminal filament technique. Mice were randomly assigned to 30-minute occlusion (n=10), 60-minute occlusion (n=10), or sham (n=5) groups. Four hours later, neurological deficits were evaluated and blood samples were obtained. Infarction volumes were calculated and plasma $S100{\beta}$, MMP-9, D-dimer, and HSP70 levels were measured using enzyme-linked immunosorbent assay. Results : The average infarction volume was $12.32{\pm}2.31mm^3$ and $46.9{\pm}7.43mm^3$ in the 30- and 60-minute groups, respectively. The mean neurological score in the two ischemic groups was $1.6{\pm}0.55$ and $3.2{\pm}0.70$, respectively. $S100{\beta}$, MMP-9, and HSP70 expressions significantly increased after 4 hours of ischemia (p=0.001). Furthermore, $S100{\beta}$ and MMP-9 expressions correlated with infarction volumes (p<0.001) and neurological deficits (p<0.001). There was no significant difference in D-dimer expression between groups (p=0.843). The area under the receiver operating characteristic curve (AUC) showed high sensitivity and specificity for MMP-9, HSP70 (AUC=1), and $S100{\beta}$ (AUC=0.98). Conclusion : $S100{\beta}$, MMP-9, and HSP70 can complement current diagnostic tools to assess cerebral infarction, suggesting their use as potential biomarkers for acute cerebral infarction.

The Study of Analytical Chemistry of the Modification of Manganese Dioxide (Report one). The Study of ${\alpha},{\beta},{\gamma}\;and\;{\delta}-MnO_2$ by Differential Heating Curves (變態二酸化망간의 分析化學的 硏究 (第一報). ${\alpha},{\beta},{\gamma}$${\delta}-MnO_2$ 의 示差熱曲線에 對한 考察)

  • Chan Ho Kim
    • Journal of the Korean Chemical Society
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    • v.15 no.5
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    • pp.236-241
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    • 1971
  • Various modifications of manganese dioxide have been discussed in terms of the chemical analysis by differential heating curve. The transformation temperatures of the modifications were observed as follows; ${\alpha}-\;and\;{\beta}-MnO_2$ are both $580^{\circ}C∼650^{\circ}C$, ${\gamma}-MnO_2$is is $405^{\circ}C~605^{\circ}C$ and ${\delta}-MnO_2$is $860^{\circ}C~875^{\circ}C$, respectively. Endothermic peaks appeared at the transformation temperatures mentioned above. The restoration temperatures of transformation is completed depending on the amounts of the given samples, but the temperatures of the top of endothermic peaks are nearly constant. The curves of ${\alpha}-,{\beta}-MnO_2$and ${\delta}-MnO_2$ show small peaks while that of ${\gamma}-MnO_2$ shows a sharp and broad peak.

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The Inclusion Complex Formation of Cyclodextrin and Congo Red in Aqueous Solution (수용액상에서 Cyclodextrin과 Congo Red 간의 복합체 형성)

  • Kim, Chang Suk;Kim, Dong Won;Bahn, Woo Kyoung
    • Analytical Science and Technology
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    • v.15 no.2
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    • pp.115-119
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    • 2002
  • The formation of inclusion complexes between cyclodextrin(CD) and Congo red was studied by spectrophotometric methods at various temperatures. The cavity sizes are 0.49 nm, 0.62 nm for $\alpha$-and $\beta$-CD, respectively. Therefore, $\alpha$-CD was not found to form an inclusion complex with Congo red due to steric hinderance. In the $\beta$-CD use two $\beta$-CD molecules formed an inclusion complex with one molecule of Congo red, from the slope of the S-shaped curve increased. Two prominent isosbestic points appear at 346 nm and 478 nm. The formation constants were decreased with the increasing temperatures, due to low binding energy between $\beta$-CD and Congo red. The thermodynamic parameters were calculated from the plot of $lnK_f$ vs 1/T. The $\Delta$H, $\Delta$S and $\Delta$G were -50.73 kJ/mol, $-108.96J/K{\cdot}mol$ and -18.26 kJ/mol, respectively.

An Analysis on Treatment Schedule of Carbon Ion Therapy to Early Stage Lung Cancer

  • Sakata, Suoh;Miyamoto, Tadaaki;Tujii, Hirohiko
    • Proceedings of the Korean Society of Medical Physics Conference
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    • 2002.09a
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    • pp.174-176
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    • 2002
  • A total of 134 patients with stage 1 of non-small cell lung cancer treated by carbon ion beam of HIMAC NIRS were investigated for control rate and delivered dose. The delivered dose of every patient was converted to biological effective dose (BED) of LQ model using fraction number, dose per fraction and alpha beta ratio which shows the maximum correlation between BED and tumor control. The BED of every patient was classified to establish a BED response curve for control. Assuming fraction numbers, dose response curves were introduced from BED response curve. The total doses to realize several control rates were obtained for the treatment of small fraction number.

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A Study of Pattern Making System by Personal Computer - For Sleeve Design - (Personal Computer를 이용한 의복설계(衣服設計) System에 관한 연구(硏究) - Sleeve Design의 Pattern화(化)에 대하여 -)

  • Cho, Young-A;Hayashi, Takaka
    • Journal of the Korean Society of Costume
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    • v.12
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    • pp.68-86
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    • 1988
  • This paper is described about applied method of personal computer for clothes-patterns. The personal Computer (Fijitsu FM-$16{\beta}$) and X-Y Plotter (GRAPHTEC GP-9101 R) were used in this study. It is studied to draft of sleeve designs automartically in this paper. The Basic Language is used and the programs were main program and subroutine programs. The results are as follows; 1) The Y's system of sleeve sloper is selected in this study. 2) The co-ordinate points were indicated relative location of all necessary in drafting of sleeve designs. 3) In the variations of sleeve sloper, Puff sleeve and Raglan sleeve were selected. Programs for drafting of them were developed. 4) About the drafting of Raglan curve, it is gotten adequate curve using sprine function. 5) Clothes-Pattern are making very correctly and quickly by using computer.

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Impact of Parameters of Nonlinear Breach Progression Curve on Outflow Rate (저수지 붕괴함수의 매개변수 결정이 유량과 침수범위에 미치는 영향)

  • Lee, Khil-Ha
    • Journal of Environmental Science International
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    • v.28 no.2
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    • pp.211-217
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    • 2019
  • A Numerical modeling approach is usually applied to reproduce the physical phenomena of a fill dam-break. The accuracy of the dam-break model depends on the physical structure that defines input variables such as the storage volume, breach formation and progress, and the parameters of the model, which are subjective as they are prescribed by users. In this study, a sensitivity analysis was performed for the nonlinear breach progression curve that was already developed, which includes four parameters. The study focuses on the two of the parameters which control the breach forming time and peak discharge. The model is coupled with a two-dimensional flood simulation model (FLO-2D) to examine flood coverage and depth. It is generally observed that the parameter ${\beta}$ controls only the breach forming time, the parameter ${\gamma}$ is particularly sensitive to the peak flow.

Evaluation of Effectiveness on Delineation System Using Virtual Driving Simulator (가상주행 시뮬레이터를 활용한 시선유도시설 효과평가 연구)

  • Park, Jejin;Kim, Ducknyung;Park, Yongjin;Song, Wonchul
    • International Journal of Highway Engineering
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    • v.19 no.5
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    • pp.163-171
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    • 2017
  • PURPOSES : Traffic safety facilities are used to prevent traffic accidents before they occur by providing drivers with information on traffic situations and the geometric design of roads. However, some facilities not defined in guidelines do not meet installation criteria, yet are being installed and used in order to increase efficiency in traffic flow and prevent traffic accidents in a specific expressway zone. In this study, we have evaluated the effect of delineation system which are not defined in the guideline criteria. METHODS : Different virtual scenarios were created for roads using expressway median barrier chevron signs, with a driving simulator used to evaluate the installation and operational effect of such signs. Ten experiments were performed with left- and right-curved roads at curve radius intervals of 500 m, from 500 m to 2,500 m. RESULTS : For sections with a curve radius of more than 1,500 m, drivers had a clear tendency toward stable driving regardless of delineation system. When a chevron sign is installed on a protection fence in the road curving left, an expanded installation is recommended up to the section with a curve radius of 1,000 m. According to the analysis results for the RHB (Relative High Beta spectrum), driving concentration also improved up to a curve radius of 1,000 m. CONCLUSIONS :The experiment result indicates the extent of biasing within a lane and the manipulation amount of steering handle, were analyzed and found to be affected by curve radius and road alignment regardless of delineation system.